AMITRIL |
ELAVIL |
AMITRIPTYLINE |
ENDEP |
AMITID |
ETRAFON-FORTE |
LIMBITROL |
ETRAFON-A |
10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZO(A,D)HEPTALENE-DELTA(5),GAMMA-PROPYLAMINE |
AMITRYPTILINE |
5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTATRIENE |
ELAVIL® |
10,11-DIHYDRO-5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO(A,D)CYCLOHEPTENE |
5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTENE |
5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO[A,D][1,4]CYCLOHEPTADIENE |
AMITRIPTILINA |
3-(10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE |
AMITRIPTYLINUM |
AMITRIPTYLIN |
ENDEP® |
3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYL-1-PROPANAMINE |
pubchem.compound:2160 |
chembl:CHEMBL629 |
chemidplus:50-48-6 |
drugbank:00321 |
rxcui:704 |
FDA Approval | approved |
Drug Class | Small Molecule |
Drug Indications | analgesic |
Drug Categories | dibenzocycloheptenes |
Drug Categories | analgesics, non-narcotic |
Year of Approval | 1961 |
Drug Class | antidepressive agents, tricyclic |
Drug Categories | adrenergic alpha-1 receptor antagonists |
Drug Categories | adrenergic alpha-antagonists |
Drug Categories | adrenergic antagonists |
Drug Categories | agents producing tachycardia |
Drug Categories | agents that produce hypertension |
Drug Categories | agents that reduce seizure threshold |
Drug Categories | anticholinergic agents |
Drug Categories | combined inhibitors of serotonin/norepinephrine reuptake |
Drug Categories | cytochrome p-450 cyp2c19 inhibitors (strength unknown) |
Drug Categories | cytochrome p-450 cyp2c8 inhibitors (moderate) |
Drug Categories | cytochrome p-450 cyp3a substrates |
Drug Categories | cytochrome p-450 cyp3a5 substrates |
Drug Categories | cytochrome p-450 enzyme inhibitors |
Drug Categories | cytochrome p-450 substrates |
Drug Categories | drugs that are mainly renally excreted |
Drug Categories | histamine antagonists |
Drug Categories | histamine h1 antagonists |
Drug Categories | moderate risk qtc-prolonging agents |
Drug Categories | muscarinic antagonists |
Drug Categories | neurotoxic agents |
Drug Categories | p-glycoprotein substrates |
Drug Categories | qtc prolonging agents |
Drug Categories | serotonergic drugs shown to increase risk of serotonin syndrome |
Drug Categories | serotonin 5-ht2 receptor antagonists |
Drug Categories | serotonin agents |
Drug Categories | serotonin receptor antagonists |
Drug Categories | tertiary amine tricyclic antidepressants |
Drug Categories | tricyclics and other norepinephrine-reuptake inhibitors |
Drug Categories | ugt1a1 inhibitors |
Drug Categories | ugt1a1 substrates |
Drug Categories | ugt1a4 substrates |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Details of the Assay for Interaction | Antagonism of [<sup>3</sup>H]mepyramine binding |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Trial Name | OMS-103HP |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
AMITRIPTYLINE | DrugBank Drug Name |
50-48-6 | CAS Number |
Adepril | Drug Brand |
Drug Type | small molecule |
Drug Groups | approved |
Drug Categories | adrenergic alpha-1 receptor antagonists |
AMITRIPTYLINE | Primary Drug Name |
Drug Class | antidepressive agents, tricyclic |
Year of Approval | 1961 |
Drug Indications | analgesic |
Drug Class | Small Molecule |
FDA Approval | approved |
C28819 | NCI drug code |
CHEMBL629 | ChEMBL Drug ID |
AMITRIPTYLINE | GuideToPharmacology Ligand Name |
D0Y5UG | TTD Drug ID |