DGIdb - BEPRIDIL Drug Record

BEPRIDIL chembl:CHEMBL1008 Approved

Alternate Names:

BEPRIDIL
VASCOR
BEPADIN
VASCOR®
CERM-1978
drugbank:01244
chemidplus:64706-54-3
pubchem.compound:2351
rxcui:1436
chembl:CHEMBL1008

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	1990
Drug Class	anti-arrhythmia agents
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Indications	Anti-Arrhythmia Agents
FDA Approval	1990

(2 More Sources)

Publications:

Chouabe et al., Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs., Therapie
Yumoto et al., 2004, Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock., J. Cardiovasc. Pharmacol.
Chouabe et al., 1998, HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers., Mol. Pharmacol.
Kovacic et al., 1992, Inhibition of sodium pump by bepridil. An in vitro and microcalorimetric study., Biochem. Pharmacol.
Raess et al., 1990, Inhibition of erythrocyte Ca2(+)-pump by Ca2+ antagonists., Biochem. Pharmacol.
Smith et al., 1990, The effects of reported Ca2+ sensitisers on the rates of Ca2+ release from cardiac troponin C and the troponin-tropomyosin complex., Br. J. Pharmacol.
Lamers et al., 1985, Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase., Biochem. Pharmacol.
Fuchs et al., 1986, Effects of bepridil on heart mitochondrial membrane and the isolated rat heart preparation., Arzneimittelforschung
Bezprozvanny et al., 1995, Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967)., Mol. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Wang et al., 2002, Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil., J. Biol. Chem.
MacLachlan et al., 1990, Binding of a calcium sensitizer, bepridil, to cardiac troponin C. A fluorescence stopped-flow kinetic, circular dichroism, and proton nuclear magnetic resonance study., J. Biol. Chem.
Kleerekoper et al., 1998, Identification of binding sites for bepridil and trifluoperazine on cardiac troponin C., J. Biol. Chem.
Abusamhadneh et al., 2001, Interaction of bepridil with the cardiac troponin C/troponin I complex., FEBS Lett.
Taguchi M et al., 2006, Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias., Biol Pharm Bull
Lamers et al., 1987, The effects of felodipine and bepridil on calcium-stimulated calmodulin binding and calcium pumping ATPase of cardiac sarcolemma before and after removal of endogenous calmodulin., Mol. Cell. Biochem.

BEPRIDIL TNNC1

Interaction Score: 7.42

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12060657 2351672 9525919 11591369

Sources:
TdgClinicalTrial TEND
BEPRIDIL CALM1

Interaction Score: 6.18

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
2964559 2933041

Sources:
TEND
BEPRIDIL ATP1A1

Interaction Score: 3.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1329768 2148481 2207500 2933041 2938592

Sources:
TdgClinicalTrial TEND
BEPRIDIL CACNA1A

Interaction Score: 2.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7565636 17016423 17139284

Sources:
TdgClinicalTrial TEND
BEPRIDIL KCNQ1

Interaction Score: 2.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10860024 14716203 9765513

Sources:
TdgClinicalTrial TEND
BEPRIDIL SCN5A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
BEPRIDIL ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
BEPRIDIL CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16508157

Sources:
PharmGKB
BEPRIDIL IDH1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BEPRIDIL EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: BEPRIDIL
- Version: 01-August-2011
Alternate Names:

BEPRIDIL Primary Drug Name

Drug Info:

Drug Class anti-arrhythmia agents

Year of Approval 1990

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: BEPRIDIL
- Version: January-2014
Alternate Names:

Drug Info:

FDA Approval 1990

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Publications:
PharmGKB: bepridil
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Taguchi M et al., 2006, Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias., Biol Pharm Bull
TTD: Bepridil
- Version: 2020.06.01
Alternate Names:

D0Y4JJ TTD Drug ID

Drug Info:

Publications:
DTC: BEPRIDIL
- Version: 02-September-2020
Alternate Names:

CHEMBL1008 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1008
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

BEPRIDIL Drug Record

BEPRIDIL chembl:CHEMBL1008 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12060657 2351672 9525919 11591369

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 2964559 2933041

Sources: TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1329768 2148481 2207500 2933041 2938592

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 7565636 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10860024 14716203 9765513

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16508157

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: BEPRIDIL

Alternate Names: BEPRIDIL Primary Drug Name

Drug Info: Drug Class anti-arrhythmia agents Year of Approval 1990 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: BEPRIDIL

Alternate Names:

Drug Info: FDA Approval 1990 Drug Indications Anti-Arrhythmia Agents Drug Indications Antihypertensive Agents

Publications:

PharmGKB: bepridil

Alternate Names:

Drug Info:

Publications: Taguchi M et al., 2006, Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias., Biol Pharm Bull

TTD: Bepridil

Alternate Names: D0Y4JJ TTD Drug ID

Drug Info:

Publications:

DTC: BEPRIDIL

Alternate Names: CHEMBL1008 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1008

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12060657 2351672 9525919 11591369

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

binder

PMIDs:
2964559 2933041

Sources:
TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1329768 2148481 2207500 2933041 2938592

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
7565636 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10860024 14716203 9765513

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16508157

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

BEPRIDIL Primary Drug Name

Drug Info:

Drug Class anti-arrhythmia agents

Year of Approval 1990

Drug Class antihypertensive agents

Drug Info:

FDA Approval 1990

Drug Indications Anti-Arrhythmia Agents

Drug Indications Antihypertensive Agents

Publications:

Taguchi M et al., 2006, Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias., Biol Pharm Bull

Alternate Names:

D0Y4JJ TTD Drug ID

Alternate Names:

CHEMBL1008 ChEMBL Drug ID