• CABAZITAXEL chembl:CHEMBL1201748 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    JEVTANA
    CABAZITAXEL
    TXD 258
    CABAZITAXEL ACETONATE
    TXD-258
    JEVTANA KIT
    XRP 6258
    XRP-6258
    TXD258
    XRP6258
    CABAZITAXELUM
    JEVANTA®
    TAXOID XRP6258
    chembl:CHEMBL1201748
    drugbank:06772
    pubchem.compound:9854073
    chemidplus:183133-96-2
    rxcui:996051

    Drug Info:

    FDA Approval approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    Drug Class antineoplastic agent
    Year of Approval 2010
    Drug Categories taxoids
    Drug Categories cardiotoxic antineoplastic agents
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories microtubule inhibition
    Drug Categories microtubule inhibitors
    Drug Categories oatp1b1/slco1b1 inhibitors
    Drug Categories oatp1b3 inhibitors
    Drug Categories p-glycoprotein inhibitors
    Drug Categories p-glycoprotein substrates
    Drug Categories p-glycoprotein substrates with narrow therapeutic index
    (6 More Sources)
  • Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25670080


    Sources:
    CIViC

  • Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 0.24

    Interaction Types & Directionality:
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name cabazitaxel, XRP6258,Jevtana
    Novel drug target Established target
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.23

    Interaction Types & Directionality:
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name cabazitaxel, XRP6258,Jevtana
    Novel drug target Established target
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB