DGIdb - CLOTRIMAZOLE Drug Record

CLOTRIMAZOLE chembl:CHEMBL104 Approved

Alternate Names:

MYCIL GOLD
MYCELEX
PRIVACOM
CANESTEN CRM COMBI
BAY-5097
FUNGEDERM
GYNE-LOTRIMIN COMBINATION PACK
CLOTRIMAZOLE
CANESTEN INTERNAL
GNF-PF-3499
GYNE-LOTRIMIN 3
GYNE-LOTRIMIN
MYCELEX-G
ACTAVALL
GYNE-LOTRIMIN 3 COMBINATION PACK
MYCELEX-7
CANESTEN AF
CANDIDEN
MASNODERM
NSC-257473
GYNIX
ABTRIM
TRIMYSTEN
TRIVAGIZOLE 3
CANESTEN
MYCELEX-7 COMBINATION PACK
CANESTEN VC
CANESTEN®
1-(ALPHA-(2-CHLOROPHENYL)BENZHYDRYL)IMIDAZOLE
LOTRIMIN®
1-((2-CHLOROPHENYL)DIPHENYLMETHYL)-1H-IMIDAZOLE
MYCELEX (TN)
1-(O-CHLOROTRITYL)IMIDAZOLE
1-(O-CHLORO-ALPHA,ALPHA-DIPHENYLBENZYL)IMIDAZOLE
1-(Α-(2-CHLOROPHENYL)BENZHYDRYL)IMIDAZOLE
LOTRIMIN (TN)
1-(O-CHLORO-Α,Α-DIPHENYLBENZYL)IMIDAZOLE
chemidplus:23593-75-1
drugbank:00257
rxcui:2623
chembl:CHEMBL104
pubchem.compound:2812

Drug Info:

Drug Categories	stomatological preparations
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp2b6 inducers
Drug Categories	antiinfectives and antiseptics for local oral treatment
Drug Categories	antifungals for dermatological use
Drug Categories	antifungals for topical use
Drug Categories	azole antifungals
Drug Categories	bsep/abcb11 inhibitors
Drug Categories	bsep/abcb11 substrates
Drug Categories	cytochrome p-450 cyp2a6 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp2b6 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp2b6 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp2c9 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp3a inducers (strong)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 cyp3a7 inducers
Drug Categories	cytochrome p-450 cyp3a7 inducers (strong)
Drug Categories	cytochrome p-450 cyp3a7 inducers (weak)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	dermatologicals
Drug Categories	gynecological antiinfectives and antiseptics
Drug Categories	imidazole and triazole derivatives
Drug Categories	imidazole derivatives
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	oatp1b1/slco1b1 substrates
Drug Categories	oatp1b3 inducers
Drug Categories	p-glycoprotein inducers
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates

(2 More Sources)

Publications:

Brugnara et al., 1996, Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease., J. Clin. Invest.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Wu SN et al., 1999, Inhibition of Ca2+-activated K+ current by clotrimazole in rat anterior pituitary GH3 cells., Neuropharmacology
Rufo PA et al., 1996, The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells., J Clin Invest
Jyrkkärinne J et al., 2008, Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship., J Med Chem
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Faucette et al., 2004, Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers., Drug Metab. Dispos.
Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact
Smith CM et al., 2005, Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers., J Biochem Mol Toxicol
Svecova L et al., 2008, Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression., Drug Metab Dispos
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem
Auerbach SS et al., 2003, Alternatively spliced isoforms of the human constitutive androstane receptor., Nucleic Acids Res
Kanno Y et al., 2010, A consecutive three alanine residue insertion mutant of human CAR: a novel CAR ligand screening system in HepG2 cells., J Toxicol Sci

CLOTRIMAZOLE KCNN4

Interaction Score: 1.35

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
8636434 11752352 10428416 8903326

Sources:
DrugBank GuideToPharmacology
CLOTRIMAZOLE HCAR2

Interaction Score: 0.59

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
12799447 20686338

Sources:
DrugBank
CLOTRIMAZOLE TRPM2

Interaction Score: 0.39

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOTRIMAZOLE CYTH2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CFL1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE TRPM4

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOTRIMAZOLE NR1I3

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18983136

Sources:
DTC GuideToPharmacology
CLOTRIMAZOLE CXCR2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOTRIMAZOLE TRPM8

Interaction Score: 0.12

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOTRIMAZOLE AVPR2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC
CLOTRIMAZOLE NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

activator (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
14977870 20869355 15849716 17998298

Sources:
DrugBank GuideToPharmacology PharmGKB
CLOTRIMAZOLE JUN

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE CDK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE RAPGEF4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE THPO

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE NPSR1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE TSHR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE HIF1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE GLP1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE ADRB2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE HSP90AA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOTRIMAZOLE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOTRIMAZOLE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE BAZ2B

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE KCNH2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE KDM4A

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOTRIMAZOLE GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00257

Version: 5.1.7

Alternate Names:

CLOTRIMAZOLE DrugBank Drug Name

23593-75-1 CAS Number

Akin Anti-Fungal Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

Svecova L et al., 2008, Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression., Drug Metab Dispos

Smith CM et al., 2005, Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers., J Biochem Mol Toxicol

Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact

DTC: CLOTRIMAZOLE

Version: 02-September-2020

Alternate Names:

CHEMBL104 ChEMBL Drug ID

Drug Info:

Publications:

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

Jyrkkärinne J et al., 2008, Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship., J Med Chem

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

TTD: Clotrimazole
- Version: 2020.06.01
Alternate Names:

D09GOS TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650114
- Version: 29-September-2020
Alternate Names:

CLOTRIMAZOLE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL104
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: clotrimazole
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	False

Specific Action of the Ligand	None
Endogenous Drug?	False
Direct Interaction?	False

CLOTRIMAZOLE	DrugBank Drug Name
23593-75-1	CAS Number
Akin Anti-Fungal	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

inhibitor (inhibitory)
blocker (inhibitory)

agonist (activating)
activator (activating)

CLOTRIMAZOLE Drug Record

CLOTRIMAZOLE chembl:CHEMBL104 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 8636434 11752352 10428416 8903326

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: partial agonist (activating)

Interaction Info:

PMIDs: 12799447 20686338

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 18983136

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23437772

Sources: DTC

Interaction Types & Directionality: agonist (activating) activator (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False

PMIDs: 14977870 20869355 15849716 17998298

Sources: DrugBank GuideToPharmacology PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
8636434 11752352 10428416 8903326

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

partial agonist (activating)

PMIDs:
12799447 20686338

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18983136

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
23437772

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

activator (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
14977870 20869355 15849716 17998298

Sources:
DrugBank GuideToPharmacology PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159