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CARBACHOL Drug Record

  • Summary
  • Interactions
  • Claims
  • CARBACHOL chembl:CHEMBL14 Approved

    Alternate Names:

    CARBACHOLINE CHLORIDE
    CARBAMOYLCHOLINE CHLORIDE
    CARBASTAT
    MIOSTAT
    DORYL
    CARBACHOL
    2-(CARBAMOYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM
    CAR405
    2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM CHLORIDE
    (2-CARBAMOYLOXYETHYL)TRIMETHYLAMMONIUM CHLORIDE
    (2-CARBAMOYLOXY-ETHYL)-TRIMETHYL-AMMONIUM
    (2-HYDROXYETHYL)TRIMETHYL AMMONIUM CHLORIDE CARBAMATE
    (2-HYDROXYETHYL)TRIMETHYLAMMONIUM CHLORIDE CARBAMATE
    2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINUM CHLORIDE
    CHOLINE CARBAMATE CHLORIDE
    CHOLINE CHLORINE CARBAMATE
    CARBACHOL CHLORIDE
    CARBAMYLCHOLINE
    pubchem.compound:5831
    rxcui:1999
    drugbank:00411
    chemidplus:51-83-2
    chembl:CHEMBL14

    Drug Info:

    Drug Class antiglaucomic agents
    Year of Approval 1972
    FDA Approval 1972
    Drug Class small molecule
    Drug Indications Antiglaucomic Agents
    (2 More Sources)

    Publications:

    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    An et al., 2010, Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms., Proc. Natl. Acad. Sci. U.S.A.
    Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett
    Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett
    Weiner et al., 2004, Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias., Am J Pharmacogenomics
    Sawatzky et al., 2003, Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cells., Am. J. Physiol. Lung Cell Mol. Physiol.
    Peter et al., 2004, Modulation of the M2 muscarinic acetylcholine receptor activity with monoclonal anti-M2 receptor antibody fragments., J. Biol. Chem.
    May et al., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators., J. Pharmacol. Exp. Ther.
    Zuchner et al., 2005, Down-regulation of muscarinic acetylcholine receptor M2 adversely affects the expression of Alzheimer's disease-relevant genes and proteins., J. Neurochem.
    Sterin-Borda et al., 2002, Therapeutic use of muscarinic acetylcholine receptor peptide to prevent mice chagasic cardiac dysfunction., J. Mol. Cell. Cardiol.
    Hillmann P et al., 2009, Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling., J Med Chem
  • CARBACHOL   CHRNA2

    Interaction Score: 4.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352 20498043


    Sources:
    TdgClinicalTrial TEND TTD

  • CARBACHOL   P2RY2

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19419204


    Sources:
    DTC

  • CARBACHOL   CHRM2

    Interaction Score: 1.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12948933 15485827 15333678 16181410 12505062


    Sources:
    TdgClinicalTrial TEND

  • CARBACHOL   CHRM1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    22507963 21930376 15059034


    Sources:
    DTC TdgClinicalTrial TEND

  • CARBACHOL   CHRM3

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M3 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TEND: CARBACHOL

    • Version: 01-August-2011

    Alternate Names:
    CARBACHOL Primary Drug Name

    Drug Info:
    Year of Approval 1972
    Drug Class antiglaucomic agents

    Publications:

  • TdgClinicalTrial: CARBACHOL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antiglaucomic Agents
    Drug Class small molecule
    FDA Approval 1972

    Publications:

  • DTC: CARBACHOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL14 ChEMBL Drug ID

    Drug Info:

    Publications:
    Melancon BJ et al., 2012, Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor., Bioorg Med Chem Lett
    Lebois EP et al., 2011, Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071., Bioorg Med Chem Lett
    Hillmann P et al., 2009, Key determinants of nucleotide-activated G protein-coupled P2Y(2) receptor function revealed by chemical and pharmacological experiments, mutagenesis and homology modeling., J Med Chem

  • TTD: Carbachol

    • Version: 2020.06.01

    Alternate Names:
    D0U7BW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL14

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL14

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21