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COLCHICINE Drug Record

  • Summary
  • Interactions
  • Claims
  • COLCHICINE chembl:CHEMBL107 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    GLOPERBA
    COLCHICINE
    MITIGARE
    NSC-757
    COLCRYS
    BENZO(A)HEPTALEN-9(5H)-ONE
    COLCHICINA
    CONDYLON
    N-(1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDROBENZO[A]HEPTALEN-7-YL)ACETAMIDE
    COLSALOID
    COLCHICIN
    COLCHICINUM
    (S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE
    COLGOUT
    N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE
    N-ACETYLTRIMETHYLCOLCHICINIC ACID METHYL ETHER
    drugbank:01394
    chembl:CHEMBL87
    chemidplus:64-86-8
    rxcui:2683
    pubchem.compound:6167
    chembl:CHEMBL107

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of gout
    Drug Class gout suppressants
    Year of Approval approved before 1982
    (4 More Sources)

    Publications:

    Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
    Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
    Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
    Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
    Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
    Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
    Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
    Ceccatelli et al., 1991, Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment., Proc. Natl. Acad. Sci. U.S.A.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Mader et al., 2004, Dual mode of signalling of the axotomy reaction: retrograde electric stimulation or block of retrograde transport differently mimic the reaction of motoneurons to nerve transection in the rat brainstem., J. Neurotrauma
    Pozas et al., 1999, Fra-1 immunoreactivity in the rat brain during normal postnatal development and after injury in adulthood., Neurosci. Res.
    Yalcıntepe S et al., 2016, The CYP4502D6 *4 and *6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients., Eur J Drug Metab Pharmacokinet
    Roberts RL et al., 2015, Pharmacogenetic considerations in the treatment of gout., Pharmacogenomics
    Acharya et al., 2009, Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity., Biochemistry
    Finkelstein et al., 2010, Colchicine poisoning: the dark side of an ancient drug., Clin Toxicol (Phila)
    Cerquaglia et al., 2005, Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update., Curr Drug Targets Inflamm Allergy
    Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Yee et al., 2005, Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies., Clin. Cancer Res.
    Lu Y et al., 2012, An overview of tubulin inhibitors that interact with the colchicine binding site., Pharm Res
    Dalbeth N et al., 2014, Mechanism of action of colchicine in the treatment of gout., Clin Ther
    Kasturi et al., 1984, Colchicine inhibition of insulin induction of stearoyl-CoA desaturase and fatty acid synthetase in cultured avian liver explants., Arch. Biochem. Biophys.
    Antoniou et al., 2004, Th1 cytokine pattern (IL-12 and IL-18) in bronchoalveolar lavage fluid (BALF) before and after treatment with interferon gamma-1b (IFN-gamma-1b) or colchicine in patients with idiopathic pulmonary fibrosis (IPF/UIP)., Sarcoidosis Vasc Diffuse Lung Dis
    Geddes et al., 1994, Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2., Brain Res.
    Dvorak et al., 2003, Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation., Mol. Pharmacol.
    Twentyman et al., 1990, Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin)., Br. J. Cancer
    Danielsen et al., 1983, Biosynthesis of intestinal microvillar proteins. Role of the Golgi complex and microtubules., Biochem. J.
    Huang et al., 2005, Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes., J. Biol. Chem.
    Stromskaya et al., 1998, Influence of exogenous RAR alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines., Br. J. Cancer
    Dvorák et al., 2007, Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes., Mol. Cell. Endocrinol.
    Cronstein et al., 1995, Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils., J. Clin. Invest.
    Torre et al., Effects of interleukin-8 on suppression of human lymphocyte polarization and migration by anti-LFA-1 antibody., Eur. Cytokine Netw.
    Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.
    Lakkakorpi et al., 1997, Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading., Exp. Cell Res.
  • COLCHICINE   MAP2

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7511033


    Sources:
    NCI

  • COLCHICINE   SRI

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1975203


    Sources:
    NCI

  • COLCHICINE   SCD

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6148915


    Sources:
    NCI

  • COLCHICINE   TUBA3C

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC

  • COLCHICINE   TUBB4A

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC

  • COLCHICINE   TUBB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    19527023 16166440 20814887 15720245 23750455 25937236 25061803 25805446 24502232 25938266 24773591 22814904 20586571 25151572


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBB1

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   IL18

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15281431


    Sources:
    NCI

  • COLCHICINE   TUBB2A

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name colchicine,Colcrys
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC TdgClinicalTrial ChemblInteractions

  • COLCHICINE   TUBB2B

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBA1C

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBA4A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBA3D

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBA1B

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBB8

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBB6

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBA3E

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBB3

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBA1A

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   TUBB4B

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    23750455 25937236 25061803 25805446 24502232 25938266 24773591


    Sources:
    DTC ChemblInteractions

  • COLCHICINE   ANPEP

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6651778


    Sources:
    NCI

  • COLCHICINE   ITGB2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7543498 1363595


    Sources:
    NCI

  • COLCHICINE   NTF3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1946455


    Sources:
    NCI

  • COLCHICINE   GFAP

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15307907 10211779


    Sources:
    NCI

  • COLCHICINE   RARA

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9667638 17291686


    Sources:
    NCI

  • COLCHICINE   NRG1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7666195


    Sources:
    NCI

  • COLCHICINE   TUB

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • COLCHICINE   CREBBP

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   SLC2A4

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16239226


    Sources:
    NCI

  • COLCHICINE   CYP2B6

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12815172


    Sources:
    NCI

  • COLCHICINE   BDNF

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1946455


    Sources:
    NCI

  • COLCHICINE   PIK3CG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9434625


    Sources:
    NCI

  • COLCHICINE   JUN

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   CXCL8

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   PAX8

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25876828


    Sources:
    TEND PharmGKB

  • COLCHICINE   RORC

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300 25645282


    Sources:
    DTC PharmGKB

  • COLCHICINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • COLCHICINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • COLCHICINE   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • COLCHICINE   ATAD5

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • COLCHICINE   GMNN

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COLCHICINE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: COLCHICINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval approved before 1982
    Drug Class gout suppressants

    Publications:

  • TdgClinicalTrial: COLCHICINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of gout
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • DTC: COLCHICINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL107 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
    Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem

  • NCI: COLCHICINE

    • Version: 14-September-2017

    Alternate Names:
    C385 NCI drug code

    Drug Info:

    Publications:
    Ceccatelli et al., 1991, Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment., Proc. Natl. Acad. Sci. U.S.A.
    Kasturi et al., 1984, Colchicine inhibition of insulin induction of stearoyl-CoA desaturase and fatty acid synthetase in cultured avian liver explants., Arch. Biochem. Biophys.
    Cronstein et al., 1995, Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils., J. Clin. Invest.

  • PharmGKB: colchicine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Roberts RL et al., 2015, Pharmacogenetic considerations in the treatment of gout., Pharmacogenomics
    Yalcıntepe S et al., 2016, The CYP4502D6 *4 and *6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients., Eur J Drug Metab Pharmacokinet

  • TTD: Colchicine

    • Version: 2020.06.01

    Alternate Names:
    D09DHY TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL107

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL107

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21