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AMIODARONE Drug Record

  • Summary
  • Interactions
  • Claims
  • AMIODARONE chembl:CHEMBL633 Approved

    Alternate Names:

    CORDARONE
    L-3428
    AMIODARONE
    PACERONE
    SKF-33134A
    AMIODARONE HYDROCHLORIDE
    2-BUTYL-3-(3,5-DIIODO-4-(2-DIETHYLAMINOETHOXY)BENZOYL)BENZOFURAN
    2-N-BUTYL-3',5'-DIIODO-4'-N-DIETHYLAMINOETHOXY-3-BENZOYLBENZOFURAN
    CORDARONE®
    AMIODARONA
    AMIODARONUM
    2-BUTYL-3-BENZOFURANYL 4-(2-(DIETHYLAMINO)ETHOXY)-3,5-DIIODOPHENYL KETONE
    drugbank:01118
    pubchem.compound:2157
    rxcui:703
    chembl:CHEMBL633
    chemidplus:1951-25-3

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antiarrhytmic agent
    Drug Class vasodilator agents
    Year of Approval 1985
    Drug Class anti-arrhythmia agents
    (3 More Sources)

    Publications:

    Yang P et al., 2002, Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes., Circulation
    Roden DM, 2004, Drug-induced prolongation of the QT interval., N Engl J Med
    Waldhauser et al., 2008, Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues., Br. J. Pharmacol.
    Varró et al., 2004, Theoretical possibilities for the development of novel antiarrhythmic drugs., Curr. Med. Chem.
    Wang et al., 2008, Potassium channel currents in rat mesenchymal stem cells and their possible roles in cell proliferation., Clin. Exp. Pharmacol. Physiol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Doggrell et al., 2002, Present and future pharmacotherapy for heart failure., Expert Opin Pharmacother
    Disatnik MH et al., 1991, Regulation of beta-adrenoceptors by thyroid hormone and amiodarone in rat myocardiac cells in culture., Biochem Pharmacol
    Drvota V et al., 1999, The effect of amiodarone on the beta-adrenergic receptor is due to a downregulation of receptor protein and not to a receptor-ligand interaction., Biochem Biophys Res Commun
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Ricaurte et al., 2006, Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity., Ann Pharmacother
    Cappiello et al., 1995, Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis., J. Endocrinol. Invest.
    Baritussio et al., 2001, Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes., Am. J. Physiol. Lung Cell Mol. Physiol.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Benaim G et al., 2006, Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole., J Med Chem
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
  • AMIODARONE   SQLE

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16451055


    Sources:
    DTC

  • AMIODARONE   SFTPA1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11597911


    Sources:
    NCI

  • AMIODARONE   CYP2J2

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19923256


    Sources:
    PharmGKB

  • AMIODARONE   NOS1AP

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMIODARONE   KCNE1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMIODARONE   TG

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8778159


    Sources:
    NCI

  • AMIODARONE   ADRB1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    negative modulator (inhibitory)
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name amiodarone HCl,Amio-Aqueous IV
    Novel drug target Established target

    PMIDs:
    12083991 1672592 10049740


    Sources:
    TdgClinicalTrial TEND

  • AMIODARONE   CALCA

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AMIODARONE   KCNH2

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name amiodarone HCl,Amio-Aqueous IV
    Novel drug target Established target

    PMIDs:
    11997281 14999113 18604229 14754422 18505444 11752352


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • AMIODARONE   ADRA1A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name amiodarone HCl,Amio-Aqueous IV
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • AMIODARONE   CYP3A5

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • AMIODARONE   SCN5A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMIODARONE   MTOR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMIODARONE   CBX1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AMIODARONE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AMIODARONE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528 16537817


    Sources:
    NCI PharmGKB

  • AMIODARONE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AMIODARONE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • AMIODARONE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • AMIODARONE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC PharmGKB

  • AMIODARONE   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: AMIODARONE

    • Version: 01-August-2011

    Alternate Names:
    AMIODARONE Primary Drug Name

    Drug Info:
    Drug Class anti-arrhythmia agents
    Year of Approval 1985
    Drug Class vasodilator agents

    Publications:

  • TdgClinicalTrial: AMIODARONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiarrhytmic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: AMIODARONE

    • Version: 14-September-2017

    Alternate Names:
    C236 NCI drug code

    Drug Info:

    Publications:
    Ricaurte et al., 2006, Simvastatin-amiodarone interaction resulting in rhabdomyolysis, azotemia, and possible hepatotoxicity., Ann Pharmacother
    Baritussio et al., 2001, Amiodarone inhibits lung degradation of SP-A and perturbs the distribution of lysosomal enzymes., Am. J. Physiol. Lung Cell Mol. Physiol.
    Cappiello et al., 1995, Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis., J. Endocrinol. Invest.

  • DTC: AMIODARONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL633 ChEMBL Drug ID

    Drug Info:

    Publications:
    Benaim G et al., 2006, Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole., J Med Chem
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: amiodarone

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Lee CA et al., 2010, Identification of novel substrates for human cytochrome P450 2J2., Drug Metab Dispos
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Amiodarone

    • Version: 2020.06.01

    Alternate Names:
    D0L5WM TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL633

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21