• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

BETRIXABAN Drug Record

  • Summary
  • Interactions
  • Claims
  • BETRIXABAN chembl:CHEMBL512351 Approved

    Alternate Names:

    PRT-054021
    BETRIXABAN
    PRT054021
    BEVYXXA
    N-(5-CHLOROPYRIDIN-2-YL)-2-[[4-(N,N-DIMETHYLCARBAMIMIDOYL)BENZOYL]AMINO]-5-METHOXYBENZAMIDE
    N-(5-CHLOROPYRIDIN-2-YL)-2-(4-(N,N-DIMETHYLCARBAMIMIDOYL)BENZAMIDO)-5-METHOXYBENZAMIDE
    rxcui:1927851
    pubchem.compound:10275777
    chembl:CHEMBL512351
    drugbank:12364
    chemidplus:330942-05-7

    Drug Info:

    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antithrombotic
    (0 More Sources)

    Publications:

    Chan NC et al., 2015, Profile of betrixaban and its potential in the prevention and treatment of venous thromboembolism., Vasc Health Risk Manag
    Zhang P et al., 2009, Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor., Bioorg Med Chem Lett
    Cabral KP et al., 2015, The role of factor Xa inhibitors in venous thromboembolism treatment., Vasc Health Risk Manag
    Connolly SJ et al., 2013, Betrixaban compared with warfarin in patients with atrial fibrillation: results of a phase 2, randomized, dose-ranging study (Explore-Xa)., Eur Heart J
  • BETRIXABAN   F10

    Interaction Score: 20.61

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name betrixaban, PRT054021, Factor Xa inhibitor
    Novel drug target Established target
    Mechanism of Interaction Coagulation factor X inhibitor

    PMIDs:
    26170684 19297154 25673997 23487517


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • TdgClinicalTrial: BETRIXABAN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antithrombotic
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • TTD: BETRIXABAN

    • Version: 2020.06.01

    Alternate Names:
    D0J0BU TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL512351

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL512351

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21