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CLOTRIMAZOLE Drug Record

  • Summary
  • Interactions
  • Claims
  • CLOTRIMAZOLE chembl:CHEMBL104 Approved

    Alternate Names:

    MYCIL GOLD
    MYCELEX
    PRIVACOM
    CANESTEN CRM COMBI
    BAY-5097
    FUNGEDERM
    GYNE-LOTRIMIN COMBINATION PACK
    CLOTRIMAZOLE
    CANESTEN INTERNAL
    GNF-PF-3499
    GYNE-LOTRIMIN 3
    GYNE-LOTRIMIN
    MYCELEX-G
    ACTAVALL
    GYNE-LOTRIMIN 3 COMBINATION PACK
    MYCELEX-7
    CANESTEN AF
    CANDIDEN
    MASNODERM
    NSC-257473
    GYNIX
    ABTRIM
    TRIMYSTEN
    TRIVAGIZOLE 3
    CANESTEN
    MYCELEX-7 COMBINATION PACK
    CANESTEN VC
    CANESTEN®
    1-(ALPHA-(2-CHLOROPHENYL)BENZHYDRYL)IMIDAZOLE
    LOTRIMIN®
    1-((2-CHLOROPHENYL)DIPHENYLMETHYL)-1H-IMIDAZOLE
    MYCELEX (TN)
    1-(O-CHLOROTRITYL)IMIDAZOLE
    1-(O-CHLORO-ALPHA,ALPHA-DIPHENYLBENZYL)IMIDAZOLE
    1-(Α-(2-CHLOROPHENYL)BENZHYDRYL)IMIDAZOLE
    LOTRIMIN (TN)
    1-(O-CHLORO-Α,Α-DIPHENYLBENZYL)IMIDAZOLE
    chemidplus:23593-75-1
    drugbank:00257
    rxcui:2623
    chembl:CHEMBL104
    pubchem.compound:2812

    Drug Info:

    Drug Categories stomatological preparations
    Drug Categories cytochrome p-450 cyp2c19 inhibitors (moderate)
    Drug Categories cytochrome p-450 cyp2b6 inducers
    Drug Categories antiinfectives and antiseptics for local oral treatment
    Drug Categories antifungals for dermatological use
    Drug Categories antifungals for topical use
    Drug Categories azole antifungals
    Drug Categories bsep/abcb11 inhibitors
    Drug Categories bsep/abcb11 substrates
    Drug Categories cytochrome p-450 cyp2a6 inhibitors (strong)
    Drug Categories cytochrome p-450 cyp2b6 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp2b6 inhibitors (strong)
    Drug Categories cytochrome p-450 cyp2c8 inhibitors (strong)
    Drug Categories cytochrome p-450 cyp2c9 inhibitors (strong)
    Drug Categories cytochrome p-450 cyp3a inducers (strong)
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a7 inducers
    Drug Categories cytochrome p-450 cyp3a7 inducers (strong)
    Drug Categories cytochrome p-450 cyp3a7 inducers (weak)
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 substrates
    Drug Categories dermatologicals
    Drug Categories gynecological antiinfectives and antiseptics
    Drug Categories imidazole and triazole derivatives
    Drug Categories imidazole derivatives
    Drug Categories oatp1b1/slco1b1 inhibitors
    Drug Categories oatp1b1/slco1b1 substrates
    Drug Categories oatp1b3 inducers
    Drug Categories p-glycoprotein inducers
    Drug Categories p-glycoprotein inhibitors
    Drug Categories p-glycoprotein substrates
    (2 More Sources)

    Publications:

    Rufo PA et al., 1996, The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells., J Clin Invest
    Wu SN et al., 1999, Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells., Neuropharmacology
    Brugnara et al., 1996, Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease., J. Clin. Invest.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Jyrkkärinne J et al., 2008, Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship., J Med Chem
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
    Smith CM et al., 2005, Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers., J Biochem Mol Toxicol
    Svecova L et al., 2008, Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression., Drug Metab Dispos
    Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact
    Faucette et al., 2004, Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers., Drug Metab. Dispos.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
    Auerbach SS et al., 2003, Alternatively spliced isoforms of the human constitutive androstane receptor., Nucleic Acids Res
    Kanno Y et al., 2010, A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells., J Toxicol Sci
  • CLOTRIMAZOLE   KCNN4

    Interaction Score: 1.35

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    8903326 10428416 8636434 11752352


    Sources:
    DrugBank GuideToPharmacology

  • CLOTRIMAZOLE   HCAR2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    12799447 20686338


    Sources:
    DrugBank

  • CLOTRIMAZOLE   TRPM2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLOTRIMAZOLE   CYTH2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   CFL1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16680159


    Sources:
    DTC

  • CLOTRIMAZOLE   TRPM4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLOTRIMAZOLE   NR1I3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    18983136


    Sources:
    DTC GuideToPharmacology

  • CLOTRIMAZOLE   CXCR2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CLOTRIMAZOLE   TRPM8

    Interaction Score: 0.12

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLOTRIMAZOLE   AVPR2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23437772


    Sources:
    DTC

  • CLOTRIMAZOLE   NR1I2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    activator (activating)
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False

    PMIDs:
    15849716 17998298 20869355 14977870


    Sources:
    PharmGKB DrugBank GuideToPharmacology

  • CLOTRIMAZOLE   JUN

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16680159


    Sources:
    DTC

  • CLOTRIMAZOLE   CDK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16680159


    Sources:
    DTC

  • CLOTRIMAZOLE   RAPGEF4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   THPO

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   NPSR1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   TSHR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   HIF1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   PPARD

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   GLP1R

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   ADRB2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   HSP90AA1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   CBX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16680159


    Sources:
    DTC

  • CLOTRIMAZOLE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CLOTRIMAZOLE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CLOTRIMAZOLE   ATXN2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   BAZ2B

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   KCNH2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   KDM4A

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • CLOTRIMAZOLE   GMNN

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00257

    • Version: 5.1.7

    Alternate Names:
    CLOTRIMAZOLE DrugBank Drug Name
    23593-75-1 CAS Number
    Akin Anti-Fungal Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups vet_approved

    Publications:
    Smith CM et al., 2005, Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers., J Biochem Mol Toxicol
    Svecova L et al., 2008, Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression., Drug Metab Dispos
    Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact

  • DTC: CLOTRIMAZOLE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL104 ChEMBL Drug ID

    Drug Info:

    Publications:
    MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
    Jyrkkärinne J et al., 2008, Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship., J Med Chem
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Clotrimazole

    • Version: 2020.06.01

    Alternate Names:
    D09GOS TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650114

    • Version: 29-September-2020

    Alternate Names:
    CLOTRIMAZOLE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL104

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: clotrimazole

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21