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AZATHIOPRINE Drug Record

  • Summary
  • Interactions
  • Claims
  • AZATHIOPRINE chembl:CHEMBL1542 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    KENTAPRINE
    BERKAPRINE
    AZASAN
    AZAPRESS
    BW-57-322
    AZAMUNE
    IMURAN
    NSC-39084
    IMMUNOPRIN 50
    AZATHIOPRINE
    OPRISINE 50
    6-((1-METHYL-4-NITRO-1H-IMIDAZOL-5-YL)THIO)-1H-PURINE
    IMURAN (TN)
    IMURAN®
    6-(1'-METHYL-4'-NITRO-5'-IMIDAZOLYL)-MERCAPTOPURINE
    AZASAN®
    chembl:CHEMBL1542
    drugbank:00993
    pubchem.compound:2265
    chemidplus:446-86-6
    rxcui:1256

    Drug Info:

    (4 More Sources)

    Publications:

    Rostaing et al., 1996, Serological markers of autoimmunity in renal transplant patients before and after alpha-interferon therapy for chronic hepatitis C., Am. J. Nephrol.
    Lee MN et al., 2015, Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine., Inflamm Bowel Dis
    Smith MA et al., 2009, Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease., Aliment Pharmacol Ther
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Kim HS et al., 2017, A coding variant in <i>FTO</i> confers susceptibility to thiopurine-induced leukopenia in East Asian patients with IBD., Gut
    Ban H et al., 2010, The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease., J Gastroenterol
    Heap GA et al., 2014, HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants., Nat Genet
    Steponaitiene R et al., 2016, TPMT and ITPA genetic variants in Lithuanian inflammatory bowel disease patients: Prevalence and azathioprine-related side effects., Adv Med Sci
    Zabala-Fernández W et al., 2011, A pharmacogenetics study of TPMT and ITPA genes detects a relationship with side effects and clinical response in patients with inflammatory bowel disease receiving Azathioprine., J Gastrointestin Liver Dis
    Okada Y et al., 2009, Pro32Thr polymorphism of inosine triphosphate pyrophosphatase gene predicts efficacy of low-dose azathioprine for patients with systemic lupus erythematosus., Clin Pharmacol Ther
    Hawwa AF et al., 2008, Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine., Br J Clin Pharmacol
    Ansari A et al., 2008, Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease., Aliment Pharmacol Ther
    Zelinkova Z et al., 2006, Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression., Clin Gastroenterol Hepatol
    Breen DP et al., 2005, Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation., Liver Transpl
    Nieszporek et al., 1990, [Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A]., Pol. Arch. Med. Wewn.
    Stocco G et al., 2014, Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease., J Clin Gastroenterol
    Kishibe M et al., 2018, Severe thiopurine-induced leukocytopenia and hair loss in Japanese patients with defective NUDT15 variant: Retrospective case-control study., J Dermatol
    Cargnin S et al., 2018, Diagnostic accuracy of NUDT15 gene variants for thiopurine-induced leukopenia: a systematic review and meta-analysis., Pharmacol Res
    Shih YC et al., 2019, Azathioprine-induced myelosuppression in two pemphigus vulgaris patients with homozygous polymorphism of NUDT15., J Dermatol
    Kakuta Y et al., 2018, NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study., J Gastroenterol
    Soler AM et al., 2018, TPMT and NUDT15 genes are both related to mercaptopurine intolerance in acute lymphoblastic leukaemia patients from Uruguay., Br J Haematol
    Zhu X et al., 2016, NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease., Aliment Pharmacol Ther
    Zgheib NK et al., 2017, NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon., Pediatr Blood Cancer
    Valerie NC et al., 2016, NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine., Cancer Res
    Shah SA et al., 2017, Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients., J Gastroenterol Hepatol
    Ailing Z et al., 2016, Further evidence that a variant of the gene NUDT15 may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report., J Clin Pharm Ther
    Suzuki H et al., 2016, Genotyping NUDT15 can predict the dose reduction of 6-MP for children with acute lymphoblastic leukemia especially at a preschool age., J Hum Genet
    Wong FC et al., 2016, NUDT15 variant and thiopurine-induced leukopenia in Hong Kong., Hong Kong Med J
    Lee YJ et al., 2016, NUDT15 variant is the most common variant associated with thiopurine-induced early leukopenia and alopecia in Korean pediatric patients with Crohn's disease., Eur J Gastroenterol Hepatol
    Asada A et al., 2016, NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease., J Gastroenterol
    Liang DC et al., 2016, NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia., Pharmacogenomics J
    Kakuta Y et al., 2016, NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD., Pharmacogenomics J
    Tanaka Y et al., 2015, Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia., Br J Haematol
    Yang SK et al., 2014, A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia., Nat Genet
    Moriyama T et al., 2016, NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity., Nat Genet
  • AZATHIOPRINE   NUDT15

    Interaction Score: 18.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30101994 30048756 30035323 29923122 28146264 27604507 27577869 27558924 27530327 27416873 27381176 27193222 27095468 26735160 26590936 26503813 26076924 26033531 25108385 26878724


    Sources:
    CIViC PharmGKB FDA

  • AZATHIOPRINE   DDRGK1

    Interaction Score: 4.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21961091


    Sources:
    PharmGKB

  • AZATHIOPRINE   ITPA

    Interaction Score: 4.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26674571 21961091 19129747 18662289 18616518 16431304 15973722


    Sources:
    PharmGKB

  • AZATHIOPRINE   HLA-DQA1

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25217962


    Sources:
    PharmGKB

  • AZATHIOPRINE   PPAT

    Interaction Score: 1.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Amidophosphoribosyltransferase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • AZATHIOPRINE   FTO

    Interaction Score: 0.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27558924


    Sources:
    PharmGKB

  • AZATHIOPRINE   AOX1

    Interaction Score: 0.99

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19500084


    Sources:
    PharmGKB

  • AZATHIOPRINE   TSHB

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8955758


    Sources:
    NCI

  • AZATHIOPRINE   TYMSOS

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26332308


    Sources:
    PharmGKB

  • AZATHIOPRINE   PTH

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2216934


    Sources:
    NCI

  • AZATHIOPRINE   TPMT

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • AZATHIOPRINE   GSTM1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23787247


    Sources:
    PharmGKB

  • AZATHIOPRINE   ABCC4

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20393862


    Sources:
    PharmGKB

  • AZATHIOPRINE   HLA-DRB1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25217962


    Sources:
    PharmGKB

  • AZATHIOPRINE   TYMS

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26332308


    Sources:
    PharmGKB

  • AZATHIOPRINE   HBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZATHIOPRINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AZATHIOPRINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AZATHIOPRINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AZATHIOPRINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AZATHIOPRINE   ATAD5

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZATHIOPRINE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZATHIOPRINE   IDH1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AZATHIOPRINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AZATHIOPRINE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: AZATHIOPRINE

    • Version: 14-September-2017

    Alternate Names:
    C290 NCI drug code

    Drug Info:

    Publications:
    Rostaing et al., 1996, Serological markers of autoimmunity in renal transplant patients before and after alpha-interferon therapy for chronic hepatitis C., Am. J. Nephrol.
    Nieszporek et al., 1990, [Selected parameters of calcium and phosphate metabolism in patients after kidney transplantation and administration of azathioprine or cyclosporin A]., Pol. Arch. Med. Wewn.

  • DTC: AZATHIOPRINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1542 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

  • PharmGKB: azathioprine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Lee MN et al., 2015, Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine., Inflamm Bowel Dis
    Smith MA et al., 2009, Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease., Aliment Pharmacol Ther
    Ban H et al., 2010, The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease., J Gastroenterol

  • CIViC: AZATHIOPRINE

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Moriyama T et al., 2016, NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity., Nat Genet

  • TTD: Azathioprine

    • Version: 2020.06.01

    Alternate Names:
    D07QCE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1542

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1542

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Azathioprine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21