DGIdb - ACITRETIN Drug Record

ACITRETIN chembl:CHEMBL1131 Approved

Alternate Names:

RO 10-1670
SORIATANE
ACITRETIN
ETRETIN
NEOTIGASON
RO-101670000
ACITRETINE
ACITRETINA
ALL-TRANS-3,7-DIMETHYL-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-2,4,6,8-NONATETRAENOIC ACID
(ALL-E)-9-(4-METHOXY-2,3,6-TRIMETHYLPHENYL)-3,7-DIMETHYL-2,4,6,8-NONATETRAENOIC ACID
ACETRETIN
SORIATANE®
ACITRETINUM
chembl:CHEMBL1131
rxcui:16818
pubchem.compound:5284513
drugbank:00459
chemidplus:55079-83-9

Drug Info:

FDA Approval	1996
Drug Class	small molecule
Drug Indications	Keratolytic Agents
Year of Approval	1996
Drug Class	keratolytic agents

(4 More Sources)

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Berggren Söderlund et al., 1995, Expression of human all-trans-retinoic acid receptor beta and its ligand-binding domain in Escherichia coli., Biochem. J.
Tippmann et al., 2009, Up-regulation of the alpha-secretase ADAM10 by retinoic acid receptors and acitretin., FASEB J.
Zouboulis, Retinoids--which dermatological indications will benefit in the near future?, Skin Pharmacol. Appl. Skin Physiol.
Hettmannsperger et al., 1992, Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol., J. Invest. Dermatol.
Schmitt et al., 1987, Systemic administration of etretin increases epidermal interleukin I in the rat., Br. J. Dermatol.
Orfanos et al., 1997, Current use and future potential role of retinoids in dermatology., Drugs
Saurat, 1999, Retinoids and psoriasis: novel issues in retinoid pharmacology and implications for psoriasis treatment., J. Am. Acad. Dermatol.
Tian et al., 1997, The isolation and characterization of purified heterocomplexes of recombinant retinoic acid receptor and retinoid X receptor ligand binding domains., Biochemistry
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

ACITRETIN RXRG

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
17016423 17139284 9074840

Sources:
ChemblInteractions
ACITRETIN RXRB

Interaction Score: 1.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
17016423 17139284

Sources:
ChemblInteractions
ACITRETIN RARB

Interaction Score: 1.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
7755585 19144697 11586072

Sources:
ChemblInteractions
ACITRETIN RARG

Interaction Score: 0.97

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
10592235 17016423 17139284

Sources:
ChemblInteractions
ACITRETIN RARA

Interaction Score: 0.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
10459139 19144697 9153406 9074840

Sources:
TdgClinicalTrial ChemblInteractions TEND
ACITRETIN IL1B

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1431212 2954576

Sources:
NCI
ACITRETIN STAT3

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ACITRETIN RXRA

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
9153406 9074840

Sources:
ChemblInteractions
ACITRETIN RAPGEF4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN KAT2A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN PLK1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN USP1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ACITRETIN GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ACITRETIN
- Version: 01-August-2011
Alternate Names:

ACITRETIN Primary Drug Name

Drug Info:

Drug Class keratolytic agents

Year of Approval 1996

Publications:
TdgClinicalTrial: ACITRETIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Keratolytic Agents

Drug Class small molecule

FDA Approval 1996

Publications:

NCI: ACITRETIN

Version: 14-September-2017

Alternate Names:

C985 NCI drug code

Drug Info:

Publications:

Hettmannsperger et al., 1992, Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol., J. Invest. Dermatol.

NCI: ETRETIN
- Version: 14-September-2017
Alternate Names:

C985 NCI drug code

Drug Info:

Publications:

Schmitt et al., 1987, Systemic administration of etretin increases epidermal interleukin I in the rat., Br. J. Dermatol.
TTD: Acitretin
- Version: 2020.06.01
Alternate Names:

D05QDC TTD Drug ID

Drug Info:

Publications:
DTC: ACITRETIN
- Version: 02-September-2020
Alternate Names:

CHEMBL1131 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1131
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1131
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Retinoid receptor agonist
Direct Interaction	yes

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Retinoid receptor agonist

ACITRETIN Drug Record

ACITRETIN chembl:CHEMBL1131 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 17016423 17139284 9074840

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor agonist

PMIDs: 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Retinoid receptor agonist

PMIDs: 7755585 19144697 11586072

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 10592235 17016423 17139284

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Retinoid receptor agonist

PMIDs: 10459139 19144697 9153406 9074840

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1431212 2954576

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoid receptor agonist Direct Interaction yes

PMIDs: 9153406 9074840

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: ACITRETIN

Alternate Names: ACITRETIN Primary Drug Name

Drug Info: Drug Class keratolytic agents Year of Approval 1996

Publications:

TdgClinicalTrial: ACITRETIN

Alternate Names:

Drug Info: Drug Indications Keratolytic Agents Drug Class small molecule FDA Approval 1996

Publications:

NCI: ACITRETIN

Alternate Names: C985 NCI drug code

Drug Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
17016423 17139284 9074840

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
7755585 19144697 11586072

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
10592235 17016423 17139284

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Retinoid receptor agonist

PMIDs:
10459139 19144697 9153406 9074840

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
1431212 2954576

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoid receptor agonist

Direct Interaction yes

PMIDs:
9153406 9074840

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ACITRETIN Primary Drug Name

Drug Info:

Drug Class keratolytic agents

Year of Approval 1996

Drug Info:

Drug Indications Keratolytic Agents

Drug Class small molecule

FDA Approval 1996

Alternate Names:

C985 NCI drug code

Publications:

Hettmannsperger et al., 1992, Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol., J. Invest. Dermatol.

Alternate Names:

C985 NCI drug code

Publications:

Schmitt et al., 1987, Systemic administration of etretin increases epidermal interleukin I in the rat., Br. J. Dermatol.

Alternate Names:

D05QDC TTD Drug ID

Alternate Names:

CHEMBL1131 ChEMBL Drug ID