DGIdb - DEFEROXAMINE Drug Record

DEFEROXAMINE chembl:CHEMBL556 Approved

Alternate Names:

NSC-527604
DESFERRIOXAMINE
DEFEROXAMINE
DESFERAL
DEFEROXAMINUM
DFOA
DÉFEROXAMINE
DFO
DFOM
DEFERRIOXAMINE B
DEFEROXAMIN
DEFEROXAMINA
DEFERRIOXAMINE
drugbank:00746
pubchem.compound:2973
chemidplus:70-51-9
chembl:CHEMBL556
rxcui:3131

Drug Info:

(0 More Sources)

Publications:

Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.
Kweon et al., 2006, Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate., J. Biol. Chem.
Wartenberg et al., 2003, Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species., FASEB J.
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Asikainen et al., 2005, Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells., Free Radic. Biol. Med.
Wagner et al., 2003, Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1)., FASEB J.
Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.
Sarioğlu et al., 1997, Effects of deferoxamine and sympathectomy on endothelin-1-induced contraction and acetylcholine-induced relaxation following subarachnoid hemorrhage in carotid artery., Gen. Pharmacol.
Yu et al., 1998, Structural and functional analysis of SFT, a stimulator of Fe Transport., J. Biol. Chem.
Graven et al., 1998, Hypoxic regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase., Am. J. Physiol.
Goldbaum et al., 2001, Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress., J. Neurochem.
Kim et al., 2006, Treatment with deferoxamine increases neurons from neural stem/progenitor cells., Brain Res.
Bachoual et al., 2007, Biological effects of particles from the paris subway system., Chem. Res. Toxicol.

DEFEROXAMINE UBE2D1

Interaction Score: 8.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9694900

Sources:
NCI
DEFEROXAMINE NEUROD1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16697980

Sources:
NCI
DEFEROXAMINE MMP12

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
DEFEROXAMINE CXCL2

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17883261

Sources:
NCI
DEFEROXAMINE WT1

Interaction Score: 1.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12738801

Sources:
NCI
DEFEROXAMINE EDN1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9112092

Sources:
NCI
DEFEROXAMINE GAPDH

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9486123

Sources:
NCI
DEFEROXAMINE TGM2

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9194688

Sources:
NCI
DEFEROXAMINE MMP2

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
DEFEROXAMINE DDIT3

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8794898

Sources:
NCI
DEFEROXAMINE HSPA4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11579132

Sources:
NCI
DEFEROXAMINE HIF1A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15780758

Sources:
NCI
DEFEROXAMINE ABCB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12514119

Sources:
NCI
DEFEROXAMINE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16950787

Sources:
NCI

DTC: DEFEROXAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL556 ChEMBL Drug ID

Drug Info:

Publications:

Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

NCI: DEFEROXAMINE

Version: 14-September-2017

Alternate Names:

C416 NCI drug code

Drug Info:

Publications:

Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.

Kim et al., 2006, Treatment with deferoxamine increases neurons from neural stem/progenitor cells., Brain Res.

Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.

NCI: DESFERRIOXAMINE

Version: 14-September-2017

Alternate Names:

C416 NCI drug code

Drug Info:

Publications:

Yu et al., 1998, Structural and functional analysis of SFT, a stimulator of Fe Transport., J. Biol. Chem.

Wartenberg et al., 2003, Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species., FASEB J.

Wagner et al., 2003, Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1)., FASEB J.

ChemblDrugs: chembl:CHEMBL556
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

DEFEROXAMINE Drug Record

DEFEROXAMINE chembl:CHEMBL556 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9694900

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16697980

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17883261

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12738801

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9112092

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9486123

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9194688

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8794898

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11579132

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15780758

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12514119

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16950787

Sources: NCI

DTC: DEFEROXAMINE

Alternate Names: CHEMBL556 ChEMBL Drug ID

Drug Info:

Publications: Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

NCI: DEFEROXAMINE

Alternate Names: C416 NCI drug code

Drug Info:

NCI: DESFERRIOXAMINE

Alternate Names: C416 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL556

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
9694900

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16697980

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17883261

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12738801

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9112092

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9486123

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9194688

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8794898

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11579132

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15780758

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12514119

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16950787

Sources:
NCI

Alternate Names:

CHEMBL556 ChEMBL Drug ID

Publications:

Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

Alternate Names:

C416 NCI drug code

Alternate Names:

C416 NCI drug code