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ACETAZOLAMIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • ACETAZOLAMIDE chembl:CHEMBL20 Approved

    Alternate Names:

    ACETAZOLAMIDE
    EYTAZOX
    L 579486
    DIAMOX
    NSC-145177
    DIAMOX SR
    ACETAZOLAMIDA
    5-ACETYLAMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
    ACETAZOLAMID
    ACETAZOLAMIDE 250MG
    ACÉTAZOLAMIDE
    2-ACETYLAMINO-1,3,4-THIADIAZOLE-5-SULFONAMIDE
    N-[5-(AMINOSULFONYL)-1,3,5-THIADIAZOL-2-YL]ACETAMIDE
    ACETAZOLAMIDUM
    N-[5-(AMINOSULFONYL)-1,3,4-THIADIAZOL-2-YL]ACETAMIDE
    5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
    DIAMOX®
    pubchem.compound:1986
    chemidplus:59-66-5
    chembl:CHEMBL20
    rxcui:167
    drugbank:00819

    Drug Info:

    Year of Approval 1953
    Drug Class antiglaucomic agent
    Drug Class diuretics
    Drug Class anticonvulsants
    FDA Approval 1953
    Drug Class small molecule
    Drug Indications antiglaucomic agent
    Drug Indications Diuretics
    Drug Indications Anticonvulsants
    (4 More Sources)

    Publications:

    Avvaru et al., 2010, Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors., Bioorg. Med. Chem. Lett.
    Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
    Tuettenberg et al., 2001, Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study., Neurosci. Lett.
    Puscas et al., 1996, Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action., J. Pharmacol. Exp. Ther.
    Meierkord et al., 2000, Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition., Naunyn Schmiedebergs Arch. Pharmacol.
    Puscas et al., 2001, Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action., Int J Clin Pharmacol Ther
    Perez Velazquez, 2003, Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity., Eur. J. Neurosci.
    Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
    Xiang et al., 2004, Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis., Acta Pharmacol. Sin.
    Mu et al., 2003, [Differential protein analysis in rat renal proximal tubule epithelial cells in response to acetazolamide and its relation with the inhibition of AQP1]., Yao Xue Xue Bao
    Oshio et al., 2003, Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production., Acta Neurochir. Suppl.
    Ma et al., 2004, Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte., Acta Pharmacol. Sin.
    Xiang et al., 2002, Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma., Acta Pharmacol. Sin.
    Her Y et al., 2011, Stevens-Johnson syndrome induced by acetazolamide., J Dermatol
    LoGrasso et al., 1991, Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine., Biochemistry
    Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem
  • ACETAZOLAMIDE   AQP1

    Interaction Score: 11.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15169637 12830709 14753499 14704128 12147198


    Sources:
    NCI

  • ACETAZOLAMIDE   CA3

    Interaction Score: 5.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    1909176 20605094


    Sources:
    NCI

  • ACETAZOLAMIDE   CA1

    Interaction Score: 3.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Carbonic anhydrase I inhibitor

    PMIDs:
    8667211 10651143 18336310 11430635 12956733 10713865


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ACETAZOLAMIDE   MMP12

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • ACETAZOLAMIDE   CA12

    Interaction Score: 1.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Carbonic anhydrase XII inhibitor

    PMIDs:
    18336310


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ACETAZOLAMIDE   AQP4

    Interaction Score: 1.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18572411


    Sources:
    DTC

  • ACETAZOLAMIDE   CA2

    Interaction Score: 1.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction Carbonic anhydrase II inhibitor

    PMIDs:
    20605094 18336310


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ACETAZOLAMIDE   CA4

    Interaction Score: 1.2

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Carbonic anhydrase IV inhibitor
    Direct Interaction yes

    PMIDs:
    20605094 18336310


    Sources:
    ChemblInteractions

  • ACETAZOLAMIDE   MMP2

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24074025


    Sources:
    DTC

  • ACETAZOLAMIDE   HLA-B

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21342230


    Sources:
    PharmGKB

  • ACETAZOLAMIDE   NOS1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11711216


    Sources:
    NCI

  • TEND: ACETAZOLAMIDE

    • Version: 01-August-2011

    Alternate Names:
    ACETAZOLAMIDE Primary Drug Name

    Drug Info:
    Drug Class anticonvulsants
    Drug Class diuretics
    Drug Class antiglaucomic agent

    Publications:

  • TdgClinicalTrial: ACETAZOLAMIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Anticonvulsants
    Drug Indications Diuretics
    Drug Indications antiglaucomic agent

    Publications:

  • NCI: ACETAZOLAMIDE

    • Version: 14-September-2017

    Alternate Names:
    C28809 NCI drug code

    Drug Info:

    Publications:
    Xiang et al., 2002, Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma., Acta Pharmacol. Sin.
    LoGrasso et al., 1991, Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine., Biochemistry
    Tuettenberg et al., 2001, Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study., Neurosci. Lett.

  • DTC: ACETAZOLAMIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL20 ChEMBL Drug ID

    Drug Info:

    Publications:
    Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
    Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

  • PharmGKB: acetazolamide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Her Y et al., 2011, Stevens-Johnson syndrome induced by acetazolamide., J Dermatol

  • TTD: Acetazolamide

    • Version: 2020.06.01

    Alternate Names:
    D0E1SW TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL20

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL20

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21