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CYTISINICLINE Drug Record

  • Summary
  • Interactions
  • Claims
  • CYTISINICLINE chembl:CHEMBL497939

    Alternate Names:

    CYTISINICLINE
    6039 SOPHARMA
    NSC-407282
    CYTISINE
    TABEX
    (-)-CYTISINE
    SOPHORIN
    BAPTITOXINE
    ULEXIN
    LABURNIN
    CYTISIN
    SOPHORINE
    (1R,5S)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-8H-PYRIDO[1,2A][1,5]DIAZOCIN-8-ONE
    BAPTITOXIN
    chembl:CHEMBL497939
    drugbank:09028
    pubchem.compound:10235
    rxcui:1723152
    chemidplus:485-35-8

    Drug Info:

    (0 More Sources)

    Publications:

    Walker et al., 2014, Cytisine versus nicotine for smoking cessation., N. Engl. J. Med.
    Houlihan et al., 2001, Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors., J. Neurochem.
    Rollema H et al., 2010, Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence., Br J Pharmacol
  • CYTISINICLINE   CHRNB2

    Interaction Score: 1.55

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    20331614


    Sources:
    TTD

  • CYTISINICLINE   CHRNA7

    Interaction Score: 1.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    25517706 11553677


    Sources:
    TTD

  • CYTISINICLINE   CHRNA4

    Interaction Score: 0.98

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    25517706 11553677


    Sources:
    TTD

  • CYTISINICLINE   CHRNB4

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CYTISINICLINE   CHRNA2

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TTD: CYTISINE

    • Version: 2020.06.01

    Alternate Names:
    D08XPW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL497939

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21