DGIdb - BUTABARBITAL Drug Record

BUTABARBITAL chembl:CHEMBL449 Approved

Alternate Names:

SECBUTABARBITAL
SECBUTOBARBITONE
BUTABARBITAL
5-SEC-BUTYL-5-ETHYLBARBITURIC ACID
5-ETHYL-5-(1-METHYLPROPYL)BARBITURIC ACID
BUTISOL
5-SEC-BUTYL-5-ETHYL-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
5-SEC-BUTYL-5-ETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
5-ETHYL-5-(1-METHYLPROPYL)-2,4,6(1H,3H,5H)-PYRIMIDINETRIONE
BUTISOL®
chembl:CHEMBL449
rxcui:477631
pubchem.compound:2479
chemidplus:125-40-6
drugbank:00237

Drug Info:

Year of Approval	approved before 1982
Drug Class	hypnotics and sedatives
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hypnotics and Sedatives
Drug Categories	anticholinergic agents
Drug Categories	anticonvulsants
Drug Categories	barbiturates
Drug Categories	drugs that are mainly renally excreted
Drug Categories	nervous system
Drug Categories	nicotinic antagonists
Drug Categories	psycholeptics

(1 More Sources)

Publications:

Arias et al., 2005, Anesthetics as chemical tools to study the structure and function of nicotinic acetylcholine receptors., Curr. Protein Pept. Sci.
Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.
Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.
Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

BUTABARBITAL GRIK5

Interaction Score: 2.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11264449 10487207

Sources:
DrugBank
BUTABARBITAL GRIK3

Interaction Score: 1.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10487207 11264449

Sources:
DrugBank
BUTABARBITAL GRIK4

Interaction Score: 1.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10487207 11264449

Sources:
DrugBank
BUTABARBITAL GRIK1

Interaction Score: 1.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10487207 11264449

Sources:
DrugBank
BUTABARBITAL CHRNA10

Interaction Score: 1.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16248797 10487207 11264449

Sources:
DrugBank
BUTABARBITAL GRIK2

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
DrugBank TdgClinicalTrial TEND
BUTABARBITAL GRIA4

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10487207 11264449

Sources:
DrugBank
BUTABARBITAL GRIA3

Interaction Score: 0.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10487207 11264449

Sources:
DrugBank
BUTABARBITAL GRIA2

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
DrugBank TdgClinicalTrial TEND
BUTABARBITAL GRIA1

Interaction Score: 0.29

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10487207 11264449

Sources:
DrugBank
BUTABARBITAL CHRNA4

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND
BUTABARBITAL CHRNA7

Interaction Score: 0.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA1

Interaction Score: 0.15

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
DrugBank TdgClinicalTrial TEND TTD
BUTABARBITAL GABRA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA6

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BUTABARBITAL GABRA3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

DrugBank: DB00237

Version: 5.1.7

Alternate Names:

BUTABARBITAL DrugBank Drug Name

125-40-6 CAS Number

Butalan Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups illicit

Publications:

Mehta et al., 1999, An update on GABAA receptors., Brain Res. Brain Res. Rev.

Yamakura et al., 2001, Anesthetics and ion channels: molecular models and sites of action., Annu. Rev. Pharmacol. Toxicol.

Krasowski et al., 1999, General anaesthetic actions on ligand-gated ion channels., Cell. Mol. Life Sci.

TEND: BUTABARBITAL
- Version: 01-August-2011
Alternate Names:

BUTABARBITAL Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: BUTABARBITAL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TTD: Butabarbital
- Version: 2020.06.01
Alternate Names:

D0A4JK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL449
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

BUTABARBITAL	DrugBank Drug Name
125-40-6	CAS Number
Butalan	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	illicit

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

BUTABARBITAL Drug Record

BUTABARBITAL chembl:CHEMBL449 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 11264449 10487207

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10487207 11264449

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10487207 11264449

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10487207 11264449

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16248797 10487207 11264449

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10487207 11264449

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10487207 11264449

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 10487207

Sources: DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10487207 11264449

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16248797 11264449 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11264449 16248797 10487207

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: positive modulator (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 10209232 11264449

Sources: DrugBank TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

DrugBank: DB00237

Alternate Names: BUTABARBITAL DrugBank Drug Name 125-40-6 CAS Number Butalan Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups illicit

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
11264449 10487207

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10487207 11264449

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10487207 11264449

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10487207 11264449

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16248797 10487207 11264449

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10487207 11264449

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10487207 11264449

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 10487207

Sources:
DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10487207 11264449

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16248797 11264449 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11264449 16248797 10487207

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

positive modulator (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
10209232 11264449

Sources:
DrugBank TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Alternate Names:

BUTABARBITAL DrugBank Drug Name

125-40-6 CAS Number

Butalan Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups illicit

Alternate Names:

BUTABARBITAL Primary Drug Name

Drug Info:

Drug Class hypnotics and sedatives

Year of Approval approved before 1982

Drug Info:

Drug Indications Hypnotics and Sedatives

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

D0A4JK TTD Drug ID