DGIdb - CHLORZOXAZONE Drug Record

CHLORZOXAZONE chembl:CHEMBL1371 Approved

Alternate Names:

NSC-26189
PARAFON
CHLORZOXAZONE
PARAFON FORTE DSC
PARAFLEX
PARAFON-FORTE
PARAFON FORTE
STRIFON
STRIFON FORTE DSC
5-CHLORO-2-HYDROXYBENZOXAZOLE
5-CHLOROBENZOXAZOLIDONE
CHLORZOXAZONUM
CHLORZOXANE
5-CHLORO-2-BENZOXAZOLINONE
5-CHLORO-2-BENZOXAZOLOL
CHLORZOXAZONA
5-CHLORO-2(3H)-BENZOXAZOLONE
CLORZOXAZONE
CHLORZOXAZON
PARAFLEX®
5-CHLOROBENZOXAZOLIN-2-ONE
2-HYDROXY-5-CHLOROBENZOXAZOLE
CLORZOXAZONA
5-CHLORO-2-BENZOXAZOLONE
5-CHLORO-3H-BENZOOXAZOL-2-ONE
pubchem.compound:2733
chemidplus:95-25-0
drugbank:00356
rxcui:2410
chembl:CHEMBL1371

Drug Info:

Drug Class	muscle relaxants
Year of Approval	approved before 1982
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Muscle Relaxants

(4 More Sources)

Publications:

Syme et al., 2000, Pharmacological activation of cloned intermediate- and small-conductance Ca(2+)-activated K(+) channels., Am. J. Physiol., Cell Physiol.
Dong et al., 2006, Chlorzoxazone inhibits contraction of rat thoracic aorta., Eur. J. Pharmacol.
Alviña et al., 2010, KCa channels as therapeutic targets in episodic ataxia type-2., J. Neurosci.
Palmer et al., 2001, An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)., Br J Clin Pharmacol
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

CHLORZOXAZONE KCNN4

Interaction Score: 12.37

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Intermediate conductance calcium-activated potassium channel protein 4 opener

PMIDs:
None found

Sources:
ChemblInteractions TTD
CHLORZOXAZONE KCNMA1

Interaction Score: 7.73

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10712246 16859676 20505091

Sources:
TdgClinicalTrial TEND
CHLORZOXAZONE CYP3A43

Interaction Score: 3.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11736864

Sources:
NCI
CHLORZOXAZONE CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
CHLORZOXAZONE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: CHLORZOXAZONE
- Version: 01-August-2011
Alternate Names:

CHLORZOXAZONE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class muscle relaxants

Publications:
TdgClinicalTrial: CHLORZOXAZONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Muscle Relaxants

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
NCI: CHLORZOXAZONE
- Version: 14-September-2017
Alternate Names:

C28926 NCI drug code

Drug Info:

Publications:

Palmer et al., 2001, An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)., Br J Clin Pharmacol
PharmGKB: chlorzoxazone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Chlorzoxazone
- Version: 2020.06.01
Alternate Names:

D08ZEB TTD Drug ID

Drug Info:

Publications:
DTC: CHLORZOXAZONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1371 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1371
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1371
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Intermediate conductance calcium-activated potassium channel protein 4 opener

Trial Name	-
Novel drug target	Established target

CHLORZOXAZONE Drug Record

CHLORZOXAZONE chembl:CHEMBL1371 Approved

Alternate Names:

Drug Info:

Publications:

CHLORZOXAZONE KCNN4

Interaction Types & Directionality: activator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Intermediate conductance calcium-activated potassium channel protein 4 opener

PMIDs: None found

Sources: ChemblInteractions TTD

CHLORZOXAZONE KCNMA1

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10712246 16859676 20505091

Sources: TdgClinicalTrial TEND

CHLORZOXAZONE CYP3A43

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11736864

Sources: NCI

CHLORZOXAZONE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

CHLORZOXAZONE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: CHLORZOXAZONE

Alternate Names: CHLORZOXAZONE Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class muscle relaxants

Publications:

TdgClinicalTrial: CHLORZOXAZONE

Alternate Names:

Drug Info: Drug Indications Muscle Relaxants Drug Class small molecule FDA Approval Approved before 1982

Publications:

NCI: CHLORZOXAZONE

Alternate Names: C28926 NCI drug code

Drug Info:

Publications: Palmer et al., 2001, An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)., Br J Clin Pharmacol

PharmGKB: chlorzoxazone

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Chlorzoxazone

Alternate Names: D08ZEB TTD Drug ID

Drug Info:

Publications:

DTC: CHLORZOXAZONE

Alternate Names: CHEMBL1371 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1371

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1371

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Intermediate conductance calcium-activated potassium channel protein 4 opener

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10712246 16859676 20505091

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
11736864

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CHLORZOXAZONE Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class muscle relaxants

Drug Info:

Drug Indications Muscle Relaxants

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

C28926 NCI drug code

Publications:

Palmer et al., 2001, An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)., Br J Clin Pharmacol

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D08ZEB TTD Drug ID

Alternate Names:

CHEMBL1371 ChEMBL Drug ID