DGIdb - CURCUMIN Drug Record

CURCUMIN chembl:CHEMBL116438 Antineoplastic

Alternate Names:

E-100
NSC-32982
E100
NSC-687842
CURCUMIN
CI-75300
INS-100(I)
DIFERULOYLMETHANE
NATURAL YELLOW 3
E 100
INS NO. 100(I)

Drug Info:

Drug Type	small molecule
Drug Groups	approved
Drug Groups	experimental
Drug Groups	investigational
Drug Categories	alkanes
Drug Categories	analgesics
Drug Categories	analgesics, non-narcotic
Drug Categories	anti-inflammatory agents
Drug Categories	antineoplastic agents
Drug Categories	antirheumatic agents
Drug Categories	benzene derivatives
Drug Categories	catechols
Drug Categories	central nervous system agents
Drug Categories	coloring agents
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	cytochrome p-450 cyp1a2 inhibitors
Drug Categories	cytochrome p-450 cyp1a2 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp2b6 inhibitors
Drug Categories	cytochrome p-450 cyp2b6 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp2c9 inhibitors
Drug Categories	cytochrome p-450 cyp2c9 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp2d6 inhibitors
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp3a inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strong)
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	diarylheptanoids
Drug Categories	enzyme inhibitors
Drug Categories	heptanes
Drug Categories	hydrocarbons, acyclic
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	peripheral nervous system agents
Drug Categories	phenols
Drug Categories	sensory system agents

(3 More Sources)

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Koeberle A et al., 2014, SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase., J Med Chem
Mayadevi M et al., 2012, Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II., Bioorg Med Chem
Belakavadi et al., 2005, Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase., Mol. Cell. Biochem.
Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem
Bartik L et al., 2010, Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention., J Nutr Biochem
Wang W et al., 2016, Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators., PLoS One
Wang et al., 2008, Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB., Brain Res.
Xu et al., 2007, Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats., Brain Res.
Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem
Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer
Lee CA et al., 2015, Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design., Drug Metab Dispos
Minassi A et al., 2013, Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?, J Nat Prod
Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod
Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
Liu Z et al., 2009, Curcumin is a potent DNA hypomethylation agent., Bioorg Med Chem Lett
Lenhart JA et al., 2010, "Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: design, synthesis, and biological characterization., J Med Chem
Byeon SR et al., 2013, Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment., Bioorg Med Chem Lett
Depeille et al., 2005, Combined effects of GSTP1 and MRP1 in melanoma drug resistance., Br. J. Cancer
van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact
Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.
Basu et al., 2005, Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity., Proc. Natl. Acad. Sci. U.S.A.
Zheng et al., 2006, Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor., Am. J. Physiol. Gastrointest. Liver Physiol.
Hu GX et al., 2010, Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3., Bioorg Med Chem Lett
Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
Nan et al., 2005, Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells., Thromb. Res.
Shim et al., 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin., Chem. Biol.
López-Lázaro M et al., 2007, Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells., J Nat Prod
Ikonomov et al., 2002, Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects., Endocrinology
Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod
Prehm P, 2013, Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5., Food Chem Toxicol
Nishiyama T et al., 2005, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice., J Agric Food Chem
Hintzpeter J et al., 2015, Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1., Chem Biol Interact

CURCUMIN EP300

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
CURCUMIN ABCC5

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Prehm P, 2013, Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5., Food Chem Toxicol
CURCUMIN TUBB8

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN TUBA1A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

CURCUMIN PTGS2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Koeberle A et al., 2014, SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase., J Med Chem

CURCUMIN TUBA3C

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN CAMK2A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Mayadevi M et al., 2012, Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II., Bioorg Med Chem
CURCUMIN DFFB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Belakavadi et al., 2005, Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase., Mol. Cell. Biochem.

CURCUMIN VDR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Batie S et al., 2013, Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists., Bioorg Med Chem

Bartik L et al., 2010, Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention., J Nutr Biochem

CURCUMIN CFTR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wang W et al., 2016, Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators., PLoS One

CURCUMIN BDNF

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wang et al., 2008, Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB., Brain Res.

Xu et al., 2007, Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats., Brain Res.

CURCUMIN ERBB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem
CURCUMIN ERBB2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem
CURCUMIN ABCB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer

CURCUMIN ABCG2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee CA et al., 2015, Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design., Drug Metab Dispos

CURCUMIN EGFR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem
CURCUMIN TUBB6

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN NFE2L2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Minassi A et al., 2013, Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?, J Nat Prod
CURCUMIN SMAD3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod
CURCUMIN TUBB4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN TUBB2B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN GSTM1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
CURCUMIN TUBB3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN DNMT1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Liu Z et al., 2009, Curcumin is a potent DNA hypomethylation agent., Bioorg Med Chem Lett

CURCUMIN APP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lenhart JA et al., 2010, "Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: design, synthesis, and biological characterization., J Med Chem

Byeon SR et al., 2013, Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment., Bioorg Med Chem Lett

CURCUMIN GSTP1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Depeille et al., 2005, Combined effects of GSTP1 and MRP1 in melanoma drug resistance., Br. J. Cancer

van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact

CURCUMIN WT1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.
CURCUMIN TUBA1C

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN TUBB4B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN UGT1A7

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Basu et al., 2005, Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity., Proc. Natl. Acad. Sci. U.S.A.

CURCUMIN CTGF

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Zheng et al., 2006, Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor., Am. J. Physiol. Gastrointest. Liver Physiol.

CURCUMIN TUBA1B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN HSD17B3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hu GX et al., 2010, Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3., Bioorg Med Chem Lett
CURCUMIN TUBB2A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN DDIT3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis
CURCUMIN TUBB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN THBD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nan et al., 2005, Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells., Thromb. Res.
CURCUMIN ERBB3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem
CURCUMIN TUBA4A

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN ANPEP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Shim et al., 2003, Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin., Chem. Biol.
CURCUMIN TUBB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN TUBA3E

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

CURCUMIN PTGS1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Koeberle A et al., 2014, SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase., J Med Chem

CURCUMIN TOP1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

López-Lázaro M et al., 2007, Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells., J Nat Prod
CURCUMIN TUBA3D

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
CURCUMIN SLC2A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ikonomov et al., 2002, Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects., Endocrinology
CURCUMIN PTGES

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod
CURCUMIN SMAD2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod
CURCUMIN PPARG

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nishiyama T et al., 2005, Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice., J Agric Food Chem
CURCUMIN CBR1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hintzpeter J et al., 2015, Curcumin is a tight-binding inhibitor of the most efficient human daunorubicin reductase--Carbonyl reductase 1., Chem Biol Interact
CURCUMIN IAPP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN KDM4E

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CA9

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CA12

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN XDH

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN ALPPL2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN GMNN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN HPGD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN MMP9

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN ALPI

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CA2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN NOS2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN MAPT

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CA14

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN USP2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CA1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN USP1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN ABCB4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN GLS

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CA6

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CYP3A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN DNMT3B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN MMP13

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CURCUMIN CA4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

DrugBank: DB11672

Version: 5.1.7

Alternate Names:

CURCUMIN DrugBank Drug Name

458-37-7 CAS Number

Kaydia Patch Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups experimental

Publications:

Bartik L et al., 2010, Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention., J Nutr Biochem

van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact

Prehm P, 2013, Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5., Food Chem Toxicol

NCI: CURCUMIN

Version: 14-September-2017

Alternate Names:

C401 NCI drug code

Drug Info:

Publications:

Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.

Nan et al., 2005, Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells., Thromb. Res.

Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer

DTC: CURCUMIN

Version: 02-September-2020

Alternate Names:

CHEMBL116438 ChEMBL Drug ID

Drug Info:

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Schieferdecker S et al., 2015, Myxochelins target human 5-lipoxygenase., J Nat Prod

PharmGKB: curcumin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Lee CA et al., 2015, Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design., Drug Metab Dispos

Wang W et al., 2016, Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators., PLoS One

TTD: Curcumin
- Version: 2020.06.01
Alternate Names:

D07SDQ TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103579
- Version: 29-September-2020
Alternate Names:

CURCUMIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL116438
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

CURCUMIN	DrugBank Drug Name
458-37-7	CAS Number
Kaydia Patch	Drug Brand

CURCUMIN Drug Record

CURCUMIN chembl:CHEMBL116438 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Prehm P, 2013, Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5., Food Chem Toxicol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Koeberle A et al., 2014, SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase., J Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Mayadevi M et al., 2012, Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Belakavadi et al., 2005, Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase., Mol. Cell. Biochem.

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wang W et al., 2016, Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators., PLoS One

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lee CA et al., 2015, Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design., Drug Metab Dispos

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Minassi A et al., 2013, Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?, J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Liu Z et al., 2009, Curcumin is a potent DNA hypomethylation agent., Bioorg Med Chem Lett

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Depeille et al., 2005, Combined effects of GSTP1 and MRP1 in melanoma drug resistance., Br. J. Cancer van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Prehm P, 2013, Curcumin analogue identified as hyaluronan export inhibitor by virtual docking to the ABC transporter MRP5., Food Chem Toxicol

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Koeberle A et al., 2014, SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Mayadevi M et al., 2012, Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Belakavadi et al., 2005, Mechanism of inhibition of ascites tumor growth in mice by curcumin is mediated by NF-kB and caspase activated DNase., Mol. Cell. Biochem.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Wang W et al., 2016, Robust Stimulation of W1282X-CFTR Channel Activity by a Combination of Allosteric Modulators., PLoS One

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Limtrakul et al., 2004, Modulation of human multidrug-resistance MDR-1 gene by natural curcuminoids., BMC Cancer

Interaction Types & Directionality:

n/a

Publications:

Lee CA et al., 2015, Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design., Drug Metab Dispos

Interaction Types & Directionality:

n/a

Publications:

Wada K et al., 2015, Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Minassi A et al., 2013, Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?, J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Liu Z et al., 2009, Curcumin is a potent DNA hypomethylation agent., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Depeille et al., 2005, Combined effects of GSTP1 and MRP1 in melanoma drug resistance., Br. J. Cancer

van Iersel ML et al., 1997, Interactions of alpha, beta-unsaturated aldehydes and ketones with human glutathione S-transferase P1-1., Chem Biol Interact

Interaction Types & Directionality:

n/a

Publications:

Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Basu et al., 2005, Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity., Proc. Natl. Acad. Sci. U.S.A.

Interaction Types & Directionality:

n/a

Publications:

Zheng et al., 2006, Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor., Am. J. Physiol. Gastrointest. Liver Physiol.

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Hu GX et al., 2010, Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Scott et al., 2004, Curcumin-induced GADD153 gene up-regulation in human colon cancer cells., Carcinogenesis

Interaction Types & Directionality:

n/a

Publications:

Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem