DGIdb - ACETAZOLAMIDE Drug Record

ACETAZOLAMIDE chembl:CHEMBL20 Approved

Alternate Names:

ACETAZOLAMIDE
EYTAZOX
L 579486
DIAMOX
NSC-145177
DIAMOX SR
ACETAZOLAMIDA
5-ACETYLAMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
ACETAZOLAMID
ACETAZOLAMIDE 250MG
ACÉTAZOLAMIDE
2-ACETYLAMINO-1,3,4-THIADIAZOLE-5-SULFONAMIDE
N-[5-(AMINOSULFONYL)-1,3,5-THIADIAZOL-2-YL]ACETAMIDE
ACETAZOLAMIDUM
N-[5-(AMINOSULFONYL)-1,3,4-THIADIAZOL-2-YL]ACETAMIDE
5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
DIAMOX®
pubchem.compound:1986
chemidplus:59-66-5
chembl:CHEMBL20
rxcui:167
drugbank:00819

Drug Info:

Year of Approval	1953
Drug Class	antiglaucomic agent
Drug Class	diuretics
Drug Class	anticonvulsants
FDA Approval	1953
Drug Class	small molecule
Drug Indications	antiglaucomic agent
Drug Indications	Diuretics
Drug Indications	Anticonvulsants

(4 More Sources)

Publications:

Avvaru et al., 2010, Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors., Bioorg. Med. Chem. Lett.
Mincione et al., 2008, The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents., Curr. Pharm. Des.
Tuettenberg et al., 2001, Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study., Neurosci. Lett.
Puscas et al., 1996, Nonsteroidal anti-inflammatory drugs activate carbonic anhydrase by a direct mechanism of action., J. Pharmacol. Exp. Ther.
Meierkord et al., 2000, Sodium bromide: effects on different patterns of epileptiform activity, extracellular pH changes and GABAergic inhibition., Naunyn Schmiedebergs Arch. Pharmacol.
Puscas et al., 2001, Indomethacin activates carbonic anhydrase and antagonizes the effect of the specific carbonic anhydrase inhibitor acetazolamide, by a direct mechanism of action., Int J Clin Pharmacol Ther
Perez Velazquez, 2003, Bicarbonate-dependent depolarizing potentials in pyramidal cells and interneurons during epileptiform activity., Eur. J. Neurosci.
Puscas et al., 1999, Vasodilatory effect of diuretics is dependent on inhibition of vascular smooth muscle carbonic anhydrase by a direct mechanism of action., Drugs Exp Clin Res
Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem
Xiang et al., 2004, Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis., Acta Pharmacol. Sin.
Mu et al., 2003, [Differential protein analysis in rat renal proximal tubule epithelial cells in response to acetazolamide and its relation with the inhibition of AQP1]., Yao Xue Xue Bao
Oshio et al., 2003, Aquaporin-1 deletion reduces osmotic water permeability and cerebrospinal fluid production., Acta Neurochir. Suppl.
Ma et al., 2004, Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte., Acta Pharmacol. Sin.
Xiang et al., 2002, Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma., Acta Pharmacol. Sin.
Her Y et al., 2011, Stevens-Johnson syndrome induced by acetazolamide., J Dermatol
LoGrasso et al., 1991, Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine., Biochemistry
Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

ACETAZOLAMIDE AQP1

Interaction Score: 11.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15169637 12830709 14753499 14704128 12147198

Sources:
NCI
ACETAZOLAMIDE CA3

Interaction Score: 5.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
1909176 20605094

Sources:
NCI
ACETAZOLAMIDE CA1

Interaction Score: 3.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase I inhibitor

PMIDs:
8667211 10651143 18336310 11430635 12956733 10713865

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ACETAZOLAMIDE MMP12

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
ACETAZOLAMIDE CA12

Interaction Score: 1.87

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase XII inhibitor

PMIDs:
18336310

Sources:
TdgClinicalTrial ChemblInteractions TEND
ACETAZOLAMIDE AQP4

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18572411

Sources:
DTC
ACETAZOLAMIDE CA2

Interaction Score: 1.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Carbonic anhydrase II inhibitor

PMIDs:
20605094 18336310

Sources:
TdgClinicalTrial ChemblInteractions TEND
ACETAZOLAMIDE CA4

Interaction Score: 1.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase IV inhibitor

Direct Interaction yes

PMIDs:
20605094 18336310

Sources:
ChemblInteractions
ACETAZOLAMIDE MMP2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24074025

Sources:
DTC
ACETAZOLAMIDE HLA-B

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21342230

Sources:
PharmGKB
ACETAZOLAMIDE NOS1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11711216

Sources:
NCI

TEND: ACETAZOLAMIDE
- Version: 01-August-2011
Alternate Names:

ACETAZOLAMIDE Primary Drug Name

Drug Info:

Drug Class anticonvulsants

Drug Class diuretics

Drug Class antiglaucomic agent

Publications:
TdgClinicalTrial: ACETAZOLAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Diuretics

Drug Indications antiglaucomic agent

Publications:

NCI: ACETAZOLAMIDE

Version: 14-September-2017

Alternate Names:

C28809 NCI drug code

Drug Info:

Publications:

Xiang et al., 2002, Acetazolamide suppresses tumor metastasis and related protein expression in mice bearing Lewis lung carcinoma., Acta Pharmacol. Sin.

LoGrasso et al., 1991, Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine., Biochemistry

Tuettenberg et al., 2001, Nitric oxide modulates cerebral blood flow stimulation by acetazolamide in the rat cortex: a laser Doppler scanning study., Neurosci. Lett.

DTC: ACETAZOLAMIDE

Version: 02-September-2020

Alternate Names:

CHEMBL20 ChEMBL Drug ID

Drug Info:

Publications:

Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

PharmGKB: acetazolamide
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Her Y et al., 2011, Stevens-Johnson syndrome induced by acetazolamide., J Dermatol
TTD: Acetazolamide
- Version: 2020.06.01
Alternate Names:

D0E1SW TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL20
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL20
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Carbonic anhydrase I inhibitor

Mechanism of Interaction	Carbonic anhydrase IV inhibitor
Direct Interaction	yes

ACETAZOLAMIDE Drug Record

ACETAZOLAMIDE chembl:CHEMBL20 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15169637 12830709 14753499 14704128 12147198

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 1909176 20605094

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Carbonic anhydrase I inhibitor

PMIDs: 8667211 10651143 18336310 11430635 12956733 10713865

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Carbonic anhydrase XII inhibitor

PMIDs: 18336310

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18572411

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Carbonic anhydrase II inhibitor

PMIDs: 20605094 18336310

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Carbonic anhydrase IV inhibitor Direct Interaction yes

PMIDs: 20605094 18336310

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24074025

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21342230

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11711216

Sources: NCI

TEND: ACETAZOLAMIDE

Alternate Names: ACETAZOLAMIDE Primary Drug Name

Drug Info: Drug Class anticonvulsants Drug Class diuretics Drug Class antiglaucomic agent

Publications:

TdgClinicalTrial: ACETAZOLAMIDE

Alternate Names:

Drug Info: Drug Indications Anticonvulsants Drug Indications Diuretics Drug Indications antiglaucomic agent

Publications:

NCI: ACETAZOLAMIDE

Alternate Names: C28809 NCI drug code

Drug Info:

DTC: ACETAZOLAMIDE

Alternate Names: CHEMBL20 ChEMBL Drug ID

Drug Info:

Publications: Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

PharmGKB: acetazolamide

Alternate Names:

Drug Info:

Publications: Her Y et al., 2011, Stevens-Johnson syndrome induced by acetazolamide., J Dermatol

TTD: Acetazolamide

Alternate Names: D0E1SW TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL20

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL20

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15169637 12830709 14753499 14704128 12147198

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
1909176 20605094

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase I inhibitor

PMIDs:
8667211 10651143 18336310 11430635 12956733 10713865

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Carbonic anhydrase XII inhibitor

PMIDs:
18336310

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
18572411

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Carbonic anhydrase II inhibitor

PMIDs:
20605094 18336310

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Carbonic anhydrase IV inhibitor

Direct Interaction yes

PMIDs:
20605094 18336310

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24074025

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21342230

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11711216

Sources:
NCI

Alternate Names:

ACETAZOLAMIDE Primary Drug Name

Drug Info:

Drug Class anticonvulsants

Drug Class diuretics

Drug Class antiglaucomic agent

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Diuretics

Drug Indications antiglaucomic agent

Alternate Names:

C28809 NCI drug code

Alternate Names:

CHEMBL20 ChEMBL Drug ID

Publications:

Day JA et al., 2013, Investigating the selectivity of metalloenzyme inhibitors., J Med Chem

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

Publications:

Her Y et al., 2011, Stevens-Johnson syndrome induced by acetazolamide., J Dermatol

Alternate Names:

D0E1SW TTD Drug ID