DGIdb - CYCLOBENZAPRINE Drug Record

CYCLOBENZAPRINE chembl:CHEMBL669 Approved

Alternate Names:

CYCLOBENZAPRINE
MK-130 (AS THE BASE)
TNX-102
FLEXERIL
CICLOBENZAPRINA
N,N-DIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-DELTA(5,GAMMA)-PROPYLAMINE
N,N-DIMETHYL-5H-DIBENZO(A,D)CYCLOHEPTENE-Δ5,Γ-PROPYLAMINE
FEXMID
MK-130
(3-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE-PROPYL)-DIMETHYL-AMINE
CYCLOBENZAPRINUM
AMRIX®
chembl:CHEMBL669
rxcui:21949
pubchem.compound:2895
drugbank:00924
chemidplus:303-53-7

Drug Info:

Drug Categories	antidepressive agents, tricyclic
FDA Approval	1977
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Tricyclic
Drug Class	antidepressive agents, tricyclic
Year of Approval	1977
Drug Categories	agents that reduce seizure threshold
Drug Categories	centrally-mediated muscle relaxation
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	neurotoxic agents
Drug Categories	photosensitizing agents
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	ugt1a4 substrates

(4 More Sources)

Publications:

Kobayashi et al., 1996, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems., Eur. J. Pharmacol.
Mestres J et al., 2011, Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome., Clin Pharmacol Ther
Honda et al., 2003, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors., Eur. J. Pharmacol.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Obach RS et al., 2004, Human liver aldehyde oxidase: inhibition by 239 drugs., J Clin Pharmacol
Hutchinson MR et al., 2010, Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity., Neuroscience

CYCLOBENZAPRINE AOX1

Interaction Score: 1.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
14681337

Sources:
DrugBank
CYCLOBENZAPRINE TLR4

Interaction Score: 0.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21975349 20381591

Sources:
DrugBank
CYCLOBENZAPRINE HTR6

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
21975349

Sources:
DrugBank
CYCLOBENZAPRINE HTR2A

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8884233 21975349 12498911

Sources:
TEND TdgClinicalTrial TTD DrugBank
CYCLOBENZAPRINE HTR7

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
21975349

Sources:
DrugBank
CYCLOBENZAPRINE SLC6A2

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21975349

Sources:
DrugBank
CYCLOBENZAPRINE HTR2B

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
21975349

Sources:
DrugBank
CYCLOBENZAPRINE SLC6A4

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21975349

Sources:
DrugBank
CYCLOBENZAPRINE CYP3A5

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
CYCLOBENZAPRINE HTR2C

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
21975349

Sources:
DrugBank
CYCLOBENZAPRINE ADRA2C

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CYCLOBENZAPRINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOBENZAPRINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00924

Version: 5.1.7

Alternate Names:

CYCLOBENZAPRINE DrugBank Drug Name

303-53-7 CAS Number

Ag-cyclobenzaprine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents that reduce seizure threshold

Publications:

Mestres J et al., 2011, Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome., Clin Pharmacol Ther

Kobayashi et al., 1996, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems., Eur. J. Pharmacol.

Honda et al., 2003, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors., Eur. J. Pharmacol.

TEND: CYCLOBENZAPRINE
- Version: 01-August-2011
Alternate Names:

CYCLOBENZAPRINE Primary Drug Name

Drug Info:

Year of Approval 1977

Drug Class antidepressive agents, tricyclic

Publications:
TdgClinicalTrial: CYCLOBENZAPRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1977

Publications:
PharmGKB: cyclobenzaprine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
DTC: CYCLOBENZAPRINE
- Version: 02-September-2020
Alternate Names:

CHEMBL669 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Cyclobenzaprine
- Version: 2020.06.01
Alternate Names:

D01KHH TTD Drug ID

Drug Info:

Publications:
TTD: TNX-102
- Version: 2020.06.01
Alternate Names:

D0NN8N TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL669
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

CYCLOBENZAPRINE	DrugBank Drug Name
303-53-7	CAS Number
Ag-cyclobenzaprine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	agents that reduce seizure threshold

Trial Name	-
Novel drug target	Established target

CYCLOBENZAPRINE Drug Record

CYCLOBENZAPRINE chembl:CHEMBL669 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 14681337

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21975349 20381591

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 21975349

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8884233 21975349 12498911

Sources: TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 21975349

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21975349

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 21975349

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21975349

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 21975349

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00924

Alternate Names: CYCLOBENZAPRINE DrugBank Drug Name 303-53-7 CAS Number Ag-cyclobenzaprine Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories agents that reduce seizure threshold

TEND: CYCLOBENZAPRINE

Alternate Names: CYCLOBENZAPRINE Primary Drug Name

Drug Info: Year of Approval 1977 Drug Class antidepressive agents, tricyclic

Publications:

TdgClinicalTrial: CYCLOBENZAPRINE

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents, Tricyclic Drug Class small molecule FDA Approval 1977

Publications:

PharmGKB: cyclobenzaprine

Alternate Names:

Drug Info:

Publications: Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

DTC: CYCLOBENZAPRINE

Alternate Names: CHEMBL669 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Cyclobenzaprine

Alternate Names: D01KHH TTD Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
14681337

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21975349 20381591

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
21975349

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8884233 21975349 12498911

Sources:
TEND TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
21975349

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21975349

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
21975349

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21975349

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
21975349

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CYCLOBENZAPRINE DrugBank Drug Name

303-53-7 CAS Number

Ag-cyclobenzaprine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents that reduce seizure threshold

Alternate Names:

CYCLOBENZAPRINE Primary Drug Name

Drug Info:

Year of Approval 1977

Drug Class antidepressive agents, tricyclic

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1977

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Alternate Names:

CHEMBL669 ChEMBL Drug ID

Alternate Names:

D01KHH TTD Drug ID

Alternate Names:

D0NN8N TTD Drug ID