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AMOXAPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • AMOXAPINE chembl:CHEMBL1113 Approved

    Alternate Names:

    AMOXAPINE
    ASENDIS
    CL-67772
    DEFANYL
    ASENDIN
    AMOXAPIN
    2-CHLORO-11-(1-PIPERAZINYL)DIBENZ(B,F)(1,4)OXAZEPINE
    AMOXAPINA
    AMOXIPINE
    ASENDIN®
    AMOXEPINE
    DESMETHYLLOXAPIN
    AMOXAPINUM
    drugbank:00543
    chemidplus:14028-44-5
    rxcui:722
    chembl:CHEMBL1113
    pubchem.compound:2170

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antidepressant
    Drug Class antidepressive agents, tricyclic
    Year of Approval 1980
    Drug Categories adrenergic alpha-1 receptor antagonists
    Drug Categories adrenergic alpha-antagonists
    Drug Categories adrenergic antagonists
    Drug Categories agents producing tachycardia
    Drug Categories agents that produce hypertension
    Drug Categories agents that reduce seizure threshold
    Drug Categories anticholinergic agents
    Drug Categories antidepressive agents, tetracyclic
    Drug Categories antidepressive agents, tricyclic
    Drug Categories antipsychotic agents
    Drug Categories combined inhibitors of serotonin/norepinephrine reuptake
    Drug Categories cytochrome p-450 cyp2d6 inhibitors
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories dopamine d2 receptor antagonists
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories histamine antagonists
    Drug Categories histamine h1 antagonists
    Drug Categories muscarinic antagonists
    Drug Categories neurotoxic agents
    Drug Categories p-glycoprotein inhibitors
    Drug Categories potential qtc-prolonging agents
    Drug Categories qtc prolonging agents
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 5-ht1 receptor antagonists
    Drug Categories serotonin 5-ht2 receptor antagonists
    Drug Categories serotonin receptor antagonists
    (6 More Sources)

    Publications:

    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
    Buckley et al., 1998, Can the fatal toxicity of antidepressant drugs be predicted with pharmacological and toxicological data?, Drug Saf
    Wei et al., 1990, [Comparison of the affinities of amoxapine and loxapine for various receptors in rat brain and the receptor down-regulation after chronic administration]., Yao Xue Xue Bao
    Richelson, 1983, Antimuscarinic and other receptor-blocking properties of antidepressants., Mayo Clin. Proc.
    Richelson et al., 1984, Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro., J. Pharmacol. Exp. Ther.
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Spurlock et al., Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter., Neuropharmacology
    Burstein et al., 2005, Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist., J. Pharmacol. Exp. Ther.
    Gozlan et al., 1991, [Preclinical pharmacology of amoxapine and amitriptyline. Implications of serotoninergic and opiodergic systems in their central effect in rats]., Encephale
    Lim et al., 2005, Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist., J. Pharmacol. Exp. Ther.
    Nasu et al., 2000, Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice., Biopharm Drug Dispos
    Pälvimäki et al., 1996, Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor., Psychopharmacology (Berl.)
    Glusa et al., 2000, Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT(2B) receptors., Br. J. Pharmacol.
  • AMOXAPINE   SLC6A2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    9537821 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • AMOXAPINE   SLC6A4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CRx-150, amoxapine plus dipyridamole
    Novel drug target Established target
    Trial Name CRx-119

    PMIDs:
    9537821 7984281


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • AMOXAPINE   HTR6

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    7908055


    Sources:
    DrugBank GuideToPharmacology

  • AMOXAPINE   HRH4

    Interaction Score: 0.11

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    15947036


    Sources:
    DrugBank

  • AMOXAPINE   DRD4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dopamine receptor antagonist

    PMIDs:
    16135699


    Sources:
    DrugBank ChemblInteractions

  • AMOXAPINE   HTR3A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1666997


    Sources:
    DrugBank

  • AMOXAPINE   HTR7

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7908055


    Sources:
    DrugBank

  • AMOXAPINE   DRD3

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    16135699


    Sources:
    DrugBank ChemblInteractions

  • AMOXAPINE   DRD5

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMOXAPINE   CHRM1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6130192 6086881 9589848


    Sources:
    DrugBank

  • AMOXAPINE   HTR1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1666997


    Sources:
    DrugBank

  • AMOXAPINE   HTR2B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10821800


    Sources:
    DrugBank

  • AMOXAPINE   GABRA1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    9589848 1966571


    Sources:
    DrugBank

  • AMOXAPINE   ADRA1A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6086881 9589848 1966571


    Sources:
    DrugBank

  • AMOXAPINE   ADRA2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6086881 9589848


    Sources:
    DrugBank

  • AMOXAPINE   DRD1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Dopamine receptor antagonist

    PMIDs:
    11180191


    Sources:
    DTC DrugBank ChemblInteractions

  • AMOXAPINE   DRD2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Dopamine receptor antagonist
    Direct Interaction yes

    PMIDs:
    1966571 11180191


    Sources:
    DrugBank ChemblInteractions

  • AMOXAPINE   NAT1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Norepinephrine transporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMOXAPINE   HTR2C

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10821800


    Sources:
    DrugBank

  • AMOXAPINE   THPO

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMOXAPINE   HTR1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1666997


    Sources:
    DrugBank

  • AMOXAPINE   SLC6A3

    Interaction Score: 0.02

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • AMOXAPINE   HRH1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6086881


    Sources:
    DrugBank

  • AMOXAPINE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8876023


    Sources:
    DrugBank

  • AMOXAPINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC FDA PharmGKB

  • AMOXAPINE   HTT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin transporter inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMOXAPINE   KCNH2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMOXAPINE   TP53

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMOXAPINE   VDR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00543

    • Version: 5.1.7

    Alternate Names:
    AMOXAPINE DrugBank Drug Name
    14028-44-5 CAS Number
    Adisen Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories adrenergic agents

    Publications:
    Nasu et al., 2000, Quantitative prediction of catalepsy induced by amoxapine, cinnarizine and cyclophosphamide in mice., Biopharm Drug Dispos
    Richelson, 1983, Antimuscarinic and other receptor-blocking properties of antidepressants., Mayo Clin. Proc.
    Buckley et al., 1998, Can the fatal toxicity of antidepressant drugs be predicted with pharmacological and toxicological data?, Drug Saf

  • TEND: AMOXAPINE

    • Version: 01-August-2011

    Alternate Names:
    AMOXAPINE Primary Drug Name

    Drug Info:
    Year of Approval 1980
    Drug Class antidepressive agents, tricyclic

    Publications:

  • TdgClinicalTrial: AMOXAPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antidepressant
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • GuideToPharmacology: 135649941

    • Version: 29-September-2020

    Alternate Names:
    AMOXAPINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: Amoxapine

    • Version: 2020.06.01

    Alternate Names:
    D09IOI TTD Drug ID

    Drug Info:

    Publications:

  • DTC: AMOXAPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1113 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1113

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1113

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: amoxapine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Amoxapine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21