DGIdb - CARBIDOPA Drug Record

CARBIDOPA chembl:CHEMBL1200748 Approved

Alternate Names:

CARBIDOPA HYDRATE
MK-486
CARBIDOPA MONOHYDRATE
LODOSYN
CARBIDOPA ANHYDROUS
CARBIDOPA
L-ALPHA-(3,4-DIHYDROXYBENZYL)-ALPHA-HYDRAZINOPROPIONIC ACID MONOHYDRATE
CDP536
(S)-(-)-CARBIDOPA HYDRATE
(S)-CARBIDOPA HYDRATE
(2S)-3-(3,4-DIHYDROXYPHENYL)-2-HYDRAZINYL-2-METHYLPROPANOIC ACID MONOHYDRATE
(2S)-3-(3,4-DIHYDROXYPHENYL)-2-HYDRAZINYL-2-METHYLPROPANOIC ACID HYDRATE
CARBIDOPUM MONOHYDRICUM
(ALPHAS)-ALPHA-HYDRAZINO-3,4-DIHYDROXY-ALPHA-METHYLBENZENEPROPANOIC ACID MONOHYDRATE
(S)-(−)-CARBIDOPA HYDRATE
(-)-L-ALPHA-HYDRAZINO-3,4-DIHYDROXY-ALPHA-METHYLHYDROCINNAMIC ACID MONOHYDRATE
chemidplus:38821-49-7
pubchem.compound:38101
rxcui:2019
chembl:CHEMBL1200748

Drug Info:

Year of Approval	approved before 1982
Drug Class	antiparkinson agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiparkinson agent

(3 More Sources)

Publications:

Kaufmann et al., 2003, Norepinephrine precursor therapy in neurogenic orthostatic hypotension., Circulation
Orlefors et al., 2006, Carbidopa pretreatment improves image interpretation and visualisation of carcinoid tumours with 11C-5-hydroxytryptophan positron emission tomography., Eur. J. Nucl. Med. Mol. Imaging
Calabrese et al., 2007, In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state., J. Neurochem.
Yee et al., 2001, Blood-brain barrier and neuronal membrane transport of 6-[18F]fluoro-L-DOPA., Biochem. Pharmacol.
Gilbert et al., 2000, The aromatic-L-amino acid decarboxylase inhibitor carbidopa is selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells., Clin. Cancer Res.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Durso et al., 2000, Variable absorption of carbidopa affects both peripheral and central levodopa metabolism., J Clin Pharmacol
Schwahn B et al., 2001, Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences., Am J Pharmacogenomics

CARBIDOPA DDC

Interaction Score: 20.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name DM-1992

Novel drug target Established target

Trial Name entacapone/levodopa/carbidopa,Stalevo

PMIDs:
12885750 16184369 17241115 11709201 11106255 11752352 10934669

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
CARBIDOPA MTHFR

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12083967

Sources:
PharmGKB
CARBIDOPA HPGD

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBIDOPA KDM4E

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBIDOPA ALDH1A1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBIDOPA HSD17B10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBIDOPA MAPT

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBIDOPA KDM4A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBIDOPA EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: CARBIDOPA
- Version: 01-August-2011
Alternate Names:

CARBIDOPA Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: CARBIDOPA
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiparkinson agent

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: carbidopa
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Schwahn B et al., 2001, Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences., Am J Pharmacogenomics
DTC: CARBIDOPA
- Version: 02-September-2020
Alternate Names:

CHEMBL1201236 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Carbidopa
- Version: 2020.06.01
Alternate Names:

D0P7JZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1200748
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1200748
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	DM-1992
Novel drug target	Established target
Trial Name	entacapone/levodopa/carbidopa,Stalevo

CARBIDOPA Drug Record

CARBIDOPA chembl:CHEMBL1200748 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name DM-1992 Novel drug target Established target Trial Name entacapone/levodopa/carbidopa,Stalevo

PMIDs: 12885750 16184369 17241115 11709201 11106255 11752352 10934669

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12083967

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: CARBIDOPA

Alternate Names: CARBIDOPA Primary Drug Name

Drug Info: Drug Class antiparkinson agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: CARBIDOPA

Alternate Names:

Drug Info: Drug Indications antiparkinson agent Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: carbidopa

Alternate Names:

Drug Info:

Publications: Schwahn B et al., 2001, Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences., Am J Pharmacogenomics

DTC: CARBIDOPA

Alternate Names: CHEMBL1201236 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Carbidopa

Alternate Names: D0P7JZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1200748

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1200748

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name DM-1992

Novel drug target Established target

Trial Name entacapone/levodopa/carbidopa,Stalevo

PMIDs:
12885750 16184369 17241115 11709201 11106255 11752352 10934669

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
12083967

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CARBIDOPA Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval approved before 1982

Drug Info:

Drug Indications antiparkinson agent

Drug Class Small Molecule

FDA Approval approved

Publications:

Schwahn B et al., 2001, Polymorphisms in the methylenetetrahydrofolate reductase gene: clinical consequences., Am J Pharmacogenomics

Alternate Names:

CHEMBL1201236 ChEMBL Drug ID

Alternate Names:

D0P7JZ TTD Drug ID