DGIdb - CHLOROTHIAZIDE Drug Record

CHLOROTHIAZIDE chembl:CHEMBL842 Approved

Alternate Names:

SALURIC
NSC-25693
DIURIL
CHLOROTHIAZIDE
CHLORTHIAZIDE
DIURIL®
CLOROTIAZIDA
CHLOROTHIAZID
6-CHLORO-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA6-BENZO[1,2,4]THIADIAZINE-7-SULFONIC ACID AMIDE
MECHLOZID
UROFLUX
CHLOROTHIAZIDUM
6-CHLORO-7-SULFAMOYL-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
drugbank:00880
chembl:CHEMBL842
chemidplus:58-94-6
pubchem.compound:2720
rxcui:2396

Drug Info:

Year of Approval	approved before 1982
Drug Class	diuretics
Drug Class	antihypertensive agents
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents

(2 More Sources)

Publications:

Thakker, Molecular pathology of renal chloride channels in Dent's disease and Bartter's syndrome., Exp. Nephrol.
Reinalter et al., 2004, Pharmacotyping of hypokalaemic salt-losing tubular disorders., Acta Physiol. Scand.
Wilson et al., 2003, Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4., Proc. Natl. Acad. Sci. U.S.A.
Schmidt et al., 2001, Clinical, biochemical and molecular genetic data in five children with Gitelman's syndrome., Horm. Metab. Res.
Maki et al., 2004, Four novel mutations in the thiazide-sensitive Na-Cl co-transporter gene in Japanese patients with Gitelman's syndrome., Nephrol. Dial. Transplant.
Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
Puscas et al., 1999, The inhibitory effect of diuretics on carbonic anhydrases., Res. Commun. Mol. Pathol. Pharmacol.
Weiner et al., 2003, Renal and hepatic expression of the ammonium transporter proteins, Rh B Glycoprotein and Rh C Glycoprotein., Acta Physiol. Scand.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Verlander et al., 2003, Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney., Am. J. Physiol. Renal Physiol.
Singh S et al., 2018, Genome Wide Association Study Identifies the <i>HMGCS2</i> Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients., J Am Heart Assoc

CHLOROTHIAZIDE HMGCS2

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29523524

Sources:
PharmGKB
CHLOROTHIAZIDE SLC12A3

Interaction Score: 4.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
11014932 15283765 12515852 11456284 15069170

Sources:
TdgClinicalTrial ChemblInteractions TEND
CHLOROTHIAZIDE CA2

Interaction Score: 3.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
14656370 11752352 12388412 10954127

Sources:
TdgClinicalTrial TEND TTD
CHLOROTHIAZIDE CA4

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TdgClinicalTrial TEND
CHLOROTHIAZIDE CA1

Interaction Score: 2.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TdgClinicalTrial TEND
CHLOROTHIAZIDE KCNMA1

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND

TEND: CHLOROTHIAZIDE
- Version: 01-August-2011
Alternate Names:

CHLOROTHIAZIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class diuretics

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: CHLOROTHIAZIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Publications:
PharmGKB: chlorothiazide
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Singh S et al., 2018, Genome Wide Association Study Identifies the <i>HMGCS2</i> Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients., J Am Heart Assoc
TTD: Chlorothiazide
- Version: 2020.06.01
Alternate Names:

D0M9WM TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL842
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL842
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Thiazide-sensitive sodium-chloride cotransporter inhibitor
Direct Interaction	yes
Trial Name	-

Novel drug target	Established target
Trial Name	-

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

CHLOROTHIAZIDE Drug Record

CHLOROTHIAZIDE chembl:CHEMBL842 Approved

Alternate Names:

Drug Info:

Publications:

CHLOROTHIAZIDE HMGCS2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29523524

Sources: PharmGKB

CHLOROTHIAZIDE SLC12A3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor Direct Interaction yes Trial Name -

PMIDs: 11014932 15283765 12515852 11456284 15069170

Sources: TdgClinicalTrial ChemblInteractions TEND

CHLOROTHIAZIDE CA2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 14656370 11752352 12388412 10954127

Sources: TdgClinicalTrial TEND TTD

CHLOROTHIAZIDE CA4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10713865 10954127

Sources: TdgClinicalTrial TEND

CHLOROTHIAZIDE CA1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10713865 10954127

Sources: TdgClinicalTrial TEND

CHLOROTHIAZIDE KCNMA1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

TEND: CHLOROTHIAZIDE

Alternate Names: CHLOROTHIAZIDE Primary Drug Name

Drug Info: Drug Class antihypertensive agents Drug Class diuretics Year of Approval approved before 1982

Publications:

TdgClinicalTrial: CHLOROTHIAZIDE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Diuretics Drug Class small molecule

Publications:

PharmGKB: chlorothiazide

Alternate Names:

Drug Info:

Publications: Singh S et al., 2018, Genome Wide Association Study Identifies the <i>HMGCS2</i> Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients., J Am Heart Assoc

TTD: Chlorothiazide

Alternate Names: D0M9WM TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL842

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL842

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
29523524

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Thiazide-sensitive sodium-chloride cotransporter inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
11014932 15283765 12515852 11456284 15069170

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
14656370 11752352 12388412 10954127

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10713865 10954127

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Alternate Names:

CHLOROTHIAZIDE Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Drug Class diuretics

Year of Approval approved before 1982

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Drug Class small molecule

Publications:

Singh S et al., 2018, Genome Wide Association Study Identifies the <i>HMGCS2</i> Locus to be Associated With Chlorthalidone Induced Glucose Increase in Hypertensive Patients., J Am Heart Assoc

Alternate Names:

D0M9WM TTD Drug ID