DGIdb - COLCHICINE Drug Record

COLCHICINE chembl:CHEMBL107 ApprovedAntineoplasticImmunotherapy

Alternate Names:

GLOPERBA
COLCHICINE
MITIGARE
NSC-757
COLCRYS
BENZO(A)HEPTALEN-9(5H)-ONE
COLCHICINA
CONDYLON
N-(1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDROBENZO[A]HEPTALEN-7-YL)ACETAMIDE
COLSALOID
COLCHICIN
COLCHICINUM
(S)-N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE
COLGOUT
N-(5,6,7,9-TETRAHYDRO-1,2,3,10-TETRAMETHOXY-9-OXOBENZO[A]HEPTALEN-7-YL)ACETAMIDE
N-ACETYLTRIMETHYLCOLCHICINIC ACID METHYL ETHER
drugbank:01394
chembl:CHEMBL87
chemidplus:64-86-8
rxcui:2683
pubchem.compound:6167
chembl:CHEMBL107

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of gout
Drug Class	gout suppressants
Year of Approval	approved before 1982
Drug Categories	preparations with no effect on uric acid metabolism
Drug Categories	antigout preparations
Drug Categories	agents causing muscle toxicity
Drug Categories	cytochrome p-450 cyp2b6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2e1 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	immunosuppressive agents
Drug Categories	p-glycoprotein inducers
Drug Categories	p-glycoprotein substrates

(6 More Sources)

Publications:

Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
Ceccatelli et al., 1991, Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment., Proc. Natl. Acad. Sci. U.S.A.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Mader et al., 2004, Dual mode of signalling of the axotomy reaction: retrograde electric stimulation or block of retrograde transport differently mimic the reaction of motoneurons to nerve transection in the rat brainstem., J. Neurotrauma
Pozas et al., 1999, Fra-1 immunoreactivity in the rat brain during normal postnatal development and after injury in adulthood., Neurosci. Res.
Yalcıntepe S et al., 2016, The CYP4502D6 4 and 6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients., Eur J Drug Metab Pharmacokinet
Roberts RL et al., 2015, Pharmacogenetic considerations in the treatment of gout., Pharmacogenomics
Acharya et al., 2009, Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity., Biochemistry
Finkelstein et al., 2010, Colchicine poisoning: the dark side of an ancient drug., Clin Toxicol (Phila)
Cerquaglia et al., 2005, Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update., Curr Drug Targets Inflamm Allergy
Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Yee et al., 2005, Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies., Clin. Cancer Res.
Lu Y et al., 2012, An overview of tubulin inhibitors that interact with the colchicine binding site., Pharm Res
Dalbeth N et al., 2014, Mechanism of action of colchicine in the treatment of gout., Clin Ther
Kasturi et al., 1984, Colchicine inhibition of insulin induction of stearoyl-CoA desaturase and fatty acid synthetase in cultured avian liver explants., Arch. Biochem. Biophys.
Antoniou et al., 2004, Th1 cytokine pattern (IL-12 and IL-18) in bronchoalveolar lavage fluid (BALF) before and after treatment with interferon gamma-1b (IFN-gamma-1b) or colchicine in patients with idiopathic pulmonary fibrosis (IPF/UIP)., Sarcoidosis Vasc Diffuse Lung Dis
Geddes et al., 1994, Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2., Brain Res.
Dvorak et al., 2003, Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation., Mol. Pharmacol.
Twentyman et al., 1990, Chemosensitisation by verapamil and cyclosporin A in mouse tumour cells expressing different levels of P-glycoprotein and CP22 (sorcin)., Br. J. Cancer
Danielsen et al., 1983, Biosynthesis of intestinal microvillar proteins. Role of the Golgi complex and microtubules., Biochem. J.
Huang et al., 2005, Disruption of microtubules ablates the specificity of insulin signaling to GLUT4 translocation in 3T3-L1 adipocytes., J. Biol. Chem.
Stromskaya et al., 1998, Influence of exogenous RAR alpha gene on MDR1 expression and P-glycoprotein function in human and rodent cell lines., Br. J. Cancer
Dvorák et al., 2007, Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes., Mol. Cell. Endocrinol.
Cronstein et al., 1995, Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils., J. Clin. Invest.
Torre et al., Effects of interleukin-8 on suppression of human lymphocyte polarization and migration by anti-LFA-1 antibody., Eur. Cytokine Netw.
Sandrock et al., 1995, ARIA is concentrated in nerve terminals at neuromuscular junctions and at other synapses., J. Neurosci.
Lakkakorpi et al., 1997, Phosphatidylinositol 3-kinase association with the osteoclast cytoskeleton, and its involvement in osteoclast attachment and spreading., Exp. Cell Res.

COLCHICINE MAP2

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7511033

Sources:
NCI
COLCHICINE SCD

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6148915

Sources:
NCI
COLCHICINE TUBB4A

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC
COLCHICINE SRI

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1975203

Sources:
NCI
COLCHICINE TUBA3C

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC
COLCHICINE TUBB

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

binder

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
19527023 16166440 20814887 15720245 23750455 25937236 25061803 25805446 24502232 25938266 24773591 22814904 20586571 25151572

Sources:
DTC DrugBank ChemblInteractions GuideToPharmacology
COLCHICINE IL18

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15281431

Sources:
NCI
COLCHICINE TUBB1

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284

Sources:
DTC ChemblInteractions
COLCHICINE TUBB2A

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name colchicine,Colcrys

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC TdgClinicalTrial ChemblInteractions
COLCHICINE TUBB2B

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBA3D

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBB8

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBA3E

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBB6

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBA1C

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBA1B

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBA4A

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBB3

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBB4B

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE TUBA1A

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
COLCHICINE ITGB2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7543498 1363595

Sources:
NCI
COLCHICINE ANPEP

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6651778

Sources:
NCI
COLCHICINE NTF3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1946455

Sources:
NCI
COLCHICINE GFAP

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15307907 10211779

Sources:
NCI
COLCHICINE RARA

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9667638 17291686

Sources:
NCI
COLCHICINE NRG1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7666195

Sources:
NCI
COLCHICINE GLRA2

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
COLCHICINE TUB

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
COLCHICINE BRD4

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
COLCHICINE CREBBP

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE SLC2A4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16239226

Sources:
NCI
COLCHICINE CYP2B6

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12815172

Sources:
NCI
COLCHICINE GLRA1

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
COLCHICINE BDNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1946455

Sources:
NCI
COLCHICINE JUN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE PIK3CG

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9434625

Sources:
NCI
COLCHICINE CXCL8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE PAX8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25876828

Sources:
TEND PharmGKB
COLCHICINE RORC

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 25645282

Sources:
DTC PharmGKB
COLCHICINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
COLCHICINE CYP2C19

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
COLCHICINE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
COLCHICINE ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
COLCHICINE GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB01394

Version: 5.1.7

Alternate Names:

64-86-8 CAS Number

Colchicine Tab 0.6mg Drug Brand

Colchicine Tab 1mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents causing muscle toxicity

Publications:

Lu Y et al., 2012, An overview of tubulin inhibitors that interact with the colchicine binding site., Pharm Res

Yee et al., 2005, Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies., Clin. Cancer Res.

Dalbeth N et al., 2014, Mechanism of action of colchicine in the treatment of gout., Clin Ther

TEND: COLCHICINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval approved before 1982

Drug Class gout suppressants

Publications:
TdgClinicalTrial: COLCHICINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of gout

Drug Class Small Molecule

FDA Approval approved

Publications:

DTC: COLCHICINE

Version: 02-September-2020

Alternate Names:

CHEMBL107 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem

Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem

NCI: COLCHICINE

Version: 14-September-2017

Alternate Names:

C385 NCI drug code

Drug Info:

Publications:

Ceccatelli et al., 1991, Expanded distribution of mRNA for nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 in the rat brain after colchicine treatment., Proc. Natl. Acad. Sci. U.S.A.

Kasturi et al., 1984, Colchicine inhibition of insulin induction of stearoyl-CoA desaturase and fatty acid synthetase in cultured avian liver explants., Arch. Biochem. Biophys.

Torre et al., Effects of interleukin-8 on suppression of human lymphocyte polarization and migration by anti-LFA-1 antibody., Eur. Cytokine Netw.

PharmGKB: colchicine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Roberts RL et al., 2015, Pharmacogenetic considerations in the treatment of gout., Pharmacogenomics

Yalcıntepe S et al., 2016, The CYP4502D6 4 and 6 alleles are the molecular genetic markers for drug response: implications in colchicine non-responder FMF patients., Eur J Drug Metab Pharmacokinet

TTD: Colchicine
- Version: 2020.06.01
Alternate Names:

D09DHY TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL107
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL107
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 135650118
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Tubulin inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Novel drug target	Established target
Trial Name	colchicine,Colcrys
Mechanism of Interaction	Tubulin inhibitor

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Antagonist

64-86-8	CAS Number
Colchicine Tab 0.6mg	Drug Brand
Colchicine Tab 1mg	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	agents causing muscle toxicity

inhibitor (inhibitory)
binder

COLCHICINE Drug Record

COLCHICINE chembl:CHEMBL107 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7511033

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6148915

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1975203

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory) binder

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 19527023 16166440 20814887 15720245 23750455 25937236 25061803 25805446 24502232 25938266 24773591 22814904 20586571 25151572

Sources: DTC DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15281431

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name colchicine,Colcrys Mechanism of Interaction Tubulin inhibitor

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tubulin inhibitor

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tubulin inhibitor

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Interaction Types & Directionality:

n/a

PMIDs:
7511033

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6148915

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
1975203

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

binder

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
19527023 16166440 20814887 15720245 23750455 25937236 25061803 25805446 24502232 25938266 24773591 22814904 20586571 25151572

Sources:
DTC DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
15281431

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591 19527023 20586571 15720245 20814887 17016423 17139284

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name colchicine,Colcrys

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
7543498 1363595

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6651778

Sources:
NCI