DGIdb - ASENAPINE Drug Record

ASENAPINE chembl:CHEMBL3187365 Approved

Alternate Names:

ASENAPINE
SYCREST

Drug Info:

Drug Class	antipsychotic agents
Year of Approval	2009
FDA Approval	approved
Drug Class	Small molecule
Drug Indications	antipsychotic agent

(1 More Sources)

Publications:

Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Tadori et al., 2011, Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors., Eur. J. Pharmacol.
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

ASENAPINE HTR5A

Interaction Score: 0.68

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
ASENAPINE HRH2

Interaction Score: 0.37

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
ASENAPINE HTR6

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial
ASENAPINE HTR7

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
ASENAPINE DRD4

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial
ASENAPINE HTR1B

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial GuideToPharmacology
ASENAPINE DRD3

Interaction Score: 0.15

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21658377 21655346

Sources:
TdgClinicalTrial
ASENAPINE HTR2B

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
ASENAPINE HTR2C

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial
ASENAPINE HTR1A

Interaction Score: 0.12

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

Endogenous Drug? False

PMIDs:
18308814 10592235

Sources:
TdgClinicalTrial GuideToPharmacology
ASENAPINE HTR2A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial GuideToPharmacology
ASENAPINE DRD2

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

Direct Interaction? True

PMIDs:
18308814 21658377 21655346

Sources:
TdgClinicalTrial TEND GuideToPharmacology
ASENAPINE HTR1E

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ASENAPINE ADRA2B

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814

Sources:
TdgClinicalTrial
ASENAPINE HRH1

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial GuideToPharmacology
ASENAPINE ADRA2C

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial
ASENAPINE ADRA2A

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial
ASENAPINE ADRA1A

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial
ASENAPINE DRD1

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
ASENAPINE HTR1D

Interaction Score: 0.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

TdgClinicalTrial: ASENAPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antipsychotic agent

Drug Class Small molecule

FDA Approval approved

Publications:
TEND: ASENAPINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 2009

Drug Class antipsychotic agents

Publications:
TTD: Asenapine
- Version: 2020.06.01
Alternate Names:

D00JRA TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL3187365
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 135650779
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:

Endogenous Drug?	False
Specific Action of the Ligand	Full agonist
Trial Name	Asenapine

Novel drug target	Established target
Trial Name	Asenapine
Endogenous Drug?	False

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Trial Name	Asenapine

agonist (activating)
antagonist (inhibitory)

agonist (activating)
antagonist (inhibitory)

ASENAPINE Drug Record

ASENAPINE chembl:CHEMBL3187365 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Asenapine

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Asenapine

PMIDs: 18308814 10592235 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 10592235 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Full agonist Trial Name Asenapine

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 21658377 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Asenapine

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 10592235 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Asenapine Endogenous Drug? False

PMIDs: 18308814 10592235

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 18308814 10592235 21655346

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target Direct Interaction? True

PMIDs: 18308814 21658377 21655346

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Asenapine

PMIDs: 18308814

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Trial Name Asenapine

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 21655346

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21658377 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

Endogenous Drug? False

PMIDs:
18308814 10592235

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
18308814 10592235 21655346

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

Direct Interaction? True

PMIDs:
18308814 21658377 21655346

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Asenapine

PMIDs:
18308814

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Trial Name Asenapine

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology