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CORTICOTROPIN Drug Record

  • Summary
  • Interactions
  • Claims
  • CORTICOTROPIN chembl:CHEMBL1201610 ApprovedImmunotherapy

    Alternate Names:

    REPOSITORY CORTICOTROPIN
    ACTHAR
    ACTH
    ADRENOMONE
    ADRENOCORTICOTROPIN
    CORTIGEL
    CORTROPHIN
    ACTHAR GEL
    H.P. ACTHAR GEL
    CORTICOTROPIN, REPOSITORY
    ADRENOCORTICOTROPIC HORMONE
    CORTICOTROPIN
    PURIFIED CORTROPHIN GEL
    CORTICOTROPHIN
    POMC(138-176)
    chembl:CHEMBL1201610
    chemidplus:12427-33-7
    rxcui:376
    drugbank:01285

    Drug Info:

    Year of Approval 1950
    Drug Class diagnostic agents
    FDA Approval 1950
    Drug Class protein
    Drug Indications Diagnostic Agents
    Drug Groups investigational
    Drug Categories adrenal cortex hormones
    Drug Categories corticosteroids
    Drug Categories corticosteroids for systemic use
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 substrates
    (5 More Sources)

    Publications:

    Suri et al., 2006, A case of ACTH-independent bilateral macronodular adrenal hyperplasia and severe congestive heart failure., J. Endocrinol. Invest.
    Johnston et al., 2007, Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis., Reproduction
    Hruby et al., 2007, Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor., Curr Top Med Chem
    Lin et al., 2007, Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia., Clin. Endocrinol. (Oxf)
    Carey et al., 2006, Infusion of ACTH stimulates expression of adrenal ACTH receptor and steroidogenic acute regulatory protein mRNA in fetal sheep., Am. J. Physiol. Endocrinol. Metab.
    Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology
    Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.
    Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology
    Chen et al., 2007, Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling., Biochemistry
    Li et al., 2006, Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats., Eur. J. Pharmacol.
    Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.
    Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.
    Colby et al., 2003, Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action., Pharmacology
    Zhao et al., 2006, Purinergic receptor ligands stimulate pro-opiomelanocortin gene expression in AtT-20 pituitary corticotroph cells., J. Neuroendocrinol.
    Matejec et al., 2005, Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity., Neuroendocrinology
    Wagner et al., 2006, Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro., Horm. Metab. Res.
    Hellman et al., 2006, Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indication., World J Surg
    Dinan et al., 2006, Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?, Gastroenterology
    Lafeuillade et al., 1996, Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells., J. Cell. Physiol.
  • CORTICOTROPIN   CRH

    Interaction Score: 4.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    16503922 16534240 16523405 16467980 16472586


    Sources:
    DrugBank

  • CORTICOTROPIN   MC2R

    Interaction Score: 4.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Melanocortin receptor 2 agonist
    Trial Name -

    PMIDs:
    17185906 17636172 17584128 17223989 16478774


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • CORTICOTROPIN   NR5A1

    Interaction Score: 1.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12239114 12530657


    Sources:
    NCI

  • CORTICOTROPIN   THBS1

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8698834


    Sources:
    NCI

  • CORTICOTROPIN   MC5R

    Interaction Score: 1.01

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CORTICOTROPIN   TPM3

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17877367


    Sources:
    NCI

  • CORTICOTROPIN   MC3R

    Interaction Score: 0.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CORTICOTROPIN   MC1R

    Interaction Score: 0.68

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CORTICOTROPIN   LDLR

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11956163


    Sources:
    NCI

  • CORTICOTROPIN   TGM2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2444616


    Sources:
    NCI

  • CORTICOTROPIN   MC4R

    Interaction Score: 0.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CORTICOTROPIN   NTRK2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11360665


    Sources:
    NCI

  • CORTICOTROPIN   BDNF

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16330021


    Sources:
    NCI

  • CORTICOTROPIN   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12571407


    Sources:
    NCI

  • DrugBank: DB01285

    • Version: 5.1.7

    Alternate Names:
    CORTICOTROPIN DrugBank Drug Name
    12427-33-7 CAS Number
    Acthar Drug Brand

    Drug Info:
    Drug Type biotech
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Zhao et al., 2006, Purinergic receptor ligands stimulate pro-opiomelanocortin gene expression in AtT-20 pituitary corticotroph cells., J. Neuroendocrinol.
    Matejec et al., 2005, Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity., Neuroendocrinology
    Wagner et al., 2006, Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro., Horm. Metab. Res.

  • GuideToPharmacology: 135651598

    • Version: 29-September-2020

    Alternate Names:
    POMC Gene Symbol (for Endogenous Peptides)
    ACTH GuideToPharmacology Ligand Name

    Drug Info:
    Name of the Ligand Species (if a Peptide) Human

    Publications:

  • TEND: CORTICOTROPIN

    • Version: 01-August-2011

    Alternate Names:
    CORTICOTROPIN Primary Drug Name

    Drug Info:
    Drug Class diagnostic agents
    Year of Approval 1950

    Publications:

  • TdgClinicalTrial: CORTICOTROPIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Diagnostic Agents
    Drug Class protein
    FDA Approval 1950

    Publications:

  • NCI: ADRENOCORTICOTROPIN

    • Version: 14-September-2017

    Alternate Names:
    C212 NCI drug code

    Drug Info:

    Publications:
    Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

  • NCI: ACTH

    • Version: 14-September-2017

    Alternate Names:
    C212 NCI drug code

    Drug Info:

    Publications:
    Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology
    Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology
    Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.

  • NCI: CORTICOTROPIN

    • Version: 14-September-2017

    Alternate Names:
    C212 NCI drug code

    Drug Info:

    Publications:
    Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.

  • ChemblInteractions: CHEMBL1201610

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1201610

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21