DGIdb - DEXMEDETOMIDINE Drug Record

DEXMEDETOMIDINE chembl:CHEMBL778 Approved

Alternate Names:

MPV-1440
DEXMEDETOMIDINE
PRECEDEX
MPV 1440
DEXMEDETOMIDINA
(+)-MEDETOMIDINE
DEXMÉDÉTOMIDINE
DEXMEDETOMIDINUM
DEXMEDETOMIDIN
(+)-4-((S)-ALPHA,2,3-TRIMETHYLBENZYL)IMIDAZOLE
(S)-MEDETOMIDINE
PRECEDEX®
chembl:CHEMBL778
pubchem.compound:5311068
chemidplus:113775-47-6
drugbank:00633
rxcui:48937

Drug Info:

Year of Approval	1999
Drug Class	hypnotics and sedatives
Drug Class	analgesics
FDA Approval	1999
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Indications	Analgesics
Drug Categories	agents producing tachycardia
Drug Categories	agents that produce hypertension
Drug Categories	anesthetics
Drug Categories	anesthetics, general
Drug Categories	central alpha-2 adrenergic agonist
Drug Categories	cytochrome p-450 cyp1a2 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	miscellaneous anxiolytics sedatives and hypnotics

(4 More Sources)

Publications:

Scheibner et al., 2002, Alpha 2-adrenoceptors in the enteric nervous system: a study in alpha 2A-adrenoceptor-deficient mice., Br. J. Pharmacol.
Dawson et al., 2004, Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action., Anesthesiology
Ozdogan et al., 2004, The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice., Eur. J. Pharmacol.
Fairbanks et al., 2002, alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy., J. Pharmacol. Exp. Ther.
Davies et al., 2004, Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala., Neuropsychopharmacology
Menon et al., 2007, Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans., J. Am. Coll. Cardiol.
Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep

DEXMEDETOMIDINE ADRA2A

Interaction Score: 0.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Partial agonist

PMIDs:
11834617 15087625 15306201 11752127 14583739 17692748 21104443

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD
DEXMEDETOMIDINE PRKCB

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DEXMEDETOMIDINE ADRA2B

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
DEXMEDETOMIDINE ADRA2C

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
DEXMEDETOMIDINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXMEDETOMIDINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXMEDETOMIDINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEXMEDETOMIDINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00633

Version: 5.1.7

Alternate Names:

DEXMEDETOMIDINE DrugBank Drug Name

113775-47-6 CAS Number

Dexdor Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

Dawson et al., 2004, Dexmedetomidine enhances analgesic action of nitrous oxide: mechanisms of action., Anesthesiology

Ozdogan et al., 2004, The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice., Eur. J. Pharmacol.

Fairbanks et al., 2002, alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy., J. Pharmacol. Exp. Ther.

TEND: DEXMEDETOMIDINE
- Version: 01-August-2011
Alternate Names:

DEXMEDETOMIDINE Primary Drug Name

Drug Info:

Drug Class analgesics

Drug Class hypnotics and sedatives

Year of Approval 1999

Publications:
TdgClinicalTrial: DEXMEDETOMIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Analgesics

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:
PharmGKB: dexmedetomidine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep
DTC: DEXMEDETOMIDINE
- Version: 02-September-2020
Alternate Names:

CHEMBL778 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Dexmedetomidine
- Version: 2020.06.01
Alternate Names:

D0U3DU TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650174
- Version: 29-September-2020
Alternate Names:

DEXMEDETOMIDINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL778
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Partial agonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	True

DEXMEDETOMIDINE	DrugBank Drug Name
113775-47-6	CAS Number
Dexdor	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

DEXMEDETOMIDINE Drug Record

DEXMEDETOMIDINE chembl:CHEMBL778 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Partial agonist

PMIDs: 11834617 15087625 15306201 11752127 14583739 17692748 21104443

Sources: DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00633

Alternate Names: DEXMEDETOMIDINE DrugBank Drug Name 113775-47-6 CAS Number Dexdor Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups vet_approved

TEND: DEXMEDETOMIDINE

Alternate Names: DEXMEDETOMIDINE Primary Drug Name

Drug Info: Drug Class analgesics Drug Class hypnotics and sedatives Year of Approval 1999

Publications:

TdgClinicalTrial: DEXMEDETOMIDINE

Alternate Names:

Drug Info: Drug Indications Analgesics Drug Indications Hypnotics and Sedatives Drug Class small molecule

Publications:

PharmGKB: dexmedetomidine

Alternate Names:

Drug Info:

Publications: Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep

DTC: DEXMEDETOMIDINE

Alternate Names: CHEMBL778 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Dexmedetomidine

Alternate Names: D0U3DU TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135650174

Alternate Names: DEXMEDETOMIDINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL778

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Partial agonist

PMIDs:
11834617 15087625 15306201 11752127 14583739 17692748 21104443

Sources:
DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DEXMEDETOMIDINE DrugBank Drug Name

113775-47-6 CAS Number

Dexdor Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Alternate Names:

DEXMEDETOMIDINE Primary Drug Name

Drug Info:

Drug Class analgesics

Drug Class hypnotics and sedatives

Year of Approval 1999

Drug Info:

Drug Indications Analgesics

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

Publications:

Yağar S et al., 2011, The role of the ADRA2A C1291G genetic polymorphism in response to dexmedetomidine on patients undergoing coronary artery surgery., Mol Biol Rep

Alternate Names:

CHEMBL778 ChEMBL Drug ID

Alternate Names:

D0U3DU TTD Drug ID

Alternate Names:

DEXMEDETOMIDINE GuideToPharmacology Ligand Name