DGIdb - ATROPINE Drug Record

ATROPINE chembl:CHEMBL517712 Approved

Alternate Names:

ATROPINE
ISOPTO ATROPINE
ATROPINE (AUTOINJECTOR)
ATROJECT
ATROPHATE
ATROPEN

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	nerve agent antidote
Drug Class	mydriatics
Year of Approval	approved before 1982
Drug Class	bronchodilator agents
Drug Class	anti-arrhythmia agents
Drug Categories	mydriatics
Drug Categories	agents producing tachycardia
Drug Categories	agents that produce hypertension
Drug Categories	antiarrhythmic agents
Drug Categories	anticholinergic agents
Drug Categories	antimuscarinics antispasmodics
Drug Categories	belladonna alkaloids, tertiary amines
Drug Categories	belladonna and derivatives, plain
Drug Categories	bsep/abcb11 substrates
Drug Categories	moderate risk qtc-prolonging agents
Drug Categories	mydriatics and cycloplegics
Drug Categories	ophthalmologicals
Drug Categories	qtc prolonging agents
Drug Categories	sensory organs

(5 More Sources)

Publications:

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh
Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
May et al., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators., J. Pharmacol. Exp. Ther.
Nelson et al., 2006, Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor., J. Pharmacol. Exp. Ther.
Roman et al., 2005, Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors., Brain Res.
Minaba et al., 2006, Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals., FEBS J.
Cembala et al., 2007, Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors., Eur. J. Pharmacol.
Zheng et al., 2004, Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells., J. Huazhong Univ. Sci. Technol. Med. Sci.
Furuya et al., 1998, Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts., Anat. Embryol.
Buresi et al., 2005, Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro., Am. J. Physiol. Gastrointest. Liver Physiol.
Smulders CJ et al., 2005, Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism., Eur J Pharmacol
Jensen AA et al., 2004, Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay., Biochem Pharmacol

ATROPINE GUCA2A

Interaction Score: 2.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9623669

Sources:
NCI
ATROPINE CXCL10

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15315164

Sources:
NCI
ATROPINE F2R

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15345469

Sources:
NCI
ATROPINE CHRM5

Interaction Score: 0.41

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7855217 11752352 17139284 17016423

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
ATROPINE CHRM2

Interaction Score: 0.35

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist

Specific Action of the Ligand Antagonist

PMIDs:
15333678 16188951 7855217 16248990 17087737 17588565

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
ATROPINE CHRM4

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name inhaled atropine

Direct Interaction? True

PMIDs:
7855217 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
ATROPINE CHRNB2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15733544

Sources:
DrugBank
ATROPINE CHRM1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
23062550 7855217 17139284 17016423

Sources:
TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
ATROPINE GLRA1

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15081878

Sources:
DrugBank
ATROPINE CHRM3

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M3 antagonist

Direct Interaction yes

Trial Name inhaled atropine

PMIDs:
7855217 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
ATROPINE CYP19A1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2128054

Sources:
NCI
ATROPINE CHRNA4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15733544

Sources:
DrugBank
ATROPINE CYP3A5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2128054

Sources:
NCI
ATROPINE ADRA2A

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ATROPINE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00572

Version: 5.1.7

Alternate Names:

51-55-8 CAS Number

ATNAA atropine and pralidoxime chloride Auto-Injector Drug Brand

ATROPEN Auto-Injector Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

May et al., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators., J. Pharmacol. Exp. Ther.

Nelson et al., 2006, Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor., J. Pharmacol. Exp. Ther.

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)

TEND: ATROPINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class anti-arrhythmia agents

Drug Class bronchodilator agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: ATROPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications nerve agent antidote

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: ATROPINE

Version: 14-September-2017

Alternate Names:

C28840 NCI drug code

Drug Info:

Publications:

Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh

Buresi et al., 2005, Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro., Am. J. Physiol. Gastrointest. Liver Physiol.

Furuya et al., 1998, Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts., Anat. Embryol.

DTC: ATROPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL517712 ChEMBL Drug ID

Drug Info:

Publications:

Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
TTD: Atropine
- Version: 2020.06.01
Alternate Names:

D0RG3O TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135652667
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL517712
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL517712
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Direct Interaction	yes
Mechanism of Interaction	Muscarinic acetylcholine receptor M2 antagonist
Specific Action of the Ligand	Antagonist

Novel drug target	Established target
Trial Name	inhaled atropine
Direct Interaction?	True

Mechanism of Interaction	Muscarinic acetylcholine receptor M3 antagonist
Direct Interaction	yes
Trial Name	inhaled atropine

51-55-8	CAS Number
ATNAA atropine and pralidoxime chloride Auto-Injector	Drug Brand
ATROPEN Auto-Injector	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

ATROPINE Drug Record

ATROPINE chembl:CHEMBL517712 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9623669

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15315164

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15345469

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 7855217 11752352 17139284 17016423

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist Specific Action of the Ligand Antagonist

PMIDs: 15333678 16188951 7855217 16248990 17087737 17588565

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name inhaled atropine Direct Interaction? True

PMIDs: 7855217 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15733544

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: 23062550 7855217 17139284 17016423

Sources: TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 15081878

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Muscarinic acetylcholine receptor M3 antagonist Direct Interaction yes Trial Name inhaled atropine

PMIDs: 7855217 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2128054

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15733544

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2128054

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00572

Alternate Names: 51-55-8 CAS Number ATNAA atropine and pralidoxime chloride Auto-Injector Drug Brand ATROPEN Auto-Injector Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups vet_approved

TEND: ATROPINE

Alternate Names:

Drug Info: Drug Class anti-arrhythmia agents Drug Class bronchodilator agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: ATROPINE

Alternate Names:

Drug Info: Drug Indications nerve agent antidote Drug Class Small Molecule FDA Approval approved

Publications:

NCI: ATROPINE

Alternate Names: C28840 NCI drug code

Drug Info:

DTC: ATROPINE

Interaction Types & Directionality:

n/a

PMIDs:
9623669

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15315164

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15345469

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7855217 11752352 17139284 17016423

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist

Specific Action of the Ligand Antagonist

PMIDs:
15333678 16188951 7855217 16248990 17087737 17588565

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name inhaled atropine

Direct Interaction? True

PMIDs:
7855217 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
15733544

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
23062550 7855217 17139284 17016423

Sources:
TEND DTC TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
15081878

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M3 antagonist

Direct Interaction yes

Trial Name inhaled atropine

PMIDs:
7855217 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
2128054

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15733544

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
2128054

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

51-55-8 CAS Number

ATNAA atropine and pralidoxime chloride Auto-Injector Drug Brand

ATROPEN Auto-Injector Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Drug Info:

Drug Class anti-arrhythmia agents

Drug Class bronchodilator agents

Year of Approval approved before 1982

Drug Info:

Drug Indications nerve agent antidote

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C28840 NCI drug code

Alternate Names:

CHEMBL517712 ChEMBL Drug ID

Publications:

Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett

Alternate Names:

D0RG3O TTD Drug ID