DGIdb - CYCLOTHIAZIDE Drug Record

CYCLOTHIAZIDE chembl:CHEMBL61593 Approved

Alternate Names:

ANHYDRON
35483
CYCLOTHIAZIDE
FLUIDIL
6-CHLORO-3,4-DIHYDRO-3-(2-NORBORNEN-5-YL)-7-SULFAMOYL-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
CYCLOTHIAZIDUM
6-CHLORO-3-(2-NORBORNEN-5-YL)-7-SULFAMYL-3,4-DIHYDRO-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
6-CHLORO-3,4-DIHYDRO-3-(2-NORBORNEN-5-YL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
CICLOTIAZIDE
6-CHLORO-3,4-DIHYDRO-3-(5-NORBORNEN-2-YL)-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
ANHYDRON®
AQUIREL®
CICLOTIAZIDA
rxcui:22033
pubchem.compound:2910
chemidplus:2259-96-3
chembl:CHEMBL61593
drugbank:00606

Drug Info:

Drug Categories	receptors, ampa
Drug Class	antihypertensive agents
Year of Approval	approved before 1982
Drug Class	diuretics
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents
Drug Categories	genito urinary system and sex hormones
Drug Categories	gynecological antiinfectives and antiseptics
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	hyperglycemia-associated agents
Drug Categories	oat1/slc22a6 inhibitors

(4 More Sources)

Publications:

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Liljequist et al., 1995, Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons., Biochem. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Temperini et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference., Bioorg. Med. Chem.
Temperini C et al., 2009, Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference., J Med Chem
Larson et al., 1994, Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus., Neuroreport
Rammes et al., 1999, Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide., Pflugers Arch.
Fleck et al., 1996, AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide., J. Neurophysiol.
Pirotte et al., 1998, 4H-1,2,4-Pyridothiadiazine 1,1-dioxides and 2,3-dihydro-4H-1,2, 4-pyridothiadiazine 1,1-dioxides chemically related to diazoxide and cyclothiazide as powerful positive allosteric modulators of (R/S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors: design, synthesis, pharmacology, and structure-activity relationships., J. Med. Chem.
Rammes et al., 1996, Interactions of 2,3-benzodiazepines and cyclothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices., Br. J. Pharmacol.
Bukhari SA et al., 2014, Computer aided screening of secreted frizzled-related protein 4 (SFRP4): a potential control for diabetes mellitus., Molecules

CYCLOTHIAZIDE SFRP4

Interaction Score: 5.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25019556

Sources:
DrugBank
CYCLOTHIAZIDE FXYD2

Interaction Score: 4.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
CYCLOTHIAZIDE CA1

Interaction Score: 1.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19119014 19115843 8003661 9929558 8793745 9685234 8882618

Sources:
DrugBank
CYCLOTHIAZIDE SLC12A3

Interaction Score: 0.63

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
CYCLOTHIAZIDE CA2

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8615854 11752352

Sources:
TTD DrugBank
CYCLOTHIAZIDE GRIA4

Interaction Score: 0.26

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CYCLOTHIAZIDE GRIA3

Interaction Score: 0.2

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CYCLOTHIAZIDE GRIA1

Interaction Score: 0.17

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CYCLOTHIAZIDE GRIA2

Interaction Score: 0.12

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CYCLOTHIAZIDE RECQL

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00606

Version: 5.1.7

Alternate Names:

CYCLOTHIAZIDE DrugBank Drug Name

2259-96-3 CAS Number

Acquirel Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories amides

Publications:

Larson et al., 1994, Effects of cyclothiazide on synaptic responses in slices of adult and neonatal rat hippocampus., Neuroreport

Rammes et al., 1999, Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide., Pflugers Arch.

Fleck et al., 1996, AMPA receptor heterogeneity in rat hippocampal neurons revealed by differential sensitivity to cyclothiazide., J. Neurophysiol.

TEND: CYCLOTHIAZIDE
- Version: 01-August-2011
Alternate Names:

CYCLOTHIAZIDE Primary Drug Name

Drug Info:

Drug Class diuretics

Year of Approval approved before 1982

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: CYCLOTHIAZIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Publications:
TTD: Cyclothiazide
- Version: 2020.06.01
Alternate Names:

D03CNS TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178100987
- Version: 29-September-2020
Alternate Names:

CYCLOTHIAZIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: CYCLOTHIAZIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL61593 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL61593
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL61593
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Thiazide-sensitive sodium-chloride cotransporter inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Positive
Endogenous Drug?	False
Direct Interaction?	False

CYCLOTHIAZIDE	DrugBank Drug Name
2259-96-3	CAS Number
Acquirel	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	amides

Trial Name	-
Novel drug target	Established target

CYCLOTHIAZIDE Drug Record

CYCLOTHIAZIDE chembl:CHEMBL61593 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25019556

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19119014 19115843 8003661 9929558 8793745 9685234 8882618

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 8615854 11752352

Sources: TTD DrugBank

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Positive Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Positive Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Positive Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Positive Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00606

Alternate Names: CYCLOTHIAZIDE DrugBank Drug Name 2259-96-3 CAS Number Acquirel Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories amides

TEND: CYCLOTHIAZIDE

Alternate Names: CYCLOTHIAZIDE Primary Drug Name

Drug Info: Drug Class diuretics Year of Approval approved before 1982 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: CYCLOTHIAZIDE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Diuretics Drug Class small molecule

Publications:

TTD: Cyclothiazide

Alternate Names: D03CNS TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 178100987

Alternate Names: CYCLOTHIAZIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:

DTC: CYCLOTHIAZIDE

Alternate Names: CHEMBL61593 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL61593

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL61593

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25019556

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19119014 19115843 8003661 9929558 8793745 9685234 8882618

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
8615854 11752352

Sources:
TTD DrugBank

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Positive

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CYCLOTHIAZIDE DrugBank Drug Name

2259-96-3 CAS Number

Acquirel Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories amides

Alternate Names:

CYCLOTHIAZIDE Primary Drug Name

Drug Info:

Drug Class diuretics

Year of Approval approved before 1982

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Alternate Names:

D03CNS TTD Drug ID

Alternate Names:

CYCLOTHIAZIDE GuideToPharmacology Ligand Name

Alternate Names:

CHEMBL61593 ChEMBL Drug ID