DGIdb - AZATHIOPRINE Drug Record

AZATHIOPRINE chembl:CHEMBL1542 ApprovedAntineoplasticImmunotherapy

Alternate Names:

KENTAPRINE
BERKAPRINE
AZASAN
AZAPRESS
BW-57-322
AZAMUNE
IMURAN
NSC-39084
IMMUNOPRIN 50
AZATHIOPRINE
OPRISINE 50
6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO)-1H-PURINE
IMURAN (TN)
IMURAN®
6-(1'-METHYL-4'-NITRO-5'-IMIDAZOLYL)-MERCAPTOPURINE
AZASAN®
chembl:CHEMBL1542
drugbank:00993
pubchem.compound:2265
chemidplus:446-86-6
rxcui:1256

Drug Info:

(4 More Sources)

Publications:

Rostaing et al., 1996, Serological markers of autoimmunity in renal transplant patients before and after alpha-interferon therapy for chronic hepatitis C., Am. J. Nephrol.
Lee MN et al., 2015, Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine., Inflamm Bowel Dis
Smith MA et al., 2009, Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease., Aliment Pharmacol Ther
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Kim HS et al., 2017, A coding variant in <i>FTO</i> confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD., Gut
Ban H et al., 2010, The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease., J Gastroenterol
Heap GA et al., 2014, HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants., Nat Genet
Steponaitiene R et al., 2016, TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects., Adv Med Sci
Zabala-Fernández W et al., 2011, A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine., J Gastrointestin Liver Dis
Okada Y et al., 2009, Pro32Thr polymorphism of inosine triphosphate pyrophosphatase gene predicts efficacy of low-dose azathioprine for patients with systemic lupus erythematosus., Clin Pharmacol Ther
Hawwa AF et al., 2008, Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine., Br J Clin Pharmacol
Ansari A et al., 2008, Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease., Aliment Pharmacol Ther
Zelinkova Z et al., 2006, Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression., Clin Gastroenterol Hepatol
Breen DP et al., 2005, Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation., Liver Transpl
Nieszporek et al., 1990, [Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A]., Pol. Arch. Med. Wewn.
Stocco G et al., 2014, Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease., J Clin Gastroenterol
Kishibe M et al., 2018, Severe thiopurine-induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case-control study., J Dermatol
Cargnin S et al., 2018, Diagnostic accuracy of NUDT15 gene variants for thiopurine-induced leukopenia: a systematic review and meta-analysis., Pharmacol Res
Shih YC et al., 2019, Azathioprine-induced myelosuppression in two pemphigus vulgaris patients with homozygous polymorphism of NUDT15., J Dermatol
Kakuta Y et al., 2018, NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study., J Gastroenterol
Soler AM et al., 2018, TPMT and NUDT15 genes are both related to mercaptopurine intolerance in acute lymphoblastic leukaemia patients from Uruguay., Br J Haematol
Zhu X et al., 2016, NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease., Aliment Pharmacol Ther
Zgheib NK et al., 2017, NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon., Pediatr Blood Cancer
Valerie NC et al., 2016, NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine., Cancer Res
Shah SA et al., 2017, Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients., J Gastroenterol Hepatol
Ailing Z et al., 2016, Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report., J Clin Pharm Ther
Suzuki H et al., 2016, Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age., J Hum Genet
Wong FC et al., 2016, NUDT15 variant and thiopurine-induced leukopenia in Hong Kong., Hong Kong Med J
Lee YJ et al., 2016, NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease., Eur J Gastroenterol Hepatol
Asada A et al., 2016, NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease., J Gastroenterol
Liang DC et al., 2016, NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia., Pharmacogenomics J
Kakuta Y et al., 2016, NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD., Pharmacogenomics J
Tanaka Y et al., 2015, Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia., Br J Haematol
Yang SK et al., 2014, A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia., Nat Genet
Moriyama T et al., 2016, NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity., Nat Genet

AZATHIOPRINE NUDT15

Interaction Score: 19.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30101994 30048756 30035323 29923122 28146264 27604507 27577869 27558924 27530327 27416873 27381176 27193222 27095468 26735160 26590936 26503813 26076924 26033531 25108385 26878724

Sources:
CIViC PharmGKB FDA
AZATHIOPRINE DDRGK1

Interaction Score: 5.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21961091

Sources:
PharmGKB
AZATHIOPRINE ITPA

Interaction Score: 5.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26674571 21961091 19129747 18662289 18616518 16431304 15973722

Sources:
PharmGKB
AZATHIOPRINE HLA-DQA1

Interaction Score: 1.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25217962

Sources:
PharmGKB
AZATHIOPRINE PPAT

Interaction Score: 1.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Amidophosphoribosyltransferase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD
AZATHIOPRINE FTO

Interaction Score: 1.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27558924

Sources:
PharmGKB
AZATHIOPRINE AOX1

Interaction Score: 1.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19500084

Sources:
PharmGKB
AZATHIOPRINE TSHB

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8955758

Sources:
NCI
AZATHIOPRINE TYMSOS

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26332308

Sources:
PharmGKB
AZATHIOPRINE PTH

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2216934

Sources:
NCI
AZATHIOPRINE TPMT

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
AZATHIOPRINE GSTM1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23787247

Sources:
PharmGKB
AZATHIOPRINE ABCC4

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20393862

Sources:
PharmGKB
AZATHIOPRINE HLA-DRB1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25217962

Sources:
PharmGKB
AZATHIOPRINE TYMS

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26332308

Sources:
PharmGKB
AZATHIOPRINE HBB

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZATHIOPRINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
AZATHIOPRINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
AZATHIOPRINE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
AZATHIOPRINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
AZATHIOPRINE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZATHIOPRINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZATHIOPRINE IDH1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZATHIOPRINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
AZATHIOPRINE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: AZATHIOPRINE

Version: 14-September-2017

Alternate Names:

C290 NCI drug code

Drug Info:

Publications:

Rostaing et al., 1996, Serological markers of autoimmunity in renal transplant patients before and after alpha-interferon therapy for chronic hepatitis C., Am. J. Nephrol.

Nieszporek et al., 1990, [Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A]., Pol. Arch. Med. Wewn.

DTC: AZATHIOPRINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1542 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: azathioprine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Lee MN et al., 2015, Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine., Inflamm Bowel Dis

Smith MA et al., 2009, Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease., Aliment Pharmacol Ther

Ban H et al., 2010, The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease., J Gastroenterol

CIViC: AZATHIOPRINE
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Moriyama T et al., 2016, NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity., Nat Genet
TTD: Azathioprine
- Version: 2020.06.01
Alternate Names:

D07QCE TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1542
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1542
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Azathioprine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Amidophosphoribosyltransferase inhibitor

AZATHIOPRINE Drug Record

AZATHIOPRINE chembl:CHEMBL1542 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30101994 30048756 30035323 29923122 28146264 27604507 27577869 27558924 27530327 27416873 27381176 27193222 27095468 26735160 26590936 26503813 26076924 26033531 25108385 26878724

Sources: CIViC PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21961091

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26674571 21961091 19129747 18662289 18616518 16431304 15973722

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25217962

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Amidophosphoribosyltransferase inhibitor

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27558924

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19500084

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8955758

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26332308

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2216934

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23787247

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20393862

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25217962

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26332308

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Interaction Types & Directionality:

n/a

PMIDs:
30101994 30048756 30035323 29923122 28146264 27604507 27577869 27558924 27530327 27416873 27381176 27193222 27095468 26735160 26590936 26503813 26076924 26033531 25108385 26878724

Sources:
CIViC PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
21961091

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26674571 21961091 19129747 18662289 18616518 16431304 15973722

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25217962

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Amidophosphoribosyltransferase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
27558924

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19500084

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8955758

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26332308

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2216934

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
23787247

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20393862

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25217962

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26332308

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C290 NCI drug code

Alternate Names:

CHEMBL1542 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Publications:

Moriyama T et al., 2016, NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity., Nat Genet