DGIdb - DACARBAZINE Drug Record

DACARBAZINE chembl:CHEMBL476 ApprovedAntineoplasticImmunotherapy

Alternate Names:

DTIC
DIC
NSC-45388
NCI C04717
DACARBAZINE
DTIC-DOME
5-(DIMETHYLTRIAZENO)IMIDAZOLE-4-CARBOXAMIDE
NCI-C04717
4-(DIMETHYLTRIAZENO)IMIDAZOLE-5-CARBOXAMIDE
BIOCARBAZINE
DACARBAZINUM
IMIDAZOLE CARBOXAMIDE
IMIDAZOLE-4-CARBOXAMIDE, 5-(3,3-DIMETHYL-1-TRIAZENO)-
(E)-DACARBAZINE
4-(5)-(3,3-DIMETHYL-1-TRIAZENO)IMIDAZOLE-5(4)-CARBOXAMIDE
4-(3,3-DIMETHYL-1-TRIAZENO)IMIDAZOLE-5-CARBOXAMIDE
DACARBAZINA
5-(3,3-DIMETHYLTRIAZENO)IMIDAZOLE-4-CARBOXAMIDE
DTIE
ICDMT
DTIC-DOME (TN)
NSC 45388
HSDB 3219
DTIC-DOME®
DTCI
5-(3,3-DIMETHYL-1-TRIAZENO)IMIDAZOLE-4-CARBOXAMIDE
DACARBAZIN
chemidplus:4342-03-4
chembl:CHEMBL476
drugbank:00851
rxcui:3098

Drug Info:

Drug Categories	triazenes
Drug Class	antineoplastic agents
Year of Approval	1975
FDA Approval	1975
Drug Class	small molecule
Drug Indications	Antineoplastic Agents
Drug Categories	alkylating activity
Drug Categories	alkylating drugs
Drug Categories	cytochrome p-450 cyp1a2 substrates with a narrow therapeutic index
Drug Categories	cytochrome p-450 cyp2e1 substrates with a narrow therapeutic index
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted

(5 More Sources)

Publications:

Lewis BC et al., 2016, Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy., Pharmacogenet Genomics
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Akkemik et al., 2010, Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study., J Enzyme Inhib Med Chem
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Lönn et al., 1987, Prevention of dacarbazine damage of human neoplastic cell DNA by aphidicolin., Cancer Res.
Garbisa et al., 1997, Suppression of metastatic potential and up-regulation of gelatinases and uPA in LLC by protracted in vivo treatment with dacarbazine or razoxane., Int. J. Cancer
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Ma et al., Immunohistochemical analysis of DNA mismatch repair protein and O6-methylguanine-DNA methyltransferase in melanoma metastases in relation to clinical response to DTIC-based chemotherapy., Oncol. Rep.
Singh et al., 1983, Comparison of the mutagenic responses of 12 anticancer drugs at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci in Chinese hamster ovary cells., Environ Mutagen
Shibuya et al., 2003, Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins., Melanoma Res.
Altés A et al., 2013, Pharmacogenetic analysis in the treatment of Hodgkin lymphoma., Leuk Lymphoma

DACARBAZINE POLA2

Interaction Score: 24.35

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17139284 17016423 3098406

Sources:
TEND TdgClinicalTrial DrugBank
DACARBAZINE PGD

Interaction Score: 2.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10592235 20235752

Sources:
DrugBank
DACARBAZINE ADK

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6317371

Sources:
NCI
DACARBAZINE GSTM1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23323945

Sources:
PharmGKB
DACARBAZINE MGMT

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12168066

Sources:
NCI
DACARBAZINE CYP1A1

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27428168

Sources:
PharmGKB
DACARBAZINE BAX

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14512787

Sources:
NCI
DACARBAZINE PLAU

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9378540

Sources:
NCI
DACARBAZINE CXCL8

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACARBAZINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 27428168

Sources:
DTC PharmGKB
DACARBAZINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DACARBAZINE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DACARBAZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DACARBAZINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB00851

Version: 5.1.7

Alternate Names:

DACARBAZINE DrugBank Drug Name

4342-03-4 CAS Number

DTIC Drug Brand

Drug Info:

Drug Categories imidazoles

Drug Type small molecule

Drug Groups approved

Publications:

Lönn et al., 1987, Prevention of dacarbazine damage of human neoplastic cell DNA by aphidicolin., Cancer Res.

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Akkemik et al., 2010, Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study., J Enzyme Inhib Med Chem

TEND: DACARBAZINE
- Version: 01-August-2011
Alternate Names:

DACARBAZINE Primary Drug Name

Drug Info:

Year of Approval 1975

Drug Class antineoplastic agents

Publications:
TdgClinicalTrial: DACARBAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antineoplastic Agents

Drug Class small molecule

FDA Approval 1975

Publications:

NCI: DACARBAZINE

Version: 14-September-2017

Alternate Names:

C411 NCI drug code

Drug Info:

Publications:

Singh et al., 1983, Comparison of the mutagenic responses of 12 anticancer drugs at the hypoxanthine-guanine phosphoribosyl transferase and adenosine kinase loci in Chinese hamster ovary cells., Environ Mutagen

Shibuya et al., 2003, Induction of apoptosis and/or necrosis following exposure to antitumour agents in a melanoma cell line, probably through modulation of Bcl-2 family proteins., Melanoma Res.

Garbisa et al., 1997, Suppression of metastatic potential and up-regulation of gelatinases and uPA in LLC by protracted in vivo treatment with dacarbazine or razoxane., Int. J. Cancer

DTC: DACARBAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL476 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: DTIC

Version: 14-September-2017

Alternate Names:

C411 NCI drug code

Drug Info:

Publications:

Ma et al., Immunohistochemical analysis of DNA mismatch repair protein and O6-methylguanine-DNA methyltransferase in melanoma metastases in relation to clinical response to DTIC-based chemotherapy., Oncol. Rep.

PharmGKB: dacarbazine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Lewis BC et al., 2016, Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy., Pharmacogenet Genomics

Altés A et al., 2013, Pharmacogenetic analysis in the treatment of Hodgkin lymphoma., Leuk Lymphoma

TTD: Dacarbazine
- Version: 2020.06.01
Alternate Names:

D0Y7ZU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL476
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

DACARBAZINE	DrugBank Drug Name
4342-03-4	CAS Number
DTIC	Drug Brand

Drug Categories	imidazoles
Drug Type	small molecule
Drug Groups	approved

Trial Name	-
Novel drug target	Established target

DACARBAZINE Drug Record

DACARBAZINE chembl:CHEMBL476 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17139284 17016423 3098406

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 10592235 20235752

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6317371

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23323945

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12168066

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27428168

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14512787

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9378540

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300 27428168

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

DrugBank: DB00851

Alternate Names: DACARBAZINE DrugBank Drug Name 4342-03-4 CAS Number DTIC Drug Brand

Drug Info: Drug Categories imidazoles Drug Type small molecule Drug Groups approved

TEND: DACARBAZINE

Alternate Names: DACARBAZINE Primary Drug Name

Drug Info: Year of Approval 1975 Drug Class antineoplastic agents

Publications:

TdgClinicalTrial: DACARBAZINE

Alternate Names:

Drug Info: Drug Indications Antineoplastic Agents Drug Class small molecule FDA Approval 1975

Publications:

NCI: DACARBAZINE

Alternate Names: C411 NCI drug code

Drug Info:

DTC: DACARBAZINE

Alternate Names: CHEMBL476 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

NCI: DTIC

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17139284 17016423 3098406

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
10592235 20235752

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
6317371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23323945

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12168066

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
27428168

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
14512787

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9378540

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300 27428168

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

DACARBAZINE DrugBank Drug Name

4342-03-4 CAS Number

DTIC Drug Brand

Drug Info:

Drug Categories imidazoles

Drug Type small molecule

Drug Groups approved

Alternate Names:

DACARBAZINE Primary Drug Name

Drug Info:

Year of Approval 1975

Drug Class antineoplastic agents

Drug Info:

Drug Indications Antineoplastic Agents

Drug Class small molecule

FDA Approval 1975

Alternate Names:

C411 NCI drug code

Alternate Names:

CHEMBL476 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

C411 NCI drug code

Publications:

Ma et al., Immunohistochemical analysis of DNA mismatch repair protein and O6-methylguanine-DNA methyltransferase in melanoma metastases in relation to clinical response to DTIC-based chemotherapy., Oncol. Rep.

Alternate Names:

D0Y7ZU TTD Drug ID