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DEFEROXAMINE Drug Record

  • Summary
  • Interactions
  • Claims
  • DEFEROXAMINE chembl:CHEMBL556 Approved

    Alternate Names:

    NSC-527604
    DESFERRIOXAMINE
    DEFEROXAMINE
    DESFERAL
    DEFEROXAMINUM
    DFOA
    DÉFEROXAMINE
    DFO
    DFOM
    DEFERRIOXAMINE B
    DEFEROXAMIN
    DEFEROXAMINA
    DEFERRIOXAMINE
    drugbank:00746
    pubchem.compound:2973
    chemidplus:70-51-9
    chembl:CHEMBL556
    rxcui:3131

    Drug Info:

    (0 More Sources)

    Publications:

    Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.
    Kweon et al., 2006, Constitutive overexpression of Nrf2-dependent heme oxygenase-1 in A549 cells contributes to resistance to apoptosis induced by epigallocatechin 3-gallate., J. Biol. Chem.
    Wartenberg et al., 2003, Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species., FASEB J.
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
    Asikainen et al., 2005, Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells., Free Radic. Biol. Med.
    Wagner et al., 2003, Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1)., FASEB J.
    Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.
    Sarioğlu et al., 1997, Effects of deferoxamine and sympathectomy on endothelin-1-induced contraction and acetylcholine-induced relaxation following subarachnoid hemorrhage in carotid artery., Gen. Pharmacol.
    Yu et al., 1998, Structural and functional analysis of SFT, a stimulator of Fe Transport., J. Biol. Chem.
    Graven et al., 1998, Hypoxic regulation of endothelial glyceraldehyde-3-phosphate dehydrogenase., Am. J. Physiol.
    Goldbaum et al., 2001, Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress., J. Neurochem.
    Kim et al., 2006, Treatment with deferoxamine increases neurons from neural stem/progenitor cells., Brain Res.
    Bachoual et al., 2007, Biological effects of particles from the paris subway system., Chem. Res. Toxicol.
  • DEFEROXAMINE   UBE2D1

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9694900


    Sources:
    NCI

  • DEFEROXAMINE   NEUROD1

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16697980


    Sources:
    NCI

  • DEFEROXAMINE   MMP12

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • DEFEROXAMINE   CXCL2

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17883261


    Sources:
    NCI

  • DEFEROXAMINE   WT1

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12738801


    Sources:
    NCI

  • DEFEROXAMINE   EDN1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9112092


    Sources:
    NCI

  • DEFEROXAMINE   GAPDH

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9486123


    Sources:
    NCI

  • DEFEROXAMINE   TGM2

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9194688


    Sources:
    NCI

  • DEFEROXAMINE   MMP2

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • DEFEROXAMINE   DDIT3

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8794898


    Sources:
    NCI

  • DEFEROXAMINE   HSPA4

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11579132


    Sources:
    NCI

  • DEFEROXAMINE   HIF1A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15780758


    Sources:
    NCI

  • DEFEROXAMINE   ABCB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12514119


    Sources:
    NCI

  • DEFEROXAMINE   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16950787


    Sources:
    NCI

  • DTC: DEFEROXAMINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL556 ChEMBL Drug ID

    Drug Info:

    Publications:
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

  • NCI: DEFEROXAMINE

    • Version: 14-September-2017

    Alternate Names:
    C416 NCI drug code

    Drug Info:

    Publications:
    Zhang et al., 1997, Pharmacologic inhibition of transglutaminase-induced cross-linking of Alzheimer's amyloid beta-peptide., Life Sci.
    Kim et al., 2006, Treatment with deferoxamine increases neurons from neural stem/progenitor cells., Brain Res.
    Jeong et al., 1996, Quinone thioether-mediated DNA damage, growth arrest, and gadd153 expression in renal proximal tubular epithelial cells., Mol. Pharmacol.

  • NCI: DESFERRIOXAMINE

    • Version: 14-September-2017

    Alternate Names:
    C416 NCI drug code

    Drug Info:

    Publications:
    Yu et al., 1998, Structural and functional analysis of SFT, a stimulator of Fe Transport., J. Biol. Chem.
    Wartenberg et al., 2003, Regulation of the multidrug resistance transporter P-glycoprotein in multicellular tumor spheroids by hypoxia-inducible factor (HIF-1) and reactive oxygen species., FASEB J.
    Wagner et al., 2003, Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1)., FASEB J.

  • ChemblDrugs: chembl:CHEMBL556

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21