DGIdb - CAPSAICIN Drug Record

CAPSAICIN chembl:CHEMBL294199 Approved

Alternate Names:

ZOSTRIX
QUTENZA
FEMA NO. 3404
CAPSAICIN
ZACIN
ZOSTRIX HP
NGX-1998
ALGRX 4975
ALGRX-4975
NSC-56353
NGX-4010
QUTENZA®
ISODECENOIC ACID VANILLYLAMIDE
TRANS-8-METHYL-N-VANILLYL-6-NONENAMIDE
(E)-8-METHYL-N-VANILLYL-6-NONENAMIDE
chembl:CHEMBL294199
chemidplus:404-86-4
drugbank:06774
pubchem.compound:1548943
rxcui:1992

Drug Info:

Drug Categories	polyunsaturated alkamides
Drug Categories	fatty acids, unsaturated
FDA Approval	approved
FDA Approval	not approved (orphan status)
Drug Class	Small molecule
Drug Indications	analgesic
Drug Categories	basic lotions and liniments
Drug Categories	capsaicin and similar agents
Drug Categories	capsaicin, antagonists & inhibitors
Drug Categories	cholinesterase inhibitors
Drug Categories	cytochrome p-450 cyp1a2 inducers (strength unknown)
Drug Categories	cytochrome p-450 cyp1a2 substrates
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	dermatologicals
Drug Categories	monoamine oxidase a inhibitors for interaction with monoamine oxidase a substrates
Drug Categories	musculo-skeletal system
Drug Categories	topical products for joint and muscular pain

(4 More Sources)

Publications:

Mannion et al., 1999, Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity., Proc. Natl. Acad. Sci. U.S.A.
Reilly et al., 2003, Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells., Chem. Res. Toxicol.
Oikawa et al., 2006, Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper., Free Radic. Res.
Suzuki et al., 1985, Regional distribution of a novel pituitary protein (7B2) in the rat spinal cord: effect of neonatal capsaicin treatment and thoracic cord transection., Neurosci. Lett.
Anand et al., 2011, Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch., Br J Anaesth
Wallace et al., 2011, Qutenza®: a capsaicin 8% patch for the management of postherpetic neuralgia., Expert Rev Neurother
Joung et al., 2007, Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target., Antioxid. Redox Signal.
Malcangio et al., 2000, Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord., Eur. J. Neurosci.
Lee et al., 2007, Capsaicin promotes the development of burst-forming units--erythroid (BFU-E) from mouse bone marrow cells., Exp. Mol. Med.
Kim et al., 1997, Proliferation and repair of guinea pig tracheal epithelium after neuropeptide depletion and injury in vivo., Am. J. Physiol.
Sharkey et al., 1999, Immediate-early gene expression in the inferior mesenteric ganglion and colonic myenteric plexus of the guinea pig., J. Neurosci.
Knight et al., 1997, Localization of leukaemia inhibitory factor to airway epithelium and its amplification of contractile responses to tachykinins., Br. J. Pharmacol.
Sweeney et al., 1989, Morphine, capsaicin and K+ release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord., J. Pharmacol. Exp. Ther.
Okere et al., 2004, Capsaicin increases GFAP and glutamine synthetase immunoreactivity in rat arcuate nucleus and median eminence., Neuroreport
Han et al., 2006, Effects of capsaicin on P-gp function and expression in Caco-2 cells., Biochem. Pharmacol.
Kuramori C et al., 2009, Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus., Biochem Biophys Res Commun

CAPSAICIN SCG5

Interaction Score: 6.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3858706

Sources:
NCI
CAPSAICIN RNASEH2A

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10087087

Sources:
NCI
CAPSAICIN PHB2

Interaction Score: 2.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19116139

Sources:
DrugBank
CAPSAICIN PCNA

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9435579

Sources:
NCI
CAPSAICIN EPOR

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17603282

Sources:
NCI
CAPSAICIN LIF

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9138695

Sources:
NCI
CAPSAICIN TRPV1

Interaction Score: 0.5

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Trial Name Adlea

Novel drug target Established target

Trial Name Transacin

PMIDs:
21852280 21158551

Sources:
DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
CAPSAICIN NT5E

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2492344

Sources:
NCI
CAPSAICIN NTF3

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10651868

Sources:
NCI
CAPSAICIN GFAP

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15076747

Sources:
NCI
CAPSAICIN CFTR

Interaction Score: 0.11

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Potentiation

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CAPSAICIN BDNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10430952

Sources:
NCI
CAPSAICIN ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16674925

Sources:
NCI
CAPSAICIN CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12641434 17015277

Sources:
NCI
CAPSAICIN NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17979524

Sources:
NCI DTC
CAPSAICIN ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CAPSAICIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB06774

Version: 5.1.7

Alternate Names:

CAPSAICIN DrugBank Drug Name

404-86-4 CAS Number

1st Medxpatch With Lidocaine 4% Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alkaloids

Publications:

Kuramori C et al., 2009, Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus., Biochem Biophys Res Commun

Anand et al., 2011, Topical capsaicin for pain management: therapeutic potential and mechanisms of action of the new high-concentration capsaicin 8% patch., Br J Anaesth

Wallace et al., 2011, Qutenza®: a capsaicin 8% patch for the management of postherpetic neuralgia., Expert Rev Neurother

TdgClinicalTrial: CAPSAICIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small molecule

FDA Approval not approved (orphan status)

Publications:

NCI: CAPSAICIN

Version: 14-September-2017

Alternate Names:

C339 NCI drug code

Drug Info:

Publications:

Mannion et al., 1999, Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity., Proc. Natl. Acad. Sci. U.S.A.

Han et al., 2006, Effects of capsaicin on P-gp function and expression in Caco-2 cells., Biochem. Pharmacol.

Malcangio et al., 2000, Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord., Eur. J. Neurosci.

DTC: CAPSAICIN
- Version: 02-September-2020
Alternate Names:

CHEMBL294199 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Capsaicin
- Version: 2020.06.01
Alternate Names:

D0U5CE TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 53801090
- Version: 29-September-2020
Alternate Names:

CAPSAICIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL294199
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL294199
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	Adlea
Novel drug target	Established target
Trial Name	Transacin

Specific Action of the Ligand	Potentiation
Endogenous Drug?	False

CAPSAICIN	DrugBank Drug Name
404-86-4	CAS Number
1st Medxpatch With Lidocaine 4%	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	alkaloids

activator (activating)
agonist (activating)

CAPSAICIN Drug Record

CAPSAICIN chembl:CHEMBL294199 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3858706

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10087087

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19116139

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9435579

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17603282

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9138695

Sources: NCI

Interaction Types & Directionality: activator (activating) agonist (activating)

Interaction Info: Trial Name Adlea Novel drug target Established target Trial Name Transacin

PMIDs: 21852280 21158551

Sources: DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2492344

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10651868

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15076747

Sources: NCI

Interaction Types & Directionality: activator (activating)

Interaction Info: Specific Action of the Ligand Potentiation Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10430952

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16674925

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12641434 17015277

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17979524

Sources: NCI DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB06774

Alternate Names: CAPSAICIN DrugBank Drug Name 404-86-4 CAS Number 1st Medxpatch With Lidocaine 4% Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories alkaloids

TdgClinicalTrial: CAPSAICIN

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small molecule FDA Approval not approved (orphan status)

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
3858706

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10087087

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19116139

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9435579

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17603282

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9138695

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Trial Name Adlea

Novel drug target Established target

Trial Name Transacin

PMIDs:
21852280 21158551

Sources:
DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
2492344

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10651868

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15076747

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Potentiation

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
10430952

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16674925

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12641434 17015277

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17979524

Sources:
NCI DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CAPSAICIN DrugBank Drug Name

404-86-4 CAS Number

1st Medxpatch With Lidocaine 4% Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alkaloids

Drug Info:

Drug Indications analgesic

Drug Class Small molecule

FDA Approval not approved (orphan status)

Alternate Names:

C339 NCI drug code

Alternate Names:

CHEMBL294199 ChEMBL Drug ID

Alternate Names:

D0U5CE TTD Drug ID

Alternate Names:

CAPSAICIN GuideToPharmacology Ligand Name