DGIdb - ABEMACICLIB Drug Record

ABEMACICLIB chembl:CHEMBL3301610 ApprovedAntineoplastic

Alternate Names:

VERZENIO
ABEMACICLIB
VERZENIOS
LY-2835219
HY-16297A
LY2835219
CS-1230
LY 2835219
chembl:CHEMBL3301610
pubchem.compound:46220502
chemidplus:1231929-97-7
drugbank:12001

Drug Info:

Pharmaceutical Developer	Eli Lilly
Source Reported Drug Name(s)	LY2835219
Drug Class	CDK/Rb Inhibitor
Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational
Drug Categories	amines
Drug Categories	antineoplastic agents
Drug Categories	antineoplastic and immunomodulating agents
Drug Categories	bcrp/abcg2 inhibitors
Drug Categories	bcrp/abcg2 substrates
Drug Categories	cytochrome p-450 cyp1a2 inhibitors
Drug Categories	cytochrome p-450 cyp1a2 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2b6 inhibitors
Drug Categories	cytochrome p-450 cyp2b6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2c8 inhibitors
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2c9 inhibitors
Drug Categories	cytochrome p-450 cyp2c9 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2d6 inhibitors
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a inhibitors
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	kinase inhibitor
Drug Categories	mate 1 inhibitors
Drug Categories	mate 1 substrates
Drug Categories	mate 1 substrates with a narrow therapeutic index
Drug Categories	mate 2 inhibitors
Drug Categories	mate inhibitors
Drug Categories	mate substrates
Drug Categories	oct2 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	protein kinase inhibitors
Drug Categories	pyridines

(9 More Sources)

Publications:

Patnaik et al., 2016, Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors., Cancer Discov
von Witzleben et al., 2015, Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway., Cancer Res.
Gelbert et al., 2014, Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine., Invest New Drugs
Glover et al., 1992, Gastroenteritis outbreak at an industrial camp--British Columbia., Can. Commun. Dis. Rep.
Sherr et al., 2016, Targeting CDK4 and CDK6: From Discovery to Therapy., Cancer Discov
Xue Y et al., 2019, CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary., Nat Commun
Xue Y et al., 2019, SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer., Nat Commun

ABEMACICLIB SMARCA4

Interaction Score: 1.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30718512 30718506

Sources:
CIViC
ABEMACICLIB CCND2

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers
ABEMACICLIB CCND3

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

ABEMACICLIB CDK6

Interaction Score: 1.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction CDK6/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
24919854

Sources:
CancerCommons TTD DrugBank GuideToPharmacology ChemblInteractions

ABEMACICLIB CDK4

Interaction Score: 0.98

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction CDK4/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
24919854

Sources:
ClearityFoundationBiomarkers CancerCommons OncoKB TTD DrugBank GuideToPharmacology ChemblInteractions

ABEMACICLIB CDKN2A

Interaction Score: 0.92

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

Approval Status Phase I

PMIDs:
27217383 26183925

Sources:
ClearityFoundationBiomarkers OncoKB JAX-CKB
ABEMACICLIB CCND1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers
ABEMACICLIB KRAS

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Evidence Type Actionable

Approval Status Phase I

PMIDs:
1291017 27217383 26658964

Sources:
JAX-CKB CIViC CGI
ABEMACICLIB NRAS

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type melanoma

Response Type sensitive

Approval Status Phase I

PMIDs:
27217383

Sources:
JAX-CKB
ABEMACICLIB ERBB2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Alteration ERBB2:norm;ESR1:over

Drug family CDK4/6 inhibitor

PMIDs:
None found

Sources:
FDA PharmGKB CGI
ABEMACICLIB PGR

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ABEMACICLIB ESR1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family CDK4/6 inhibitor

Alteration ERBB2:norm;ESR1:over

PMIDs:
None found

Sources:
FDA PharmGKB CGI
ABEMACICLIB ESR2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ABEMACICLIB TP53

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family CDK4/CDK6 inhibitor

Alteration TP53:.

Indication/Tumor Type colorectal cancer

PMIDs:
27217383

Sources:
JAX-CKB CGI

DrugBank: DB12001

Version: 5.1.7

Alternate Names:

ABEMACICLIB DrugBank Drug Name

1231929-97-7 CAS Number

Verzenio Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Gelbert et al., 2014, Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine., Invest New Drugs

CancerCommons: LY2835219
- Version: 25-July-2013
Alternate Names:

LY2835219 Drug Trade Name

LY2835219 Drug Development Name

Drug Info:

Drug Class CDK/Rb Inhibitor

Source Reported Drug Name(s) LY2835219

Pharmaceutical Developer Eli Lilly

Publications:

CGI: Abemaciclib

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Glover et al., 1992, Gastroenteritis outbreak at an industrial camp--British Columbia., Can. Commun. Dis. Rep.

Sherr et al., 2016, Targeting CDK4 and CDK6: From Discovery to Therapy., Cancer Discov

JAX-CKB: Abemaciclib

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Patnaik et al., 2016, Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors., Cancer Discov

von Witzleben et al., 2015, Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway., Cancer Res.

CIViC: ABEMACICLIB

Version: 14-September-2020

Alternate Names:

Drug Info:

Publications:

Patnaik et al., 2016, Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors., Cancer Discov

Xue Y et al., 2019, CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary., Nat Commun

Xue Y et al., 2019, SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer., Nat Commun

TTD: LY2835219
- Version: 2020.06.01
Alternate Names:

D05SBO TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178103954
- Version: 29-September-2020
Alternate Names:

ABEMACICLIB GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblInteractions: CHEMBL3301610
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL3301610
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: abemaciclib
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
ClearityFoundationBiomarkers: LY2835219
- Version: 26-July-2013
Alternate Names:

Drug Info:

Publications:
OncoKB: Abemaciclib
- Version: 23-July-2020
Alternate Names:

Drug Info:

Publications:
FDA: Abemaciclib
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	CDK6/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Details of the Assay for Interaction	CDK4/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Indication/Tumor Type	non-small cell lung carcinoma
Response Type	sensitive
Approval Status	Phase I

Indication/Tumor Type	non-small cell lung carcinoma
Evidence Type	Actionable
Approval Status	Phase I

Indication/Tumor Type	melanoma
Response Type	sensitive
Approval Status	Phase I

Drug family	CDK4/CDK6 inhibitor
Alteration	TP53:.
Indication/Tumor Type	colorectal cancer

ABEMACICLIB	DrugBank Drug Name
1231929-97-7	CAS Number
Verzenio	Drug Brand

ABEMACICLIB Drug Record

ABEMACICLIB chembl:CHEMBL3301610 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30718512 30718506

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationBiomarkers

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationBiomarkers

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction CDK6/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 24919854

Sources: CancerCommons TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction CDK4/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: 24919854

Sources: ClearityFoundationBiomarkers CancerCommons OncoKB TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type non-small cell lung carcinoma Response Type sensitive Approval Status Phase I

PMIDs: 27217383 26183925

Sources: ClearityFoundationBiomarkers OncoKB JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationBiomarkers

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type non-small cell lung carcinoma Evidence Type Actionable Approval Status Phase I

PMIDs: 1291017 27217383 26658964

Sources: JAX-CKB CIViC CGI

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type melanoma Response Type sensitive Approval Status Phase I

PMIDs: 27217383

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: Alteration ERBB2:norm;ESR1:over Drug family CDK4/6 inhibitor

PMIDs: None found

Sources: FDA PharmGKB CGI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Drug family CDK4/6 inhibitor Alteration ERBB2:norm;ESR1:over

PMIDs: None found

Sources: FDA PharmGKB CGI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Drug family CDK4/CDK6 inhibitor Alteration TP53:. Indication/Tumor Type colorectal cancer

PMIDs: 27217383

Sources: JAX-CKB CGI

DrugBank: DB12001

Alternate Names: ABEMACICLIB DrugBank Drug Name 1231929-97-7 CAS Number Verzenio Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

Publications: Gelbert et al., 2014, Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine., Invest New Drugs

CancerCommons: LY2835219

Alternate Names: LY2835219 Drug Trade Name LY2835219 Drug Development Name

Drug Info: Drug Class CDK/Rb Inhibitor Source Reported Drug Name(s) LY2835219 Pharmaceutical Developer Eli Lilly

Publications:

CGI: Abemaciclib

Alternate Names:

Drug Info:

Publications: Glover et al., 1992, Gastroenteritis outbreak at an industrial camp--British Columbia., Can. Commun. Dis. Rep. Sherr et al., 2016, Targeting CDK4 and CDK6: From Discovery to Therapy., Cancer Discov

JAX-CKB: Abemaciclib

Alternate Names:

Drug Info:

CIViC: ABEMACICLIB

Alternate Names:

Drug Info:

TTD: LY2835219

Interaction Types & Directionality:

n/a

PMIDs:
30718512 30718506

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction CDK6/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
24919854

Sources:
CancerCommons TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction CDK4/cyclin D1 complex expressed in and purified from insect cells. Assays used the methanesulfonate salt of the compound.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
24919854

Sources:
ClearityFoundationBiomarkers CancerCommons OncoKB TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Response Type sensitive

Approval Status Phase I

PMIDs:
27217383 26183925

Sources:
ClearityFoundationBiomarkers OncoKB JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationBiomarkers

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type non-small cell lung carcinoma

Evidence Type Actionable

Approval Status Phase I

PMIDs:
1291017 27217383 26658964

Sources:
JAX-CKB CIViC CGI

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type melanoma

Response Type sensitive

Approval Status Phase I

PMIDs:
27217383

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

Alteration ERBB2:norm;ESR1:over

Drug family CDK4/6 inhibitor

PMIDs:
None found

Sources:
FDA PharmGKB CGI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family CDK4/6 inhibitor

Alteration ERBB2:norm;ESR1:over

PMIDs:
None found

Sources:
FDA PharmGKB CGI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family CDK4/CDK6 inhibitor

Alteration TP53:.

Indication/Tumor Type colorectal cancer

PMIDs:
27217383

Sources:
JAX-CKB CGI

Alternate Names:

ABEMACICLIB DrugBank Drug Name

1231929-97-7 CAS Number

Verzenio Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Gelbert et al., 2014, Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine., Invest New Drugs

Alternate Names:

LY2835219 Drug Trade Name

LY2835219 Drug Development Name

Drug Info:

Drug Class CDK/Rb Inhibitor

Source Reported Drug Name(s) LY2835219

Pharmaceutical Developer Eli Lilly

Publications:

Glover et al., 1992, Gastroenteritis outbreak at an industrial camp--British Columbia., Can. Commun. Dis. Rep.

Sherr et al., 2016, Targeting CDK4 and CDK6: From Discovery to Therapy., Cancer Discov

Alternate Names:

D05SBO TTD Drug ID

Alternate Names:

ABEMACICLIB GuideToPharmacology Ligand Name