DGIdb - BMS-690514 Drug Record

BMS-690514 chembl:CHEMBL3545396 Antineoplastic

Alternate Names:

BMS 690514
BMS-690514

Drug Info:

Drug Class	Kinase Inhibitors

(3 More Sources)

Publications:

Wong et al., 2011, Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families., Clin. Cancer Res.
Soria et al., 2013, Phase I-IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours., Eur. J. Cancer

BMS-690514 ERBB4

Interaction Score: 0.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Receptor protein-tyrosine kinase erbB-4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions
BMS-690514 ERBB2

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Receptor protein-tyrosine kinase erbB-2 inhibitor

Notes

PMIDs:
21531814

Sources:
JAX-CKB TALC MyCancerGenome GuideToPharmacology ChemblInteractions
BMS-690514 EGFR

Interaction Score: 0.31

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type predicted – sensitive

Approval Status Phase II

PMIDs:
23490650

Sources:
JAX-CKB TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions
BMS-690514 KDR

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions
BMS-690514 FLT3

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
BMS-690514 FLT1

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
BMS-690514 FLT4

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

MyCancerGenome: BMS-690514
- Version: 20-Jun-2017
Alternate Names:

BMS-690514 Development Name

EVRI Development Name

Drug Info:

Drug Class Kinase Inhibitors

Publications:

JAX-CKB: BMS-690514

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Soria et al., 2013, Phase I-IIa study of BMS-690514, an EGFR, HER-2 and -4 and VEGFR-1 to -3 oral tyrosine kinase inhibitor, in patients with advanced or metastatic solid tumours., Eur. J. Cancer

Wong et al., 2011, Antitumor and antiangiogenic activities of BMS-690514, an inhibitor of human EGF and VEGF receptor kinase families., Clin. Cancer Res.

GuideToPharmacology: 223366208
- Version: 29-September-2020
Alternate Names:

BMS-690514 GuideToPharmacology Ligand Name

Drug Info:

Publications:
TALC: BMS-690514
- Version: 12-May-2016
Alternate Names:

BMS-690514 Primary Drug Name

BMS-690514 Drug Synonym

EVR1 Drug Synonym

Drug Info:

Publications:
TTD: BMS-690514
- Version: 2020.06.01
Alternate Names:

D0R6UV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL3545396
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL3545396
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Notes
Mechanism of Interaction	Receptor protein-tyrosine kinase erbB-4 inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Receptor protein-tyrosine kinase erbB-2 inhibitor
Notes

Indication/Tumor Type	non-small cell lung carcinoma
Response Type	predicted – sensitive
Approval Status	Phase II

Notes
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Direct Interaction	yes
Mechanism of Interaction	Vascular endothelial growth factor receptor inhibitor

BMS-690514	Primary Drug Name
BMS-690514	Drug Synonym
EVR1	Drug Synonym

BMS-690514	Development Name
EVRI	Development Name

BMS-690514 Drug Record

BMS-690514 chembl:CHEMBL3545396 Antineoplastic

Alternate Names:

Drug Info:

Publications:

BMS-690514 ERBB4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Receptor protein-tyrosine kinase erbB-4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: TALC MyCancerGenome ChemblInteractions

BMS-690514 ERBB2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Receptor protein-tyrosine kinase erbB-2 inhibitor Notes

PMIDs: 21531814

Sources: JAX-CKB TALC MyCancerGenome GuideToPharmacology ChemblInteractions

BMS-690514 EGFR

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Indication/Tumor Type non-small cell lung carcinoma Response Type predicted – sensitive Approval Status Phase II

PMIDs: 23490650

Sources: JAX-CKB TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions

BMS-690514 KDR

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions

BMS-690514 FLT3

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: TTD GuideToPharmacology

BMS-690514 FLT1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs: None found

Sources: ChemblInteractions

BMS-690514 FLT4

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs: None found

Sources: ChemblInteractions

MyCancerGenome: BMS-690514

Alternate Names: BMS-690514 Development Name EVRI Development Name

Drug Info: Drug Class Kinase Inhibitors

Publications:

JAX-CKB: BMS-690514

Alternate Names:

Drug Info:

GuideToPharmacology: 223366208

Alternate Names: BMS-690514 GuideToPharmacology Ligand Name

Drug Info:

Publications:

TALC: BMS-690514

Alternate Names: BMS-690514 Primary Drug Name BMS-690514 Drug Synonym EVR1 Drug Synonym

Drug Info:

Publications:

TTD: BMS-690514

Alternate Names: D0R6UV TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL3545396

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL3545396

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Receptor protein-tyrosine kinase erbB-4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC MyCancerGenome ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Receptor protein-tyrosine kinase erbB-2 inhibitor

Notes

PMIDs:
21531814

Sources:
JAX-CKB TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type predicted – sensitive

Approval Status Phase II

PMIDs:
23490650

Sources:
JAX-CKB TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

BMS-690514 Development Name

EVRI Development Name

Drug Info:

Drug Class Kinase Inhibitors

Alternate Names:

BMS-690514 GuideToPharmacology Ligand Name

Alternate Names:

BMS-690514 Primary Drug Name

BMS-690514 Drug Synonym

EVR1 Drug Synonym

Alternate Names:

D0R6UV TTD Drug ID