DGIdb - BIPERIDEN Drug Record

BIPERIDEN chembl:CHEMBL1101 Approved

Alternate Names:

BIPERIDEN
AKINETON
KL 373

Drug Info:

FDA Approval	1959
Drug Class	small molecule
Drug Indications	Antidyskinetics
Year of Approval	1959
Drug Class	antidyskinetics

(1 More Sources)

Publications:

Vasudevan SR et al., 2012, Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor., J Med Chem
Eltze et al., 1994, Involvement of muscarinic M2 and M3, but not of M1 and M4 receptors in vagally stimulated contractions of rabbit bronchus/trachea., Pulm Pharmacol
Eltze, 1999, Multiple mechanisms of action: the pharmacological profile of budipine., J. Neural Transm. Suppl.
Hosoi et al., 1999, Evaluation of in vivo binding properties of 3H-NMPB and 3H-QNB in mouse brain., J Neural Transm (Vienna)
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pehl et al., 1998, Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus., Aliment. Pharmacol. Ther.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

BIPERIDEN CHRNA2

Interaction Score: 4.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
BIPERIDEN CHRM1

Interaction Score: 2.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8081071 10370904 10907719 11752352 9798802 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
BIPERIDEN HRH1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22793499

Sources:
DTC

TEND: BIPERIDEN
- Version: 01-August-2011
Alternate Names:

BIPERIDEN Primary Drug Name

Drug Info:

Drug Class antidyskinetics

Year of Approval 1959

Publications:
TdgClinicalTrial: BIPERIDEN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidyskinetics

Drug Class small molecule

FDA Approval 1959

Publications:
DTC: BIPERIDEN
- Version: 02-September-2020
Alternate Names:

CHEMBL1101 ChEMBL Drug ID

Drug Info:

Publications:

Vasudevan SR et al., 2012, Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor., J Med Chem
TTD: Biperiden
- Version: 2020.06.01
Alternate Names:

D0B4TN TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1101
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

BIPERIDEN Drug Record

BIPERIDEN chembl:CHEMBL1101 Approved

Alternate Names:

Drug Info:

Publications:

BIPERIDEN CHRNA2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

BIPERIDEN CHRM1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8081071 10370904 10907719 11752352 9798802 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

BIPERIDEN HRH1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22793499

Sources: DTC

TEND: BIPERIDEN

Alternate Names: BIPERIDEN Primary Drug Name

Drug Info: Drug Class antidyskinetics Year of Approval 1959

Publications:

TdgClinicalTrial: BIPERIDEN

Alternate Names:

Drug Info: Drug Indications Antidyskinetics Drug Class small molecule FDA Approval 1959

Publications:

DTC: BIPERIDEN

Alternate Names: CHEMBL1101 ChEMBL Drug ID

Drug Info:

Publications: Vasudevan SR et al., 2012, Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor., J Med Chem

TTD: Biperiden

Alternate Names: D0B4TN TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1101

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8081071 10370904 10907719 11752352 9798802 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
22793499

Sources:
DTC

Alternate Names:

BIPERIDEN Primary Drug Name

Drug Info:

Drug Class antidyskinetics

Year of Approval 1959

Drug Info:

Drug Indications Antidyskinetics

Drug Class small molecule

FDA Approval 1959

Alternate Names:

CHEMBL1101 ChEMBL Drug ID

Publications:

Vasudevan SR et al., 2012, Shape-based reprofiling of FDA-approved drugs for the H₁ histamine receptor., J Med Chem

Alternate Names:

D0B4TN TTD Drug ID