• Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22137933


    Sources:
    DTC

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator
    ligand

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Specific Binding Site for Interaction benzodiazepine site

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND TTD

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name alprazolam,Xanax, Xanax XR

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name AZ-002, Staccato alprazolam
    Novel drug target Established target
    Trial Name alprazolam,Xanax, Xanax XR

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name AZ-002, Staccato alprazolam

  • Interaction Score: 0.09

    Interaction Types & Directionality:
    positive modulator (activating)
    allosteric modulator

    Interaction Info:
    Trial Name AZ-002, Staccato alprazolam
    Novel drug target Established target
    Trial Name alprazolam,Xanax, Xanax XR

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    allosteric modulator
    positive modulator (activating)

    Interaction Info:
    Specific Binding Site for Interaction benzodiazepine site
    Specific Action of the Ligand Positive
    Endogenous Drug? False

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name alprazolam,Xanax, Xanax XR

    PMIDs:
    None found


  • Interaction Score: 0.08

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Trial Name alprazolam,Xanax, Xanax XR
    Novel drug target Established target
    Trial Name AZ-002, Staccato alprazolam

    PMIDs:
    None found


  • Interaction Score: 0.07

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes
    Trial Name alprazolam,Xanax, Xanax XR

    PMIDs:
    None found


  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12218154


    Sources:
    NCI

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AZ-002, Staccato alprazolam
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32112986


    Sources:
    PharmGKB