AXITINIB Drug Record
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AXITINIB chembl:CHEMBL1289926 ApprovedAntineoplastic
Alternate Names:
AG-13736 INLYTA AXITINIB AG-013736 AXITINIBUM AG 013736 N-METHYL-2-({3-[(E)-2-(PYRIDIN-2-YL)VINYL]-1H-INDAZOL-6-YL}SULFANYL)BENZAMIDE INLYTA® AG013736 drugbank:06626 chemidplus:319460-85-0 chembl:CHEMBL1289926 rxcui:1242999 pubchem.compound:6450551 Drug Info:
FDA Approval Renal cell carcinoma Drug Class Kinase Inhibitors FDA Approval approved Drug Class Small molecule Drug Indications antineoplastic agent Pharmaceutical Developer Pfizer Pharmaceutical Developer Novartis Source Reported Drug Name(s) Axitinib/AG013736/Inlyta Drug Class Kinase Inhibitor Drug Categories benzoates Drug Categories acids, carbocyclic Drug Categories amides Drug Categories benzamides and benzamide derivatives Drug Categories benzene derivatives Drug Categories cytochrome p-450 cyp3a substrates Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index Drug Categories cytochrome p-450 cyp3a5 substrates Drug Categories cytochrome p-450 substrates Drug Categories heterocyclic compounds, fused-ring Drug Categories indazoles Drug Categories kinase inhibitor Drug Categories oatp1b1/slco1b1 inhibitors Drug Categories p-glycoprotein inhibitors Drug Categories p-glycoprotein substrates Drug Categories receptor tyrosine kinase inhibitors Drug Categories tyrosine kinase inhibitors Drug Categories ugt1a1 substrates Publications:
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inhibitor (inhibitory) Interaction Info:
Reported Cancer Type Prostate -
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inhibitor (inhibitory) Interaction Info:
Reported Cancer Type Prostate Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor Direct Interaction yes -
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inhibitor (inhibitory) Interaction Info:
Reported Cancer Type Prostate Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor inhibitor -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True -
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n/a Interaction Info:
Alteration VHL:. Drug family [VEGFR inhibitor] combination therapy [Sorafenib,Sunitinib,Bevacizumab,Axitinib] -
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inhibitor (inhibitory) Interaction Info:
Trial Name axitinib, AG-013736 Novel drug target Established target Reported Cancer Type Prostate -
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inhibitor (inhibitory) Interaction Info:
Notes Trial Name axitinib, AG-013736 Novel drug target Established target -
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
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n/a Interaction Info:
Trial Name axitinib, AG-013736 Novel drug target Established target
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AXITINIB DrugBank Drug Name 319460-85-0 CAS Number Inlyta Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Groups investigational -
- Version: 25-July-2013
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Axitinib PubChem Drug Name 6450551 PubChem Drug ID Inlyta Drug Trade Name Drug Info:
Drug Class Kinase Inhibitor Source Reported Drug Name(s) Axitinib/AG013736/Inlyta Pharmaceutical Developer Novartis Publications:
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- Version: 20-Jun-2017
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AG-013736 Development Name AXITINIB Generic Name INLYTA Trade Name Drug Info:
Drug Class Kinase Inhibitors FDA Approval Renal cell carcinoma Publications:
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- Version: January-2014
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Drug Indications antineoplastic agent Drug Class Small molecule FDA Approval approved Publications:
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AXITINIB Primary Drug Name AXITINIB Drug Generic Name INLYTA Drug Trade Name Drug Info:
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- Version: 29-September-2020
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AXITINIB GuideToPharmacology Ligand Name Drug Info:
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CHEMBL1289926 ChEMBL Drug ID Drug Info:
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D01ZRI TTD Drug ID Drug Info:
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- Version: ChEMBL_27
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- Version: 30-February-2014
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- Version: chembl_23
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