DGIdb - ASPIRIN Drug Record

ASPIRIN chembl:CHEMBL25 Approved

Alternate Names:

NU-SEALS 75
ACETYLSALIC ACID
ECOTRIN
EQUI-PRIN
PAYNOCIL
SALICYLIC ACID ACETATE
DISPRIN DIRECT
NU-SEALS CARDIO 75
8-HOUR BAYER
MICROPIRIN EC
BAYER EXTRA STRENGTH
ANADIN ALL NIGHT
BAY1019036
DANAMEP
ENPRIN
VAZALORE
ALKA RAPID
ACETYLSALICYLIC ACID
NU-SEALS 600
PLATET
ANGETTES 75
NSC-406186
LEVIUS
POSTMI 300
ASPRO CLR
GENCARDIA
ACETOSALIC ACID
MAX STRGH ASPRO CLR
POSTMI 75
MEASURIN
PLATET 300
NU-SEALS 300
ASPIRIN
DURLAZA
NSC-27223
DISPRIN CV
ACENTERINE
ASPERGUM
AZETYLSALIZYLSÄURE
BENASPIR
O-(ACETYLOXY)BENZOIC ACID
O-ACETOXYBENZOIC ACID
CAPRIN
PHARMACIN
2-ACETOXYBENZENECARBOXYLIC ACID
ACYLPYRIN
ACETYLSALICYLATE
BUFFERIN
O-ACETYLSALICYLIC ACID
SALCETOGEN
ACETYONYL
TRIAMINICIN
ACETOPHEN®
ACIDE ACÉTYLSALICYLIQUE
SALETIN
ACETICYL
SOLPYRON
ASPIRDROPS
ACETOPHEN
EASPRIN
ÁCIDO ACETILSALICÍLICO
ACETONYL
ACETOSAL
ACETYSALICYLIC ACID
ASATARD
SOLPRIN
PERSISTIN
O-CARBOXYPHENYL ACETATE
2-ACETOXYBENZOATE
ENDOSPRIN
ECOLEN
ACETYSAL
2-CARBOXYPHENYL ACETATE
ACIDUM ACETYLSALICYLICUM
ACETOL
SOLPRIN ACID
TEMPERAL
TOLDEX
ASPIRIN®
ASA
TASPRIN
ENDYDOL
2-(ACETYLOXY)BENZOATE
ACETYLIN
BIALPIRINIA
ACARD
POLOPIRYNA
2-ACETOXYBENZOIC ACID
PREMASPIN
RHODINE
ACIDE 2-(ACÉTYLOXY)BENZOÏQUE
O-(ACETYLOXY)BENZOATE
EMPIRIN
SALOSPIR
ACETOSALIN
CARDIOASPIRINA
O-ACETOXYBENZOATE
RHEUMINTABLETTEN
ACETYLSALICYLSÄURE
ACETARD
pubchem.compound:2244
chemidplus:50-78-2
chembl:CHEMBL25
drugbank:00945
rxcui:1191

Drug Info:

Drug Class	anti-inflammatory agents, non-steroidal
Drug Class	anticoagulants
Year of Approval	not approved by the fda

(5 More Sources)

Publications:

Lee HY et al., 2009, The HLA allele marker for differentiating ASA hypersensitivity phenotypes., Allergy
Kim SH et al., 2005, The human leucocyte antigen-DRB11302-DQB10609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria., Clin Exp Allergy
Verschuren JJ et al., 2013, Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction., Int J Cardiol
Li Q et al., 2007, Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin., Pharmacogenomics
Jefferson BK et al., 2005, Aspirin resistance and a single gene., Am J Cardiol
Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem
Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost
Abiru et al., 2002, Aspirin and NS-398 inhibit hepatocyte growth factor-induced invasiveness of human hepatoma cells., Hepatology
Kim BS et al., 2010, Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity., Pharmacogenet Genomics
Whitehead et al., 2007, Effects of triflusal and aspirin in a rat model of cerebral ischemia., Stroke
Jayaraj et al., 2000, Duodenal ulcer prevalence: experimental evidence for the possible role of dietary lipids., J. Gastroenterol. Hepatol.
Kim SH et al., 2007, Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma., Pharmacogenet Genomics
Shiotani A et al., 2009, The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy., J Gastroenterol
Domhan et al., 2004, Role of apoptosis and CD95-receptor/ligand system in aspirin- and Helicobacter pylori-induced cell death., Eur. J. Clin. Invest.
Oh SH et al., 2011, Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients., Pharmacogenomics
Dror et al., 1994, Aplasia cutis congenita, elevated alpha-fetoprotein, and a distinct amniotic fluid acetylcholinesterase electrophoretic band., Am J Perinatol
Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med
Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Liao X et al., 2012, Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival., N Engl J Med
Hedberg ML et al., 2019, Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for <i>PIK3CA</i>-altered head and neck cancer., J Exp Med
Xiang Q et al., 2017, Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis., Curr Pharm Des
Xiang Q et al., 2013, Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics., Pharmacogenomics
Lewis JP et al., 2013, Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes., Circ Cardiovasc Genet
Jalil NJ et al., 2015, The Implication of the Polymorphisms of COX-1, UGT1A6, and CYP2C9 among Cardiovascular Disease (CVD) Patients Treated with Aspirin., J Pharm Pharm Sci
Harmsze AM et al., 2010, CYP2C192 and CYP2C93 alleles are associated with stent thrombosis: a case-control study., Eur Heart J
Floyd CN et al., 2014, The PlA1/A2 polymorphism of glycoprotein IIIa in relation to efficacy of antiplatelet drugs: a systematic review and meta-analysis., Br J Clin Pharmacol
Cayla G et al., 2011, Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis., JAMA
Abderrazek F et al., 2010, The GPIIIa PlA polymorphism and the platelet hyperactivity in Tunisian patients with stable coronary artery disease treated with aspirin., Thromb Res
Lim E et al., 2007, Dose-related efficacy of aspirin after coronary surgery in patients With Pl(A2) polymorphism (NCT00262275)., Ann Thorac Surg
Dropinski J et al., 2007, Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease., Thromb Res
Lev EI et al., 2007, Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel., Thromb Res
Cooke GE et al., 2006, Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination., J Am Coll Cardiol
Morawski W et al., 2005, Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism., J Thorac Cardiovasc Surg
Papp E et al., 2005, Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation?, Ann Pharmacother
Undas A et al., 2001, Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury., Circulation
Szczeklik A et al., 2000, Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa., Br J Haematol
Michelson AD et al., 2000, Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists., Circulation
Undas A et al., 1999, Platelet glycoprotein IIIa polymorphism, aspirin, and thrombin generation., Lancet
Chung et al., 1998, Effects of aspirin on arylamine N-acetyltransferase activity in Klebsiella pneumoniae., Drug Chem Toxicol
Kim JM et al., 2010, Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics., Pharmacogenomics
Slattery et al., 2008, Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions., Int. J. Cancer
Iglesias-Serret et al., 2003, Transcriptional and translational control of Mcl-1 during apoptosis., Arch. Biochem. Biophys.
Giusti B et al., 2008, Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment., Atherosclerosis
Angiolillo DJ et al., 2005, Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene., Am J Cardiol
Angiolillo DJ et al., 2004, 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment., Blood Coagul Fibrinolysis
Pasaje CF et al., 2011, A possible association of EMID2 polymorphisms with aspirin hypersensitivity in asthma., Immunogenetics
Chan et al., 2007, Aspirin and the risk of colorectal cancer in relation to the expression of COX-2., N. Engl. J. Med.
Heath et al., 1996, Glycation-induced inactivation of malate dehydrogenase protection by aspirin and a lens molecular chaperone, alpha-crystallin., Biochim. Biophys. Acta
Yeh et al., Effects of aspirin on arylamine N -acetyltransferase activity and DNA adducts in human bladder tumour cells., J Appl Toxicol
Chen et al., 2003, Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer., Clin. Cancer Res.
Park HJ et al., 2008, Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population., J Clin Pharm Ther
Shuvalova YA et al., 2012, Association between polymorphisms of eNOS and GPx-1 genes, activity of free-radical processes and in-stent restenosis., Mol Cell Biochem
Kim SH et al., 2009, Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria., Allergy
Kim TH et al., 2008, Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics., Clin Exp Allergy
Towndrow et al., 2000, Stress- and growth-related gene expression are independent of chemical-induced prostaglandin E(2) synthesis in renal epithelial cells., Chem. Res. Toxicol.
López-Farré et al., 2007, Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study., J. Proteome Res.
Mousa et al., 2001, Comparison of the effect of different platelet GPIIb/IIa antagonists on the dynamics of platelet/fibrin-mediated clot strength induced using thromboelastography., Thromb. Res.
Weksler, 2000, Antiplatelet agents in stroke prevention. combination therapy: present and future., Cerebrovasc. Dis.
Cho SH et al., 2013, Association analysis of tapasin polymorphisms with aspirin-exacerbated respiratory disease in asthmatics., Pharmacogenet Genomics
Kawashima et al., 1985, Aspirin inhibition of 1 alpha-hydroxyvitamin D3 or parathyroid hormone induced hypercalcemia in vivo in rats. A mechanism independent of prostaglandin biosynthesis inhibition., Biochem. Pharmacol.
Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut
Pasaje CF et al., 2010, Association of SLC6A12 variants with aspirin-intolerant asthma in a Korean population., Ann Hum Genet
Serebruany et al., 2004, Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial., Eur. J. Pharmacol.
Shiotani A et al., 2011, Renin-angiotensin system associated with risk of upper GI mucosal injury induced by low dose aspirin: renin angiotensin system genes' polymorphism., Dig Dis Sci
Palikhe NS et al., 2008, Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma., Respir Med
Palikhe N et al., 2008, Analysis of high-affinity IgE receptor (FcepsilonR1) polymorphisms in patients with aspirin-intolerant chronic urticaria., Allergy Asthma Proc
Wang Z et al., 2013, Polymorphisms and high on-aspirin platelet reactivity after off-pump coronary artery bypass grafting., Scand Cardiovasc J
Fujiwara T et al., 2007, Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity., Pharmacogenomics J
Kim SH et al., 2005, Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma., Clin Exp Allergy
Ayuso P et al., 2015, Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients., Pharmacogenet Genomics
Esmaeilzadeh H et al., 2015, Pharmacogenetic tests to predict the efficacy of aspirin desensitization in patients with aspirin-exacerbated respiratory diseases; HLA-DQB302., Expert Rev Respir Med
Kupstyte N et al., 2015, Effect of clinical factors and gene polymorphism of CYP2C192, 17 and CYP4F2*3 on early stent thrombosis., Pharmacogenomics
Tatarunas V et al., 2014, The role of clinical parameters and of CYP2C19 G681 and CYP4F2 G1347A polymorphisms on platelet reactivity during dual antiplatelet therapy., Blood Coagul Fibrinolysis
Sánchez-Borges M et al., 2009, The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria., J Investig Allergol Clin Immunol
Mastalerz L et al., 2006, Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant., Br J Dermatol
Mastalerz L et al., 2004, Hypersensitivity to aspirin: common eicosanoid alterations in urticaria and asthma., J Allergy Clin Immunol
Grosser et al., 2003, Heme oxygenase-1 induction may explain the antioxidant profile of aspirin., Biochem. Biophys. Res. Commun.
Matsubara Y et al., 2008, Enhancing effect of the (145)Met-allele of GPIb alpha on platelet sensitivity to aspirin under high-shear conditions., Thromb Res
Undas A et al., 2003, Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism., Circulation
Choi JH et al., 2004, HLA association in aspirin-intolerant asthma: DPB1*0301 as a strong marker in a Korean population., J Allergy Clin Immunol
Dekker JW et al., 1997, Aspirin-induced asthma and HLA-DRB1 and HLA-DPB1 genotypes., Clin Exp Allergy

ASPIRIN GP1BA

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18417193 17245331

Sources:
PharmGKB
ASPIRIN FCER1G

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18595682 18534082

Sources:
PharmGKB
ASPIRIN HLA-DPB1

Interaction Score: 2.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15007363 15784113 19392989 9179433

Sources:
PharmGKB
ASPIRIN F13A1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12515735

Sources:
PharmGKB
ASPIRIN LTC4S

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19862937 16433794 15100686

Sources:
PharmGKB
ASPIRIN SLC6A12

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20597903

Sources:
PharmGKB
ASPIRIN TAPBP

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23736108

Sources:
PharmGKB
ASPIRIN GP6

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16493486

Sources:
PharmGKB
ASPIRIN P2RY1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22940005 17559347 15757620

Sources:
PharmGKB
ASPIRIN ITGA2

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22940005 17157856 16493486 16214444 15205592

Sources:
PharmGKB
ASPIRIN ITGB3

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23834376 22028352 20138334 17184645 16675000 16581111 16493486 16458133 16153930 15840736 11723016 11054089 10704169 10459913

Sources:
PharmGKB
ASPIRIN ZBTB22

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN HLA-DPB2

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN SLC30A9

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN CHIA

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN FSIP1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN COL26A1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21086123

Sources:
PharmGKB
ASPIRIN CEP68

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN PEAR1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28820077 23859572 23392654

Sources:
PharmGKB
ASPIRIN TBXAS1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449675

Sources:
PharmGKB
ASPIRIN IRS2

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18059035

Sources:
NCI
ASPIRIN TNFRSF11A

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26398624

Sources:
PharmGKB
ASPIRIN HMOX1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12927812

Sources:
NCI
ASPIRIN B4GALT2

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN IL4

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20921925

Sources:
PharmGKB
ASPIRIN TBXA2R

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23688183 17245331 15898979

Sources:
PharmGKB
ASPIRIN HNMT

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19178400

Sources:
PharmGKB
ASPIRIN ME3

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8611656

Sources:
NCI
ASPIRIN CYP4F2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25712182 24418943

Sources:
PharmGKB
ASPIRIN ITGA2B

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11583738 11096182

Sources:
NCI
ASPIRIN PLCG1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26398624

Sources:
PharmGKB
ASPIRIN PTGER3

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17496729

Sources:
PharmGKB
ASPIRIN HLA-DQB1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26366802 19392989 15784113

Sources:
PharmGKB
ASPIRIN TSC1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN GC

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17555340

Sources:
NCI
ASPIRIN TLR3

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN COL18A1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11353854

Sources:
NCI
ASPIRIN PLA2G4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26398624

Sources:
PharmGKB
ASPIRIN NAT2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9839158 20602614

Sources:
NCI PharmGKB
ASPIRIN PTGER2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17496729

Sources:
PharmGKB
ASPIRIN AFP

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7515237

Sources:
NCI
ASPIRIN PTGIR

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17496729

Sources:
PharmGKB
ASPIRIN HGF

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11981761

Sources:
NCI
ASPIRIN AGT

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20824505

Sources:
PharmGKB
ASPIRIN PTGS1

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
23651359 22940005 20938371 16493486

Sources:
DTC ChemblInteractions TEND PharmGKB
ASPIRIN F2R

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15381054

Sources:
NCI
ASPIRIN PTH

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4004906

Sources:
NCI
ASPIRIN THRA

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN FAS

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15200494

Sources:
NCI
ASPIRIN HLA-DRB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19392989 15784113

Sources:
PharmGKB
ASPIRIN FGF2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9071932

Sources:
NCI
ASPIRIN NOS3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22890915

Sources:
PharmGKB
ASPIRIN NRG1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10921413

Sources:
NCI
ASPIRIN GFAP

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17194886

Sources:
NCI
ASPIRIN DDIT3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10688535

Sources:
NCI
ASPIRIN UGT1A6

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN ADORA1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19019667

Sources:
PharmGKB
ASPIRIN PTGS2

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
17522398

Sources:
ChemblInteractions TEND CIViC PharmGKB
ASPIRIN NTRK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28820077 23859572

Sources:
PharmGKB
ASPIRIN TGFB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19138248

Sources:
PharmGKB
ASPIRIN IL1B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19448967

Sources:
PharmGKB
ASPIRIN HMGCR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ASPIRIN MCL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12941295

Sources:
NCI
ASPIRIN ACE

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18727619

Sources:
PharmGKB
ASPIRIN CXCL8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12576442

Sources:
NCI
ASPIRIN NAT1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10547619

Sources:
NCI
ASPIRIN PIK3CA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23094721 30683736

Sources:
CIViC
ASPIRIN CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26517138 20833683 22931300

Sources:
DTC PharmGKB
ASPIRIN PPARG

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ASPIRIN CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC PharmGKB
ASPIRIN CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
ASPIRIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: ASPIRIN
- Version: 01-August-2011
Alternate Names:

ASPIRIN Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class anticoagulants

Drug Class anti-inflammatory agents, non-steroidal

Publications:

NCI: ASPIRIN

Version: 14-September-2017

Alternate Names:

C287 NCI drug code

Drug Info:

Publications:

Whitehead et al., 2007, Effects of triflusal and aspirin in a rat model of cerebral ischemia., Stroke

Ma et al., 2001, Platelets modulate gastric ulcer healing: role of endostatin and vascular endothelial growth factor release., Proc. Natl. Acad. Sci. U.S.A.

Kawashima et al., 1985, Aspirin inhibition of 1 alpha-hydroxyvitamin D3 or parathyroid hormone induced hypercalcemia in vivo in rats. A mechanism independent of prostaglandin biosynthesis inhibition., Biochem. Pharmacol.

NCI: ASA
- Version: 14-September-2017
Alternate Names:

C287 NCI drug code

Drug Info:

Publications:

López-Farré et al., 2007, Relationship between vitamin D binding protein and aspirin resistance in coronary ischemic patients: a proteomic study., J. Proteome Res.

DTC: ASPIRIN

Version: 02-September-2020

Alternate Names:

CHEMBL25 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem

PharmGKB: aspirin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Kim BS et al., 2010, Effect of single nucleotide polymorphisms within the interleukin-4 promoter on aspirin intolerance in asthmatics and interleukin-4 promoter activity., Pharmacogenet Genomics

Kim SH et al., 2009, Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma., Respir Med

Kim SH et al., 2007, Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma., Pharmacogenet Genomics

CIViC: ASPIRIN

Version: 14-September-2020

Alternate Names:

Drug Info:

Publications:

Hedberg ML et al., 2019, Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for <i>PIK3CA</i>-altered head and neck cancer., J Exp Med

Liao X et al., 2012, Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival., N Engl J Med

Chan et al., 2007, Aspirin and the risk of colorectal cancer in relation to the expression of COX-2., N. Engl. J. Med.

TTD: Aspirin
- Version: 2020.06.01
Alternate Names:

D0GY5Z TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL25
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL25
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Cyclooxygenase inhibitor
Direct Interaction	yes

ASPIRIN Drug Record

ASPIRIN chembl:CHEMBL25 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18417193 17245331

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18595682 18534082

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15007363 15784113 19392989 9179433

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12515735

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19862937 16433794 15100686

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20597903

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23736108

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16493486

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22940005 17559347 15757620

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22940005 17157856 16493486 16214444 15205592

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23834376 22028352 20138334 17184645 16675000 16581111 16493486 16458133 16153930 15840736 11723016 11054089 10704169 10459913

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21086123

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28820077 23859572 23392654

Interaction Types & Directionality:

n/a

PMIDs:
18417193 17245331

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18595682 18534082

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15007363 15784113 19392989 9179433

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12515735

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19862937 16433794 15100686

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20597903

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23736108

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16493486

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22940005 17559347 15757620

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22940005 17157856 16493486 16214444 15205592

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23834376 22028352 20138334 17184645 16675000 16581111 16493486 16458133 16153930 15840736 11723016 11054089 10704169 10459913

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21086123

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28820077 23859572 23392654

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21449675

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18059035

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26398624

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12927812

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20921925

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23688183 17245331 15898979

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19178400