DGIdb - ATROPINE Drug Record

ATROPINE chembl:CHEMBL517712 Approved

Alternate Names:

ATROPINE
ISOPTO ATROPINE
ATROPINE (AUTOINJECTOR)
ATROJECT
ATROPHATE
ATROPEN

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	nerve agent antidote
Drug Class	mydriatics
Year of Approval	approved before 1982
Drug Class	bronchodilator agents
Drug Class	anti-arrhythmia agents

(3 More Sources)

Publications:

Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh
Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
Nelson et al., 2006, Constitutive activity and inverse agonism at the M2 muscarinic acetylcholine receptor., J. Pharmacol. Exp. Ther.
Roman et al., 2005, Nicotinic-receptor potentiator drugs, huprine X and galantamine, increase ACh release by blocking AChE activity but not acting on nicotinic receptors., Brain Res.
Minaba et al., 2006, Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype. Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals., FEBS J.
Cembala et al., 2007, Allosteric interaction of the neuromuscular blockers vecuronium and pancuronium with recombinant human muscarinic M2 receptors., Eur. J. Pharmacol.
May et al., 2005, Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators., J. Pharmacol. Exp. Ther.
Zheng et al., 2004, Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells., J. Huazhong Univ. Sci. Technol. Med. Sci.
Furuya et al., 1998, Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts., Anat. Embryol.
Buresi et al., 2005, Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro., Am. J. Physiol. Gastrointest. Liver Physiol.

ATROPINE GUCA2A

Interaction Score: 3.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9623669

Sources:
NCI
ATROPINE CHRM4

Interaction Score: 1.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name inhaled atropine

PMIDs:
7855217 17016423 17139284

Sources:
TdgClinicalTrial TEND
ATROPINE CHRM2

Interaction Score: 0.99

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist

Trial Name inhaled atropine

PMIDs:
7855217 16188951 16248990 17087737 17588565 15333678

Sources:
TdgClinicalTrial ChemblInteractions TEND
ATROPINE CHRM5

Interaction Score: 0.96

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name inhaled atropine

Novel drug target Established target

PMIDs:
7855217 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
ATROPINE CXCL10

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15315164

Sources:
NCI
ATROPINE F2R

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15345469

Sources:
NCI
ATROPINE CHRM1

Interaction Score: 0.54

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

Trial Name inhaled atropine

PMIDs:
7855217 17016423 17139284 23062550

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND
ATROPINE CHRM3

Interaction Score: 0.48

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M3 antagonist

Direct Interaction yes

Trial Name inhaled atropine

PMIDs:
7855217 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
ATROPINE CYP19A1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2128054

Sources:
NCI
ATROPINE CYP3A5

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2128054

Sources:
NCI
ATROPINE AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ATROPINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class anti-arrhythmia agents

Drug Class bronchodilator agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: ATROPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications nerve agent antidote

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: ATROPINE

Version: 14-September-2017

Alternate Names:

C28840 NCI drug code

Drug Info:

Publications:

Ashirmetov et al., [The role of the parasympathetic nervous system in the regulation of microsomal monooxygenase activity in the liver of rats]., Fiziol Zh

Buresi et al., 2005, Activation of proteinase-activated receptor-1 inhibits neurally evoked chloride secretion in the mouse colon in vitro., Am. J. Physiol. Gastrointest. Liver Physiol.

Furuya et al., 1998, Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts., Anat. Embryol.

DTC: ATROPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL517712 ChEMBL Drug ID

Drug Info:

Publications:

Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett
TTD: Atropine
- Version: 2020.06.01
Alternate Names:

D0RG3O TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL517712
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL517712
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	inhaled atropine

Direct Interaction	yes
Mechanism of Interaction	Muscarinic acetylcholine receptor M2 antagonist
Trial Name	inhaled atropine

Mechanism of Interaction	Muscarinic acetylcholine receptor M1 antagonist
Direct Interaction	yes
Trial Name	inhaled atropine

Mechanism of Interaction	Muscarinic acetylcholine receptor M3 antagonist
Direct Interaction	yes
Trial Name	inhaled atropine

ATROPINE Drug Record

ATROPINE chembl:CHEMBL517712 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9623669

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name inhaled atropine

PMIDs: 7855217 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist Trial Name inhaled atropine

PMIDs: 7855217 16188951 16248990 17087737 17588565 15333678

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name inhaled atropine Novel drug target Established target

PMIDs: 7855217 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15315164

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15345469

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist Direct Interaction yes Trial Name inhaled atropine

PMIDs: 7855217 17016423 17139284 23062550

Sources: DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Muscarinic acetylcholine receptor M3 antagonist Direct Interaction yes Trial Name inhaled atropine

PMIDs: 7855217 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2128054

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2128054

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: ATROPINE

Alternate Names:

Drug Info: Drug Class anti-arrhythmia agents Drug Class bronchodilator agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: ATROPINE

Alternate Names:

Drug Info: Drug Indications nerve agent antidote Drug Class Small Molecule FDA Approval approved

Publications:

NCI: ATROPINE

Alternate Names: C28840 NCI drug code

Drug Info:

DTC: ATROPINE

Alternate Names: CHEMBL517712 ChEMBL Drug ID

Drug Info:

Publications: Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett

TTD: Atropine

Alternate Names: D0RG3O TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL517712

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL517712

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
9623669

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name inhaled atropine

PMIDs:
7855217 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Muscarinic acetylcholine receptor M2 antagonist

Trial Name inhaled atropine

PMIDs:
7855217 16188951 16248990 17087737 17588565 15333678

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name inhaled atropine

Novel drug target Established target

PMIDs:
7855217 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
15315164

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15345469

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M1 antagonist

Direct Interaction yes

Trial Name inhaled atropine

PMIDs:
7855217 17016423 17139284 23062550

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Muscarinic acetylcholine receptor M3 antagonist

Direct Interaction yes

Trial Name inhaled atropine

PMIDs:
7855217 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
2128054

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2128054

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Class anti-arrhythmia agents

Drug Class bronchodilator agents

Year of Approval approved before 1982

Drug Info:

Drug Indications nerve agent antidote

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C28840 NCI drug code

Alternate Names:

CHEMBL517712 ChEMBL Drug ID

Publications:

Poslusney MS et al., 2012, Synthesis and biological characterization of a series of novel diaryl amide M₁ antagonists., Bioorg Med Chem Lett

Alternate Names:

D0RG3O TTD Drug ID