DGIdb - AMOXAPINE Drug Record

AMOXAPINE chembl:CHEMBL1113 Approved

Alternate Names:

AMOXAPINE
ASENDIS
CL-67772
DEFANYL
ASENDIN
AMOXAPIN
2-CHLORO-11-(1-PIPERAZINYL)DIBENZ(B,F)(1,4)OXAZEPINE
AMOXAPINA
AMOXIPINE
ASENDIN®
AMOXEPINE
DESMETHYLLOXAPIN
AMOXAPINUM
drugbank:00543
chemidplus:14028-44-5
rxcui:722
chembl:CHEMBL1113
pubchem.compound:2170

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidepressant
Drug Class	antidepressive agents, tricyclic
Year of Approval	1980

(5 More Sources)

Publications:

Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Spurlock et al., Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter., Neuropharmacology
Burstein et al., 2005, Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist., J. Pharmacol. Exp. Ther.
Nasu et al., 2000, Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice., Biopharm Drug Dispos
Wei et al., 1990, [Comparison of the affinities of amoxapine and loxapine for various receptors in rat brain and the receptor down-regulation after chronic administration]., Yao Xue Xue Bao

AMOXAPINE SLC6A2

Interaction Score: 0.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17016423 17139284 9537821

Sources:
TdgClinicalTrial TEND GuideToPharmacology
AMOXAPINE SLC6A4

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-150, amoxapine plus dipyridamole

Novel drug target Established target

Trial Name CRx-119

PMIDs:
7984281 9537821

Sources:
TdgClinicalTrial TEND GuideToPharmacology
AMOXAPINE HTR6

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7908055

Sources:
GuideToPharmacology
AMOXAPINE DRD5

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMOXAPINE DRD4

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine receptor antagonist

PMIDs:
16135699

Sources:
ChemblInteractions
AMOXAPINE DRD3

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
16135699

Sources:
ChemblInteractions
AMOXAPINE DRD1

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine receptor antagonist

PMIDs:
11180191

Sources:
DTC ChemblInteractions
AMOXAPINE NAT1

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Norepinephrine transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMOXAPINE DRD2

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
11180191 1966571

Sources:
ChemblInteractions
AMOXAPINE THPO

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMOXAPINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC PharmGKB FDA
AMOXAPINE HTT

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMOXAPINE KCNH2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMOXAPINE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMOXAPINE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: AMOXAPINE
- Version: 01-August-2011
Alternate Names:

AMOXAPINE Primary Drug Name

Drug Info:

Year of Approval 1980

Drug Class antidepressive agents, tricyclic

Publications:
TdgClinicalTrial: AMOXAPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Publications:
GuideToPharmacology: 135649941
- Version: 29-September-2020
Alternate Names:

AMOXAPINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Amoxapine
- Version: 2020.06.01
Alternate Names:

D09IOI TTD Drug ID

Drug Info:

Publications:
DTC: AMOXAPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1113 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1113
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1113
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: amoxapine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Amoxapine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	CRx-150, amoxapine plus dipyridamole
Novel drug target	Established target
Trial Name	CRx-119

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Mechanism of Interaction	Dopamine receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Norepinephrine transporter inhibitor
Direct Interaction	yes

Mechanism of Interaction	Serotonin transporter inhibitor
Direct Interaction	yes

AMOXAPINE Drug Record

AMOXAPINE chembl:CHEMBL1113 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 17016423 17139284 9537821

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CRx-150, amoxapine plus dipyridamole Novel drug target Established target Trial Name CRx-119

PMIDs: 7984281 9537821

Sources: TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 7908055

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Dopamine receptor antagonist

PMIDs: 16135699

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes

PMIDs: 16135699

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Dopamine receptor antagonist

PMIDs: 11180191

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Norepinephrine transporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes

PMIDs: 11180191 1966571

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC PharmGKB FDA

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin transporter inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: AMOXAPINE

Alternate Names: AMOXAPINE Primary Drug Name

Drug Info: Year of Approval 1980 Drug Class antidepressive agents, tricyclic

Publications:

TdgClinicalTrial: AMOXAPINE

Alternate Names:

Drug Info: Drug Indications antidepressant Drug Class Small Molecule FDA Approval approved

Publications:

GuideToPharmacology: 135649941

Alternate Names: AMOXAPINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Amoxapine

Alternate Names: D09IOI TTD Drug ID

Drug Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17016423 17139284 9537821

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-150, amoxapine plus dipyridamole

Novel drug target Established target

Trial Name CRx-119

PMIDs:
7984281 9537821

Sources:
TdgClinicalTrial TEND GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
7908055

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine receptor antagonist

PMIDs:
16135699

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
16135699

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Dopamine receptor antagonist

PMIDs:
11180191

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Norepinephrine transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
11180191 1966571

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin transporter inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

AMOXAPINE Primary Drug Name

Drug Info:

Year of Approval 1980

Drug Class antidepressive agents, tricyclic

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

AMOXAPINE GuideToPharmacology Ligand Name

Alternate Names:

D09IOI TTD Drug ID

Alternate Names:

CHEMBL1113 ChEMBL Drug ID