AMOXAPINE Drug Record
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AMOXAPINE chembl:CHEMBL1113 Approved
Alternate Names:
AMOXAPINE ASENDIS CL-67772 DEFANYL ASENDIN AMOXAPIN 2-CHLORO-11-(1-PIPERAZINYL)DIBENZ(B,F)(1,4)OXAZEPINE AMOXAPINA AMOXIPINE ASENDIN® AMOXEPINE DESMETHYLLOXAPIN AMOXAPINUM drugbank:00543 chemidplus:14028-44-5 rxcui:722 chembl:CHEMBL1113 pubchem.compound:2170 Drug Info:
FDA Approval approved Drug Class Small Molecule Drug Indications antidepressant Drug Class antidepressive agents, tricyclic Year of Approval 1980 Drug Categories adrenergic alpha-1 receptor antagonists Drug Categories adrenergic alpha-antagonists Drug Categories adrenergic antagonists Drug Categories agents producing tachycardia Drug Categories agents that produce hypertension Drug Categories agents that reduce seizure threshold Drug Categories anticholinergic agents Drug Categories antidepressive agents, tetracyclic Drug Categories antidepressive agents, tricyclic Drug Categories antipsychotic agents Drug Categories combined inhibitors of serotonin/norepinephrine reuptake Drug Categories cytochrome p-450 cyp2d6 inhibitors Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown) Drug Categories cytochrome p-450 enzyme inhibitors Drug Categories cytochrome p-450 substrates Drug Categories dopamine d2 receptor antagonists Drug Categories heterocyclic compounds, fused-ring Drug Categories histamine antagonists Drug Categories histamine h1 antagonists Drug Categories muscarinic antagonists Drug Categories neurotoxic agents Drug Categories p-glycoprotein inhibitors Drug Categories potential qtc-prolonging agents Drug Categories qtc prolonging agents Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome Drug Categories serotonin 5-ht1 receptor antagonists Drug Categories serotonin 5-ht2 receptor antagonists Drug Categories serotonin receptor antagonists Publications:
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inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True -
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inhibitor (inhibitory) Interaction Info:
Trial Name CRx-150, amoxapine plus dipyridamole Novel drug target Established target Trial Name CRx-119 -
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antagonist (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False -
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antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Dopamine receptor antagonist -
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antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes -
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antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes -
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antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Dopamine receptor antagonist -
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antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes -
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inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Norepinephrine transporter inhibitor Direct Interaction yes -
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inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Serotonin transporter inhibitor Direct Interaction yes
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Alternate Names:
AMOXAPINE DrugBank Drug Name 14028-44-5 CAS Number Adisen Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Categories adrenergic agents Publications:
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AMOXAPINE Primary Drug Name Drug Info:
Year of Approval 1980 Drug Class antidepressive agents, tricyclic Publications:
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- Version: January-2014
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Drug Indications antidepressant Drug Class Small Molecule FDA Approval approved Publications:
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- Version: 29-September-2020
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AMOXAPINE GuideToPharmacology Ligand Name Drug Info:
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CHEMBL1113 ChEMBL Drug ID Drug Info:
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- Version: ChEMBL_27
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- Version: chembl_23
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