DGIdb - CLOTRIMAZOLE Drug Record

CLOTRIMAZOLE chembl:CHEMBL104 Approved

Alternate Names:

MYCIL GOLD
MYCELEX
PRIVACOM
CANESTEN CRM COMBI
BAY-5097
FUNGEDERM
GYNE-LOTRIMIN COMBINATION PACK
CLOTRIMAZOLE
CANESTEN INTERNAL
GNF-PF-3499
GYNE-LOTRIMIN 3
GYNE-LOTRIMIN
MYCELEX-G
ACTAVALL
GYNE-LOTRIMIN 3 COMBINATION PACK
MYCELEX-7
CANESTEN AF
CANDIDEN
MASNODERM
NSC-257473
GYNIX
ABTRIM
TRIMYSTEN
TRIVAGIZOLE 3
CANESTEN
MYCELEX-7 COMBINATION PACK
CANESTEN VC
CANESTEN®
1-(ALPHA-(2-CHLOROPHENYL)BENZHYDRYL)IMIDAZOLE
LOTRIMIN®
1-((2-CHLOROPHENYL)DIPHENYLMETHYL)-1H-IMIDAZOLE
MYCELEX (TN)
1-(O-CHLOROTRITYL)IMIDAZOLE
1-(O-CHLORO-ALPHA,ALPHA-DIPHENYLBENZYL)IMIDAZOLE
1-(Α-(2-CHLOROPHENYL)BENZHYDRYL)IMIDAZOLE
LOTRIMIN (TN)
1-(O-CHLORO-Α,Α-DIPHENYLBENZYL)IMIDAZOLE
chemidplus:23593-75-1
drugbank:00257
rxcui:2623
chembl:CHEMBL104
pubchem.compound:2812

Drug Info:

(0 More Sources)

Publications:

Jyrkkärinne J et al., 2008, Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship., J Med Chem
MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Faucette et al., 2004, Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers., Drug Metab. Dispos.
Dring AM et al., 2010, Rational quantitative structure-activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands., Chem Biol Interact
Smith CM et al., 2005, Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers., J Biochem Mol Toxicol
Svecova L et al., 2008, Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression., Drug Metab Dispos
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Sassano MF et al., 2013, Colloidal aggregation causes inhibition of G protein-coupled receptors., J Med Chem

CLOTRIMAZOLE CYTH2

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CFL1

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE NR1I3

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
18983136

Sources:
DTC
CLOTRIMAZOLE AVPR2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23437772

Sources:
DTC
CLOTRIMAZOLE CXCR2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOTRIMAZOLE JUN

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE NR1I2

Interaction Score: 0.09

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

PMIDs:
14977870 20869355 15849716 17998298

Sources:
PharmGKB
CLOTRIMAZOLE CDK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE RAPGEF4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE THPO

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE NPSR1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE TSHR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE ADRB2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE HIF1A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE HSP90AA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE GLP1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CLOTRIMAZOLE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOTRIMAZOLE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOTRIMAZOLE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE BAZ2B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE KDM4A

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CLOTRIMAZOLE GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DTC: CLOTRIMAZOLE

Version: 02-September-2020

Alternate Names:

CHEMBL104 ChEMBL Drug ID

Drug Info:

Publications:

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

Jyrkkärinne J et al., 2008, Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship., J Med Chem

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

TTD: Clotrimazole
- Version: 2020.06.01
Alternate Names:

D09GOS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL104
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: clotrimazole
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

activator (activating)
agonist (activating)

CLOTRIMAZOLE Drug Record

CLOTRIMAZOLE chembl:CHEMBL104 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 18983136

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23437772

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: activator (activating) agonist (activating)

Interaction Info:

PMIDs: 14977870 20869355 15849716 17998298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
18983136

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23437772

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

activator (activating)

agonist (activating)

PMIDs:
14977870 20869355 15849716 17998298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300