DGIdb - CARBACHOL Drug Record

CARBACHOL chembl:CHEMBL14 Approved

Alternate Names:

CARBACHOLINE CHLORIDE
CARBAMOYLCHOLINE CHLORIDE
CARBASTAT
MIOSTAT
DORYL
CARBACHOL
2-(CARBAMOYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM
CAR405
2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM CHLORIDE
(2-CARBAMOYLOXYETHYL)TRIMETHYLAMMONIUM CHLORIDE
(2-CARBAMOYLOXY-ETHYL)-TRIMETHYL-AMMONIUM
(2-HYDROXYETHYL)TRIMETHYL AMMONIUM CHLORIDE CARBAMATE
(2-HYDROXYETHYL)TRIMETHYLAMMONIUM CHLORIDE CARBAMATE
2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINUM CHLORIDE
CHOLINE CARBAMATE CHLORIDE
CHOLINE CHLORINE CARBAMATE
CARBACHOL CHLORIDE
CARBAMYLCHOLINE
pubchem.compound:5831
rxcui:1999
drugbank:00411
chemidplus:51-83-2
chembl:CHEMBL14

Drug Info:

Drug Class	antiglaucomic agents
Year of Approval	1972
FDA Approval	1972
Drug Class	small molecule
Drug Indications	Antiglaucomic Agents

(2 More Sources)

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
An et al., 2010, Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms., Proc. Natl. Acad. Sci. U.S.A.
Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett
Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett
Weiner et al., 2004, Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias., Am J Pharmacogenomics
Sawatzky et al., 2003, Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells., Am. J. Physiol. Lung Cell Mol. Physiol.
Peter et al., 2004, Modulation of the M2 muscarinic acetylcholine receptor activity with monoclonal anti-M2 receptor antibody fragments., J. Biol. Chem.
May et al., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators., J. Pharmacol. Exp. Ther.
Zuchner et al., 2005, Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins., J. Neurochem.
Sterin-Borda et al., 2002, Therapeutic use of muscarinic acetylcholine receptor peptide to prevent mice chagasic cardiac dysfunction., J. Mol. Cell. Cardiol.
Hillmann P et al., 2009, Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling., J Med Chem

CARBACHOL CHRNA2

Interaction Score: 4.81

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 20498043

Sources:
TdgClinicalTrial TEND TTD
CARBACHOL P2RY2

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19419204

Sources:
DTC
CARBACHOL CHRM2

Interaction Score: 1.7

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12948933 15485827 15333678 16181410 12505062

Sources:
TdgClinicalTrial TEND
CARBACHOL CHRM1

Interaction Score: 0.88

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
22507963 21930376 15059034

Sources:
DTC TdgClinicalTrial TEND
CARBACHOL CHRM3

Interaction Score: 0.18

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M3 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TEND: CARBACHOL
- Version: 01-August-2011
Alternate Names:

CARBACHOL Primary Drug Name

Drug Info:

Year of Approval 1972

Drug Class antiglaucomic agents

Publications:
TdgClinicalTrial: CARBACHOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiglaucomic Agents

Drug Class small molecule

FDA Approval 1972

Publications:

DTC: CARBACHOL

Version: 02-September-2020

Alternate Names:

CHEMBL14 ChEMBL Drug ID

Drug Info:

Publications:

Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett

Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett

Hillmann P et al., 2009, Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling., J Med Chem

TTD: Carbachol
- Version: 2020.06.01
Alternate Names:

D0U7BW TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL14
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL14
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Muscarinic acetylcholine receptor M3 agonist
Direct Interaction	yes

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

CARBACHOL Drug Record

CARBACHOL chembl:CHEMBL14 Approved

Alternate Names:

Drug Info:

Publications:

CARBACHOL CHRNA2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 11752352 20498043

Sources: TdgClinicalTrial TEND TTD

CARBACHOL P2RY2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19419204

Sources: DTC

CARBACHOL CHRM2

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12948933 15485827 15333678 16181410 12505062

Sources: TdgClinicalTrial TEND

CARBACHOL CHRM1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 22507963 21930376 15059034

Sources: DTC TdgClinicalTrial TEND

CARBACHOL CHRM3

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Muscarinic acetylcholine receptor M3 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TEND: CARBACHOL

Alternate Names: CARBACHOL Primary Drug Name

Drug Info: Year of Approval 1972 Drug Class antiglaucomic agents

Publications:

TdgClinicalTrial: CARBACHOL

Alternate Names:

Drug Info: Drug Indications Antiglaucomic Agents Drug Class small molecule FDA Approval 1972

Publications:

DTC: CARBACHOL

Alternate Names: CHEMBL14 ChEMBL Drug ID

Drug Info:

TTD: Carbachol

Alternate Names: D0U7BW TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL14

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL14

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 11752352 20498043

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
19419204

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12948933 15485827 15333678 16181410 12505062

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
22507963 21930376 15059034

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M3 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

CARBACHOL Primary Drug Name

Drug Info:

Year of Approval 1972

Drug Class antiglaucomic agents

Drug Info:

Drug Indications Antiglaucomic Agents

Drug Class small molecule

FDA Approval 1972

Alternate Names:

CHEMBL14 ChEMBL Drug ID

Alternate Names:

D0U7BW TTD Drug ID