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BROMAZEPAM Drug Record

  • Summary
  • Interactions
  • Claims
  • BROMAZEPAM chembl:CHEMBL277062 Approved

    Alternate Names:

    RO-5-3350
    RO-53350
    LEXOTAN
    LECTOPAM
    BROMAZEPAM
    NSC-140669
    BROMAZEPAM CIV
    BROMAZEPAMUM
    drugbank:01558
    rxcui:1749
    pubchem.compound:2441
    chemidplus:1812-30-2
    chembl:CHEMBL277062

    Drug Info:

    Drug Categories gaba agents
    Drug Class hypnotics and sedatives
    Year of Approval approved before 1982
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Hypnotics and Sedatives
    Drug Groups investigational
    Drug Categories benzodiazepine hypnotics and sedatives
    Drug Categories benzodiazepines and benzodiazepine derivatives
    Drug Categories cytochrome p-450 cyp2e1 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories hypnotics and sedatives
    Drug Categories muscle relaxants
    Drug Categories muscle relaxants, centrally acting agents
    (2 More Sources)

    Publications:

    Riss et al., 2008, Benzodiazepines in epilepsy: pharmacology and pharmacokinetics., Acta Neurol. Scand.
    Möhler et al., 2002, A new benzodiazepine pharmacology., J. Pharmacol. Exp. Ther.
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem
  • BROMAZEPAM   GABRR3

    Interaction Score: 0.37

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456 11752090


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRR2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRR1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRQ

    Interaction Score: 0.14

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRP

    Interaction Score: 0.13

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRE

    Interaction Score: 0.13

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRD

    Interaction Score: 0.13

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRG1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRA1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    ligand
    positive modulator (activating)
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456 29950725 23038269


    Sources:
    TEND TdgClinicalTrial DrugBank

  • BROMAZEPAM   GABRB1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRB3

    Interaction Score: 0.12

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRB2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRG3

    Interaction Score: 0.11

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRA4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRA6

    Interaction Score: 0.1

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRA5

    Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRA2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRA3

    Interaction Score: 0.09

    Interaction Types & Directionality:
    potentiator

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    18384456


    Sources:
    TEND TdgClinicalTrial

  • BROMAZEPAM   GABRG2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    18384456


    Sources:
    TEND

  • BROMAZEPAM   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • BROMAZEPAM   CYP2D6

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DrugBank: DB01558

    • Version: 5.1.7

    Alternate Names:
    BROMAZEPAM DrugBank Drug Name
    1812-30-2 CAS Number
    Alti-bromazepam 1.5mg Tablets Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups illicit

    Publications:
    Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
    Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem

  • TEND: BROMAZEPAM

    • Version: 01-August-2011

    Alternate Names:
    BROMAZEPAM Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class hypnotics and sedatives

    Publications:

  • TdgClinicalTrial: BROMAZEPAM

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hypnotics and Sedatives
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • TTD: Bromazepam

    • Version: 2020.06.01

    Alternate Names:
    D0E3FD TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL277062

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: bromazepam

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21