DGIdb - AMISULPRIDE Drug Record

AMISULPRIDE chembl:CHEMBL243712 Approved

Alternate Names:

AMISULPRIDE
APD-421
SOLIAN
DAN-2163
SOLIAN 400
SOLIAN 200
APD421
SOLIAN 50
SOLIAN 100
4-AMINO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-(ETHYLSULFONYL)-2-METHOXYBENZAMIDE
AMINOSULTOPRIDE
4-AMINO-N-((1-ETHYL-2-PYRROLIDINYL)METHYL)-5-(ETHYLSULFONYL)-O-ANISAMIDE
(±)-AMISULPRIDE
chemidplus:71675-85-9
drugbank:06288
chembl:CHEMBL243712
rxcui:46303
pubchem.compound:2159

Drug Info:

FDA Approval	not approved
Drug Class	Small Molecule
Drug Indications	antipsychotic agent
Drug Indications	antiemetic
Drug Class	antipsychotic agents
Year of Approval	not approved by the fda

(2 More Sources)

Publications:

Opgen-Rhein C et al., 2010, Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample., Pharmacogenomics
Rosenzweig et al., 2002, A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers., Hum Psychopharmacol
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Horacek et al., 2006, Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia., CNS Drugs
Kang SG et al., 2015, DRD2 genotypic and haplotype variation is associated with improvements in negative symptoms after 6 weeks' amisulpride treatment., J Clin Psychopharmacol
Delacrétaz A et al., 2017, Association of variants in SH2B1 and RABEP1 with worsening of low-density lipoprotein and glucose parameters in patients treated with psychotropic drugs., Gene
Wang R et al., 2018, ABCB1 1199G > A Polymorphism Impacts Transport Ability of P-gp-Mediated Antipsychotics., DNA Cell Biol
Zhang JP et al., 2016, Pharmacogenetic Associations of Antipsychotic Drug-Related Weight Gain: A Systematic Review and Meta-analysis., Schizophr Bull
Czerwensky F et al., 2013, MC4R rs489693: a clinical risk factor for second generation antipsychotic-related weight gain?, Int J Neuropsychopharmacol
Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
Malhotra AK et al., 2012, Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain., Arch Gen Psychiatry
Kang SG et al., 2017, rs7968606 polymorphism of ANKS1B is associated with improvement in the PANSS general score of schizophrenia caused by amisulpride., Hum Psychopharmacol
Crisafulli C et al., 2012, Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics., Eur Arch Psychiatry Clin Neurosci

AMISULPRIDE ANKS1B

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28332719

Sources:
PharmGKB
AMISULPRIDE MC4R

Interaction Score: 2.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27217270 23920449 23799528 22566560

Sources:
PharmGKB
AMISULPRIDE SH2B1

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
AMISULPRIDE RABEP1

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28694205

Sources:
PharmGKB
AMISULPRIDE DRD3

Interaction Score: 0.53

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name amisulpride,Solian

PMIDs:
12404702 11873706 16696579

Sources:
TdgClinicalTrial TEND
AMISULPRIDE DRD2

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name amisulpride,Solian

Novel drug target Established target

Trial Name APD421

PMIDs:
25679126 12404702 11873706 16696579

Sources:
TdgClinicalTrial TEND PharmGKB TTD
AMISULPRIDE HTR2C

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20504252

Sources:
PharmGKB
AMISULPRIDE HTR1A

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22120873

Sources:
PharmGKB
AMISULPRIDE ABCB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29443543

Sources:
PharmGKB

TEND: AMISULPRIDE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval not approved by the fda

Drug Class antipsychotic agents

Publications:
TdgClinicalTrial: APD421
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiemetic

Drug Class Small molecule

FDA Approval not approved

Publications:
TdgClinicalTrial: AMISULPRIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antipsychotic agent

Drug Class Small Molecule

FDA Approval not approved

Publications:

PharmGKB: amisulpride

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Opgen-Rhein C et al., 2010, Association of HTR2C, but not LEP or INSIG2, genes with antipsychotic-induced weight gain in a German sample., Pharmacogenomics

Kang SG et al., 2015, DRD2 genotypic and haplotype variation is associated with improvements in negative symptoms after 6 weeks' amisulpride treatment., J Clin Psychopharmacol

Wang R et al., 2018, ABCB1 1199G > A Polymorphism Impacts Transport Ability of P-gp-Mediated Antipsychotics., DNA Cell Biol

TTD: Amisulpride
- Version: 2020.06.01
Alternate Names:

D03ELL TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL243712
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	amisulpride,Solian

AMISULPRIDE Drug Record

AMISULPRIDE chembl:CHEMBL243712 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28332719

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27217270 23920449 23799528 22566560

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28694205

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name amisulpride,Solian

PMIDs: 12404702 11873706 16696579

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name amisulpride,Solian Novel drug target Established target Trial Name APD421

PMIDs: 25679126 12404702 11873706 16696579

Sources: TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20504252

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22120873

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29443543

Sources: PharmGKB

TEND: AMISULPRIDE

Alternate Names:

Drug Info: Year of Approval not approved by the fda Drug Class antipsychotic agents

Publications:

TdgClinicalTrial: APD421

Alternate Names:

Drug Info: Drug Indications antiemetic Drug Class Small molecule FDA Approval not approved

Publications:

TdgClinicalTrial: AMISULPRIDE

Alternate Names:

Drug Info: Drug Indications antipsychotic agent Drug Class Small Molecule FDA Approval not approved

Publications:

PharmGKB: amisulpride

Alternate Names:

Drug Info:

TTD: Amisulpride

Alternate Names: D03ELL TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL243712

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
28332719

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27217270 23920449 23799528 22566560

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
28694205

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name amisulpride,Solian

PMIDs:
12404702 11873706 16696579

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name amisulpride,Solian

Novel drug target Established target

Trial Name APD421

PMIDs:
25679126 12404702 11873706 16696579

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
20504252

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22120873

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29443543

Sources:
PharmGKB

Drug Info:

Year of Approval not approved by the fda

Drug Class antipsychotic agents

Drug Info:

Drug Indications antiemetic

Drug Class Small molecule

FDA Approval not approved

Drug Info:

Drug Indications antipsychotic agent

Drug Class Small Molecule

FDA Approval not approved

Alternate Names:

D03ELL TTD Drug ID