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CYCLOTHIAZIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • CYCLOTHIAZIDE chembl:CHEMBL61593 Approved

    Alternate Names:

    ANHYDRON
    35483
    CYCLOTHIAZIDE
    FLUIDIL
    6-CHLORO-3,4-DIHYDRO-3-(2-NORBORNEN-5-YL)-7-SULFAMOYL-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
    CYCLOTHIAZIDUM
    6-CHLORO-3-(2-NORBORNEN-5-YL)-7-SULFAMYL-3,4-DIHYDRO-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
    6-CHLORO-3,4-DIHYDRO-3-(2-NORBORNEN-5-YL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
    CICLOTIAZIDE
    6-CHLORO-3,4-DIHYDRO-3-(5-NORBORNEN-2-YL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
    ANHYDRON®
    AQUIREL®
    CICLOTIAZIDA
    rxcui:22033
    pubchem.compound:2910
    chemidplus:2259-96-3
    chembl:CHEMBL61593
    drugbank:00606

    Drug Info:

    Drug Categories receptors, ampa
    Drug Class antihypertensive agents
    Year of Approval approved before 1982
    Drug Class diuretics
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Diuretics
    Drug Indications Antihypertensive Agents
    Drug Categories genito urinary system and sex hormones
    Drug Categories gynecological antiinfectives and antiseptics
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories hyperglycemia-associated agents
    Drug Categories oat1/slc22a6 inhibitors
    (4 More Sources)

    Publications:

    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Liljequist et al., 1995, Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons., Biochem. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
    Temperini C et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference., J Med Chem
    Larson et al., 1994, Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus., Neuroreport
    Rammes et al., 1999, Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide., Pflugers Arch.
    Fleck et al., 1996, AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide., J. Neurophysiol.
    Pirotte et al., 1998, 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships., J. Med. Chem.
    Rammes et al., 1996, Interactions of 2,3-benzodiazepines and cyclothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices., Br. J. Pharmacol.
    Bukhari SA et al., 2014, Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus., Molecules
  • CYCLOTHIAZIDE   SFRP4

    Interaction Score: 5.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    25019556


    Sources:
    DrugBank

  • CYCLOTHIAZIDE   FXYD2

    Interaction Score: 4.73

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CYCLOTHIAZIDE   CA1

    Interaction Score: 1.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19119014 19115843 8003661 9929558 8793745 9685234 8882618


    Sources:
    DrugBank

  • CYCLOTHIAZIDE   SLC12A3

    Interaction Score: 0.63

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • CYCLOTHIAZIDE   CA2

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    8615854 11752352


    Sources:
    TTD DrugBank

  • CYCLOTHIAZIDE   GRIA4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CYCLOTHIAZIDE   GRIA3

    Interaction Score: 0.2

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CYCLOTHIAZIDE   GRIA1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CYCLOTHIAZIDE   GRIA2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    allosteric modulator

    Interaction Info:
    Specific Action of the Ligand Positive
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CYCLOTHIAZIDE   RECQL

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00606

    • Version: 5.1.7

    Alternate Names:
    CYCLOTHIAZIDE DrugBank Drug Name
    2259-96-3 CAS Number
    Acquirel Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories amides

    Publications:
    Larson et al., 1994, Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus., Neuroreport
    Rammes et al., 1999, Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide., Pflugers Arch.
    Fleck et al., 1996, AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide., J. Neurophysiol.

  • TEND: CYCLOTHIAZIDE

    • Version: 01-August-2011

    Alternate Names:
    CYCLOTHIAZIDE Primary Drug Name

    Drug Info:
    Drug Class diuretics
    Year of Approval approved before 1982
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: CYCLOTHIAZIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications Diuretics
    Drug Class small molecule

    Publications:

  • TTD: Cyclothiazide

    • Version: 2020.06.01

    Alternate Names:
    D03CNS TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 178100987

    • Version: 29-September-2020

    Alternate Names:
    CYCLOTHIAZIDE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • DTC: CYCLOTHIAZIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL61593 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL61593

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL61593

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21