DGIdb - DEFEROXAMINE Drug Record

DEFEROXAMINE chembl:CHEMBL556 Approved

Alternate Names:

NSC-527604
DESFERRIOXAMINE
DEFEROXAMINE
DESFERAL
DEFEROXAMINUM
DFOA
DÉFEROXAMINE
DFO
DFOM
DEFERRIOXAMINE B
DEFEROXAMIN
DEFEROXAMINA
DEFERRIOXAMINE
drugbank:00746
pubchem.compound:2973
chemidplus:70-51-9
chembl:CHEMBL556
rxcui:3131

Drug Info:

Drug Categories	siderophores
Drug Categories	iron chelating agents
Drug Categories	hydroxamic acids
Drug Categories	chelating agents
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	heavy metal antagonists
Drug Categories	iron chelating activity

(1 More Sources)

Publications:

Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.
Kweon et al., 2006, Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate., J. Biol. Chem.
Wartenberg et al., 2003, Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species., FASEB J.
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Asikainen et al., 2005, Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells., Free Radic. Biol. Med.
Wagner et al., 2003, Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1)., FASEB J.
Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.
Sarioğlu et al., 1997, Effects of deferoxamine and sympathectomy on endothelin-1-induced contraction and acetylcholine-induced relaxation following subarachnoid hemorrhage in carotid artery., Gen. Pharmacol.
Yu et al., 1998, Structural and functional analysis of SFT, a stimulator of Fe Transport., J. Biol. Chem.
Graven et al., 1998, Hypoxic regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase., Am. J. Physiol.
Goldbaum et al., 2001, Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress., J. Neurochem.
Kim et al., 2006, Treatment with deferoxamine increases neurons from neural stem/progenitor cells., Brain Res.
Bachoual et al., 2007, Biological effects of particles from the paris subway system., Chem. Res. Toxicol.
Venti A et al., 2004, The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region., Ann N Y Acad Sci

DEFEROXAMINE UBE2D1

Interaction Score: 7.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9694900

Sources:
NCI
DEFEROXAMINE NEUROD1

Interaction Score: 2.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16697980

Sources:
NCI
DEFEROXAMINE CXCL2

Interaction Score: 1.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17883261

Sources:
NCI
DEFEROXAMINE WT1

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12738801

Sources:
NCI
DEFEROXAMINE MMP12

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
DEFEROXAMINE EDN1

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9112092

Sources:
NCI
DEFEROXAMINE GAPDH

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9486123

Sources:
NCI
DEFEROXAMINE TGM2

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9194688

Sources:
NCI
DEFEROXAMINE DDIT3

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8794898

Sources:
NCI
DEFEROXAMINE MMP2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
DEFEROXAMINE HSPA4

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11579132

Sources:
NCI
DEFEROXAMINE APP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15681799

Sources:
DrugBank
DEFEROXAMINE HIF1A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15780758

Sources:
NCI
DEFEROXAMINE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12514119

Sources:
NCI
DEFEROXAMINE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16950787

Sources:
NCI

DrugBank: DB00746

Version: 5.1.7

Alternate Names:

DEFEROXAMINE DrugBank Drug Name

70-51-9 CAS Number

Deferoxamine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Hershko et al., 2005, Objectives and mechanism of iron chelation therapy., Ann. N. Y. Acad. Sci.

Cappellini et al., 2009, Overview of iron chelation therapy with desferrioxamine and deferiprone., Hemoglobin

Elihu et al., 1998, Chelation therapy in cardiovascular disease: ethylenediaminetetraacetic acid, deferoxamine, and dexrazoxane., J Clin Pharmacol

DTC: DEFEROXAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL556 ChEMBL Drug ID

Drug Info:

Publications:

Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

NCI: DEFEROXAMINE

Version: 14-September-2017

Alternate Names:

C416 NCI drug code

Drug Info:

Publications:

Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.

Kim et al., 2006, Treatment with deferoxamine increases neurons from neural stem/progenitor cells., Brain Res.

Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.

NCI: DESFERRIOXAMINE

Version: 14-September-2017

Alternate Names:

C416 NCI drug code

Drug Info:

Publications:

Yu et al., 1998, Structural and functional analysis of SFT, a stimulator of Fe Transport., J. Biol. Chem.

Wartenberg et al., 2003, Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species., FASEB J.

Wagner et al., 2003, Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1)., FASEB J.

ChemblDrugs: chembl:CHEMBL556
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

DEFEROXAMINE	DrugBank Drug Name
70-51-9	CAS Number
Deferoxamine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

DEFEROXAMINE Drug Record

DEFEROXAMINE chembl:CHEMBL556 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9694900

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16697980

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17883261

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12738801

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9112092

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9486123

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9194688

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8794898

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11579132

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15681799

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15780758

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12514119

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16950787

Sources: NCI

DrugBank: DB00746

Alternate Names: DEFEROXAMINE DrugBank Drug Name 70-51-9 CAS Number Deferoxamine Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

DTC: DEFEROXAMINE

Alternate Names: CHEMBL556 ChEMBL Drug ID

Drug Info:

Publications: Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

NCI: DEFEROXAMINE

Alternate Names: C416 NCI drug code

Drug Info:

NCI: DESFERRIOXAMINE

Alternate Names: C416 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL556

Alternate Names:

Interaction Types & Directionality:

n/a

PMIDs:
9694900

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16697980

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17883261

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12738801

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9112092

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9486123

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9194688

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8794898

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
11579132

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15681799

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15780758

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12514119

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16950787

Sources:
NCI

Alternate Names:

DEFEROXAMINE DrugBank Drug Name

70-51-9 CAS Number

Deferoxamine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

CHEMBL556 ChEMBL Drug ID

Publications:

Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

Alternate Names:

C416 NCI drug code

Alternate Names:

C416 NCI drug code