DGIdb - DESLORATADINE Drug Record

DESLORATADINE chembl:CHEMBL1172 Approved

Alternate Names:

CLARINEX
DESLORATADINE
LORATADINE RELATED COMPOUND A
MIDETORIN
NEOCLARITYN
SCH-34117
AERIUS
LORATADINE RELATED COMPOUND A RS
8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDINYLIDENE)-5H-BENZO(5,6)CYCLOHEPTA(1,2-B)PYRIDINE
DESCARBOETHOXYLORATADINE
CLARINEX®
8-CHLORO-11-PIPERIDIN-4-YLIDENE-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
8-CHLORO-6,11-DIHYDRO-11-(4-PIPERIDINYLIDENE)-5H-BENZO(5,6)CYCLOHEPTA(1,2-B)LDGACDN
rxcui:275635
chemidplus:100643-71-8
chembl:CHEMBL1172
pubchem.compound:124087
drugbank:00967

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiallergy agent
Year of Approval	2001
Drug Class	anti-allergic agents

(3 More Sources)

Publications:

Li J et al., 2020, Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria., Pharmacogenomics J
Simons et al., 2003, Efficacy and safety of desloratadine in the treatment of perennial allergic rhinitis., J. Allergy Clin. Immunol.
Cieślewicz et al., 1995, [Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction]., Pneumonol Alergol Pol
Devillier et al., 2008, Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review., Clin Pharmacokinet
Letari et al., 1994, Effects of loratadine on cytosolic Ca2+ levels and leukotriene release: novel mechanisms of action independent of the anti-histamine activity., Eur. J. Pharmacol.
Wu et al., 2004, Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor., Int. Arch. Allergy Immunol.
Dhanya et al., Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test., Indian J Dermatol Venereol Leprol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
DuBuske, 2007, Desloratadine for chronic idiopathic urticaria: a review of clinical efficacy., Am J Clin Dermatol
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Guo A et al., 2015, Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients., Arch Dermatol Res

DESLORATADINE FCER1A

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25412950

Sources:
PharmGKB
DESLORATADINE HRH1

Interaction Score: 1.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H1 receptor antagonist

Direct Interaction yes

Trial Name desloratadine , Clarinex

PMIDs:
31406237 12642846 7581058 18336052 8174605 15564772 18797058 11752352 17902729

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
DESLORATADINE PPARD

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DESLORATADINE CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: DESLORATADINE
- Version: 01-August-2011
Alternate Names:

DESLORATADINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 2001

Publications:
TdgClinicalTrial: DESLORATADINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiallergy agent

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: desloratadine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Guo A et al., 2015, Association of FCER1A genetic polymorphisms with risk for chronic spontaneous urticaria and efficacy of nonsedating H1-antihistamines in Chinese patients., Arch Dermatol Res

Li J et al., 2020, Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria., Pharmacogenomics J

DTC: DESLORATADINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1172 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Desloratadine
- Version: 2020.06.01
Alternate Names:

D01GBY TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1172
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1172
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Histamine H1 receptor antagonist
Direct Interaction	yes
Trial Name	desloratadine , Clarinex

DESLORATADINE Drug Record

DESLORATADINE chembl:CHEMBL1172 Approved

Alternate Names:

Drug Info:

Publications:

DESLORATADINE FCER1A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25412950

Sources: PharmGKB

DESLORATADINE HRH1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Histamine H1 receptor antagonist Direct Interaction yes Trial Name desloratadine , Clarinex

PMIDs: 31406237 12642846 7581058 18336052 8174605 15564772 18797058 11752352 17902729

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

DESLORATADINE PPARD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DESLORATADINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: DESLORATADINE

Alternate Names: DESLORATADINE Primary Drug Name

Drug Info: Drug Class anti-allergic agents Year of Approval 2001

Publications:

TdgClinicalTrial: DESLORATADINE

Alternate Names:

Drug Info: Drug Indications antiallergy agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: desloratadine

Alternate Names:

Drug Info:

DTC: DESLORATADINE

Alternate Names: CHEMBL1172 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Desloratadine

Alternate Names: D01GBY TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1172

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1172

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
25412950

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Histamine H1 receptor antagonist

Direct Interaction yes

Trial Name desloratadine , Clarinex

PMIDs:
31406237 12642846 7581058 18336052 8174605 15564772 18797058 11752352 17902729

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

DESLORATADINE Primary Drug Name

Drug Info:

Drug Class anti-allergic agents

Year of Approval 2001

Drug Info:

Drug Indications antiallergy agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1172 ChEMBL Drug ID

Alternate Names:

D01GBY TTD Drug ID