DGIdb - BUSPIRONE Drug Record

BUSPIRONE chembl:CHEMBL49 Approved

Alternate Names:

BUSPAR
BCI-024
BUSPIRONE
BUSPAR®
MJ-9022-1
BUSPIRON
BUSPIRONA
BUSPIRONUM
8-(4-(4-(2-PYRIMIDINYL)-1-PIPERIZINYL)BUTYL)-8-AZASPIRO(4,5)DECANE-7,9-DIONE
rxcui:1827
drugbank:00490
chembl:CHEMBL49
pubchem.compound:2477
chemidplus:36505-84-7

Drug Info:

Year of Approval	1986
Drug Class	anti-anxiety agents
FDA Approval	1986
Drug Class	small molecule
Drug Indications	Anti-anxiety Agents

(3 More Sources)

Publications:

Coccaro et al., 1990, Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans., Psychopharmacol Bull
Pache et al., 2003, Buspirone differentially modifies short-term memory function in a combined delayed matching/non-matching to position task., Eur. J. Pharmacol.
Nader et al., 1993, Interactions of buspirone or gepirone with nicotine on schedule-controlled behavior of pigeons., Behav Pharmacol
Malt et al., 2003, Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls., J Affect Disord
Boido et al., 2001, Synthesis and pharmacological evaluation of aryl/heteroaryl piperazinyl alkyl benzotriazoles as ligands for some serotonin and dopamine receptor subtypes., Farmaco
Fernández-Pérez et al., 2005, Co-administration of fluoxetine and WAY100635 improves short-term memory function., Eur. J. Pharmacol.
Rehman et al., 1999, Modification of sexual behavior of Long-Evans male rats by drugs acting on the 5-HT1A receptor., Brain Res.
Liang, 1999, Pre- or post-training injection of buspirone impaired retention in the inhibitory avoidance task: involvement of amygdala 5-HT1A receptors., Eur. J. Neurosci.
Dupuis et al., 1999, Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein., Neuropharmacology
Osei-Owusu et al., 2004, Buspirone raises blood pressure through activation of sympathetic nervous system and by direct activation of alpha1-adrenergic receptors after severe hemorrhage., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Becker et al., 1999, Prevention by 5-HT1A receptor agonists of restraint stress- and yohimbine-induced release of cholecystokinin in the frontal cortex of the freely moving rat., Neuropharmacology
de Boer et al., 1999, Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635., J. Pharmacol. Exp. Ther.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

BUSPIRONE HTR1A

Interaction Score: 1.58

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10064829 10215901 10428422 14769835 11752352 10221756 10027850

Sources:
TdgClinicalTrial TEND TTD
BUSPIRONE PRL

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2274641

Sources:
NCI
BUSPIRONE DRD2

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14522358 11224194 12781354 11421254 16214127

Sources:
TdgClinicalTrial TEND
BUSPIRONE CYP3A5

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
BUSPIRONE ALDH1A1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUSPIRONE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUSPIRONE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: BUSPIRONE
- Version: 01-August-2011
Alternate Names:

BUSPIRONE Primary Drug Name

Drug Info:

Drug Class anti-anxiety agents

Year of Approval 1986

Publications:
TdgClinicalTrial: BUSPIRONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-anxiety Agents

Drug Class small molecule

FDA Approval 1986

Publications:
NCI: BUSPIRONE
- Version: 14-September-2017
Alternate Names:

C26641 NCI drug code

Drug Info:

Publications:

Coccaro et al., 1990, Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans., Psychopharmacol Bull
PharmGKB: buspirone
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
TTD: Buspirone
- Version: 2020.06.01
Alternate Names:

D0U2OO TTD Drug ID

Drug Info:

Publications:
DTC: BUSPIRONE
- Version: 02-September-2020
Alternate Names:

CHEMBL49 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL49
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

partial agonist (activating)
agonist (activating)

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

BUSPIRONE Drug Record

BUSPIRONE chembl:CHEMBL49 Approved

Alternate Names:

Drug Info:

Publications:

BUSPIRONE HTR1A

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10064829 10215901 10428422 14769835 11752352 10221756 10027850

Sources: TdgClinicalTrial TEND TTD

BUSPIRONE PRL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2274641

Sources: NCI

BUSPIRONE DRD2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 14522358 11224194 12781354 11421254 16214127

Sources: TdgClinicalTrial TEND

BUSPIRONE CYP3A5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

BUSPIRONE ALDH1A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

BUSPIRONE NFE2L2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

BUSPIRONE EHMT2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: BUSPIRONE

Alternate Names: BUSPIRONE Primary Drug Name

Drug Info: Drug Class anti-anxiety agents Year of Approval 1986

Publications:

TdgClinicalTrial: BUSPIRONE

Alternate Names:

Drug Info: Drug Indications Anti-anxiety Agents Drug Class small molecule FDA Approval 1986

Publications:

NCI: BUSPIRONE

Alternate Names: C26641 NCI drug code

Drug Info:

Publications: Coccaro et al., 1990, Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans., Psychopharmacol Bull

PharmGKB: buspirone

Alternate Names:

Drug Info:

Publications: Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

TTD: Buspirone

Alternate Names: D0U2OO TTD Drug ID

Drug Info:

Publications:

DTC: BUSPIRONE

Alternate Names: CHEMBL49 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL49

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10064829 10215901 10428422 14769835 11752352 10221756 10027850

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
2274641

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14522358 11224194 12781354 11421254 16214127

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

BUSPIRONE Primary Drug Name

Drug Info:

Drug Class anti-anxiety agents

Year of Approval 1986

Drug Info:

Drug Indications Anti-anxiety Agents

Drug Class small molecule

FDA Approval 1986

Alternate Names:

C26641 NCI drug code

Publications:

Coccaro et al., 1990, Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans., Psychopharmacol Bull

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Alternate Names:

D0U2OO TTD Drug ID

Alternate Names:

CHEMBL49 ChEMBL Drug ID