DGIdb - CHLORPROMAZINE Drug Record

CHLORPROMAZINE chembl:CHEMBL71 Approved

Alternate Names:

CHLORPROMAZINE TANNATE
LARGACTIL
MEGAPHEN
CHLORPROMAZINE HIBENZATE
SONAZINE
SKF-2601A
J2.794D
CHLORPROMAZINE PHENOLPHTHALINATE
NSC-167745
ELMARIN
CHLORPROMAZINE
THORAZINE
NSC-226514
3-(2-CHLORO-10H-PHENOTHIAZIN-10-YL)-N,N-DIMETHYL-1-PROPANAMINE
N-(3-DIMETHYLAMINOPROPYL)-3-CHLOROPHENOTHIAZINE
CPZ
LARGACTIL®
3-(2-CHLOROPHENOTHIAZIN-10-YL)-N,N-DIMETHYL-PROPAN-1-AMINE
CHLORPROMAZINE HCL
THORAZINE®
rxcui:2403
chemidplus:50-53-3
drugbank:00477
chembl:CHEMBL71
pubchem.compound:2726

Drug Info:

Drug Categories	phenothiazines with aliphatic side-chain
Drug Groups	investigational
Drug Categories	adrenergic alpha-1 receptor antagonists
Drug Categories	adrenergic alpha-antagonists
Drug Categories	adrenergic antagonists
Drug Categories	agents producing tachycardia
Drug Categories	agents that produce hypertension
Drug Categories	agents that reduce seizure threshold
Drug Categories	anticholinergic agents
Drug Categories	antidepressive agents
Drug Categories	cholinesterase inhibitors
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2e1 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	dopamine d2 receptor antagonists
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	drugs that are mainly renally excreted
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	histamine antagonists
Drug Categories	histamine h1 antagonists
Drug Categories	hyperglycemia-associated agents
Drug Categories	muscarinic antagonists
Drug Categories	neurotoxic agents
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	photosensitizing agents
Drug Categories	qtc prolonging agents
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin 5-ht1 receptor antagonists
Drug Categories	serotonin 5-ht2 receptor antagonists
Drug Categories	serotonin agents
Drug Categories	serotonin receptor antagonists

(4 More Sources)

Publications:

Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
Kusumi et al., 2000, Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain., J Neural Transm (Vienna)
Yamada et al., 1995, Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice., Biol. Pharm. Bull.
Seeman et al., 1993, Dopamine receptor pharmacology., Curr Opin Neurol Neurosurg
Kanba et al., 1994, Affinity of neuroleptics for D1 receptor of human brain striatum., J Psychiatry Neurosci
Nguyen et al., 2001, Discovery of a novel member of the histamine receptor family., Mol. Pharmacol.
Xu et al., 2008, BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population., Pharmacogenet. Genomics
Roth et al., 1995, D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs., Psychopharmacology (Berl.)
Davies et al., 2005, The highly efficacious actions of N-desmethylclozapine at muscarinic receptors are unique and not a common property of either typical or atypical antipsychotic drugs: is M1 agonism a pre-requisite for mimicking clozapine's actions?, Psychopharmacology (Berl.)
Huerta-Bahena et al., 1983, Trifluoperazine and chlorpromazine antagonize alpha 1- but not alpha2- adrenergic effects., Mol. Pharmacol.
Cahir et al., 2005, Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat., Eur Neuropsychopharmacol
Oades et al., 2000, Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy., Behav Pharmacol
Wu et al., 2006, Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients., Acta Pharmacol. Sin.
Seeman, 2010, Dopamine D2 receptors as treatment targets in schizophrenia., Clin Schizophr Relat Psychoses
Wu et al., 2005, Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients., Neurosci. Lett.
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Arranz MJ et al., 1998, Lack of association between a polymorphism in the promoter region of the dopamine-2 receptor gene and clozapine response., Pharmacogenetics
Ohara K et al., 1998, Functional polymorphism of -141C Ins/Del in the dopamine D2 receptor gene promoter and schizophrenia., Psychiatry Res
Eum S et al., 2017, Pharmacogenetic evaluation to assess breakthrough psychosis with aripiprazole long-acting injection: a case report., BMC Psychiatry
Zhang JP et al., 2010, D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis., Am J Psychiatry
Shen YC et al., 2009, Effects of DRD2/ANKK1 gene variations and clinical factors on aripiprazole efficacy in schizophrenic patients., J Psychiatr Res
Xing Q et al., 2007, The relationship between the therapeutic response to risperidone and the dopamine D2 receptor polymorphism in Chinese schizophrenia patients., Int J Neuropsychopharmacol
Lencz et al., 2006, DRD2 promoter region variation as a predictor of sustained response to antipsychotic medication in first-episode schizophrenia patients., Am J Psychiatry
Hwang R et al., 2005, Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations., Psychopharmacology (Berl)
Suzuki A et al., 2001, The -141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients., Pharmacogenetics
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry
Palmer et al., 1978, Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol., Arch Int Pharmacodyn Ther
Church et al., 1983, The characteristics of inhibition of histamine release from human lung fragments by sodium cromoglycate, salbutamol and chlorpromazine., Br. J. Pharmacol.
Hals et al., 1988, Muscarinic cholinergic and histamine H1 receptor binding of phenothiazine drug metabolites., Life Sci.
Ruffolo et al., 1978, Kinetics of blockade of different receptors by chlorpromazine in rabbit stomach strips., Eur. J. Pharmacol.
Johnson et al., 1979, Inhibition of histamine release and ionophore-induced calcium flux in rat mast cells by lidocaine and chlorpromazine., Agents Actions
Bylund et al., 1988, Alpha-2A and alpha-2B adrenergic receptor subtypes: antagonist binding in tissues and cell lines containing only one subtype., J. Pharmacol. Exp. Ther.
Marshak et al., 1985, Drug-protein interactions: binding of chlorpromazine to calmodulin, calmodulin fragments, and related calcium binding proteins., Biochemistry
Muralidharan G et al., 1996, Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine., Eur J Clin Pharmacol
Newman-Tancredi et al., 1998, Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study., Eur. J. Pharmacol.
Cosi et al., 2001, Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells., Eur. J. Pharmacol.
Freedman et al., 1994, Expression and pharmacological characterization of the human D3 dopamine receptor., J. Pharmacol. Exp. Ther.
Monostory et al., 2004, Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors., Chem. Biol. Interact.
Thomas et al., 2003, The antipsychotic drug chlorpromazine inhibits HERG potassium channels., Br. J. Pharmacol.
Porcelli S et al., 2016, PDE7B, NMBR and EPM2A Variants and Schizophrenia: A Case-Control and Pharmacogenetics Study., Neuropsychobiology
Pomeranz et al., 1987, The effect of chlorpromazine on cholecystokinin induced gallbladder contraction., Proc. West. Pharmacol. Soc.
Giardino et al., 1990, DA2/NT receptor balance in the mesostriatal and mesolimbocortical systems after chronic treatment with typical and atypical neuroleptic drugs., Brain Res.
Wang et al., 2008, Antipsychotic drugs inhibit the function of breast cancer resistance protein., Basic Clin. Pharmacol. Toxicol.
Yoshida et al., 1985, Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs., J. Biochem.
Wang et al., 2006, Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein., Psychopharmacology (Berl.)
Hervé et al., 1996, Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein., Pharmacogenetics
Liu et al., 2003, Calmodulin is involved in heat shock signal transduction in wheat., Plant Physiol.

CHLORPROMAZINE CCK

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3628280

Sources:
NCI
CHLORPROMAZINE SMPD1

Interaction Score: 0.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2419314

Sources:
DrugBank
CHLORPROMAZINE ORM1

Interaction Score: 0.47

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
8946472

Sources:
DrugBank
CHLORPROMAZINE EPM2A

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27092952

Sources:
PharmGKB
CHLORPROMAZINE NTS

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1980851

Sources:
NCI
CHLORPROMAZINE DRD2

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
11103886 16867246 20643630 15694263 8524985 11873706 11752352 7908055 9918131 9858029 28673279 20194480 18926547 17105675 16513877 15830237 11505224

Sources:
DrugBank ChemblInteractions GuideToPharmacology PharmGKB TTD
CHLORPROMAZINE CYP2E1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15135088

Sources:
NCI
CHLORPROMAZINE DRD5

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
8104554

Sources:
DrugBank GuideToPharmacology
CHLORPROMAZINE CALM1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2986673

Sources:
DrugBank
CHLORPROMAZINE TRPC5

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology
CHLORPROMAZINE HSPA4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12857801

Sources:
NCI
CHLORPROMAZINE HTR7

Interaction Score: 0.09

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
7908055

Sources:
DrugBank NCI GuideToPharmacology
CHLORPROMAZINE HTR6

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

binder

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
7908055

Sources:
DrugBank GuideToPharmacology
CHLORPROMAZINE HRH4

Interaction Score: 0.08

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
11179435

Sources:
DrugBank
CHLORPROMAZINE DRD4

Interaction Score: 0.08

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor antagonist

Specific Action of the Ligand Antagonist

PMIDs:
8524985

Sources:
DrugBank ChemblInteractions GuideToPharmacology
CHLORPROMAZINE DRD3

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
8301582

Sources:
DrugBank ChemblInteractions GuideToPharmacology
CHLORPROMAZINE HRH1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
687395 6189542 2899826 25190 91313

Sources:
DrugBank GuideToPharmacology
CHLORPROMAZINE HTR2A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

binder

Interaction Info:

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Direct Interaction yes

Specific Action of the Ligand Inverse agonist

PMIDs:
7908055 10821438 8593484

Sources:
DrugBank ChemblInteractions GuideToPharmacology
CHLORPROMAZINE ABCG2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18834354

Sources:
NCI
CHLORPROMAZINE BDNF

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18408624

Sources:
NCI
CHLORPROMAZINE HTR1A

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
9760039 11755134

Sources:
DrugBank GuideToPharmacology
CHLORPROMAZINE HTR2C

Interaction Score: 0.03

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7908055

Sources:
DrugBank GuideToPharmacology
CHLORPROMAZINE ADRA2A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
2835476

Sources:
DrugBank GuideToPharmacology
CHLORPROMAZINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
8104554 7918347

Sources:
DrugBank GuideToPharmacology
CHLORPROMAZINE ADRA1B

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15695070

Sources:
DrugBank
CHLORPROMAZINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
6135146 15695070

Sources:
DrugBank
CHLORPROMAZINE CHRM3

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15765260

Sources:
DrugBank
CHLORPROMAZINE THPO

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPROMAZINE CHRM1

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15765260

Sources:
DrugBank
CHLORPROMAZINE ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16810505

Sources:
NCI PharmGKB
CHLORPROMAZINE ADRA2B

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHLORPROMAZINE ADRA2C

Interaction Score: 0.01

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
CHLORPROMAZINE NR1I2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CHLORPROMAZINE KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
12788816

Sources:
DrugBank
CHLORPROMAZINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17611010

Sources:
DTC PharmGKB
CHLORPROMAZINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8739822

Sources:
DTC PharmGKB
CHLORPROMAZINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLORPROMAZINE TP53

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPROMAZINE IDH1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPROMAZINE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB00477

Version: 5.1.7

Alternate Names:

CHLORPROMAZINE DrugBank Drug Name

50-53-3 CAS Number

Aminazine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Seeman et al., 1993, Dopamine receptor pharmacology., Curr Opin Neurol Neurosurg

Cahir et al., 2005, Antipsychotics lack alpha 1A/B adrenoceptor subtype selectivity in the rat., Eur Neuropsychopharmacol

Thomas et al., 2003, The antipsychotic drug chlorpromazine inhibits HERG potassium channels., Br. J. Pharmacol.

NCI: CHLORPROMAZINE

Version: 14-September-2017

Alternate Names:

C367 NCI drug code

Drug Info:

Publications:

Xu et al., 2008, BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population., Pharmacogenet. Genomics

Monostory et al., 2004, Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors., Chem. Biol. Interact.

Wang et al., 2008, Antipsychotic drugs inhibit the function of breast cancer resistance protein., Basic Clin. Pharmacol. Toxicol.

DTC: CHLORPROMAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL71 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: chlorpromazine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Suzuki A et al., 2001, The -141C Ins/Del polymorphism in the dopamine D2 receptor gene promoter region is associated with anxiolytic and antidepressive effects during treatment with dopamine antagonists in schizophrenic patients., Pharmacogenetics

Wu et al., 2005, Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients., Neurosci. Lett.

Hwang R et al., 2005, Association study of 12 polymorphisms spanning the dopamine D(2) receptor gene and clozapine treatment response in two treatment refractory/intolerant populations., Psychopharmacology (Berl)

TTD: Chlorpromazine
- Version: 2020.06.01
Alternate Names:

D01ZII TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650088
- Version: 29-September-2020
Alternate Names:

CHLORPROMAZINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL71
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL71
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Endogenous Drug?	False
Specific Action of the Ligand	Antagonist
Mechanism of Interaction	D2-like dopamine receptor antagonist

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	None

Specific Action of the Ligand	Inverse agonist
Endogenous Drug?	False

Direct Interaction	yes
Mechanism of Interaction	D2-like dopamine receptor antagonist
Specific Action of the Ligand	Antagonist

Mechanism of Interaction	Serotonin 2a (5-HT2a) receptor antagonist
Direct Interaction	yes
Specific Action of the Ligand	Inverse agonist

CHLORPROMAZINE	DrugBank Drug Name
50-53-3	CAS Number
Aminazine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

antagonist (inhibitory)
inhibitor (inhibitory)

binder
antagonist (inhibitory)

antagonist (inhibitory)
binder

binder
antagonist (inhibitory)

CHLORPROMAZINE Drug Record

CHLORPROMAZINE chembl:CHEMBL71 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3628280

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 2419314

Sources: DrugBank

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 8946472

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27092952

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1980851

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs: 11103886 16867246 20643630 15694263 8524985 11873706 11752352 7908055 9918131 9858029 28673279 20194480 18926547 17105675 16513877 15830237 11505224

Sources: DrugBank ChemblInteractions GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15135088

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 8104554

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 2986673

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand None

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12857801

Sources: NCI

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inverse agonist

PMIDs: 7908055

Sources: DrugBank NCI GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) binder

Interaction Info: Specific Action of the Ligand Inverse agonist Endogenous Drug? False

PMIDs: 7908055

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 11179435

Sources: DrugBank

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction D2-like dopamine receptor antagonist Specific Action of the Ligand Antagonist

PMIDs: 8524985

Sources: DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs: 8301582

Sources: DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 687395 6189542 2899826 25190 91313

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) binder

Interaction Info: Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist Direct Interaction yes Specific Action of the Ligand Inverse agonist

PMIDs: 7908055 10821438 8593484

Sources: DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18834354

Interaction Types & Directionality:

n/a

PMIDs:
3628280

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
2419314

Sources:
DrugBank

Interaction Types & Directionality:

binder

PMIDs:
8946472

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
27092952

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1980851

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
11103886 16867246 20643630 15694263 8524985 11873706 11752352 7908055 9918131 9858029 28673279 20194480 18926547 17105675 16513877 15830237 11505224

Sources:
DrugBank ChemblInteractions GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
15135088

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
8104554

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
2986673

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
12857801

Sources:
NCI

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
7908055

Sources:
DrugBank NCI GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

binder

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
7908055

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

binder

PMIDs:
11179435

Sources:
DrugBank

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction D2-like dopamine receptor antagonist

Specific Action of the Ligand Antagonist

PMIDs:
8524985

Sources:
DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Mechanism of Interaction D2-like dopamine receptor antagonist

PMIDs:
8301582

Sources:
DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
687395 6189542 2899826 25190 91313

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

binder

Interaction Info:

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

Direct Interaction yes

Specific Action of the Ligand Inverse agonist

PMIDs:
7908055 10821438 8593484

Sources:
DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18834354

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18408624

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
9760039 11755134

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7908055

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
2835476