DGIdb - ACEBUTOLOL Drug Record

ACEBUTOLOL chembl:CHEMBL642 Approved

Alternate Names:

C07AB04
SECTRAL
ACEBUTOLOL
SECTRAL®
3'-ACETYL-4'-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)BUTYRANILIDE
N-(3-ACETYL-4-[2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY]PHENYL)BUTANAMIDE
(+-)-ACEBUTOLOL
ACETOBUTOLOL
IL-17803A
(±)-ACEBUTOLOL
N-[3-ACETYL-4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]BUTANAMIDE
5'-BUTYRAMIDO-2'-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)ACETOPHENONE
ACEBUTOLOLUM
rxcui:149
chemidplus:37517-30-9
drugbank:01193
pubchem.compound:1978
chembl:CHEMBL642

Drug Info:

Drug Categories	propanolamines
Drug Categories	beta-blockers (beta1 selective)
Drug Class	antihypertensive agents
Year of Approval	1984
FDA Approval	1984
Drug Class	small molecule
Drug Indications	Antihypertensive Agents
Drug Groups	investigational
Drug Categories	agents causing hyperkalemia
Drug Categories	antiarrhythmic agents
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	beta blocking agents, selective
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	moderate risk qtc-prolonging agents
Drug Categories	p-glycoprotein substrates
Drug Categories	qtc prolonging agents

(5 More Sources)

Publications:

Abrahamsson, 1989, Characterization of the beta 1-adrenoceptor stimulatory effects of the partial beta 1-agonists acebutolol, xamoterol, H142/08 and H201/70., Eur. J. Pharmacol.
Fraysse et al., 2005, Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia., Environ. Toxicol. Chem.
van den Meiracker et al., 1988, Acute and long-term effects of acebutolol on systemic and renal hemodynamics, body fluid volumes, catecholamines, active renin, aldosterone, and lymphocyte beta-adrenoceptor density., J. Cardiovasc. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Lima, Relationship between beta adrenoceptor occupancy and receptor down-regulation induced by beta antagonists with intrinsic sympathomimetic activity., J. Recept. Signal Transduct. Res.
Varma et al., 1999, Inverse agonist activities of beta-adrenoceptor antagonists in rat myocardium., Br. J. Pharmacol.
Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

ACEBUTOLOL TG

Interaction Score: 2.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2878948

Sources:
NCI
ACEBUTOLOL ADRB1

Interaction Score: 1.8

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
2568935 16268148 2453744 11752352 2903243

Sources:
DTC DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD
ACEBUTOLOL ADRB2

Interaction Score: 0.46

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
8968966 16268148 10433496

Sources:
DrugBank

DrugBank: DB01193

Version: 5.1.7

Alternate Names:

37517-30-9 CAS Number

Acebutolol - 400 Drug Brand

Acebutolol Hydrochloride Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

van den Meiracker et al., 1988, Acute and long-term effects of acebutolol on systemic and renal hemodynamics, body fluid volumes, catecholamines, active renin, aldosterone, and lymphocyte beta-adrenoceptor density., J. Cardiovasc. Pharmacol.

Abrahamsson, 1989, Characterization of the beta 1-adrenoceptor stimulatory effects of the partial beta 1-agonists acebutolol, xamoterol, H142/08 and H201/70., Eur. J. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TdgClinicalTrial: ACEBUTOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1984

Publications:
TEND: ACEBUTOLOL
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1984

Drug Class antihypertensive agents

Publications:
DTC: ACEBUTOLOL
- Version: 02-September-2020
Alternate Names:

CHEMBL642 ChEMBL Drug ID

Drug Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
NCI: ACEBUTOLOL
- Version: 14-September-2017
Alternate Names:

C28806 NCI drug code

Drug Info:

Publications:

Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.
TTD: Acebutolol
- Version: 2020.06.01
Alternate Names:

D0HD9K TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL642
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 178103684
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:
PharmGKB: acebutolol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Antagonist

37517-30-9	CAS Number
Acebutolol - 400	Drug Brand
Acebutolol Hydrochloride	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

partial agonist (activating)
antagonist (inhibitory)

ACEBUTOLOL Drug Record

ACEBUTOLOL chembl:CHEMBL642 Approved

Alternate Names:

Drug Info:

Publications:

ACEBUTOLOL TG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2878948

Sources: NCI

ACEBUTOLOL ADRB1

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Antagonist

PMIDs: 2568935 16268148 2453744 11752352 2903243

Sources: DTC DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

ACEBUTOLOL ADRB2

Interaction Types & Directionality: partial agonist (activating)

Interaction Info:

PMIDs: 8968966 16268148 10433496

Sources: DrugBank

DrugBank: DB01193

Alternate Names: 37517-30-9 CAS Number Acebutolol - 400 Drug Brand Acebutolol Hydrochloride Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TdgClinicalTrial: ACEBUTOLOL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Class small molecule FDA Approval 1984

Publications:

TEND: ACEBUTOLOL

Alternate Names:

Drug Info: Year of Approval 1984 Drug Class antihypertensive agents

Publications:

DTC: ACEBUTOLOL

Alternate Names: CHEMBL642 ChEMBL Drug ID

Drug Info:

Publications: el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

NCI: ACEBUTOLOL

Alternate Names: C28806 NCI drug code

Drug Info:

Publications: Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

TTD: Acebutolol

Alternate Names: D0HD9K TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL642

Alternate Names:

Drug Info:

Publications:

GuideToPharmacology: 178103684

Alternate Names:

Drug Info:

Publications:

PharmGKB: acebutolol

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
2878948

Sources:
NCI

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Antagonist

PMIDs:
2568935 16268148 2453744 11752352 2903243

Sources:
DTC DrugBank TdgClinicalTrial TEND GuideToPharmacology PharmGKB TTD

Interaction Types & Directionality:

partial agonist (activating)

PMIDs:
8968966 16268148 10433496

Sources:
DrugBank

Alternate Names:

37517-30-9 CAS Number

Acebutolol - 400 Drug Brand

Acebutolol Hydrochloride Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1984

Drug Info:

Year of Approval 1984

Drug Class antihypertensive agents

Alternate Names:

CHEMBL642 ChEMBL Drug ID

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Alternate Names:

C28806 NCI drug code

Publications:

Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

Alternate Names:

D0HD9K TTD Drug ID