DGIdb - CURCUMIN Drug Record

CURCUMIN chembl:CHEMBL116438 Antineoplastic

Alternate Names:

E-100
NSC-32982
E100
NSC-687842
CURCUMIN
CI-75300
INS-100(I)
DIFERULOYLMETHANE
NATURAL YELLOW 3
E 100
INS NO. 100(I)

Drug Info:

(1 More Sources)

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Koeberle A et al., 2014, SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase., J Med Chem
Mayadevi M et al., 2012, Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II., Bioorg Med Chem
Belakavadi et al., 2005, Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase., Mol. Cell. Biochem.
Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem
Bartik L et al., 2010, Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention., J Nutr Biochem
Wang W et al., 2016, Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators., PLoS One
Wang et al., 2008, Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB., Brain Res.
Xu et al., 2007, Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats., Brain Res.
Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem
Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer
Lee CA et al., 2015, Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design., Drug Metab Dispos
Minassi A et al., 2013, Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?, J Nat Prod
Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod
Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
Liu Z et al., 2009, Curcumin is a potent DNA hypomethylation agent., Bioorg Med Chem Lett
Lenhart JA et al., 2010, "Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: design, synthesis, and biological characterization., J Med Chem
Byeon SR et al., 2013, Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment., Bioorg Med Chem Lett
Depeille et al., 2005, Combined effects of GSTP1 and MRP1 in melanoma drug resistance., Br. J. Cancer
van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact
Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.
Basu et al., 2005, Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity., Proc. Natl. Acad. Sci. U.S.A.
Zheng et al., 2006, Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor., Am. J. Physiol. Gastrointest. Liver Physiol.
Hu GX et al., 2010, Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3., Bioorg Med Chem Lett
Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
Nan et al., 2005, Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells., Thromb. Res.
Shim et al., 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin., Chem. Biol.
López-Lázaro M et al., 2007, Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells., J Nat Prod
Ikonomov et al., 2002, Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects., Endocrinology
Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod

CURCUMIN HSD17B3

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20346654

Sources:
DTC
CURCUMIN DNMT3B

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN DFFB

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16013440

Sources:
NCI
CURCUMIN IAPP

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN THBD

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15733976

Sources:
NCI
CURCUMIN PTGES

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25686392

Sources:
DTC
CURCUMIN WT1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16490174

Sources:
NCI
CURCUMIN CAMK2A

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22989913

Sources:
DTC
CURCUMIN SMAD2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23145932

Sources:
DTC
CURCUMIN UGT1A7

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15845768

Sources:
NCI
CURCUMIN CA6

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN ANPEP

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12954328

Sources:
NCI
CURCUMIN MMP13

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN CA14

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN ABCB4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN APP

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20666513 23601707

Sources:
DTC TTD
CURCUMIN CFTR

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27007499

Sources:
PharmGKB
CURCUMIN DNMT1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19112019

Sources:
DTC TTD
CURCUMIN CCN2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16306131

Sources:
NCI
CURCUMIN GSTM1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15044619

Sources:
NCI
CURCUMIN TUBB4A

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBA3C

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN CA9

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN MMP9

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN CA12

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN DDIT3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15271854

Sources:
NCI
CURCUMIN CA4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN ERBB3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25753330

Sources:
DTC
CURCUMIN GSTP1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15999103 9463521

Sources:
NCI
CURCUMIN ERBB4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25753330

Sources:
DTC
CURCUMIN ALPI

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN CA1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN PTGS1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24920381

Sources:
DTC TTD
CURCUMIN TUBA3D

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBA3E

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBA4A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBA1B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBA1C

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBB2B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBB6

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBB8

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBB2A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBB3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN NOS2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN XDH

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN TUBA1A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN BDNF

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18420184 17617388

Sources:
NCI
CURCUMIN TUBB4B

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN SLC2A4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12446602

Sources:
NCI
CURCUMIN CA2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CURCUMIN ALPG

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN TUBB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN TUBB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
CURCUMIN USP2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN PTGS2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24920381

Sources:
DTC TTD
CURCUMIN ABCG2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25587128

Sources:
PharmGKB
CURCUMIN TOP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18076140

Sources:
DTC
CURCUMIN GLS

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN ERBB2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25753330

Sources:
DTC
CURCUMIN ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15090070

Sources:
NCI PharmGKB
CURCUMIN EGFR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25753330

Sources:
DTC
CURCUMIN SMAD3

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23145932

Sources:
DTC
CURCUMIN VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23276449 20153625

Sources:
DTC
CURCUMIN USP1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN HPGD

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN KDM4E

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23742639

Sources:
DTC
CURCUMIN MAPT

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CURCUMIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

NCI: CURCUMIN

Version: 14-September-2017

Alternate Names:

C401 NCI drug code

Drug Info:

Publications:

Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.

Nan et al., 2005, Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells., Thromb. Res.

Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer

DTC: CURCUMIN

Version: 02-September-2020

Alternate Names:

CHEMBL116438 ChEMBL Drug ID

Drug Info:

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod

PharmGKB: curcumin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Lee CA et al., 2015, Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design., Drug Metab Dispos

Wang W et al., 2016, Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators., PLoS One

TTD: Curcumin
- Version: 2020.06.01
Alternate Names:

D07SDQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL116438
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

CURCUMIN Drug Record

CURCUMIN chembl:CHEMBL116438 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20346654

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16013440

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15733976

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25686392

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16490174

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22989913

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23145932

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15845768

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12954328

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20666513 23601707

Sources: DTC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27007499

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19112019

Sources: DTC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16306131

Interaction Types & Directionality:

n/a

PMIDs:
20346654

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16013440

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15733976

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25686392

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16490174

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22989913

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23145932

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15845768

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
12954328

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20666513 23601707

Sources:
DTC TTD

Interaction Types & Directionality:

n/a

PMIDs:
27007499

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19112019

Sources:
DTC TTD

Interaction Types & Directionality:

n/a

PMIDs:
16306131

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15044619

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23830698

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23830698

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
15271854

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found