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AMISULPRIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • AMISULPRIDE chembl:CHEMBL243712 Approved

    Alternate Names:

    AMISULPRIDE
    APD-421
    SOLIAN
    DAN-2163
    SOLIAN 400
    SOLIAN 200
    APD421
    SOLIAN 50
    SOLIAN 100
    4-AMINO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-(ETHYLSULFONYL)-2-METHOXYBENZAMIDE
    AMINOSULTOPRIDE
    4-AMINO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-(ETHYLSULFONYL)-O-ANISAMIDE
    (±)-AMISULPRIDE
    chemidplus:71675-85-9
    drugbank:06288
    chembl:CHEMBL243712
    rxcui:46303
    pubchem.compound:2159

    Drug Info:

    FDA Approval not approved
    Drug Class Small Molecule
    Drug Indications antipsychotic agent
    Drug Indications antiemetic
    Drug Class antipsychotic agents
    Year of Approval not approved by the fda
    (2 More Sources)

    Publications:

    Opgen-Rhein C et al., 2010, Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample., Pharmacogenomics
    Rosenzweig et al., 2002, A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers., Hum Psychopharmacol
    Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
    Horacek et al., 2006, Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia., CNS Drugs
    Kang SG et al., 2015, DRD2 genotypic and haplotype variation is associated with improvements in negative symptoms after 6 weeks' amisulpride treatment., J Clin Psychopharmacol
    Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
    Wang R et al., 2018, ABCB1 1199G > A Polymorphism Impacts Transport Ability of P-gp-Mediated Antipsychotics., DNA Cell Biol
    Zhang JP et al., 2016, Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis., Schizophr Bull
    Czerwensky F et al., 2013, MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?, Int J Neuropsychopharmacol
    Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
    Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry
    Kang SG et al., 2017, rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride., Hum Psychopharmacol
    Crisafulli C et al., 2012, Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics., Eur Arch Psychiatry Clin Neurosci
  • AMISULPRIDE   ANKS1B

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28332719


    Sources:
    PharmGKB

  • AMISULPRIDE   MC4R

    Interaction Score: 2.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27217270 23920449 23799528 22566560


    Sources:
    PharmGKB

  • AMISULPRIDE   SH2B1

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • AMISULPRIDE   RABEP1

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28694205


    Sources:
    PharmGKB

  • AMISULPRIDE   DRD3

    Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name amisulpride,Solian

    PMIDs:
    12404702 11873706 16696579


    Sources:
    TdgClinicalTrial TEND

  • AMISULPRIDE   DRD2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name amisulpride,Solian
    Novel drug target Established target
    Trial Name APD421

    PMIDs:
    25679126 12404702 11873706 16696579


    Sources:
    TdgClinicalTrial TEND PharmGKB TTD

  • AMISULPRIDE   HTR2C

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20504252


    Sources:
    PharmGKB

  • AMISULPRIDE   HTR1A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22120873


    Sources:
    PharmGKB

  • AMISULPRIDE   ABCB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29443543


    Sources:
    PharmGKB

  • TEND: AMISULPRIDE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class antipsychotic agents

    Publications:

  • TdgClinicalTrial: APD421

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiemetic
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • TdgClinicalTrial: AMISULPRIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antipsychotic agent
    Drug Class Small Molecule
    FDA Approval not approved

    Publications:

  • PharmGKB: amisulpride

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Opgen-Rhein C et al., 2010, Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample., Pharmacogenomics
    Kang SG et al., 2015, DRD2 genotypic and haplotype variation is associated with improvements in negative symptoms after 6 weeks' amisulpride treatment., J Clin Psychopharmacol
    Wang R et al., 2018, ABCB1 1199G > A Polymorphism Impacts Transport Ability of P-gp-Mediated Antipsychotics., DNA Cell Biol

  • TTD: Amisulpride

    • Version: 2020.06.01

    Alternate Names:
    D03ELL TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL243712

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21