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BUPRANOLOL Drug Record

  • Summary
  • Interactions
  • Claims
  • BUPRANOLOL chembl:CHEMBL305380

    Alternate Names:

    B-1312 [AS HYDROCHLORIDE]
    BUPRANOLOL HCL
    BUPRANOL
    KL-255 [AS HYDROCHLORIDE]
    BUPRANOLOL

    Drug Info:

    Drug Categories beta blocking agents, non-selective
    Drug Groups experimental
    Drug Categories agents causing hyperkalemia
    Drug Categories antiarrhythmic agents
    Drug Categories bradycardia-causing agents
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories potential qtc-prolonging agents
    Drug Categories qtc prolonging agents
    (0 More Sources)

    Publications:

    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
    Lenard et al., 2003, Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan., J. Pharmacol. Exp. Ther.
    Zelaszczyk et al., 2009, Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors., J. Physiol. Pharmacol.
    Matsushita et al., 2003, Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle., Eur. J. Pharmacol.
  • BUPRANOLOL   ADRB3

    Interaction Score: 1.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    12606631 14660028


    Sources:
    DrugBank GuideToPharmacology

  • BUPRANOLOL   ADRB1

    Interaction Score: 0.75

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    2903243 19439807


    Sources:
    DTC DrugBank GuideToPharmacology

  • BUPRANOLOL   ADRB2

    Interaction Score: 0.58

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    2903243 12606631


    Sources:
    DTC DrugBank GuideToPharmacology

  • DrugBank: DB08808

    • Version: 5.1.7

    Alternate Names:
    BUPRANOLOL DrugBank Drug Name
    14556-46-8 CAS Number
    Betadrenol Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups experimental
    Drug Categories adrenergic agents

    Publications:
    Zelaszczyk et al., 2009, Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors., J. Physiol. Pharmacol.
    Lenard et al., 2003, Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan., J. Pharmacol. Exp. Ther.
    Matsushita et al., 2003, Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle., Eur. J. Pharmacol.

  • DTC: BUPRANOLOL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL305380 ChEMBL Drug ID

    Drug Info:

    Publications:
    el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

  • GuideToPharmacology: 135650033

    • Version: 29-September-2020

    Alternate Names:
    BUPRANOLOL GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL305380

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21