BOSUTINIB Drug Record
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BOSUTINIB chembl:CHEMBL288441 ApprovedAntineoplasticImmunotherapy
Alternate Names:
BOSUTINIB MONOHYDRATE BOSULIF SKI-606 SK-606 BOSUTINIB SKI 606 BOSUTINIBUM SK 606 4-((2,4-DICHLORO-5-METHOXYPHENYL)AMINO)-6-METHOXY-7-(3-(4-METHYL-1-PIPERAZINYL)PROPOXY)-3-QUINOLINECARBONITRILE 4-((2,4-DICHLORO-5-METHOXYPHENYL)AMINO)-6-METHOXY-7-(3-(4-METHYLPIPERAZIN-1-YL)PROPOXY)QUINOLINE-3-CARBONITRILE 3-QUINOLINECARBONITRILE, 4-((2,4-DICHLORO-5-METHOXYPHENYL)AMINO)-6-METHYL-1-PIPERAZINYL)PROPOXY)- BOSULIF® chemidplus:380843-75-4 pubchem.compound:5328940 drugbank:06616 chembl:CHEMBL288441 rxcui:1307619 Drug Info:
FDA Approval Chronic myelogenous leukemia (Philadelphia chromosome positive) Drug Class Kinase Inhibitors FDA Approval not approved Drug Class Small molecule Drug Indications antineoplastic agent Drug Categories cytochrome p-450 cyp2c8 inhibitors Drug Categories cytochrome p-450 cyp2c8 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp3a inhibitors Drug Categories cytochrome p-450 cyp3a substrates Drug Categories cytochrome p-450 cyp3a4 inhibitors Drug Categories cytochrome p-450 cyp3a4 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 enzyme inhibitors Drug Categories cytochrome p-450 substrates Drug Categories heterocyclic compounds, fused-ring Drug Categories immunosuppressive agents Drug Categories kinase inhibitor Drug Categories p-glycoprotein inhibitors Drug Categories p-glycoprotein substrates Drug Categories p-glycoprotein substrates with narrow therapeutic index Drug Categories tyrosine kinase inhibitors Publications:
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Variant Effect gain-of-function Pathway activation Clinical Status NCCN guidelines -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False PMIDs:
27196758
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inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Tyrosine-protein kinase HCK inhibitor -
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inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False
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BOSUTINIB DrugBank Drug Name 380843-75-4 CAS Number Bosulif Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Categories amines Publications:
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- Version: 20-Jun-2017
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SKI-606 Development Name BOSUTINIB Generic Name BOSULIF Trade Name Drug Info:
Drug Class Kinase Inhibitors FDA Approval Chronic myelogenous leukemia (Philadelphia chromosome positive) Publications:
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- Version: January-2014
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Drug Indications antineoplastic agent Drug Class Small molecule FDA Approval not approved Publications:
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BOSUTINIB Primary Drug Name BOSUTINIB Drug Generic Name SKI-606 Drug Synonym Drug Info:
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- Version: 29-September-2020
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BOSUTINIB GuideToPharmacology Ligand Name Drug Info:
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- Version: ChEMBL_27
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- Version: chembl_23
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