DGIdb - BUTABARBITAL Drug Record

BUTABARBITAL chembl:CHEMBL449 Approved

Alternate Names:

SECBUTABARBITAL
SECBUTOBARBITONE
BUTABARBITAL
5-SEC-BUTYL-5-ETHYLBARBITURIC ACID
5-ETHYL-5-(1-METHYLPROPYL)BARBITURIC ACID
BUTISOL
5-SEC-BUTYL-5-ETHYL-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
5-SEC-BUTYL-5-ETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
5-ETHYL-5-(1-METHYLPROPYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
BUTISOL®
chembl:CHEMBL449
rxcui:477631
pubchem.compound:2479
chemidplus:125-40-6
drugbank:00237

Drug Info:

Year of Approval	approved before 1982
Drug Class	hypnotics and sedatives
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives

(0 More Sources)

Publications:

Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

BUTABARBITAL GRIK2

Interaction Score: 1.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GRIA2

Interaction Score: 0.88

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTABARBITAL CHRNA7

Interaction Score: 0.84

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TdgClinicalTrial TEND
BUTABARBITAL CHRNA4

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA1

Interaction Score: 0.34

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND TTD
BUTABARBITAL GABRA4

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA6

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA5

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

TEND: BUTABARBITAL
- Version: 01-August-2011
Alternate Names:

BUTABARBITAL Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: BUTABARBITAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TTD: Butabarbital
- Version: 2020.06.01
Alternate Names:

D0A4JK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL449
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

BUTABARBITAL Drug Record

BUTABARBITAL chembl:CHEMBL449 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 16248797 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10209232 11264449

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

TEND: BUTABARBITAL

Alternate Names: BUTABARBITAL Primary Drug Name

Drug Info: Drug Class hypnotics and sedatives Year of Approval approved before 1982

Publications:

TdgClinicalTrial: BUTABARBITAL

Alternate Names:

Drug Info: Drug Indications Hypnotics and Sedatives Drug Class small molecule FDA Approval Approved before 1982

Publications:

TTD: Butabarbital

Alternate Names: D0A4JK TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL449

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Alternate Names:

BUTABARBITAL Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

D0A4JK TTD Drug ID