DGIdb - CLOMIPRAMINE Drug Record

CLOMIPRAMINE chembl:CHEMBL415 Approved

Alternate Names:

NSC-169865
ANAFRANIL
CLOMIPRAMINE
CHLORIMIPRAMINE
3-(3-CHLORO-10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYL-1-PROPANAMINE
G 34586
MONOCHLORIMIPRAMINE
3-CHLOROIMIPRAMINE
3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE
CLOMIPRAMINA
ANAFRANIL®
ANA586
G-34586
CLOMIPRAMINUM
chembl:CHEMBL415
rxcui:2597
drugbank:01242
pubchem.compound:2801
chemidplus:303-49-1

Drug Info:

FDA Approval	1989
Drug Class	small molecule
Drug Indications	Antidepressive Agents, Tricyclic
Drug Class	antidepressive agents, tricyclic
Year of Approval	1989

(3 More Sources)

Publications:

Whale R et al., 2000, Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine., Psychopharmacology (Berl)
Gillman, 2007, Tricyclic antidepressant pharmacology and therapeutic drug interactions updated., Br. J. Pharmacol.
Borkowska et al., [The effect of sertraline on cognitive functions in patients with obsessive-compulsive disorder]., Psychiatr. Pol.
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Suhara et al., 2003, High levels of serotonin transporter occupancy with low-dose clomipramine in comparative occupancy study with fluvoxamine using positron emission tomography., Arch. Gen. Psychiatry
Malizia et al., 1997, Demonstration of clomipramine and venlafaxine occupation at serotonin reuptake sites in man in vivo., J. Psychopharmacol. (Oxford)
Alvarez et al., 1999, Decreased platelet serotonin transporter sites and increased platelet inositol triphosphate levels in patients with unipolar depression: effects of clomipramine and fluoxetine., Clin. Pharmacol. Ther.
Larsen et al., 2004, Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects., Br. J. Pharmacol.
Jungkun et al., 2001, Long-term effects of tricyclic antidepressants on norepinephrine kinetics in humans., J Neural Transm (Vienna)
Kastrinsky DB et al., 2015, Reengineered tricyclic anti-cancer agents., Bioorg Med Chem
Antoniazzi S et al., 2017, The combination of pharmacogenetic and pharmacokinetic analyses to optimize clomipramine dosing in major depression: a case report., J Clin Pharm Ther
Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Zou YF et al., 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders., Neurosci Lett
Sarginson JE et al., 2010, FKBP5 polymorphisms and antidepressant response in geriatric depression., Am J Med Genet B Neuropsychiatr Genet
Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics
Papiol S et al., 2007, Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment., J Affect Disord
Binder EB et al., 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment., Nat Genet

CLOMIPRAMINE FKBP5

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB
CLOMIPRAMINE SLC6A4

Interaction Score: 1.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10867985 17471183 12647451 9537821 12695316 9305421 10613618 14993096

Sources:
TdgClinicalTrial TEND PharmGKB
CLOMIPRAMINE SLC6A2

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9537821 11341486

Sources:
TdgClinicalTrial TEND
CLOMIPRAMINE HTR1B

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
CLOMIPRAMINE SCN5A

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26372073

Sources:
DTC
CLOMIPRAMINE ABCB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
CLOMIPRAMINE PPARD

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOMIPRAMINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOMIPRAMINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27800629

Sources:
DTC PharmGKB
CLOMIPRAMINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC FDA
CLOMIPRAMINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOMIPRAMINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB

TEND: CLOMIPRAMINE
- Version: 01-August-2011
Alternate Names:

CLOMIPRAMINE Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class antidepressive agents, tricyclic

Publications:
TdgClinicalTrial: CLOMIPRAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1989

Publications:
DTC: CLOMIPRAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL415 ChEMBL Drug ID

Drug Info:

Publications:

Kastrinsky DB et al., 2015, Reengineered tricyclic anti-cancer agents., Bioorg Med Chem

PharmGKB: clomipramine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

Kirchheiner J et al., 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment., Pharmacogenomics

TTD: Clomipramine
- Version: 2020.06.01
Alternate Names:

D0ZS8P TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL415
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Clomipramine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

CLOMIPRAMINE Drug Record

CLOMIPRAMINE chembl:CHEMBL415 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10867985 17471183 12647451 9537821 12695316 9305421 10613618 14993096

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9537821 11341486

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21449676

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26372073

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21449676

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27800629

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

TEND: CLOMIPRAMINE

Alternate Names: CLOMIPRAMINE Primary Drug Name

Drug Info: Year of Approval 1989 Drug Class antidepressive agents, tricyclic

Publications:

TdgClinicalTrial: CLOMIPRAMINE

Alternate Names:

Drug Info: Drug Indications Antidepressive Agents, Tricyclic Drug Class small molecule FDA Approval 1989

Publications:

DTC: CLOMIPRAMINE

Alternate Names: CHEMBL415 ChEMBL Drug ID

Drug Info:

Publications: Kastrinsky DB et al., 2015, Reengineered tricyclic anti-cancer agents., Bioorg Med Chem

PharmGKB: clomipramine

Alternate Names:

Drug Info:

TTD: Clomipramine

Alternate Names: D0ZS8P TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL415

Alternate Names:

Drug Info:

Publications:

FDA: Clomipramine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
23733030 21449676 20709156 19676097 18597649 17467808 15565110

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10867985 17471183 12647451 9537821 12695316 9305421 10613618 14993096

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9537821 11341486

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26372073

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
27800629

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Alternate Names:

CLOMIPRAMINE Primary Drug Name

Drug Info:

Year of Approval 1989

Drug Class antidepressive agents, tricyclic

Drug Info:

Drug Indications Antidepressive Agents, Tricyclic

Drug Class small molecule

FDA Approval 1989

Alternate Names:

CHEMBL415 ChEMBL Drug ID

Publications:

Kastrinsky DB et al., 2015, Reengineered tricyclic anti-cancer agents., Bioorg Med Chem

Alternate Names:

D0ZS8P TTD Drug ID