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DEXAMETHASONE Drug Record

  • Summary
  • Interactions
  • Claims
  • DEXAMETHASONE chembl:CHEMBL384467 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    SPERSADEX COMP
    GPPE EAR SPY
    OZURDEX
    DECADRON
    DROPODEX
    DEXTENZA
    DECADRON-LA
    ISV-305
    FLUORMETHYLPREDNISOLONE
    DEXONE 0.5
    DEXACORTISYL
    OTO-104
    DEXONE 0.75
    DEXAFREE
    DEXONE 4
    MARTAPAN
    DECADRON-75
    DEXAMETHASONE
    DECASPRAY
    HEXADROL
    DEXAIR
    DEXACORT
    KORTICO INJECTION
    NSC-34521
    DEXAMETHASONE METASULFOBENZOATE SODIUM
    DEXYCU KIT
    OTOMIZE
    DEXAMETHASONE INTENSOL
    ORADEXON
    DEXONE 1.5
    NEODECADRON
    SOFRADEX
    DEXAMETHASONE VALERATE
    DEXONE
    DECADERM
    MAXITROL
    DEXACEN-4
    DEXAMETHASONE PALMITATE
    DALALONE
    MYMETHASONE
    TOBRADEX
    AEROSEB-DEX
    DEXSOL
    MAXIDEX
    DXM833
    DESAMETASONE
    DECADRON®
    chembl:CHEMBL384467
    drugbank:01234
    rxcui:3264
    pubchem.compound:5743
    chemidplus:50-02-2

    Drug Info:

    Drug Class Small Molecule
    FDA Approval approved
    Drug Indications antiinflammatory agent,glucocorticoid,for treatment of Meniere's disease
    Drug Class anti-inflammatory agents
    Year of Approval approved before 1982
    Drug Class glucocorticoids
    (6 More Sources)

    Publications:

    Hahn et al., 1990, Basement membrane components are potent promoters of rat intestinal epithelial cell differentiation in vitro., Gastroenterology
    Smith et al., 2000, Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes., J. Biol. Chem.
    Toebak et al., 2008, Differential suppression of dendritic cell cytokine production by anti-inflammatory drugs., Br. J. Dermatol.
    Yang JJ et al., 2012, Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia., Blood
    Alliot-Licht et al., 2005, Dexamethasone stimulates differentiation of odontoblast-like cells in human dental pulp cultures., Cell Tissue Res.
    Gummow et al., 2006, Reciprocal regulation of a glucocorticoid receptor-steroidogenic factor-1 transcription complex on the Dax-1 promoter by glucocorticoids and adrenocorticotropic hormone in the adrenal cortex., Mol. Endocrinol.
    Grote et al., 1983, No correlation between binding of glucocorticosteroids to specific cytoplasmic proteins in vivo and enzyme induction in the rat liver., Biochem. J.
    Uemura et al., 2006, Renin-angiotensin system is an important factor in hormone refractory prostate cancer., Prostate
    Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood
    Teisner et al., 1981, Serum levels of the "pregnancy-zone protein" during short-term prenatal dexamethasone therapy., Acta Obstet Gynecol Scand
    Rachwal et al., 1995, Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomas., Br. J. Cancer
    Arany et al., 1993, Interactive effects of nutrients and hormones on the expression of insulin-like growth factor binding protein-1 (IGFBP-1) mRNA and peptide, and IGF I release from isolated adult rat hepatocytes., J. Cell. Physiol.
    Brismar et al., 1991, The insulin-like growth factor binding protein-1 in low and high insulin responders before and during dexamethasone treatment., Metab. Clin. Exp.
    Nakayama et al., 1994, Dexamethasone enhancement of betaglycan (TGF-beta type III receptor) gene expression in osteoblast-like cells., Exp. Cell Res.
    Edwards et al., 1987, Modulation of gamma-glutamyltranspeptidase in normal rat hepatocytes in culture by cell density, epidermal growth factor and agents which alter cell differentiation., Carcinogenesis
    Himes BE et al., 2014, RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells., PLoS One
    Kumar et al., 1998, Differential regulation of SP-A1 and SP-A2 genes by cAMP, glucocorticoids, and insulin., Am. J. Physiol.
    Dulkerian et al., 1996, Regulation of surfactant protein D in human fetal lung., Am. J. Respir. Cell Mol. Biol.
    Asabe et al., 1996, Maternal dexamethasone treatment enhances the expression of surfactant apoprotein A in the hypoplastic lung of rabbit fetuses induced by oligohydramnios., J. Pediatr. Surg.
    Chroneos et al., 1995, Differential regulation of the mannose and SP-A receptors on macrophages., Am. J. Physiol.
    O'Reilly et al., 1988, Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line., Biochim. Biophys. Acta
    Liley et al., 1988, Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung., Proc. Natl. Acad. Sci. U.S.A.
    O'Reilly et al., 1989, Glucocorticoids regulate surfactant protein synthesis in a pulmonary adenocarcinoma cell line., Am. J. Physiol.
    Schellhase et al., 1991, Effects of maternal dexamethasone on expression of SP-A, SP-B, and SP-C in the fetal rat lung., Am. J. Respir. Cell Mol. Biol.
    Ohashi et al., 1991, Effect of dexamethasone on pulmonary surfactant metabolism in hyperoxia-treated rat lungs., Pediatr. Res.
    Mouhieddine-Gueddiche et al., 2003, Dexamethasone potentiates keratinocyte growth factor-stimulated SP-A and SP-B gene expression in alveolar epithelial cells., Pediatr. Res.
    Nakamura et al., 2000, Mechanical strain and dexamethasone selectively increase surfactant protein C and tropoelastin gene expression., Am. J. Physiol. Lung Cell Mol. Physiol.
    Butrym A et al., 2015, Polymorphisms within beta-catenin encoding gene affect multiple myeloma development and treatment., Leuk Res
    Zhang et al., Shear stress induction of C-type natriuretic peptide (CNP) in endothelial cells is independent of NO autocrine signaling., Ann Biomed Eng
    Barbour et al., 1988, Glucocorticoid regulation of the genes encoding thymidine kinase, thymidylate synthase, and ornithine decarboxylase in P1798 cells., Mol. Endocrinol.
    Tsukamoto et al., 1989, Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat., Gut
    Rhee et al., 1995, c-Myc and cyclin D3 (CcnD3) genes are independent targets for glucocorticoid inhibition of lymphoid cell proliferation., Cancer Res.
    Bortolozzi R et al., 2018, Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All)., Biochem Pharmacol
    Lehman-McKeeman et al., 1988, Induction of hepatic metallothioneins determined at isoprotein and messenger RNA levels in glucocorticoid-treated rats., Biochem. J.
    Krawiec et al., 2007, AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells., Am. J. Physiol. Endocrinol. Metab.
    He et al., 2006, Expression of survivin gene in apoptosis induced by dexamethasone in CEM cells., Zhongguo Dang Dai Er Ke Za Zhi
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Suarez et al., 1995, Expression and modulation of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid in skin fibroblasts from patients with type Ib pseudohypoparathyroidism., J. Clin. Endocrinol. Metab.
    Grummer et al., 1995, Postnatal rat lung retinoic acid receptor (RAR) mRNA expression and effects of dexamethasone on RAR beta mRNA., Pediatr. Pulmonol.
    Wang et al., 2007, Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor., Am. J. Physiol., Cell Physiol.
    Funato et al., 2006, Differential effects of antidepressants on dexamethasone-induced nuclear translocation and expression of glucocorticoid receptor., Brain Res.
    Grossman et al., 2006, Cognitive effects of intravenous hydrocortisone in subjects with PTSD and healthy control subjects., Ann. N. Y. Acad. Sci.
    Vaitkuviene et al., Study of the interaction of 1,4-dihydropyridine derivatives with glucocorticoid hormone receptors from the rat liver., Pharmacol Rep
    Warne et al., 2006, Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue., Am. J. Physiol. Endocrinol. Metab.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother
    Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem
    Caperuto et al., 2006, Distinct regulation of IRS proteins in adipose tissue from obese aged and dexamethasone-treated rats., Endocrine
    Singer et al., 1994, Relationship of serine/threonine phosphorylation/dephosphorylation signaling to glucocorticoid regulation of tight junction permeability and ZO-1 distribution in nontransformed mammary epithelial cells., J. Biol. Chem.
    Ki et al., 2005, Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression., Mol. Cell. Biol.
    Lecanda et al., 2000, Differential regulation of cadherins by dexamethasone in human osteoblastic cells., J. Cell. Biochem.
    de Waziers et al., 1992, Effects of ethanol, dexamethasone and RU 486 on expression of cytochromes P450 2B, 2E, 3A and glutathione transferase pi in a rat hepatoma cell line (Fao)., Pharmacogenetics
    Wang et al., 1995, Effects of dexamethasone on the synthesis, degradation, and secretion of apolipoprotein B in cultured rat hepatocytes., Arterioscler. Thromb. Vasc. Biol.
    Yao et al., 1999, Dexamethasone alters arachidonate release from human epithelial cells by induction of p11 protein synthesis and inhibition of phospholipase A2 activity., J. Biol. Chem.
    Williams et al., 1975, Acute effects of corticosteroids on thyroid activity in Graves' disease., J. Clin. Endocrinol. Metab.
    Yamasaki S et al., 2015, UGT1A1 *6 polymorphism predicts outcome in elderly patients with relapsed or refractory diffuse large B-cell lymphoma treated with carboplatin, dexamethasone, etoposide and irinotecan., Ann Hematol
    Testolin et al., 1997, Jun and JNK kinase are activated in thymocytes in response to VM26 and radiation but not glucocorticoids., Exp. Cell Res.
    French D et al., 2008, A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group., Blood
    Jump et al., 1993, Polyunsaturated fatty acids inhibit S14 gene transcription in rat liver and cultured hepatocytes., Proc. Natl. Acad. Sci. U.S.A.
    Hayasaka et al., 1978, Effects of epinephrine, indomethacin, acetylsalicyclic acid, dexamethasone, and cyclic AMP on the in vitro activity of lysosomal hyaluronidase from the rabbit iris., Invest. Ophthalmol. Vis. Sci.
    Cheng et al., 1995, Dexamethasone enhances accumulation of cholesteryl esters by human macrophages., Am. J. Physiol.
    Li et al., 1995, Effects of dexamethasone, heat shock, and serum responses on the inhibition of Hsc70 synthesis by antisense RNA in NIH 3T3 cells., J. Cell. Physiol.
    Yang et al., 2004, Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis., Arthritis Rheum.
    Davies et al., 2007, Expression and externalization of annexin 1 in the adrenal gland: structure and function of the adrenal gland in annexin 1-null mutant mice., Endocrinology
    Wang et al., 2007, Involvement of annexin I in the dexamethasone-mediated upregulation of A549 cells phagocytosis of apoptotic eosinophils., Immunol. Lett.
    Morand et al., 2006, Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1., Mediators Inflamm.
    John et al., 2006, Time-specific effects of perinatal glucocorticoid treatment on anterior pituitary morphology, annexin 1 expression and adrenocorticotrophic hormone secretion in the adult female rat., J. Neuroendocrinol.
    Ohene-Abuakwa et al., 2005, Two-phase culture in Diamond Blackfan anemia: localization of erythroid defect., Blood
    Nishikawa et al., 2005, Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro., Am. J. Pathol.
    Saporito et al., 1994, Systemic dexamethasone administration increases septal Trk autophosphorylation in adult rats via an induction of nerve growth factor., Mol. Pharmacol.
    Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.
    Perez-Andreu V et al., 2013, Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse., Nat Genet
    Michelini FM et al., 2013, Immunomodulatory activity of an anti-HSV-1 synthetic stigmastane analog., Bioorg Med Chem
    Favis R et al., 2011, Genetic variation associated with bortezomib-induced peripheral neuropathy., Pharmacogenet Genomics
    Wuthrich et al., 1993, Effect of dexamethasone, 6-mercaptopurine and cyclosporine A on intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression., Biochem. Pharmacol.
    Höfken et al., 1998, Membrane dipeptidase and glutathione are major components of pig pancreatic zymogen granules., Exp. Cell Res.
    Wang et al., 2004, Enhanced expression of cytosolic fatty acid binding protein and fatty acid uptake during liver regeneration in rats., Mol. Cell. Biochem.
    Rajaraman et al., 2004, Effect of dexamethasone, 2-bromopalmitate and clofibrate on L-FABP mediated hepatoma proliferation., J. Pharm. Pharmacol.
    Maeda et al., 2002, TEF-1 transcription factors regulate activity of the mouse mammary tumor virus LTR., Biochem. Biophys. Res. Commun.
    Sugimoto et al., 2002, Morphological changes induced by extracellular matrix are correlated with maturation of rat small hepatocytes., J. Cell. Biochem.
    Smit et al., 2005, Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2., J. Clin. Endocrinol. Metab.
    Muller et al., 2003, Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+., J. Am. Soc. Nephrol.
    Mazzucconi et al., 1999, Acquired inhibitor against factor IX in a child: successful treatment with high-dose immunoglobulin and dexamethasone., Haemophilia
    Meetze et al., 1993, Ontogeny of small intestinal glutaminase and glutamine synthetase in the rat: response to dexamethasone., Biol. Neonate
    Orlikowsky et al., 2005, Effect of dexamethasone on B7 regulation and T cell activation in neonates and adults., Pediatr. Res.
    Ebert et al., 2005, An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray., Blood
    Vrang et al., 2003, Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids., Brain Res.
    Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.
    Wattanathorn et al., 1996, Ethanol alone or with dexamethasone alters the kinetics of choline acetyltransferase., Eur. J. Pharmacol.
    Kretschmer XC et al., 2005, CAR and PXR: xenosensors of endocrine disrupters?, Chem Biol Interact
    Mackiewicz et al., 1993, Leukemia inhibitory factor, interferon gamma and dexamethasone regulate N-glycosylation of alpha 1-protease inhibitor in human hepatoma cells., Eur. J. Cell Biol.
    Hundertmark et al., 1999, Effect of epidermal growth factor on enzymes of phospholipid biosynthesis in lung and liver of fetal rat in vivo and in vitro., Horm. Metab. Res.
    Chan et al., 1987, Cyclosporine and dexamethasone inhibit T-lymphocyte MHC class II antigens and IL-2 receptor expression in experimental autoimmune uveitis., Immunol. Invest.
    Capes-Davis et al., 1999, Glucocorticoids differentially inhibit expression of the RET proto-oncogene., Gene Expr.
    Iu et al., 2005, Dexamethasone suppresses Smad3 pathway in osteoblastic cells., J. Endocrinol.
    Jakobsen Falk I et al., 2018, Pharmacogenetic study of the impact of ABCB1 single-nucleotide polymorphisms on lenalidomide treatment outcomes in patients with multiple myeloma: results from a phase IV observational study and subsequent phase II clinical trial., Cancer Chemother Pharmacol
    Maggini V et al., 2008, MDR1 diplotypes as prognostic markers in multiple myeloma., Pharmacogenet Genomics
    Ames SK et al., 1999, Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children., J Bone Miner Res
    Elnenaei MO et al., 2011, Genomic and metabolomic patterns segregate with responses to calcium and vitamin D supplementation., Br J Nutr
    Jehan F et al., 2008, Vitamin D receptor genotype in hypophosphatemic rickets as a predictor of growth and response to treatment., J Clin Endocrinol Metab
    Abrams SA et al., 2005, Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty., J Bone Miner Res
    Halsall JA et al., 2005, Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis., Pharmacogenet Genomics
    Tran et al., 2005, Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting., Cancer Res.
    Haber et al., 1992, Role of glucose transporters in glucocorticoid-induced insulin resistance. GLUT4 isoform in rat skeletal muscle is not decreased by dexamethasone., Diabetes
  • DEXAMETHASONE   RPS19

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15755903


    Sources:
    NCI

  • DEXAMETHASONE   SDS

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12210718


    Sources:
    NCI

  • DEXAMETHASONE   TEAD1

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12207913


    Sources:
    NCI

  • DEXAMETHASONE   S100A10

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10358078


    Sources:
    NCI

  • DEXAMETHASONE   UBR1

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17264220


    Sources:
    NCI

  • DEXAMETHASONE   CRISPLD2

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24926665


    Sources:
    PharmGKB

  • DEXAMETHASONE   ACTC1

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15988617


    Sources:
    NCI

  • DEXAMETHASONE   TSC22D3

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15728202 12707381


    Sources:
    NCI

  • DEXAMETHASONE   SFTPA1

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9486201 8969273 8906664 8572233 3382698 3194412 2610267 2015097 2014154 12538780 10781428


    Sources:
    NCI

  • DEXAMETHASONE   CHKA

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10077342


    Sources:
    NCI

  • DEXAMETHASONE   FABP1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15532708 15324484


    Sources:
    NCI

  • DEXAMETHASONE   KRT19

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15793288


    Sources:
    NCI

  • DEXAMETHASONE   HYAL2

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    212383


    Sources:
    NCI

  • DEXAMETHASONE   JUNB

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9024781


    Sources:
    NCI

  • DEXAMETHASONE   MT1F

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3342021


    Sources:
    NCI

  • DEXAMETHASONE   TGFBR3

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8143777


    Sources:
    NCI

  • DEXAMETHASONE   TDO2

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6136271


    Sources:
    NCI

  • DEXAMETHASONE   DPEP1

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9806799


    Sources:
    NCI

  • DEXAMETHASONE   CDH17

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10760957


    Sources:
    NCI

  • DEXAMETHASONE   IRS2

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16943575


    Sources:
    NCI

  • DEXAMETHASONE   PYGL

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23007406


    Sources:
    PharmGKB

  • DEXAMETHASONE   CARTPT

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12591118


    Sources:
    NCI

  • DEXAMETHASONE   VCAM1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7694584


    Sources:
    NCI

  • DEXAMETHASONE   THRSP

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8378318


    Sources:
    NCI

  • DEXAMETHASONE   TJP1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8206910


    Sources:
    NCI

  • DEXAMETHASONE   PZP

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7246081


    Sources:
    NCI

  • DEXAMETHASONE   SAG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3123380


    Sources:
    NCI

  • DEXAMETHASONE   LOH19CR1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15238419


    Sources:
    NCI

  • DEXAMETHASONE   SOAT1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7485476


    Sources:
    NCI

  • DEXAMETHASONE   SI

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2295387


    Sources:
    NCI

  • DEXAMETHASONE   ANXA1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    15022342 17158208 17644190 16883066 17076770


    Sources:
    NCI TEND

  • DEXAMETHASONE   IGFBP1

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7683312 1714534


    Sources:
    NCI

  • DEXAMETHASONE   CD86

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15718366


    Sources:
    NCI

  • DEXAMETHASONE   F9

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10215963


    Sources:
    NCI

  • DEXAMETHASONE   CCL17

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18028503


    Sources:
    NCI

  • DEXAMETHASONE   PTH1R

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7883858


    Sources:
    NCI

  • DEXAMETHASONE   NR5A1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16857744


    Sources:
    NCI

  • DEXAMETHASONE   FOLR1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15899836


    Sources:
    NCI

  • DEXAMETHASONE   CHAT

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8905330


    Sources:
    NCI

  • DEXAMETHASONE   BMP7

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • DEXAMETHASONE   LINC00251

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • DEXAMETHASONE   NPPC

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10468226


    Sources:
    NCI

  • DEXAMETHASONE   DOK5

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26590194


    Sources:
    PharmGKB

  • DEXAMETHASONE   LIF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8392465


    Sources:
    NCI

  • DEXAMETHASONE   GATA3

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24141364


    Sources:
    PharmGKB

  • DEXAMETHASONE   HSPA8

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7542664


    Sources:
    NCI

  • DEXAMETHASONE   CDK4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7664296 29408328


    Sources:
    NCI CIViC

  • DEXAMETHASONE   CDK6

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29408328


    Sources:
    CIViC

  • DEXAMETHASONE   NOTCH1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Dexamethasone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • DEXAMETHASONE   CTNNB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26521987


    Sources:
    PharmGKB

  • DEXAMETHASONE   CTLA4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21228734


    Sources:
    PharmGKB

  • DEXAMETHASONE   TG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1174132


    Sources:
    NCI

  • DEXAMETHASONE   APOB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7670964


    Sources:
    NCI

  • DEXAMETHASONE   GGT1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2890444


    Sources:
    NCI

  • DEXAMETHASONE   TYMS

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3398844 2707640


    Sources:
    NCI PharmGKB

  • DEXAMETHASONE   NR3C1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name dexamethasone intravitreal implant,Ozurdex, Posurdex
    Novel drug target Established target
    Trial Name EGP-437

    PMIDs:
    16971495 16956592 16891588 16963802 16835395 11752352 20308375 23276449


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • DEXAMETHASONE   SERPINE1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18285546


    Sources:
    PharmGKB

  • DEXAMETHASONE   RB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Ribociclib + Dexamethasone
    Indication/Tumor Type T-cell adult acute lymphocytic leukemia
    Response Type sensitive

    PMIDs:
    28151717


    Sources:
    JAX-CKB

  • DEXAMETHASONE   HTR7

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9166758


    Sources:
    NCI

  • DEXAMETHASONE   NRG1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7599067


    Sources:
    NCI

  • DEXAMETHASONE   TYMSOS

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DEXAMETHASONE   RARA

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8606853


    Sources:
    NCI

  • DEXAMETHASONE   BIRC5

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16787583


    Sources:
    NCI

  • DEXAMETHASONE   UGT1A1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25055799


    Sources:
    PharmGKB

  • DEXAMETHASONE   SLC2A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1587399


    Sources:
    NCI

  • DEXAMETHASONE   GSTP1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1302037


    Sources:
    NCI

  • DEXAMETHASONE   AGTR1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16482568


    Sources:
    NCI

  • DEXAMETHASONE   RELA

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23219855


    Sources:
    DTC

  • DEXAMETHASONE   NTRK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8145726


    Sources:
    NCI

  • DEXAMETHASONE   CDK2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10867026


    Sources:
    NCI

  • DEXAMETHASONE   RET

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10947080


    Sources:
    NCI

  • DEXAMETHASONE   GLS

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7904483


    Sources:
    NCI

  • DEXAMETHASONE   NR1I2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16054614


    Sources:
    PharmGKB

  • DEXAMETHASONE   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10320522 20727239 18827005 15883634 15864137


    Sources:
    PharmGKB

  • DEXAMETHASONE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29177954 18408561


    Sources:
    PharmGKB

  • DEXAMETHASONE   SMAD3

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15817834


    Sources:
    NCI

  • DEXAMETHASONE   CYP2C9

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DEXAMETHASONE   CYP2C19

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DEXAMETHASONE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15870285


    Sources:
    DTC NCI

  • DEXAMETHASONE   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DEXAMETHASONE   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DEXAMETHASONE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DEXAMETHASONE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: DEXAMETHASONE

    • Version: 01-August-2011

    Alternate Names:
    DEXAMETHASONE Primary Drug Name

    Drug Info:
    Drug Class glucocorticoids
    Year of Approval approved before 1982
    Drug Class anti-inflammatory agents

    Publications:

  • TdgClinicalTrial: DEXAMETHASONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent,glucocorticoid,for treatment of Meniere's disease
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: DEXAMETHASONE

    • Version: 14-September-2017

    Alternate Names:
    C422 NCI drug code

    Drug Info:

    Publications:
    Hahn et al., 1990, Basement membrane components are potent promoters of rat intestinal epithelial cell differentiation in vitro., Gastroenterology
    Smith et al., 2000, Glucocorticoids inhibit developmental stage-specific osteoblast cell cycle. Dissociation of cyclin A-cyclin-dependent kinase 2 from E2F4-p130 complexes., J. Biol. Chem.
    Toebak et al., 2008, Differential suppression of dendritic cell cytokine production by anti-inflammatory drugs., Br. J. Dermatol.

  • DTC: DEXAMETHASONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL384467 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem
    Bucki R et al., 2010, Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate., Antimicrob Agents Chemother

  • PharmGKB: dexamethasone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    French D et al., 2008, A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group., Blood
    Karol SE et al., 2016, Genetic risk factors for the development of osteonecrosis in children under age 10 treated for acute lymphoblastic leukemia., Blood
    Abrams SA et al., 2005, Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty., J Bone Miner Res

  • JAX-CKB: Dexamethasone

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Pikman et al., 2017, Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia., Clin. Cancer Res.

  • CIViC: DEXAMETHASONE

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Bortolozzi R et al., 2018, Ribociclib, a Cdk4/Cdk6 kinase inhibitor, enhances glucocorticoid sensitivity in B-acute lymphoblastic leukemia (B-All)., Biochem Pharmacol

  • TTD: Dexamethasone

    • Version: 2020.06.01

    Alternate Names:
    D0IT2G TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL384467

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL384467

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21