DGIdb - AMIFOSTINE Drug Record

AMIFOSTINE chembl:CHEMBL1006 Approved

Alternate Names:

NSC-296961
AMIFOSTINE
GAMMAPHOS
AMIFOSTINE DISULFIDE
YM-08310
WR-2721
ETHYOL
WR-2721 TRIHYDRATE
ETHIOFOS
AMIFOSTINE TRIHYDRATE
AMIFOSTINE ANHYDROUS
AMINOPROPYLAMINOETHYL THIOPHOSPHATE
SAPEP
WR-1065
AMIFOSTINE ETHIOFOS
AMIFOSTINUM
APAETP
AMIFOSTINA
chemidplus:20537-88-6
rxcui:1545987
drugbank:01143
chembl:CHEMBL1006
pubchem.compound:2141

Drug Info:

Year of Approval	1995
Drug Class	radiation-protective agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	radiation-protective agent
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	cytoprotective agent
Drug Categories	free radical scavenging activity

(2 More Sources)

Publications:

Buschini et al., 2000, Amifostine (WR-2721) selective protection against melphalan genotoxicity., Leukemia
Santini et al., 1999, The potential of amifostine: from cytoprotectant to therapeutic agent., Haematologica
Orditura et al., Amifostine: A selective cytoprotective agent of normal tissues from chemo-radiotherapy induced toxicity (Review)., Oncol. Rep.
Capizzi, 1999, The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine., Semin. Oncol.
Plasswilm et al., Microvessel density and endothelial cell proliferation after amifostine (Ethyol) administration in vivo., Anticancer Res.
Liu et al., 1997, Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine., Carcinogenesis
Vujaskovic et al., 2002, Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity., Radiat. Res.
Segreto et al., 2002, Amifostine does not prevent activation of TGFbeta1 but induces smad 7 activation in megakaryocytes irradiated in vivo., Am. J. Hematol.
Stankiewicz et al., 2002, Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats., Drug Metabol Drug Interact

AMIFOSTINE ALPPL2

Interaction Score: 3.79

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name amifostine,Ethyol

PMIDs:
10995012 10553165 10523712 10348255 10628381

Sources:
TEND TdgClinicalTrial DrugBank
AMIFOSTINE SMAD2

Interaction Score: 2.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12410567

Sources:
NCI
AMIFOSTINE GSR

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12751907

Sources:
NCI
AMIFOSTINE TGFB1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12005544

Sources:
NCI
AMIFOSTINE MYC

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9450496

Sources:
NCI

DrugBank: DB01143

Version: 5.1.7

Alternate Names:

AMIFOSTINE DrugBank Drug Name

20537-88-6 CAS Number

Amifostine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Buschini et al., 2000, Amifostine (WR-2721) selective protection against melphalan genotoxicity., Leukemia

Santini et al., 1999, The potential of amifostine: from cytoprotectant to therapeutic agent., Haematologica

Orditura et al., Amifostine: A selective cytoprotective agent of normal tissues from chemo-radiotherapy induced toxicity (Review)., Oncol. Rep.

TEND: AMIFOSTINE
- Version: 01-August-2011
Alternate Names:

AMIFOSTINE Primary Drug Name

Drug Info:

Drug Class radiation-protective agents

Year of Approval 1995

Publications:
TdgClinicalTrial: AMIFOSTINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications radiation-protective agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: AMIFOSTINE

Version: 14-September-2017

Alternate Names:

C488 NCI drug code

Drug Info:

Publications:

Liu et al., 1997, Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine., Carcinogenesis

Vujaskovic et al., 2002, Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity., Radiat. Res.

Stankiewicz et al., 2002, Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats., Drug Metabol Drug Interact

TTD: Amifostine
- Version: 2020.06.01
Alternate Names:

D06CIE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1006
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	amifostine,Ethyol

AMIFOSTINE	DrugBank Drug Name
20537-88-6	CAS Number
Amifostine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

AMIFOSTINE Drug Record

AMIFOSTINE chembl:CHEMBL1006 Approved

Alternate Names:

Drug Info:

Publications:

AMIFOSTINE ALPPL2

Interaction Types & Directionality: inducer (activating)

Interaction Info: Novel drug target Established target Trial Name amifostine,Ethyol

PMIDs: 10995012 10553165 10523712 10348255 10628381

Sources: TEND TdgClinicalTrial DrugBank

AMIFOSTINE SMAD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12410567

Sources: NCI

AMIFOSTINE GSR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12751907

Sources: NCI

AMIFOSTINE TGFB1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12005544

Sources: NCI

AMIFOSTINE MYC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9450496

Sources: NCI

DrugBank: DB01143

Alternate Names: AMIFOSTINE DrugBank Drug Name 20537-88-6 CAS Number Amifostine Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: AMIFOSTINE

Alternate Names: AMIFOSTINE Primary Drug Name

Drug Info: Drug Class radiation-protective agents Year of Approval 1995

Publications:

TdgClinicalTrial: AMIFOSTINE

Alternate Names:

Drug Info: Drug Indications radiation-protective agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: AMIFOSTINE

Alternate Names: C488 NCI drug code

Drug Info:

TTD: Amifostine

Alternate Names: D06CIE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1006

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name amifostine,Ethyol

PMIDs:
10995012 10553165 10523712 10348255 10628381

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12410567

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12751907

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12005544

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9450496

Sources:
NCI

Alternate Names:

AMIFOSTINE DrugBank Drug Name

20537-88-6 CAS Number

Amifostine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

AMIFOSTINE Primary Drug Name

Drug Info:

Drug Class radiation-protective agents

Year of Approval 1995

Drug Info:

Drug Indications radiation-protective agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C488 NCI drug code

Alternate Names:

D06CIE TTD Drug ID