• BARICITINIB chembl:CHEMBL2105759 ApprovedImmunotherapy

    Alternate Names:

    OLUMIANT
    INCB-028050
    INCB-28050
    BARICITINIB
    LY-3009104

    Drug Info:

    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational
    Drug Categories amides
    Drug Categories antineoplastic and immunomodulating agents
    Drug Categories azetines
    Drug Categories bcrp/abcg2 inhibitors
    Drug Categories bcrp/abcg2 substrates
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories immunosuppressive agents
    Drug Categories janus kinase inhibitor
    Drug Categories janus kinase inhibitors
    Drug Categories mate 2 inhibitors
    Drug Categories mate 2 substrates
    Drug Categories mate 2 substrates with a narrow therapeutic index
    Drug Categories mate inhibitors
    Drug Categories mate substrates
    Drug Categories oat1/slc22a6 inhibitors
    Drug Categories oat3/slc22a8 inhibitors
    Drug Categories oat3/slc22a8 substrates
    Drug Categories oatp1b3 inhibitors
    Drug Categories oct2 inhibitors
    Drug Categories p-glycoprotein substrates
    Drug Categories selective immunosuppressants
    Drug Categories sulfones
    Drug Categories sulfur compounds
    (1 More Sources)
  • Interaction Score: 3.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Binding affinity determined in a cell-free biochemical assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 2.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 1.78

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Binding affinity determined in a cell-free biochemical assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tyrosine-protein kinase JAK1 inhibitor
    Specific Action of the Ligand Inhibition

  • Interaction Score: 0.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank TTD

  • Interaction Score: 0.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

  • Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found