DGIdb - CLOMIPRAMINE Drug Record

CLOMIPRAMINE chembl:CHEMBL415 Approved

Alternate Names:

NSC-169865
ANAFRANIL
CLOMIPRAMINE
CHLORIMIPRAMINE
3-(3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYL-1-PROPANAMINE
G 34586
MONOCHLORIMIPRAMINE
3-CHLOROIMIPRAMINE
3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
CLOMIPRAMINA
ANAFRANIL®
ANA586
G-34586
CLOMIPRAMINUM
chembl:CHEMBL415
rxcui:2597
drugbank:01242
pubchem.compound:2801
chemidplus:303-49-1

Drug Info:

FDA Approval	1989
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Tricyclic
Drug Class	antidepressive agents, tricyclic
Year of Approval	1989
Drug Groups	investigational
Drug Categories	agents that produce hypertension
Drug Categories	agents that reduce seizure threshold
Drug Categories	combined inhibitors of serotonin/norepinephrine reuptake
Drug Categories	cytochrome p-450 cyp2b6 substrates
Drug Categories	cytochrome p-450 cyp2c19 inhibitors
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	moderate risk qtc-prolonging agents
Drug Categories	neurotoxic agents
Drug Categories	p-glycoprotein inhibitors
Drug Categories	qtc prolonging agents
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin 5-ht2 receptor antagonists
Drug Categories	serotonin receptor antagonists
Drug Categories	tertiary amine tricyclic antidepressants
Drug Categories	tricyclics and other norepinephrine-reuptake inhibitors

(5 More Sources)

Publications:

Gillman, 2007, Tricyclic antidepressant pharmacology and therapeutic drug interactions updated., Br. J. Pharmacol.
Alvarez et al., 1999, Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine., Clin. Pharmacol. Ther.
Whale R et al., 2000, Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine., Psychopharmacology (Berl)
Borkowska et al., [The effect of sertraline on cognitive functions in patients with obsessive-compulsive disorder]., Psychiatr. Pol.
Malizia et al., 1997, Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo., J. Psychopharmacol. (Oxford)
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Suhara et al., 2003, High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography., Arch. Gen. Psychiatry
Larsen et al., 2004, Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects., Br. J. Pharmacol.
Jungkun et al., 2001, Long-term effects of tricyclic antidepressants on norepinephrine kinetics in humans., J Neural Transm (Vienna)
Sargent et al., 1998, Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors., Psychopharmacology (Berl.)
Contreras et al., Cortical and septal responses to dorsal raphe nucleus stimulation in the rat: long-term clomipramine actions., Bol Estud Med Biol
Sugimoto et al., 2003, The tricyclic antidepressant clomipramine increases plasma glucose levels of mice., J. Pharmacol. Sci.
Kastrinsky DB et al., 2015, Reengineered tricyclic anti-cancer agents., Bioorg Med Chem
Antoniazzi S et al., 2017, The combination of pharmacogenetic and pharmacokinetic analyses to optimize clomipramine dosing in major depression: a case report., J Clin Pharm Ther
Hentall et al., 2000, Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus., Neuroscience
Trifunović et al., 1996, The effects of clomipramine on the excitatory action of ethanol on dopaminergic neurons of the ventral tegmental area in vitro., J. Pharmacol. Exp. Ther.
Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet
Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
Barańczyk-Kuźma et al., 2004, Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain., Acta Biochim. Pol.
Barańczyk-Kuźma et al., 2001, [Tricyclic antidepressants as inhibitors of brain glutathione-S-transferase]., Pol. Merkur. Lekarski
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CLOMIPRAMINE FKBP5

Interaction Score: 2.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18597649 21449676 20709156 19676097 15565110 23733030 17467808

Sources:
PharmGKB
CLOMIPRAMINE SLC6A4

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
17471183 10613618 10867985 12647451 9305421 9537821 12695316 14993096

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology
CLOMIPRAMINE SLC6A2

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
9537821 11341486

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
CLOMIPRAMINE GSTP1

Interaction Score: 0.23

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15094841 11899840 10592235

Sources:
DrugBank
CLOMIPRAMINE HTR2B

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9862411 1296670 14501155

Sources:
DrugBank
CLOMIPRAMINE HTR2A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9862411 10682715 8558452 1296670 14501155

Sources:
DrugBank
CLOMIPRAMINE HTR2C

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
9862411 1296670 14501155

Sources:
DrugBank
CLOMIPRAMINE HTR1B

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
CLOMIPRAMINE SCN5A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26372073

Sources:
DTC
CLOMIPRAMINE SLC6A3

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOMIPRAMINE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
CLOMIPRAMINE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOMIPRAMINE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOMIPRAMINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27800629

Sources:
DTC PharmGKB
CLOMIPRAMINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC FDA
CLOMIPRAMINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOMIPRAMINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

DrugBank: DB01242

Version: 5.1.7

Alternate Names:

CLOMIPRAMINE DrugBank Drug Name

303-49-1 CAS Number

Act Clomipramine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Gillman, 2007, Tricyclic antidepressant pharmacology and therapeutic drug interactions updated., Br. J. Pharmacol.

Alvarez et al., 1999, Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine., Clin. Pharmacol. Ther.

Borkowska et al., [The effect of sertraline on cognitive functions in patients with obsessive-compulsive disorder]., Psychiatr. Pol.

TEND: CLOMIPRAMINE
- Version: 01-August-2011
Alternate Names:

CLOMIPRAMINE Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class antidepressive agents, tricyclic

Publications:
TdgClinicalTrial: CLOMIPRAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1989

Publications:
DTC: CLOMIPRAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL415 ChEMBL Drug ID

Drug Info:

Publications:

Kastrinsky DB et al., 2015, Reengineered tricyclic anti-cancer agents., Bioorg Med Chem

PharmGKB: clomipramine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics

TTD: Clomipramine
- Version: 2020.06.01
Alternate Names:

D0ZS8P TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650111
- Version: 29-September-2020
Alternate Names:

CLOMIPRAMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL415
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Clomipramine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

CLOMIPRAMINE	DrugBank Drug Name
303-49-1	CAS Number
Act Clomipramine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

CLOMIPRAMINE Drug Record

CLOMIPRAMINE chembl:CHEMBL415 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18597649 21449676 20709156 19676097 15565110 23733030 17467808

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 17471183 10613618 10867985 12647451 9305421 9537821 12695316 14993096

Sources: TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 9537821 11341486

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15094841 11899840 10592235

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 9862411 1296670 14501155

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 9862411 10682715 8558452 1296670 14501155

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 9862411 1296670 14501155

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21449676

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26372073

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21449676

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27800629

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

DrugBank: DB01242

Alternate Names: CLOMIPRAMINE DrugBank Drug Name 303-49-1 CAS Number Act Clomipramine Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: CLOMIPRAMINE

Alternate Names: CLOMIPRAMINE Primary Drug Name

Drug Info: Year of Approval 1989 Drug Class antidepressive agents, tricyclic

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
18597649 21449676 20709156 19676097 15565110 23733030 17467808

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
17471183 10613618 10867985 12647451 9305421 9537821 12695316 14993096

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
9537821 11341486

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15094841 11899840 10592235

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
9862411 1296670 14501155

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
9862411 10682715 8558452 1296670 14501155

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
9862411 1296670 14501155

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26372073

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
27800629

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

CLOMIPRAMINE DrugBank Drug Name

303-49-1 CAS Number

Act Clomipramine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

CLOMIPRAMINE Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class antidepressive agents, tricyclic

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1989

Alternate Names:

CHEMBL415 ChEMBL Drug ID

Publications:

Kastrinsky DB et al., 2015, Reengineered tricyclic anti-cancer agents., Bioorg Med Chem

Alternate Names:

D0ZS8P TTD Drug ID

Alternate Names:

CLOMIPRAMINE GuideToPharmacology Ligand Name