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BMS-690514 Drug Record

  • Summary
  • Interactions
  • Claims
  • BMS-690514 chembl:CHEMBL3545396 Antineoplastic

    Alternate Names:

    BMS 690514
    BMS-690514

    Drug Info:

    Drug Class Kinase Inhibitors
    (3 More Sources)

    Publications:

    Wong et al., 2011, Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families., Clin. Cancer Res.
    Soria et al., 2013, Phase I-IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours., Eur. J. Cancer
  • BMS-690514   ERBB4

    Interaction Score: 0.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Receptor protein-tyrosine kinase erbB-4 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TALC MyCancerGenome ChemblInteractions

  • BMS-690514   ERBB2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Receptor protein-tyrosine kinase erbB-2 inhibitor
    Notes

    PMIDs:
    21531814


    Sources:
    JAX-CKB TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • BMS-690514   EGFR

    Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type predicted – sensitive
    Approval Status Phase II

    PMIDs:
    23490650


    Sources:
    JAX-CKB TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • BMS-690514   KDR

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • BMS-690514   FLT3

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • BMS-690514   FLT1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BMS-690514   FLT4

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MyCancerGenome: BMS-690514

    • Version: 20-Jun-2017

    Alternate Names:
    BMS-690514 Development Name
    EVRI Development Name

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • JAX-CKB: BMS-690514

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Soria et al., 2013, Phase I-IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours., Eur. J. Cancer
    Wong et al., 2011, Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families., Clin. Cancer Res.

  • GuideToPharmacology: 223366208

    • Version: 29-September-2020

    Alternate Names:
    BMS-690514 GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TALC: BMS-690514

    • Version: 12-May-2016

    Alternate Names:
    BMS-690514 Primary Drug Name
    BMS-690514 Drug Synonym
    EVR1 Drug Synonym

    Drug Info:

    Publications:

  • TTD: BMS-690514

    • Version: 2020.06.01

    Alternate Names:
    D0R6UV TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL3545396

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL3545396

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21