DGIdb - BUPRANOLOL Drug Record

BUPRANOLOL chembl:CHEMBL305380

Alternate Names:

B-1312 [AS HYDROCHLORIDE]
BUPRANOLOL HCL
BUPRANOL
KL-255 [AS HYDROCHLORIDE]
BUPRANOLOL

Drug Info:

Drug Categories	beta blocking agents, non-selective
Drug Groups	experimental
Drug Categories	agents causing hyperkalemia
Drug Categories	antiarrhythmic agents
Drug Categories	bradycardia-causing agents
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	potential qtc-prolonging agents
Drug Categories	qtc prolonging agents

(0 More Sources)

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Lenard et al., 2003, Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan., J. Pharmacol. Exp. Ther.
Zelaszczyk et al., 2009, Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors., J. Physiol. Pharmacol.
Matsushita et al., 2003, Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle., Eur. J. Pharmacol.

BUPRANOLOL ADRB3

Interaction Score: 1.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12606631 14660028

Sources:
DrugBank GuideToPharmacology
BUPRANOLOL ADRB1

Interaction Score: 0.75

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
2903243 19439807

Sources:
DTC DrugBank GuideToPharmacology
BUPRANOLOL ADRB2

Interaction Score: 0.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
2903243 12606631

Sources:
DTC DrugBank GuideToPharmacology

DrugBank: DB08808

Version: 5.1.7

Alternate Names:

BUPRANOLOL DrugBank Drug Name

14556-46-8 CAS Number

Betadrenol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups experimental

Drug Categories adrenergic agents

Publications:

Zelaszczyk et al., 2009, Four close bupranolol analogues are antagonists at the low-affinity state of beta1-adrenoceptors., J. Physiol. Pharmacol.

Lenard et al., 2003, Activation of beta2- and beta3-adrenergic receptors increases brain tryptophan., J. Pharmacol. Exp. Ther.

Matsushita et al., 2003, Characterization of beta 3-adrenoceptor-mediated relaxation in rat abdominal aorta smooth muscle., Eur. J. Pharmacol.

DTC: BUPRANOLOL
- Version: 02-September-2020
Alternate Names:

CHEMBL305380 ChEMBL Drug ID

Drug Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
GuideToPharmacology: 135650033
- Version: 29-September-2020
Alternate Names:

BUPRANOLOL GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL305380
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

BUPRANOLOL	DrugBank Drug Name
14556-46-8	CAS Number
Betadrenol	Drug Brand

Drug Type	small molecule
Drug Groups	experimental
Drug Categories	adrenergic agents

BUPRANOLOL Drug Record

BUPRANOLOL chembl:CHEMBL305380

Alternate Names:

Drug Info:

Publications:

BUPRANOLOL ADRB3

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 12606631 14660028

Sources: DrugBank GuideToPharmacology

BUPRANOLOL ADRB1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 2903243 19439807

Sources: DTC DrugBank GuideToPharmacology

BUPRANOLOL ADRB2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 2903243 12606631

Sources: DTC DrugBank GuideToPharmacology

DrugBank: DB08808

Alternate Names: BUPRANOLOL DrugBank Drug Name 14556-46-8 CAS Number Betadrenol Drug Brand

Drug Info: Drug Type small molecule Drug Groups experimental Drug Categories adrenergic agents

DTC: BUPRANOLOL

Alternate Names: CHEMBL305380 ChEMBL Drug ID

Drug Info:

Publications: el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

GuideToPharmacology: 135650033

Alternate Names: BUPRANOLOL GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL305380

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
12606631 14660028

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
2903243 19439807

Sources:
DTC DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
2903243 12606631

Sources:
DTC DrugBank GuideToPharmacology

Alternate Names:

BUPRANOLOL DrugBank Drug Name

14556-46-8 CAS Number

Betadrenol Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups experimental

Drug Categories adrenergic agents

Alternate Names:

CHEMBL305380 ChEMBL Drug ID

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Alternate Names:

BUPRANOLOL GuideToPharmacology Ligand Name