DGIdb - AMITRIPTYLINE Drug Record

AMITRIPTYLINE chembl:CHEMBL629 Approved

Alternate Names:

AMITRIL
ELAVIL
AMITRIPTYLINE
ENDEP
AMITID
ETRAFON-FORTE
LIMBITROL
ETRAFON-A
10,11-DIHYDRO-N,N-DIMETHYL-5H-DIBENZO(A,D)HEPTALENE-DELTA(5),GAMMA-PROPYLAMINE
AMITRYPTILINE
5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTATRIENE
ELAVIL®
10,11-DIHYDRO-5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO(A,D)CYCLOHEPTENE
5-(3-DIMETHYLAMINOPROPYLIDENE)-10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTENE
5-(GAMMA-DIMETHYLAMINOPROPYLIDENE)-5H-DIBENZO[A,D][1,4]CYCLOHEPTADIENE
AMITRIPTILINA
3-(10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYLPROPAN-1-AMINE
AMITRIPTYLINUM
AMITRIPTYLIN
ENDEP®
3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-N,N-DIMETHYL-1-PROPANAMINE
pubchem.compound:2160
chembl:CHEMBL629
chemidplus:50-48-6
drugbank:00321
rxcui:704

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic
Year of Approval	1961
Drug Class	antidepressive agents, tricyclic

(4 More Sources)

Publications:

Ushijima et al., 2005, Chronopharmacological study of antidepressants in forced swimming test of mice., J. Pharmacol. Exp. Ther.
Werling et al., 2007, A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder., Exp. Neurol.
Vaishnavi et al., 2004, Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity., Biol. Psychiatry
Kalia, 2005, Neurobiological basis of depression: an update., Metab. Clin. Exp.
Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
Troelsen et al., 2005, Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter., Psychopharmacology (Berl.)
Gould et al., 2006, A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters., Biol. Psychiatry
Bryson HM et al., 1996, Amitriptyline. A review of its pharmacological properties and therapeutic use in chronic pain states., Drugs Aging
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res
Huang X et al., 2013, ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients., Pharmacogenomics
de Klerk OL et al., 2013, ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder., Pharmacogenomics J
Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron
Kucia et al., Effect of antidepressants on the phospholipase A2 activity in plasma membranes of the rat brain cortex., Pol J Pharmacol
Kubera et al., 2000, The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice., Psychoneuroendocrinology
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Pandey DK et al., 2010, A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants., Pharmacol Biochem Behav
Schlienger et al., [Different effects of tricyclic (clomipramine and amitriptyline) and tetracyclic (maprotiline) antidepressors on the release of thyroid stimulating hormone, prolactin and growth hormone to thyrostimulating releasing hormone in patients with psychoaffective disorders (author's transl)]., Acta Psychiatr Belg
Linkowski et al., 1983, Prolactin and growth hormone response to levodopa in affective illness., Neuropsychobiology
Ozgocmen et al., 2006, Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns., Rheumatol. Int.

AMITRIPTYLINE SLC6A4

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name amitriptyline + ketamine,Epicept NP-1

Novel drug target Established target

Trial Name OMS-103HP

PMIDs:
16079297 17689532 14744476 15877309 9537821 16032412 16140280 8736630

Sources:
TdgClinicalTrial TEND
AMITRIPTYLINE ADA

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16283318

Sources:
NCI
AMITRIPTYLINE SLC6A2

Interaction Score: 0.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

Trial Name amitriptyline + ketamine,Epicept NP-1

PMIDs:
14744476 9537821 8736630

Sources:
TdgClinicalTrial TEND
AMITRIPTYLINE IFNG

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10996474

Sources:
NCI
AMITRIPTYLINE PRL

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6786002 6621850

Sources:
NCI
AMITRIPTYLINE PLA2G1B

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12856820

Sources:
NCI
AMITRIPTYLINE HTR2A

Interaction Score: 0.14

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
7855217 19800913

Sources:
TdgClinicalTrial
AMITRIPTYLINE ABCB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26704739 24192121 22641028 18215618

Sources:
PharmGKB
AMITRIPTYLINE DRD1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMITRIPTYLINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC FDA
AMITRIPTYLINE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
AMITRIPTYLINE CYP3A4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 9187528

Sources:
DTC PharmGKB
AMITRIPTYLINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: AMITRIPTYLINE
- Version: 01-August-2011
Alternate Names:

AMITRIPTYLINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval 1961

Publications:
TdgClinicalTrial: AMITRIPTYLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: AMITRIPTYLINE

Version: 14-September-2017

Alternate Names:

C28819 NCI drug code

Drug Info:

Publications:

Rajtar et al., 2007, Amitriptyline affects histamine-N-methyltransferase and diamine oxidase activity in rats and guinea pigs., Eur. J. Pharmacol.

Ozgocmen et al., 2006, Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns., Rheumatol. Int.

Kubera et al., 2000, The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice., Psychoneuroendocrinology

DTC: AMITRIPTYLINE
- Version: 02-September-2020
Alternate Names:

CHEMBL629 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: amitriptyline

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Huang X et al., 2013, ABCB6, ABCB1 and ABCG1 genetic polymorphisms and antidepressant response of SSRIs in Chinese depressive patients., Pharmacogenomics

Uhr M et al., 2008, Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression., Neuron

Breitenstein B et al., 2016, Association of ABCB1 gene variants, plasma antidepressant concentration, and treatment response: Results from a randomized clinical study., J Psychiatr Res

TTD: Amitriptyline
- Version: 2020.06.01
Alternate Names:

D0Y5UG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL629
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Amitriptyline
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	amitriptyline + ketamine,Epicept NP-1
Novel drug target	Established target
Trial Name	OMS-103HP

AMITRIPTYLINE Drug Record

AMITRIPTYLINE chembl:CHEMBL629 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name amitriptyline + ketamine,Epicept NP-1 Novel drug target Established target Trial Name OMS-103HP

PMIDs: 16079297 17689532 14744476 15877309 9537821 16032412 16140280 8736630

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16283318

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name OMS-103HP Novel drug target Established target Trial Name amitriptyline + ketamine,Epicept NP-1

PMIDs: 14744476 9537821 8736630

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10996474

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6786002 6621850

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12856820

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name OMS-103HP Novel drug target Established target

PMIDs: 7855217 19800913

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26704739 24192121 22641028 18215618

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300 9187528

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: AMITRIPTYLINE

Alternate Names: AMITRIPTYLINE Primary Drug Name

Drug Info: Drug Class antidepressive agents, tricyclic Year of Approval 1961

Publications:

TdgClinicalTrial: AMITRIPTYLINE

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small Molecule FDA Approval approved

Publications:

NCI: AMITRIPTYLINE

Alternate Names: C28819 NCI drug code

Drug Info:

DTC: AMITRIPTYLINE

Alternate Names: CHEMBL629 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

PharmGKB: amitriptyline

Alternate Names:

Drug Info:

TTD: Amitriptyline

Alternate Names: D0Y5UG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL629

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name amitriptyline + ketamine,Epicept NP-1

Novel drug target Established target

Trial Name OMS-103HP

PMIDs:
16079297 17689532 14744476 15877309 9537821 16032412 16140280 8736630

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
16283318

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

Trial Name amitriptyline + ketamine,Epicept NP-1

PMIDs:
14744476 9537821 8736630

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
10996474

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6786002 6621850

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12856820

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name OMS-103HP

Novel drug target Established target

PMIDs:
7855217 19800913

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
26704739 24192121 22641028 18215618

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC FDA

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300 9187528

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

AMITRIPTYLINE Primary Drug Name

Drug Info:

Drug Class antidepressive agents, tricyclic

Year of Approval 1961

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C28819 NCI drug code

Alternate Names:

CHEMBL629 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D0Y5UG TTD Drug ID