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AMITRIPTYLINE Drug Record

  • Summary
  • Interactions
  • Claims
  • AMITRIPTYLINE chembl:CHEMBL629 Approved

    Alternate Names:

    AMITRIL
    ELAVIL
    AMITRIPTYLINE
    ENDEP
    AMITID
    ETRAFON-FORTE
    LIMBITROL
    ETRAFON-A
    10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZO(A,D)HEPTALENE-DELTA(5),GAMMA-PROPYLAMINE
    AMITRYPTILINE
    5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTATRIENE
    ELAVIL®
    10,11-DIHYDRO-5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO(A,D)CYCLOHEPTENE
    5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTENE
    5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO[A,D][1,4]CYCLOHEPTADIENE
    AMITRIPTILINA
    3-(10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE
    AMITRIPTYLINUM
    AMITRIPTYLIN
    ENDEP®
    3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYL-1-PROPANAMINE
    pubchem.compound:2160
    chembl:CHEMBL629
    chemidplus:50-48-6
    drugbank:00321
    rxcui:704

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    Drug Categories dibenzocycloheptenes
    Drug Categories analgesics, non-narcotic
    Year of Approval 1961
    Drug Class antidepressive agents, tricyclic
    Drug Categories adrenergic alpha-1 receptor antagonists
    Drug Categories adrenergic alpha-antagonists
    Drug Categories adrenergic antagonists
    Drug Categories agents producing tachycardia
    Drug Categories agents that produce hypertension
    Drug Categories agents that reduce seizure threshold
    Drug Categories anticholinergic agents
    Drug Categories combined inhibitors of serotonin/norepinephrine reuptake
    Drug Categories cytochrome p-450 cyp2c19 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c8 inhibitors (moderate)
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories histamine antagonists
    Drug Categories histamine h1 antagonists
    Drug Categories moderate risk qtc-prolonging agents
    Drug Categories muscarinic antagonists
    Drug Categories neurotoxic agents
    Drug Categories p-glycoprotein substrates
    Drug Categories qtc prolonging agents
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 5-ht2 receptor antagonists
    Drug Categories serotonin agents
    Drug Categories serotonin receptor antagonists
    Drug Categories tertiary amine tricyclic antidepressants
    Drug Categories tricyclics and other norepinephrine-reuptake inhibitors
    Drug Categories ugt1a1 inhibitors
    Drug Categories ugt1a1 substrates
    Drug Categories ugt1a4 substrates
    (6 More Sources)

    Publications:

    Werling et al., 2007, A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder., Exp. Neurol.
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Kohen et al., 1996, Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor., J. Neurochem.
    Sebben et al., 1994, 5-HT6 receptors positively coupled to adenylyl cyclase in striatal neurones in culture., Neuroreport
    Liu J et al., 2013, Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline., Eur J Pharmacol
    Lucchelli et al., 2000, The interaction of antidepressant drugs with enteric 5-HT7 receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Angus et al., 1980, Pharmacological assay of cardiac H2-receptor blockade by amitriptyline and lysergic acid diethylamide., Circ. Res.
    Traiffort E et al., 1992, Pharmacological characterization and autoradiographic localization of histamine H2 receptors in human brain identified with [125I]iodoaminopotentidine., J Neurochem
    Ushijima et al., 2005, Chronopharmacological study of antidepressants in forced swimming test of mice., J. Pharmacol. Exp. Ther.
    Vaishnavi et al., 2004, Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity., Biol. Psychiatry
    Kalia, 2005, Neurobiological basis of depression: an update., Metab. Clin. Exp.
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Troelsen et al., 2005, Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter., Psychopharmacology (Berl.)
    Bryson HM et al., 1996, Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states., Drugs Aging
    Gould et al., 2006, A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters., Biol. Psychiatry
    Dilsaver SC et al., 1987, Amitriptyline supersensitizes a central cholinergic mechanism., Biol Psychiatry
    Goldman P et al., 1989, Interaction of amitriptyline with muscarinic receptor subtypes in the rat brain., Neurochem Int
    Snyder SH et al., 1977, Antidepressants and the muscarinic acetylcholine receptor., Arch Gen Psychiatry
    Benbouzid M et al., 2008, Delta-opioid receptors are critical for tricyclic antidepressant treatment of neuropathic allodynia., Biol Psychiatry
    Onali et al., 2010, Direct agonist activity of tricyclic antidepressants at distinct opioid receptor subtypes., J. Pharmacol. Exp. Ther.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Nojimoto et al., The tricyclic antidepressants amitriptyline, nortriptyline and imipramine are weak antagonists of human and rat alpha1B-adrenoceptors., Neuropharmacology
    Villard et al., 2011, Pharmacological interaction with the sigma1 (σ1)-receptor in the acute behavioral effects of antidepressants., J. Pharmacol. Sci.
    Huang X et al., 2013, ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients., Pharmacogenomics
    Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron
    Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res
    de Klerk OL et al., 2013, ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder., Pharmacogenomics J
    Freysoldt A et al., 2009, Low concentrations of amitriptyline inhibit nicotinic receptors in unmyelinated axons of human peripheral nerve., Br J Pharmacol
    Punke et al., 2007, Amitriptyline is a potent blocker of human Kv1.1 and Kv7.2/7.3 channels., Anesth. Analg.
    Lesch KP et al., 1990, 5-HT1A receptor function in depression: effect of chronic amitriptyline treatment., J Neural Transm Gen Sect
    Jenck F et al., 1993, Evidence for a role of 5-HT1C receptors in the antiserotonergic properties of some antidepressant drugs., Eur J Pharmacol
    Rossi DV et al., 2006, Chronic administration of venlafaxine fails to attenuate 5-HT1A receptor function at the level of receptor-G protein interaction., Int J Neuropsychopharmacol
    Richelson E, 1979, Tricyclic antidepressants and histamine H1 receptors., Mayo Clin Proc
    Kachur JF et al., 1988, Antihistaminic and antimuscarinic effects of amitriptyline on guinea pig ileal electrolyte transport and muscle contractility in vitro., J Pharmacol Exp Ther
    Carydakis C et al., 1986, [Direct interaction of tricyclic antidepressants with opiate binding sites in the bovine adrenal medulla]., C R Acad Sci III
    Wahlström et al., 1994, Tricyclic antidepressants inhibit opioid receptor binding in human brain and hepatic morphine glucuronidation., Pharmacol. Toxicol.
    Hamon et al., 1987, Opioid receptors and neuropeptides in the CNS in rats treated chronically with amoxapine or amitriptyline., Neuropharmacology
    Rantamäki T et al., 2011, Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade., PLoS One
    Jang et al., 2009, Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity., Chem. Biol.
    Zheng X et al., 2016, Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons., Medicine (Baltimore)
    Connelly WM et al., 2009, The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS., Br J Pharmacol
    Nguyen et al., 2001, Discovery of a novel member of the histamine receptor family., Mol. Pharmacol.
    Kucia et al., Effect of antidepressants on the phospholipase A2 activity in plasma membranes of the rat brain cortex., Pol J Pharmacol
    Syeda R et al., 2016, The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine., J Biol Chem
    Pälvimäki et al., 1996, Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor., Psychopharmacology (Berl.)
    Di Matteo et al., 2001, Role of 5-HT(2C) receptors in the control of central dopamine function., Trends Pharmacol. Sci.
    Kubera et al., 2000, The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice., Psychoneuroendocrinology
    Pandey DK et al., 2010, A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants., Pharmacol Biochem Behav
    Schlienger et al., [Different effects of tricyclic (clomipramine and amitriptyline) and tetracyclic (maprotiline) antidepressors on the release of thyroid stimulating hormone, prolactin and growth hormone to thyrostimulating releasing hormone in patients with psychoaffective disorders (author's transl)]., Acta Psychiatr Belg
    Linkowski et al., 1983, Prolactin and growth hormone response to levodopa in affective illness., Neuropsychobiology
    Charney DS et al., 1983, Alpha-2 adrenergic receptor sensitivity and the mechanism of action of antidepressant therapy. The effect of long-term amitriptyline treatment., Br J Psychiatry
    Ozdoğan et al., 2004, Loss of amitriptyline analgesia in alpha 2A-adrenoceptor deficient mice., Eur. J. Pharmacol.
    Gray AM et al., 1999, Do alpha2-adrenoceptors play an integral role in the antinociceptive mechanism of action of antidepressant compounds?, Eur J Pharmacol
    Cottingham C et al., 2014, Tricyclic antidepressants exhibit variable pharmacological profiles at the α(2A) adrenergic receptor., Biochem Biophys Res Commun
    Ozgocmen et al., 2006, Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns., Rheumatol. Int.
    Cai J et al., 2014, Potential therapeutic effects of neurotrophins for acute and chronic neurological diseases., Biomed Res Int
    O'Neill E et al., 2016, Amitriptyline protects against TNF-α-induced atrophy and reduction in synaptic markers via a Trk-dependent mechanism., Pharmacol Res Perspect
    Teschemacher et al., 1999, Inhibition of the current of heterologously expressed HERG potassium channels by imipramine and amitriptyline., Br. J. Pharmacol.
    Jo SH et al., 2000, Blockade of the HERG human cardiac K(+) channel by the antidepressant drug amitriptyline., Br J Pharmacol
  • AMITRIPTYLINE   KCNQ3

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17456683 26627826


    Sources:
    DrugBank

  • AMITRIPTYLINE   KCNA1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19694730 17456683


    Sources:
    DrugBank

  • AMITRIPTYLINE   KCNQ2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17456683


    Sources:
    DrugBank

  • AMITRIPTYLINE   SIGMAR1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17689532 21427517


    Sources:
    DrugBank

  • AMITRIPTYLINE   SLC6A4

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    16079297 17689532 14744476 15877309 9537821 16032412 8736630 16140280


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • AMITRIPTYLINE   IFNG

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10996474


    Sources:
    NCI

  • AMITRIPTYLINE   PRL

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6786002 6621850


    Sources:
    NCI

  • AMITRIPTYLINE   ADA

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16283318


    Sources:
    NCI

  • AMITRIPTYLINE   SLC6A2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    14744476 9537821 8736630


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • AMITRIPTYLINE   HRH4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    19413571 11179435


    Sources:
    DrugBank

  • AMITRIPTYLINE   HRH2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    6103762 1351926


    Sources:
    DrugBank

  • AMITRIPTYLINE   NTRK2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    24818146 19549602 27069625


    Sources:
    DrugBank

  • AMITRIPTYLINE   HTR6

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    8522988 7696602


    Sources:
    DrugBank GuideToPharmacology

  • AMITRIPTYLINE   NTRK1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    activator (activating)
    agonist (activating)

    Interaction Info:

    PMIDs:
    21666748 19549602 27149473


    Sources:
    DrugBank

  • AMITRIPTYLINE   PLA2G1B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12856820


    Sources:
    NCI

  • AMITRIPTYLINE   HTR7

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    23142373 10997731


    Sources:
    DrugBank

  • AMITRIPTYLINE   ADRA2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6305451 14757140 7855217 10478628 25128275


    Sources:
    DrugBank

  • AMITRIPTYLINE   CHRM1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    ligand
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    3567263 20504448 14603 7855217


    Sources:
    DrugBank GuideToPharmacology

  • AMITRIPTYLINE   OPRD1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17693391 19828880


    Sources:
    DrugBank

  • AMITRIPTYLINE   HTR1A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inducer (activating)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    2317317 7855217 8453978 16035959


    Sources:
    DrugBank

  • AMITRIPTYLINE   HTR1D

    Interaction Score: 0.04

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    17689532


    Sources:
    DrugBank

  • AMITRIPTYLINE   ADRA1D

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    20363235


    Sources:
    DrugBank

  • AMITRIPTYLINE   HRH1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Antagonism of [<sup>3</sup>H]mepyramine binding
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    39202 2896792 7855217


    Sources:
    DrugBank GuideToPharmacology

  • AMITRIPTYLINE   OPRK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    3013380 19828880


    Sources:
    DrugBank

  • AMITRIPTYLINE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    17689532


    Sources:
    DrugBank

  • AMITRIPTYLINE   CHRM4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    7855217


    Sources:
    GuideToPharmacology

  • AMITRIPTYLINE   CHRM5

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    7855217


    Sources:
    GuideToPharmacology

  • AMITRIPTYLINE   HTR2C

    Interaction Score: 0.03

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8876023 11339973


    Sources:
    DrugBank

  • AMITRIPTYLINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name OMS-103HP
    Novel drug target Established target

    PMIDs:
    19800913 7855217


    Sources:
    TdgClinicalTrial DrugBank

  • AMITRIPTYLINE   OPRM1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    7971731 3037421


    Sources:
    DrugBank

  • AMITRIPTYLINE   ABCB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24192121 18215618 26704739 22641028


    Sources:
    PharmGKB

  • AMITRIPTYLINE   ADRA1B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    20363235


    Sources:
    DrugBank

  • AMITRIPTYLINE   ADRA1A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    7855217 20363235


    Sources:
    DrugBank

  • AMITRIPTYLINE   CHRM2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    7855217


    Sources:
    GuideToPharmacology

  • AMITRIPTYLINE   CHRM3

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    7855217


    Sources:
    GuideToPharmacology

  • AMITRIPTYLINE   KCNH2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:

    PMIDs:
    10510461 10742304


    Sources:
    DrugBank

  • AMITRIPTYLINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMITRIPTYLINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC FDA

  • AMITRIPTYLINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AMITRIPTYLINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300 9187528


    Sources:
    DTC PharmGKB

  • AMITRIPTYLINE   CYP1A2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DrugBank: DB00321

    • Version: 5.1.7

    Alternate Names:
    AMITRIPTYLINE DrugBank Drug Name
    50-48-6 CAS Number
    Adepril Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories adrenergic alpha-1 receptor antagonists

    Publications:
    Vaishnavi et al., 2004, Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity., Biol. Psychiatry
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Bryson HM et al., 1996, Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states., Drugs Aging

  • TEND: AMITRIPTYLINE

    • Version: 01-August-2011

    Alternate Names:
    AMITRIPTYLINE Primary Drug Name

    Drug Info:
    Drug Class antidepressive agents, tricyclic
    Year of Approval 1961

    Publications:

  • TdgClinicalTrial: AMITRIPTYLINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: AMITRIPTYLINE

    • Version: 14-September-2017

    Alternate Names:
    C28819 NCI drug code

    Drug Info:

    Publications:
    Rajtar et al., 2007, Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs., Eur. J. Pharmacol.
    Ozgocmen et al., 2006, Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns., Rheumatol. Int.
    Kubera et al., 2000, The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice., Psychoneuroendocrinology

  • DTC: AMITRIPTYLINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL629 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

  • PharmGKB: amitriptyline

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Huang X et al., 2013, ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients., Pharmacogenomics
    Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron
    Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res

  • GuideToPharmacology: 135649939

    • Version: 29-September-2020

    Alternate Names:
    AMITRIPTYLINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: Amitriptyline

    • Version: 2020.06.01

    Alternate Names:
    D0Y5UG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL629

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Amitriptyline

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21