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ATROPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • ATROPINE chembl:CHEMBL517712 Approved

    Alternate Names:

    ATROPINE
    ISOPTO ATROPINE
    ATROPINE (AUTOINJECTOR)
    ATROJECT
    ATROPHATE
    ATROPEN

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications nerve agent antidote
    Drug Class mydriatics
    Year of Approval approved before 1982
    Drug Class bronchodilator agents
    Drug Class anti-arrhythmia agents
    (3 More Sources)

    Publications:

    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh
    Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
    Nelson et al., 2006, Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor., J. Pharmacol. Exp. Ther.
    Roman et al., 2005, Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors., Brain Res.
    Minaba et al., 2006, Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals., FEBS J.
    Cembala et al., 2007, Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors., Eur. J. Pharmacol.
    May et al., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators., J. Pharmacol. Exp. Ther.
    Zheng et al., 2004, Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells., J. Huazhong Univ. Sci. Technol. Med. Sci.
    Furuya et al., 1998, Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts., Anat. Embryol.
    Buresi et al., 2005, Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro., Am. J. Physiol. Gastrointest. Liver Physiol.
  • ATROPINE   GUCA2A

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9623669


    Sources:
    NCI

  • ATROPINE   CHRM4

    Interaction Score: 1.28

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name inhaled atropine

    PMIDs:
    7855217 17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • ATROPINE   CHRM2

    Interaction Score: 0.99

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist
    Trial Name inhaled atropine

    PMIDs:
    7855217 16188951 16248990 17087737 17588565 15333678


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ATROPINE   CHRM5

    Interaction Score: 0.96

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name inhaled atropine
    Novel drug target Established target

    PMIDs:
    7855217 17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • ATROPINE   CXCL10

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15315164


    Sources:
    NCI

  • ATROPINE   F2R

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15345469


    Sources:
    NCI

  • ATROPINE   CHRM1

    Interaction Score: 0.54

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist
    Direct Interaction yes
    Trial Name inhaled atropine

    PMIDs:
    7855217 17016423 17139284 23062550


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND

  • ATROPINE   CHRM3

    Interaction Score: 0.48

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Muscarinic acetylcholine receptor M3 antagonist
    Direct Interaction yes
    Trial Name inhaled atropine

    PMIDs:
    7855217 17016423 17139284


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ATROPINE   CYP19A1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2128054


    Sources:
    NCI

  • ATROPINE   CYP3A5

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2128054


    Sources:
    NCI

  • ATROPINE   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: ATROPINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Drug Class anti-arrhythmia agents
    Drug Class bronchodilator agents
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: ATROPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications nerve agent antidote
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: ATROPINE

    • Version: 14-September-2017

    Alternate Names:
    C28840 NCI drug code

    Drug Info:

    Publications:
    Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh
    Buresi et al., 2005, Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro., Am. J. Physiol. Gastrointest. Liver Physiol.
    Furuya et al., 1998, Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts., Anat. Embryol.

  • DTC: ATROPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL517712 ChEMBL Drug ID

    Drug Info:

    Publications:
    Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett

  • TTD: Atropine

    • Version: 2020.06.01

    Alternate Names:
    D0RG3O TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL517712

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL517712

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21