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AMIFOSTINE Drug Record

  • Summary
  • Interactions
  • Claims
  • AMIFOSTINE chembl:CHEMBL1006 Approved

    Alternate Names:

    NSC-296961
    AMIFOSTINE
    GAMMAPHOS
    AMIFOSTINE DISULFIDE
    YM-08310
    WR-2721
    ETHYOL
    WR-2721 TRIHYDRATE
    ETHIOFOS
    AMIFOSTINE TRIHYDRATE
    AMIFOSTINE ANHYDROUS
    AMINOPROPYLAMINOETHYL THIOPHOSPHATE
    SAPEP
    WR-1065
    AMIFOSTINE ETHIOFOS
    AMIFOSTINUM
    APAETP
    AMIFOSTINA
    chemidplus:20537-88-6
    rxcui:1545987
    drugbank:01143
    chembl:CHEMBL1006
    pubchem.compound:2141

    Drug Info:

    Year of Approval 1995
    Drug Class radiation-protective agents
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications radiation-protective agent
    (1 More Sources)

    Publications:

    Plasswilm et al., Microvessel density and endothelial cell proliferation after amifostine (Ethyol) administration in vivo., Anticancer Res.
    Buschini et al., 2000, Amifostine (WR-2721) selective protection against melphalan genotoxicity., Leukemia
    Santini et al., 1999, The potential of amifostine: from cytoprotectant to therapeutic agent., Haematologica
    Capizzi, 1999, The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine., Semin. Oncol.
    Orditura et al., Amifostine: A selective cytoprotective agent of normal tissues from chemo-radiotherapy induced toxicity (Review)., Oncol. Rep.
    Liu et al., 1997, Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine., Carcinogenesis
    Vujaskovic et al., 2002, Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity., Radiat. Res.
    Segreto et al., 2002, Amifostine does not prevent activation of TGFbeta1 but induces smad 7 activation in megakaryocytes irradiated in vivo., Am. J. Hematol.
    Stankiewicz et al., 2002, Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats., Drug Metabol Drug Interact
  • AMIFOSTINE   ALPG

    Interaction Score: 3.76

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name amifostine,Ethyol

    PMIDs:
    10628381 10995012 10553165 10348255 10523712


    Sources:
    TdgClinicalTrial TEND

  • AMIFOSTINE   SMAD2

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12410567


    Sources:
    NCI

  • AMIFOSTINE   GSR

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12751907


    Sources:
    NCI

  • AMIFOSTINE   TGFB1

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12005544


    Sources:
    NCI

  • AMIFOSTINE   MYC

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9450496


    Sources:
    NCI

  • TEND: AMIFOSTINE

    • Version: 01-August-2011

    Alternate Names:
    AMIFOSTINE Primary Drug Name

    Drug Info:
    Drug Class radiation-protective agents
    Year of Approval 1995

    Publications:

  • TdgClinicalTrial: AMIFOSTINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications radiation-protective agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: AMIFOSTINE

    • Version: 14-September-2017

    Alternate Names:
    C488 NCI drug code

    Drug Info:

    Publications:
    Liu et al., 1997, Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine., Carcinogenesis
    Vujaskovic et al., 2002, Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity., Radiat. Res.
    Stankiewicz et al., 2002, Effects of amifostine on liver oxidative stress caused by cyclophosphamide administration to rats., Drug Metabol Drug Interact

  • TTD: Amifostine

    • Version: 2020.06.01

    Alternate Names:
    D06CIE TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1006

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21