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ASENAPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • ASENAPINE chembl:CHEMBL3187365 Approved

    Alternate Names:

    ASENAPINE
    SYCREST

    Drug Info:

    Drug Class antipsychotic agents
    Year of Approval 2009
    FDA Approval approved
    Drug Class Small molecule
    Drug Indications antipsychotic agent
    Drug Categories acid reducers
    Drug Categories adrenergic alpha-1 receptor antagonists
    Drug Categories adrenergic alpha-antagonists
    Drug Categories adrenergic antagonists
    Drug Categories agents that produce hypertension
    Drug Categories antidepressive agents
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (weak)
    Drug Categories cytochrome p-450 cyp2d6 substrates
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories dopamine antagonists
    Drug Categories dopamine d2 receptor antagonists
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories histamine antagonists
    Drug Categories histamine h1 antagonists
    Drug Categories histamine h2 antagonists
    Drug Categories neurotoxic agents
    Drug Categories qtc prolonging agents
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin agents
    Drug Categories serotonin receptor agonists
    Drug Categories ugt1a4 substrates
    (2 More Sources)

    Publications:

    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Tadori et al., 2011, Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors., Eur. J. Pharmacol.
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Fagiolini et al., 2013, Asenapine for the treatment of manic and mixed episodes associated with bipolar I disorder: from clinical research to clinical practice., Expert Opin Pharmacother
  • ASENAPINE   HTR5A

    Interaction Score: 0.61

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HRH2

    Interaction Score: 0.29

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Asenapine

    PMIDs:
    18308814 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HTR6

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Asenapine

    PMIDs:
    18308814 10592235 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   DRD4

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 10592235 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HTR1B

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist
    Trial Name Asenapine

    PMIDs:
    18308814 21655346


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • ASENAPINE   HTR7

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   DRD3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21658377 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HTR2B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Asenapine

    PMIDs:
    18308814 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HTR2C

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 10592235 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   DRD2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target
    Direct Interaction? True

    PMIDs:
    18308814 21658377 21655346


    Sources:
    DrugBank TdgClinicalTrial TEND GuideToPharmacology

  • ASENAPINE   HTR1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Asenapine
    Endogenous Drug? False

    PMIDs:
    18308814 10592235


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • ASENAPINE   ADRA2B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Asenapine

    PMIDs:
    18308814


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HTR2A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    18308814 10592235 21655346


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • ASENAPINE   HTR1E

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ASENAPINE   ADRA2C

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HRH1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name Asenapine

    PMIDs:
    18308814 21655346


    Sources:
    DrugBank TdgClinicalTrial GuideToPharmacology

  • ASENAPINE   ADRB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    18308814 23356509


    Sources:
    DrugBank

  • ASENAPINE   ADRA2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   DRD1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21655346


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   ADRB2

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    18308814 23356509


    Sources:
    DrugBank

  • ASENAPINE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814


    Sources:
    DrugBank TdgClinicalTrial

  • ASENAPINE   HTR1D

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DrugBank: DB06216

    • Version: 5.1.7

    Alternate Names:
    65576-45-6 CAS Number
    Saphris Drug Brand
    Secuado Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories acid reducers

    Publications:
    Tadori et al., 2011, Functional potencies of dopamine agonists and antagonists at human dopamine D₂ and D₃ receptors., Eur. J. Pharmacol.
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat

  • TdgClinicalTrial: ASENAPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antipsychotic agent
    Drug Class Small molecule
    FDA Approval approved

    Publications:

  • TEND: ASENAPINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval 2009
    Drug Class antipsychotic agents

    Publications:

  • TTD: Asenapine

    • Version: 2020.06.01

    Alternate Names:
    D00JRA TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL3187365

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650779

    • Version: 29-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21