DGIdb - ANDROGRAPHOLIDE Drug Record

ANDROGRAPHOLIDE chembl:CHEMBL186141

Alternate Names:

NSC-383468
HMPL004
ANDROGRAPHOLIDE
HMPL-004

Drug Info:

FDA Approval	not approved
Drug Class	plant extract
Drug Indications	antiinflammatory agent,for treatment of ulcerative colitis,for treatment of Chron's disease

(0 More Sources)

Publications:

Nguyen VS et al., 2015, Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50., J Nat Prod
Chen HW et al., 2011, Inhibition of TNF-α-Induced Inflammation by andrographolide via down-regulation of the PI3K/Akt signaling pathway., J Nat Prod

ANDROGRAPHOLIDE RELA

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22026410

Sources:
DTC
ANDROGRAPHOLIDE NFKB1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name HMPL-004

PMIDs:
25615020

Sources:
DTC TdgClinicalTrial
ANDROGRAPHOLIDE AKT1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22026410

Sources:
DTC

TdgClinicalTrial: HMPL-004
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,for treatment of ulcerative colitis,for treatment of Chron's disease

Drug Class plant extract

FDA Approval not approved

Publications:

DTC: ANDROGRAPHOLIDE

Version: 02-September-2020

Alternate Names:

CHEMBL186141 ChEMBL Drug ID

Drug Info:

Publications:

Chen HW et al., 2011, Inhibition of TNF-α-Induced Inflammation by andrographolide via down-regulation of the PI3K/Akt signaling pathway., J Nat Prod

Nguyen VS et al., 2015, Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50., J Nat Prod

TTD: HMPL-004
- Version: 2020.06.01
Alternate Names:

D0G6DF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL186141
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	HMPL-004

ANDROGRAPHOLIDE Drug Record

ANDROGRAPHOLIDE chembl:CHEMBL186141

Alternate Names:

Drug Info:

Publications:

ANDROGRAPHOLIDE RELA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22026410

Sources: DTC

ANDROGRAPHOLIDE NFKB1

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name HMPL-004

PMIDs: 25615020

Sources: DTC TdgClinicalTrial

ANDROGRAPHOLIDE AKT1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22026410

Sources: DTC

TdgClinicalTrial: HMPL-004

Alternate Names:

Drug Info: Drug Indications antiinflammatory agent,for treatment of ulcerative colitis,for treatment of Chron's disease Drug Class plant extract FDA Approval not approved

Publications:

DTC: ANDROGRAPHOLIDE

Alternate Names: CHEMBL186141 ChEMBL Drug ID

Drug Info:

TTD: HMPL-004

Alternate Names: D0G6DF TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL186141

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
22026410

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name HMPL-004

PMIDs:
25615020

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
22026410

Sources:
DTC

Drug Info:

Drug Indications antiinflammatory agent,for treatment of ulcerative colitis,for treatment of Chron's disease

Drug Class plant extract

FDA Approval not approved

Alternate Names:

CHEMBL186141 ChEMBL Drug ID

Alternate Names:

D0G6DF TTD Drug ID