DGIdb - ADENOSINE PHOSPHATE Drug Record

ADENOSINE PHOSPHATE chembl:CHEMBL752

Alternate Names:

5'-ADENYLIC ACID
ADENOSINE PHOSPHATE
A-5MP
MY-B-DEN
ADENYL
NSC-20264
ADENOSINE MONOPHOSPHATE
VITAMIN B8
ADENOVITE
ADENYLATE
[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL]METHOXYPHOSPHONIC ACID
PHOSPHATE D'ADENOSINE
ADENOSINE 5'-(DIHYDROGEN PHOSPHATE)
ADENOSINE 5'-PHOSPHATE
ADENOSINI PHOSPHAS
PHOSPHADEN
ADENOSINE-5'P
ADENOSINE-5'-MONOPHOSPHORATE
5'-AMP
ADENOSINE-5'-MONOPHOSPHORIC ACID
{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYOXOLAN-2-YL]METHOXY}PHOSPHONIC ACID
ADENOSINE 5'-PHOSPHORATE
ADO5'P
5'-O-PHOSPHONOADENOSINE
ADENOSINE-5'-MONOPHOSPHATE
PHOSADEN
LYCEDAN
ADENOSINE-PHOSPHATE
[(2R,3R,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXYPHOSPHONIC ACID
CARDIOMONE
ADENYLIC ACID
ADENOSINE-5-MONOPHOSPHORATE
PA
ADENOSINE-5-MONOPHOSPHORIC ACID
5'-ADENYLATE
MUSCLE ADENYLATE
ADENOSINE-MONOPHOSPHATE
5'-ADENOSINE MONOPHOSPHATE
MY-BETA-DEN
ADENOSINE 5'-PHOSPHORIC ACID
ADENOSINE 5'-MONOPHOSPHATE
FOSFATO DE ADENOSINA
PHOSPHENTASIDE
MUSCLE ADENYLIC ACID
AMP
PADO
pubchem.compound:6083
drugbank:00131
rxcui:309
chemidplus:61-19-8
chembl:CHEMBL752

Drug Info:

Drug Categories	adenine nucleotides
Drug Groups	investigational
Drug Categories	heterocyclic compounds, fused-ring

(0 More Sources)

Publications:

Perlis et al., 2007, Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder., Biol. Psychiatry
Saha et al., 2006, Activation of the Mitf promoter by lipid-stimulated activation of p38-stress signalling to CREB., Pigment Cell Res.
Kozinn et al., 2006, Inhibition of glutamatergic activation of extracellular signal-regulated protein kinases in hippocampal neurons by the intravenous anesthetic propofol., Anesthesiology
Brenhouse et al., 2007, Differential activation of cAMP response element binding protein in discrete nucleus accumbens subregions during early and late cocaine sensitization., Behav. Neurosci.
Ulfhammer et al., 2006, TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB- and p38 MAPK-dependent., J. Thromb. Haemost.
Neurath et al., 2006, AMP-dependent protein kinase alpha 2 isoform promotes hypoxia-induced VEGF expression in human glioblastoma., Glia
Ruderman et al., 2006, Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A., Obesity (Silver Spring)
McGee et al., 2006, Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms., Clin. Exp. Pharmacol. Physiol.
Whitehead et al., 2006, Adiponectin--a key adipokine in the metabolic syndrome., Diabetes Obes Metab
Richter et al., 2006, [5'-adenosine monophosphate-activated protein kinase and lifestyle-mediated diseases]., Ugeskr. Laeg.
Park et al., 2008, Adenosine kinase and ribokinase--the RK family of proteins., Cell. Mol. Life Sci.
Leoncini et al., 2006, Adenosine kinase from rat liver: new biochemical properties., Nucleosides Nucleotides Nucleic Acids
Reger et al., 2007, Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase., Biochemistry
Ingram-Smith et al., 2007, AMP-forming acetyl-CoA synthetases in Archaea show unexpected diversity in substrate utilization., Archaea
Linne et al., 2007, Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains., FEBS Lett.
Ingram-Smith et al., 2006, Characterization of the acyl substrate binding pocket of acetyl-CoA synthetase., Biochemistry
Terrin et al., 2006, PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases., J. Cell Biol.
Porteous et al., 2006, The genetics and biology of DISC1--an emerging role in psychosis and cognition., Biol. Psychiatry
Siuciak et al., 2007, Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme., Psychopharmacology (Berl.)
Nicol et al., 2006, Role of the calcium modulated cyclases in the development of the retinal projections., Eur. J. Neurosci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Yang et al., 2006, Reduced sinoatrial cAMP content plays a role in postnatal heart rate slowing in the rabbit., Clin. Exp. Pharmacol. Physiol.
Oikonomakos NG et al., 2005, Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs., Protein Sci
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Chou et al., Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins., Mol. Pharm.
Chou et al., 2007, Lysyl-tRNA synthetase-generated lysyl-adenylate is a substrate for histidine triad nucleotide binding proteins., J. Biol. Chem.
Chou et al., 2007, Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate., J. Biol. Chem.
Xue et al., 1994, Crystal structure of fructose-1,6-bisphosphatase complexed with fructose 2,6-bisphosphate, AMP, and Zn2+ at 2.0-A resolution: aspects of synergism between inhibitors., Proc. Natl. Acad. Sci. U.S.A.
Hebeisen et al., 2008, Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites., Bioorg. Med. Chem. Lett.
Marín-Aguilar F et al., 2017, Adenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds., Int J Mol Sci
Mayes et al., 2007, Adenosine 5'-monophosphate kinase-activated protein kinase (PRKA) activators delay meiotic resumption in porcine oocytes., Biol. Reprod.

ADENOSINE PHOSPHATE ACSL1

Interaction Score: 7.1

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
17350930 16981708

Sources:
DrugBank
ADENOSINE PHOSPHATE HINT1

Interaction Score: 4.73

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
17217311 17158446 17337452

Sources:
DrugBank
ADENOSINE PHOSPHATE PRKAB1

Interaction Score: 4.73

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
16518831 16642960 16620308 16634986 16513051

Sources:
DrugBank
ADENOSINE PHOSPHATE CREB1

Interaction Score: 4.73

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
17300755 17083486 17122581 17324065 16879221

Sources:
DrugBank
ADENOSINE PHOSPHATE ADCY1

Interaction Score: 3.79

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
17229090 11752352 16895552

Sources:
DrugBank
ADENOSINE PHOSPHATE ACSS2

Interaction Score: 2.96

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
17497934 17350930 17303131 16981708

Sources:
DrugBank
ADENOSINE PHOSPHATE FBP1

Interaction Score: 1.58

Interaction Types & Directionality:

inhibitory allosteric modulator (inhibitory)

antagonist (inhibitory)

Interaction Info:

PMIDs:
7809062 18650089

Sources:
DrugBank
ADENOSINE PHOSPHATE ADK

Interaction Score: 1.58

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
18560757 17065073

Sources:
DrugBank
ADENOSINE PHOSPHATE PYGL

Interaction Score: 1.35

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
15987904 17139284 17016423

Sources:
DrugBank
ADENOSINE PHOSPHATE PRKAA1

Interaction Score: 0.49

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
28146060 17167165

Sources:
DrugBank
ADENOSINE PHOSPHATE PDE4B

Interaction Score: 0.42

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
16843095 17333137 17088426

Sources:
DrugBank
ADENOSINE PHOSPHATE PDE4D

Interaction Score: 0.22

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
17088426

Sources:
DrugBank

DrugBank: DB00131

Version: 5.1.7

Alternate Names:

ADENOSINE PHOSPHATE DrugBank Drug Name

61-19-8 CAS Number

My-B-Den Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Kostylina et al., 2008, Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A)., Cell Death Differ.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

ChemblDrugs: chembl:CHEMBL752
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

ADENOSINE PHOSPHATE	DrugBank Drug Name
61-19-8	CAS Number
My-B-Den	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

inhibitory allosteric modulator (inhibitory)
antagonist (inhibitory)

ADENOSINE PHOSPHATE Drug Record

ADENOSINE PHOSPHATE chembl:CHEMBL752

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 17350930 16981708

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 17217311 17158446 17337452

Sources: DrugBank

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 16518831 16642960 16620308 16634986 16513051

Sources: DrugBank

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 17300755 17083486 17122581 17324065 16879221

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 17229090 11752352 16895552

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 17497934 17350930 17303131 16981708

Sources: DrugBank

Interaction Types & Directionality: inhibitory allosteric modulator (inhibitory) antagonist (inhibitory)

Interaction Info:

PMIDs: 7809062 18650089

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 18560757 17065073

Sources: DrugBank

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 15987904 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: 28146060 17167165

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 16843095 17333137 17088426

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 17088426

Sources: DrugBank

DrugBank: DB00131

Alternate Names: ADENOSINE PHOSPHATE DrugBank Drug Name 61-19-8 CAS Number My-B-Den Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

ChemblDrugs: chembl:CHEMBL752

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

product of

PMIDs:
17350930 16981708

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
17217311 17158446 17337452

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
16518831 16642960 16620308 16634986 16513051

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
17300755 17083486 17122581 17324065 16879221

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
17229090 11752352 16895552

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
17497934 17350930 17303131 16981708

Sources:
DrugBank

Interaction Types & Directionality:

inhibitory allosteric modulator (inhibitory)

antagonist (inhibitory)

PMIDs:
7809062 18650089

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
18560757 17065073

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
15987904 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

activator (activating)

PMIDs:
28146060 17167165

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
16843095 17333137 17088426

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
17088426

Sources:
DrugBank

Alternate Names:

ADENOSINE PHOSPHATE DrugBank Drug Name

61-19-8 CAS Number

My-B-Den Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational