• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

BELINOSTAT Drug Record

  • Summary
  • Interactions
  • Claims
  • BELINOSTAT chembl:CHEMBL408513 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    PXD-101
    PX-105684
    NSC726630
    BELINOSTAT
    BELEODAQ
    rxcui:1543543
    chembl:CHEMBL408513
    pubchem.compound:6918638
    chemidplus:866323-14-0
    drugbank:05015

    Drug Info:

    FDA Approval Peripheral T-cell lymphoma
    Drug Class Small molecule inhibitor
    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    Drug Categories cytochrome p-450 cyp1a2 inducers
    Drug Categories cytochrome p-450 cyp1a2 inducers (weak)
    Drug Categories cytochrome p-450 cyp2a6 substrates
    Drug Categories cytochrome p-450 cyp2a6 substrates with a narrow therapeutic index
    Drug Categories cytochrome p-450 cyp2c8 inhibitors
    Drug Categories cytochrome p-450 cyp2c8 inhibitors (weak)
    Drug Categories cytochrome p-450 cyp2c9 inhibitors
    Drug Categories cytochrome p-450 cyp2c9 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c9 substrates
    Drug Categories cytochrome p-450 cyp2c9 substrates with a narrow therapeutic index
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories immunosuppressive agents
    Drug Categories p-glycoprotein substrates
    Drug Categories ugt1a1 substrates
    Drug Categories ugt1a1 substrates with narrow therapeutic index
    (8 More Sources)

    Publications:

    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett
    Hood K et al., 2016, Belinostat for Relapsed or Refractory Peripheral T-Cell Lymphoma., J Adv Pract Oncol
    Goey et al., 2016, Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer., J Clin Pharmacol
    Perruchoud et al., 1978, [Spirometry, respiratory mechanics and pulmonary gas exchange in pulmonary emphysema]., Wien Med Wochenschr
    Stumpel et al., 2012, Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia., Leukemia
    Cechová et al., 1978, [Asymmetry and symmetry of caries in the Czech population in the past]., Cesk Stomatol
    He et al., 2013, Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma., Cancer Discov
  • BELINOSTAT   FBXW7

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type hematologic cancer
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    23274910


    Sources:
    JAX-CKB

  • BELINOSTAT   HDAC7

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • BELINOSTAT   HDAC9

    Interaction Score: 0.72

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Trial Name PXD101
    Novel drug target Established target

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology

  • BELINOSTAT   HDAC1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name PXD101
    Novel drug target Established target
    Notes

    PMIDs:
    25937017 28090369


    Sources:
    DTC TdgClinicalTrial DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • BELINOSTAT   HDAC4

    Interaction Score: 0.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name PXD101
    Notes

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • BELINOSTAT   HDAC5

    Interaction Score: 0.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • BELINOSTAT   HDAC10

    Interaction Score: 0.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name PXD101
    Novel drug target Established target
    Direct Interaction yes

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC ChemblInteractions

  • BELINOSTAT   HDAC3

    Interaction Score: 0.58

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes
    Specific Action of the Ligand Inhibition

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • BELINOSTAT   HDAC6

    Interaction Score: 0.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Histone deacetylase inhibitor
    Direct Interaction yes

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • BELINOSTAT   HDAC11

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histone deacetylase inhibitor
    Trial Name PXD101

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial ChemblInteractions

  • BELINOSTAT   HDAC8

    Interaction Score: 0.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • BELINOSTAT   HDAC2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    25937017


    Sources:
    DTC TdgClinicalTrial TALC GuideToPharmacology ChemblInteractions

  • BELINOSTAT   UGT1A1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26313268


    Sources:
    FDA CIViC

  • BELINOSTAT   KMT2A

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family HDAC inhibitor
    Alteration MLL__.

    PMIDs:
    351975 22015773 357032


    Sources:
    CGI

  • DrugBank: DB05015

    • Version: 5.1.7

    Alternate Names:
    BELINOSTAT DrugBank Drug Name
    866323-14-0 CAS Number
    Beleodaq Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Hood K et al., 2016, Belinostat for Relapsed or Refractory Peripheral T-Cell Lymphoma., J Adv Pract Oncol

  • MyCancerGenome: BELINOSTAT

    • Version: 20-Jun-2017

    Alternate Names:
    BELEODAQ Trade Name

    Drug Info:
    Drug Class Small molecule inhibitor
    FDA Approval Peripheral T-cell lymphoma

    Publications:

  • TdgClinicalTrial: BELINOSTAT

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • DTC: BELINOSTAT

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL408513 ChEMBL Drug ID

    Drug Info:

    Publications:
    Kozlov MV et al., 2015, Pyridine hydroxamic acids are specific anti-HCV agents affecting HDAC6., Bioorg Med Chem Lett

  • JAX-CKB: Belinostat

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    He et al., 2013, Mcl-1 and FBW7 control a dominant survival pathway underlying HDAC and Bcl-2 inhibitor synergy in squamous cell carcinoma., Cancer Discov

  • CGI: Belinostat

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Perruchoud et al., 1978, [Spirometry, respiratory mechanics and pulmonary gas exchange in pulmonary emphysema]., Wien Med Wochenschr
    Stumpel et al., 2012, Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia., Leukemia
    Cechová et al., 1978, [Asymmetry and symmetry of caries in the Czech population in the past]., Cesk Stomatol

  • CIViC: BELINOSTAT

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Goey et al., 2016, Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer., J Clin Pharmacol

  • TALC: BELINOSTAT

    • Version: 12-May-2016

    Alternate Names:
    BELINOSTAT Primary Drug Name
    BELINOSTAT Drug Generic Name
    PXD 101 Drug Synonym

    Drug Info:

    Publications:

  • GuideToPharmacology: 187051798

    • Version: 29-September-2020

    Alternate Names:
    BELINOSTAT GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL408513

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL408513

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Belinostat

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21