DGIdb - CORTICOTROPIN Drug Record

CORTICOTROPIN chembl:CHEMBL1201610 ApprovedImmunotherapy

Alternate Names:

REPOSITORY CORTICOTROPIN
ACTHAR
ACTH
ADRENOMONE
ADRENOCORTICOTROPIN
CORTIGEL
CORTROPHIN
ACTHAR GEL
H.P. ACTHAR GEL
CORTICOTROPIN, REPOSITORY
ADRENOCORTICOTROPIC HORMONE
CORTICOTROPIN
PURIFIED CORTROPHIN GEL
CORTICOTROPHIN
POMC(138-176)
chembl:CHEMBL1201610
chemidplus:12427-33-7
rxcui:376
drugbank:01285

Drug Info:

Year of Approval	1950
Drug Class	diagnostic agents
FDA Approval	1950
Drug Class	protein
Drug Indications	Diagnostic Agents
Drug Groups	investigational
Drug Categories	adrenal cortex hormones
Drug Categories	corticosteroids
Drug Categories	corticosteroids for systemic use
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates

(5 More Sources)

Publications:

Suri et al., 2006, A case of ACTH-independent bilateral macronodular adrenal hyperplasia and severe congestive heart failure., J. Endocrinol. Invest.
Johnston et al., 2007, Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis., Reproduction
Hruby et al., 2007, Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor., Curr Top Med Chem
Lin et al., 2007, Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia., Clin. Endocrinol. (Oxf)
Carey et al., 2006, Infusion of ACTH stimulates expression of adrenal ACTH receptor and steroidogenic acute regulatory protein mRNA in fetal sheep., Am. J. Physiol. Endocrinol. Metab.
Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology
Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.
Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology
Chen et al., 2007, Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling., Biochemistry
Li et al., 2006, Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats., Eur. J. Pharmacol.
Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.
Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.
Colby et al., 2003, Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action., Pharmacology
Zhao et al., 2006, Purinergic receptor ligands stimulate pro-opiomelanocortin gene expression in AtT-20 pituitary corticotroph cells., J. Neuroendocrinol.
Matejec et al., 2005, Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity., Neuroendocrinology
Wagner et al., 2006, Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro., Horm. Metab. Res.
Hellman et al., 2006, Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indication., World J Surg
Dinan et al., 2006, Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?, Gastroenterology
Lafeuillade et al., 1996, Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells., J. Cell. Physiol.

CORTICOTROPIN CRH

Interaction Score: 4.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
16503922 16534240 16523405 16467980 16472586

Sources:
DrugBank
CORTICOTROPIN MC2R

Interaction Score: 4.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

Trial Name -

PMIDs:
17185906 17636172 17584128 17223989 16478774

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
CORTICOTROPIN NR5A1

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12239114 12530657

Sources:
NCI
CORTICOTROPIN THBS1

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8698834

Sources:
NCI
CORTICOTROPIN MC5R

Interaction Score: 1.01

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CORTICOTROPIN TPM3

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17877367

Sources:
NCI
CORTICOTROPIN MC3R

Interaction Score: 0.81

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CORTICOTROPIN MC1R

Interaction Score: 0.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CORTICOTROPIN LDLR

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11956163

Sources:
NCI
CORTICOTROPIN TGM2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2444616

Sources:
NCI
CORTICOTROPIN MC4R

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CORTICOTROPIN NTRK2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11360665

Sources:
NCI
CORTICOTROPIN BDNF

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16330021

Sources:
NCI
CORTICOTROPIN CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12571407

Sources:
NCI

DrugBank: DB01285

Version: 5.1.7

Alternate Names:

CORTICOTROPIN DrugBank Drug Name

12427-33-7 CAS Number

Acthar Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Groups investigational

Publications:

Zhao et al., 2006, Purinergic receptor ligands stimulate pro-opiomelanocortin gene expression in AtT-20 pituitary corticotroph cells., J. Neuroendocrinol.

Matejec et al., 2005, Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity., Neuroendocrinology

Wagner et al., 2006, Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro., Horm. Metab. Res.

GuideToPharmacology: 135651598
- Version: 29-September-2020
Alternate Names:

POMC Gene Symbol (for Endogenous Peptides)

ACTH GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human

Publications:
TEND: CORTICOTROPIN
- Version: 01-August-2011
Alternate Names:

CORTICOTROPIN Primary Drug Name

Drug Info:

Drug Class diagnostic agents

Year of Approval 1950

Publications:
TdgClinicalTrial: CORTICOTROPIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Diagnostic Agents

Drug Class protein

FDA Approval 1950

Publications:

NCI: ADRENOCORTICOTROPIN

Version: 14-September-2017

Alternate Names:

C212 NCI drug code

Drug Info:

Publications:

Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

NCI: ACTH

Version: 14-September-2017

Alternate Names:

C212 NCI drug code

Drug Info:

Publications:

Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology

Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology

Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.

NCI: CORTICOTROPIN
- Version: 14-September-2017
Alternate Names:

C212 NCI drug code

Drug Info:

Publications:

Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.
ChemblInteractions: CHEMBL1201610
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201610
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Melanocortin receptor 2 agonist
Trial Name	-

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	False

CORTICOTROPIN	DrugBank Drug Name
12427-33-7	CAS Number
Acthar	Drug Brand

Drug Type	biotech
Drug Groups	approved
Drug Groups	investigational

POMC	Gene Symbol (for Endogenous Peptides)
ACTH	GuideToPharmacology Ligand Name

CORTICOTROPIN Drug Record

CORTICOTROPIN chembl:CHEMBL1201610 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 16503922 16534240 16523405 16467980 16472586

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Melanocortin receptor 2 agonist Trial Name -

PMIDs: 17185906 17636172 17584128 17223989 16478774

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12239114 12530657

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8698834

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17877367

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11956163

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2444616

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11360665

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16330021

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12571407

Sources: NCI

DrugBank: DB01285

Alternate Names: CORTICOTROPIN DrugBank Drug Name 12427-33-7 CAS Number Acthar Drug Brand

Drug Info: Drug Type biotech Drug Groups approved Drug Groups investigational

GuideToPharmacology: 135651598

Alternate Names: POMC Gene Symbol (for Endogenous Peptides) ACTH GuideToPharmacology Ligand Name

Drug Info: Name of the Ligand Species (if a Peptide) Human

Publications:

TEND: CORTICOTROPIN

Alternate Names: CORTICOTROPIN Primary Drug Name

Drug Info: Drug Class diagnostic agents Year of Approval 1950

Publications:

TdgClinicalTrial: CORTICOTROPIN

Alternate Names:

Drug Info: Drug Indications Diagnostic Agents Drug Class protein FDA Approval 1950

Publications:

NCI: ADRENOCORTICOTROPIN

Alternate Names: C212 NCI drug code

Drug Info:

Publications: Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

Interaction Types & Directionality:

agonist (activating)

PMIDs:
16503922 16534240 16523405 16467980 16472586

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

Trial Name -

PMIDs:
17185906 17636172 17584128 17223989 16478774

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
12239114 12530657

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8698834

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17877367

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11956163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2444616

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
11360665

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16330021

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12571407

Sources:
NCI

Alternate Names:

CORTICOTROPIN DrugBank Drug Name

12427-33-7 CAS Number

Acthar Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Groups investigational

Alternate Names:

POMC Gene Symbol (for Endogenous Peptides)

ACTH GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human

Alternate Names:

CORTICOTROPIN Primary Drug Name

Drug Info:

Drug Class diagnostic agents

Year of Approval 1950

Drug Info:

Drug Indications Diagnostic Agents

Drug Class protein

FDA Approval 1950

Alternate Names:

C212 NCI drug code

Publications:

Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

Alternate Names:

C212 NCI drug code

Alternate Names:

C212 NCI drug code

Publications:

Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.