DGIdb - CELECOXIB Drug Record

CELECOXIB chembl:CHEMBL118 Antineoplastic

Alternate Names:

DFN-15
ONSENAL
CELEBRA
CELEBREX
CELECOXIB
DFN15
SC-58635
CELECOX®
CELECOXIBUM
CELOCOXIB
4-[5-(4-METHYLPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENE-1-SULFONAMIDE
CÉLÉCOXIB
4-[5-(4-METHYLPHENYL)-3-TRIFLUOROMETHYL)-1H-PYRAZOL-YL]BENZENESULFONAMIDE
ONSENAL®
P-(5-P-TOLYL-3-(TRIFLUOROMETHYL)PYRAZOL-1-YL)BENZENESULFONAMIDE
drugbank:00482
pubchem.compound:2662
chemidplus:169590-42-5
rxcui:140587
chembl:CHEMBL118

Drug Info:

FDA Approval	approved
Drug Class	Small molecule
Drug Indications	NSAID

(9 More Sources)

Publications:

Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics
Zhu et al., 2004, From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors., Cancer Res.
Kulp et al., 2004, 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells., Cancer Res.
Li et al., 2006, A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth., J. Gastrointest. Surg.
Tseng et al., 2006, Overcoming trastuzumab resistance in HER2-overexpressing breast cancer cells by using a novel celecoxib-derived phosphoinositide-dependent kinase-1 inhibitor., Mol. Pharmacol.
Tong et al., 2005, Neutrophil gelatinase-associated lipocalin as a survival factor., Biochem. J.
Arico et al., 2002, Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line., J. Biol. Chem.
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Li H et al., 2011, Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3)., J Med Chem
Lu et al., 2002, Cyclooxygenase-2 inhibitor celecoxib inhibits promotion of mammary tumorigenesis in rats fed a high fat diet rich in n-6 polyunsaturated fatty acids., Cancer Lett.
Sigthorsson et al., 2002, COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice., Gastroenterology
Scheiman, 2002, Outcomes studies of the gastrointestinal safety of cyclooxygenase-2 inhibitors., Cleve Clin J Med
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Reddy et al., 2002, Novel approaches for colon cancer prevention by cyclooxygenase-2 inhibitors., J. Environ. Pathol. Toxicol. Oncol.
Ahmad et al., 2002, Renal failure associated with the use of celecoxib and rofecoxib., Drug Saf
Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.
Kim et al., 2007, GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells., Carcinogenesis
Kim et al., 2006, GADD153 mediates celecoxib-induced apoptosis in cervical cancer cells., Carcinogenesis
Tsutsumi et al., 2004, Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis., Cell Death Differ.
Fabricio et al., 2005, The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Buchanan et al., 2007, Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer., Cancer Res.
Kim SH et al., 2017, Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metabolite., Arch Pharm Res
Liu R et al., 2015, Influence of genetic polymorphisms on the pharmacokinetics of celecoxib and its two main metabolites in healthy Chinese subjects., Eur J Pharm Sci
Gupta A et al., 2015, Novel Use of Pharmacogenetic Testing in the Identification of CYP2C9 Polymorphisms Related to NSAID-Induced Gastropathy., Pain Med
Prieto-Pérez R et al., 2013, Evaluation of the relationship between polymorphisms in CYP2C8 and CYP2C9 and the pharmacokinetics of celecoxib., J Clin Pharmacol
Pilotto A et al., 2007, Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms., Gastroenterology
Fries S et al., 2006, Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2., Gastroenterology
Stempak D et al., 2005, Cytochrome P450 2C9 genotype: impact on celecoxib safety and pharmacokinetics in a pediatric patient., Clin Pharmacol Ther
Kirchheiner J et al., 2003, Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites., Pharmacogenetics
Tang C et al., 2001, In-vitro metabolism of celecoxib, a cyclooxygenase-2 inhibitor, by allelic variant forms of human liver microsomal cytochrome P450 2C9: correlation with CYP2C9 genotype and in-vivo pharmacokinetics., Pharmacogenetics
Koeberle A et al., 2009, Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1., Bioorg Med Chem
Hanke T et al., 2013, Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1., Bioorg Med Chem
Koeberle A et al., 2008, Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase., J Med Chem
Sibilia et al., 2008, Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk., Br. J. Pharmacol.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Ma et al., 2002, Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance., Proc. Natl. Acad. Sci. U.S.A.
McKew JC et al., 2008, Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib., J Med Chem
Vardar-Sengül et al., 2006, Effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats., J. Periodontol.
Narayanan et al., 2006, Docosahexaenoic acid in combination with celecoxib modulates HSP70 and p53 proteins in prostate cancer cells., Int. J. Cancer
Haupt et al., 2006, Celecoxib can induce cell death independently of cyclooxygenase-2, p53, Mdm2, c-Abl and reactive oxygen species., Anticancer Drugs
Andrews et al., 2005, Celecoxib inhibits urokinase-type plasminogen activator (uPA) production in MDA-MB-231 breast cancer cells., Breast Cancer Res. Treat.
Hedberg ML et al., 2019, Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for <i>PIK3CA</i>-altered head and neck cancer., J Exp Med

CELECOXIB MT-CO2

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18498150

Sources:
DTC
CELECOXIB BCAR1

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB IL23R

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23778325

Sources:
PharmGKB
CELECOXIB ATP2A3

Interaction Score: 1.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB PTGES

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23778325 19884011 24183739 19053751

Sources:
DTC PharmGKB
CELECOXIB IGFBP3

Interaction Score: 1.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB ATP2A2

Interaction Score: 0.66

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CASP9

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB PDK1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB PDPK1

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15205346 14973075 16455452 16887935 16060857 12000750

Sources:
NCI
CELECOXIB CACNA2D4

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA2D3

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB DDIT3

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17167033 17166886 16597647 15131590 22336956

Sources:
NCI PharmGKB
CELECOXIB CACNA1E

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB COL18A1

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12232050

Sources:
NCI
CELECOXIB CACNB4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB KCNQ3

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNB3

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB KCNQ2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB KCNQ4

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNB1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB ATP2A1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB KCNQ5

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA2D2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNB2

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB PTGS2

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name celecoxib,Celebrex, Celecox

PMIDs:
12104042 12055598 12086292 11752352 12086402 12093311 22336956 19602986

Sources:
TALC TdgClinicalTrial ChemblInteractions GuideToPharmacology MyCancerGenomeClinicalTrial PharmGKB TTD
CELECOXIB CDKN1B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB GHRL

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18414388

Sources:
NCI
CELECOXIB EDN1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15539607

Sources:
NCI
CELECOXIB CA9

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CA12

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB KCNQ1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB MMP9

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB PTGER4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23778325

Sources:
PharmGKB
CELECOXIB CDKN1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA2D1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB APC

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type colorectal cancer

Response Type sensitive

Approval Status Preclinical

PMIDs:
17909047

Sources:
JAX-CKB
CELECOXIB CTNNB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA1I

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA1G

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB ALOX12

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23778325

Sources:
PharmGKB
CELECOXIB BGLAP

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16584347

Sources:
NCI
CELECOXIB STAT3

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21678971

Sources:
DTC
CELECOXIB CACNA1F

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB PLAU

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16172791

Sources:
NCI
CELECOXIB CACNA1D

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA1H

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA1B

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB HSPA4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16646082

Sources:
NCI
CELECOXIB CACNA1S

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CASP3

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB CACNA1C

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB VEGFA

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB ABL1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16917206

Sources:
NCI
CELECOXIB CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27864660 26360837 25585969 23996211 22336956 17681167 16401468 16153401 12893985 11337938

Sources:
PharmGKB FDA
CELECOXIB CYP3A5

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
CELECOXIB PTGS1

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CELECOXIB PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
CELECOXIB PIK3CA

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30683736

Sources:
CIViC
CELECOXIB RORC

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CELECOXIB CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
DTC PharmGKB
CELECOXIB NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CELECOXIB AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: CELECOXIB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications NSAID

Drug Class Small molecule

FDA Approval approved

Publications:

NCI: CELECOXIB

Version: 14-September-2017

Alternate Names:

C1728 NCI drug code

Drug Info:

Publications:

Fabricio et al., 2005, The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.

Haupt et al., 2006, Celecoxib can induce cell death independently of cyclooxygenase-2, p53, Mdm2, c-Abl and reactive oxygen species., Anticancer Drugs

Namba et al., 2007, Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells., Mol. Pharmacol.

DTC: CELECOXIB

Version: 02-September-2020

Alternate Names:

CHEMBL118 ChEMBL Drug ID

Drug Info:

Publications:

McKew JC et al., 2008, Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib., J Med Chem

Li H et al., 2011, Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3)., J Med Chem

Koeberle A et al., 2009, Discovery of benzo[g]indol-3-carboxylates as potent inhibitors of microsomal prostaglandin E(2) synthase-1., Bioorg Med Chem

JAX-CKB: Celecoxib
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Buchanan et al., 2007, Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer., Cancer Res.

PharmGKB: celecoxib

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Kraus S et al., 2013, Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial: results from a pilot study., Pharmacogenet Genomics

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Kirchheiner J et al., 2003, Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites., Pharmacogenetics

CIViC: CELECOXIB
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Hedberg ML et al., 2019, Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for <i>PIK3CA</i>-altered head and neck cancer., J Exp Med
TALC: CELECOXIB
- Version: 12-May-2016
Alternate Names:

CELEBRA Drug Trade Name

CELEBREX Drug Trade Name

CELECOXIB Drug Generic Name

Drug Info:

Publications:
GuideToPharmacology: 178100241
- Version: 29-September-2020
Alternate Names:

CELECOXIB GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Celecoxib
- Version: 2020.06.01
Alternate Names:

D03RTS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL118
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: CELECOXIB
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL118
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Celecoxib
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Notes
Novel drug target	Established target
Trial Name	celecoxib,Celebrex, Celecox

Indication/Tumor Type	colorectal cancer
Response Type	sensitive
Approval Status	Preclinical

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

CELEBRA	Drug Trade Name
CELEBREX	Drug Trade Name
CELECOXIB	Drug Generic Name

CELECOXIB Drug Record

CELECOXIB chembl:CHEMBL118 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18498150

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23778325

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23778325 19884011 24183739 19053751

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15205346 14973075 16455452 16887935 16060857 12000750

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17167033 17166886 16597647 15131590 22336956

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12232050

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Interaction Types & Directionality:

n/a

PMIDs:
18498150

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23778325

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23778325 19884011 24183739 19053751

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15205346 14973075 16455452 16887935 16060857 12000750

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17167033 17166886 16597647 15131590 22336956

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12232050

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Novel drug target Established target

Trial Name celecoxib,Celebrex, Celecox