DGIdb - CORTICOTROPIN Drug Record

CORTICOTROPIN chembl:CHEMBL1201610 ApprovedImmunotherapy

Alternate Names:

REPOSITORY CORTICOTROPIN
ACTHAR
ACTH
ADRENOMONE
ADRENOCORTICOTROPIN
CORTIGEL
CORTROPHIN
ACTHAR GEL
H.P. ACTHAR GEL
CORTICOTROPIN, REPOSITORY
ADRENOCORTICOTROPIC HORMONE
CORTICOTROPIN
PURIFIED CORTROPHIN GEL
CORTICOTROPHIN
POMC(138-176)
chembl:CHEMBL1201610
chemidplus:12427-33-7
rxcui:376
drugbank:01285

Drug Info:

Year of Approval	1950
Drug Class	diagnostic agents
FDA Approval	1950
Drug Class	protein
Drug Indications	Diagnostic Agents
Drug Groups	investigational
Drug Categories	adrenal cortex hormones
Drug Categories	corticosteroids
Drug Categories	corticosteroids for systemic use
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates

(5 More Sources)

Publications:

Lin et al., 2007, Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia., Clin. Endocrinol. (Oxf)
Carey et al., 2006, Infusion of ACTH stimulates expression of adrenal ACTH receptor and steroidogenic acute regulatory protein mRNA in fetal sheep., Am. J. Physiol. Endocrinol. Metab.
Hruby et al., 2007, Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor., Curr Top Med Chem
Johnston et al., 2007, Effects of ACTH and expression of the melanocortin-2 receptor in the neonatal mouse testis., Reproduction
Suri et al., 2006, A case of ACTH-independent bilateral macronodular adrenal hyperplasia and severe congestive heart failure., J. Endocrinol. Invest.
Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.
Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology
Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology
Chen et al., 2007, Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling., Biochemistry
Li et al., 2006, Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats., Eur. J. Pharmacol.
Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.
Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.
Colby et al., 2003, Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action., Pharmacology
Dinan et al., 2006, Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?, Gastroenterology
Hellman et al., 2006, Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indication., World J Surg
Matejec et al., 2005, Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity., Neuroendocrinology
Zhao et al., 2006, Purinergic receptor ligands stimulate pro-opiomelanocortin gene expression in AtT-20 pituitary corticotroph cells., J. Neuroendocrinol.
Wagner et al., 2006, Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro., Horm. Metab. Res.
Lafeuillade et al., 1996, Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells., J. Cell. Physiol.

CORTICOTROPIN MC1R

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Publications:
CORTICOTROPIN MC5R

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Publications:
CORTICOTROPIN MC3R

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Publications:
CORTICOTROPIN MC4R

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Publications:

CORTICOTROPIN MC2R

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

Trial Name -

Publications:

Lin et al., 2007, Severe loss-of-function mutations in the adrenocorticotropin receptor (ACTHR, MC2R) can be found in patients diagnosed with salt-losing adrenal hypoplasia., Clin. Endocrinol. (Oxf)

Carey et al., 2006, Infusion of ACTH stimulates expression of adrenal ACTH receptor and steroidogenic acute regulatory protein mRNA in fetal sheep., Am. J. Physiol. Endocrinol. Metab.

Hruby et al., 2007, Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor., Curr Top Med Chem

CORTICOTROPIN CRH

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Publications:

Dinan et al., 2006, Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker?, Gastroenterology

Hellman et al., 2006, Bilateral adrenalectomy for ectopic Cushing's syndrome-discussions on technique and indication., World J Surg

Matejec et al., 2005, Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity., Neuroendocrinology

CORTICOTROPIN NR5A1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.

Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology

CORTICOTROPIN LDLR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology

CORTICOTROPIN TPM3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chen et al., 2007, Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling., Biochemistry
CORTICOTROPIN BDNF

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Li et al., 2006, Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats., Eur. J. Pharmacol.
CORTICOTROPIN NTRK2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.

CORTICOTROPIN TGM2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

CORTICOTROPIN CYP2D6

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Colby et al., 2003, Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action., Pharmacology

CORTICOTROPIN THBS1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lafeuillade et al., 1996, Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells., J. Cell. Physiol.

DrugBank: DB01285

Version: 5.1.7

Alternate Names:

CORTICOTROPIN DrugBank Drug Name

12427-33-7 CAS Number

Acthar Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Groups investigational

Publications:

Wagner et al., 2006, Promoter polymorphisms regulating corticotrophin-releasing hormone transcription in vitro., Horm. Metab. Res.

Zhao et al., 2006, Purinergic receptor ligands stimulate pro-opiomelanocortin gene expression in AtT-20 pituitary corticotroph cells., J. Neuroendocrinol.

Matejec et al., 2005, Corticotropin-releasing hormone reduces pressure pain sensitivity in humans without involvement of beta-endorphin(1-31), but does not reduce heat pain sensitivity., Neuroendocrinology

GuideToPharmacology: 135651598
- Version: 29-September-2020
Alternate Names:

POMC Gene Symbol (for Endogenous Peptides)

ACTH GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human

Publications:
TEND: CORTICOTROPIN
- Version: 01-August-2011
Alternate Names:

CORTICOTROPIN Primary Drug Name

Drug Info:

Drug Class diagnostic agents

Year of Approval 1950

Publications:
TdgClinicalTrial: CORTICOTROPIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Diagnostic Agents

Drug Class protein

FDA Approval 1950

Publications:

NCI: ADRENOCORTICOTROPIN

Version: 14-September-2017

Alternate Names:

C212 NCI drug code

Drug Info:

Publications:

Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

NCI: ACTH

Version: 14-September-2017

Alternate Names:

C212 NCI drug code

Drug Info:

Publications:

Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology

Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology

Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.

NCI: CORTICOTROPIN
- Version: 14-September-2017
Alternate Names:

C212 NCI drug code

Drug Info:

Publications:

Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.
ChemblInteractions: CHEMBL1201610
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201610
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction	yes
Mechanism of Interaction	Melanocortin receptor 2 agonist
Trial Name	-

CORTICOTROPIN	DrugBank Drug Name
12427-33-7	CAS Number
Acthar	Drug Brand

Drug Type	biotech
Drug Groups	approved
Drug Groups	investigational

POMC	Gene Symbol (for Endogenous Peptides)
ACTH	GuideToPharmacology Ligand Name

CORTICOTROPIN Drug Record

CORTICOTROPIN chembl:CHEMBL1201610 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Melanocortin receptor 2 agonist Trial Name -

Interaction Types & Directionality: agonist (activating)

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res. Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chen et al., 2007, Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling., Biochemistry

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Li et al., 2006, Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats., Eur. J. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Colby et al., 2003, Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action., Pharmacology

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lafeuillade et al., 1996, Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells., J. Cell. Physiol.

DrugBank: DB01285

Alternate Names: CORTICOTROPIN DrugBank Drug Name 12427-33-7 CAS Number Acthar Drug Brand

Drug Info: Drug Type biotech Drug Groups approved Drug Groups investigational

GuideToPharmacology: 135651598

Alternate Names: POMC Gene Symbol (for Endogenous Peptides) ACTH GuideToPharmacology Ligand Name

Drug Info: Name of the Ligand Species (if a Peptide) Human

Publications:

TEND: CORTICOTROPIN

Alternate Names: CORTICOTROPIN Primary Drug Name

Drug Info: Drug Class diagnostic agents Year of Approval 1950

Publications:

TdgClinicalTrial: CORTICOTROPIN

Alternate Names:

Drug Info: Drug Indications Diagnostic Agents Drug Class protein FDA Approval 1950

Publications:

NCI: ADRENOCORTICOTROPIN

Alternate Names: C212 NCI drug code

Drug Info:

Publications: Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

NCI: ACTH

Alternate Names: C212 NCI drug code

Drug Info:

NCI: CORTICOTROPIN

Alternate Names: C212 NCI drug code

Drug Info:

Publications: Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.

ChemblInteractions: CHEMBL1201610

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201610

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Melanocortin receptor 2 agonist

Trial Name -

Interaction Types & Directionality:

agonist (activating)

Interaction Types & Directionality:

n/a

Publications:

Schimmer et al., 2002, SF1 polymorphisms in the mouse and steroidogenic potential., Endocr. Res.

Frigeri et al., 2002, A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants., Endocrinology

Interaction Types & Directionality:

n/a

Publications:

Gälman et al., 2002, Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol., Endocrinology

Interaction Types & Directionality:

n/a

Publications:

Chen et al., 2007, Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling., Biochemistry

Interaction Types & Directionality:

n/a

Publications:

Li et al., 2006, Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats., Eur. J. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.

Interaction Types & Directionality:

n/a

Publications:

Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

Interaction Types & Directionality:

n/a

Publications:

Colby et al., 2003, Downregulation of CYP2D16 by ACTH in the guinea pig adrenal cortex: time course, reversibility, and mechanism of action., Pharmacology

Interaction Types & Directionality:

n/a

Publications:

Lafeuillade et al., 1996, Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells., J. Cell. Physiol.

Alternate Names:

CORTICOTROPIN DrugBank Drug Name

12427-33-7 CAS Number

Acthar Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Groups investigational

Alternate Names:

POMC Gene Symbol (for Endogenous Peptides)

ACTH GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human

Alternate Names:

CORTICOTROPIN Primary Drug Name

Drug Info:

Drug Class diagnostic agents

Year of Approval 1950

Drug Info:

Drug Indications Diagnostic Agents

Drug Class protein

FDA Approval 1950

Alternate Names:

C212 NCI drug code

Publications:

Kitahara et al., 1987, Specific localization of tissue-type transglutaminase in adrenocorticotropin-producing cells of the human pituitary gland as demonstrated by immunohistochemistry., J. Clin. Endocrinol. Metab.

Alternate Names:

C212 NCI drug code

Alternate Names:

C212 NCI drug code

Publications:

Xu et al., 2000, Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain., Acta Pharmacol. Sin.