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DEXMEDETOMIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • DEXMEDETOMIDINE chembl:CHEMBL778 Approved

    Alternate Names:

    MPV-1440
    DEXMEDETOMIDINE
    PRECEDEX
    MPV 1440
    DEXMEDETOMIDINA
    (+)-MEDETOMIDINE
    DEXMÉDÉTOMIDINE
    DEXMEDETOMIDINUM
    DEXMEDETOMIDIN
    (+)-4-((S)-ALPHA,2,3-TRIMETHYLBENZYL)IMIDAZOLE
    (S)-MEDETOMIDINE
    PRECEDEX®
    chembl:CHEMBL778
    pubchem.compound:5311068
    chemidplus:113775-47-6
    drugbank:00633
    rxcui:48937

    Drug Info:

    Year of Approval 1999
    Drug Class hypnotics and sedatives
    Drug Class analgesics
    FDA Approval 1999
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Drug Indications Analgesics
    Drug Categories agents producing tachycardia
    Drug Categories agents that produce hypertension
    Drug Categories anesthetics
    Drug Categories anesthetics, general
    Drug Categories central alpha-2 adrenergic agonist
    Drug Categories cytochrome p-450 cyp1a2 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories miscellaneous anxiolytics sedatives and hypnotics
    (4 More Sources)

    Publications:

    Ozdogan et al., 2004, The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice., Eur. J. Pharmacol.
    Scheibner et al., 2002, Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice., Br. J. Pharmacol.
    Davies et al., 2004, Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala., Neuropsychopharmacology
    Fairbanks et al., 2002, alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy., J. Pharmacol. Exp. Ther.
    Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep
    Menon et al., 2007, Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans., J. Am. Coll. Cardiol.
    Dawson et al., 2004, Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action., Anesthesiology
  • DEXMEDETOMIDINE   ADRA2A

    Interaction Score: 0.68

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Partial agonist

    PMIDs:
    15306201 11834617 14583739 11752127 21104443 17692748 15087625


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • DEXMEDETOMIDINE   PRKCB

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DEXMEDETOMIDINE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DEXMEDETOMIDINE   ADRA2C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DEXMEDETOMIDINE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEXMEDETOMIDINE   CYP2C19

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEXMEDETOMIDINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEXMEDETOMIDINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00633

    • Version: 5.1.7

    Alternate Names:
    DEXMEDETOMIDINE DrugBank Drug Name
    113775-47-6 CAS Number
    Dexdor Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups vet_approved

    Publications:
    Ozdogan et al., 2004, The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice., Eur. J. Pharmacol.
    Scheibner et al., 2002, Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice., Br. J. Pharmacol.
    Davies et al., 2004, Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala., Neuropsychopharmacology

  • TEND: DEXMEDETOMIDINE

    • Version: 01-August-2011

    Alternate Names:
    DEXMEDETOMIDINE Primary Drug Name

    Drug Info:
    Drug Class analgesics
    Drug Class hypnotics and sedatives
    Year of Approval 1999

    Publications:

  • TdgClinicalTrial: DEXMEDETOMIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Analgesics
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule

    Publications:

  • PharmGKB: dexmedetomidine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep

  • DTC: DEXMEDETOMIDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL778 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Dexmedetomidine

    • Version: 2020.06.01

    Alternate Names:
    D0U3DU TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650174

    • Version: 29-September-2020

    Alternate Names:
    DEXMEDETOMIDINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL778

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21