DGIdb - ACEBUTOLOL Drug Record

ACEBUTOLOL chembl:CHEMBL642 Approved

Alternate Names:

C07AB04
SECTRAL
ACEBUTOLOL
SECTRAL®
3'-ACETYL-4'-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)BUTYRANILIDE
N-(3-ACETYL-4-[2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY]PHENYL)BUTANAMIDE
(+-)-ACEBUTOLOL
ACETOBUTOLOL
IL-17803A
(±)-ACEBUTOLOL
N-[3-ACETYL-4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]BUTANAMIDE
5'-BUTYRAMIDO-2'-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)ACETOPHENONE
ACEBUTOLOLUM
rxcui:149
chemidplus:37517-30-9
drugbank:01193
pubchem.compound:1978
chembl:CHEMBL642

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	1984
FDA Approval	1984
Drug Class	small molecule
Drug Indications	Antihypertensive Agents

(3 More Sources)

Publications:

Abrahamsson, 1989, Characterization of the beta 1-adrenoceptor stimulatory effects of the partial beta 1-agonists acebutolol, xamoterol, H142/08 and H201/70., Eur. J. Pharmacol.
Fraysse et al., 2005, Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia., Environ. Toxicol. Chem.
van den Meiracker et al., 1988, Acute and long-term effects of acebutolol on systemic and renal hemodynamics, body fluid volumes, catecholamines, active renin, aldosterone, and lymphocyte beta-adrenoceptor density., J. Cardiovasc. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

ACEBUTOLOL ADRB1

Interaction Score: 3.72

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2568935 16268148 2453744 11752352 2903243

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD
ACEBUTOLOL TG

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2878948

Sources:
NCI

TdgClinicalTrial: ACEBUTOLOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1984

Publications:
TEND: ACEBUTOLOL
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1984

Drug Class antihypertensive agents

Publications:
DTC: ACEBUTOLOL
- Version: 02-September-2020
Alternate Names:

CHEMBL642 ChEMBL Drug ID

Drug Info:

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem
NCI: ACEBUTOLOL
- Version: 14-September-2017
Alternate Names:

C28806 NCI drug code

Drug Info:

Publications:

Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.
TTD: Acebutolol
- Version: 2020.06.01
Alternate Names:

D0HD9K TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL642
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: acebutolol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

partial agonist (activating)
antagonist (inhibitory)

Trial Name	-
Novel drug target	Established target

ACEBUTOLOL Drug Record

ACEBUTOLOL chembl:CHEMBL642 Approved

Alternate Names:

Drug Info:

Publications:

ACEBUTOLOL ADRB1

Interaction Types & Directionality: partial agonist (activating) antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 2568935 16268148 2453744 11752352 2903243

Sources: DTC TdgClinicalTrial TEND PharmGKB TTD

ACEBUTOLOL TG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2878948

Sources: NCI

TdgClinicalTrial: ACEBUTOLOL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Class small molecule FDA Approval 1984

Publications:

TEND: ACEBUTOLOL

Alternate Names:

Drug Info: Year of Approval 1984 Drug Class antihypertensive agents

Publications:

DTC: ACEBUTOLOL

Alternate Names: CHEMBL642 ChEMBL Drug ID

Drug Info:

Publications: el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

NCI: ACEBUTOLOL

Alternate Names: C28806 NCI drug code

Drug Info:

Publications: Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

TTD: Acebutolol

Alternate Names: D0HD9K TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL642

Alternate Names:

Drug Info:

Publications:

PharmGKB: acebutolol

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
2568935 16268148 2453744 11752352 2903243

Sources:
DTC TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
2878948

Sources:
NCI

Drug Info:

Drug Indications Antihypertensive Agents

Drug Class small molecule

FDA Approval 1984

Drug Info:

Year of Approval 1984

Drug Class antihypertensive agents

Alternate Names:

CHEMBL642 ChEMBL Drug ID

Publications:

el Tayar N et al., 1988, Modeling of beta-adrenoceptors based on molecular electrostatic potential studies of agonists and antagonists., J Med Chem

Alternate Names:

C28806 NCI drug code

Publications:

Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

Alternate Names:

D0HD9K TTD Drug ID