DGIdb - ABCIXIMAB Drug Record

ABCIXIMAB chembl:CHEMBL1201584 Approved

Alternate Names:

ABCIXIMAB
ABCIXIMAB (GENETICAL RECOMBINATION)
C7E3
REOPRO
7E3
7E3 ANTIBODY
ANTIGPIIBIIIA
ABCIXIMAC
drugbank:00054
chembl:CHEMBL1201584
rxcui:83929
chemidplus:143653-53-6
pubchem.compound:3815015

Drug Info:

Drug Categories	proteins
Drug Categories	platelet glycoprotein gpiib-iiia complex, antagonists & inhibitors
Year of Approval	1997
Drug Class	anticoagulants
Drug Class	antiplatelet agents
FDA Approval	approved
Drug Class	monoclonal antibody
Drug Indications	anticoagulant
Drug Categories	antibodies, monoclonal
Drug Categories	antibodies, monoclonal, humanized
Drug Categories	antiplatelet agents
Drug Categories	immunoglobulin fab fragments
Drug Categories	miscellaneous therapeutic agents

(3 More Sources)

Publications:

Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
Mazzaferri et al., 2008, Abciximab: a review and update for clinicians., Expert Rev Cardiovasc Ther
Ibbotson et al., 2003, Abciximab: an updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation., Drugs
Gibbs, 2009, Point-of-care assessment of antiplatelet agents in the perioperative period: a review., Anaesth Intensive Care
Amoroso et al., 2001, Eptifibatide and abciximab exhibit equivalent antiplatelet efficacy in an experimental model of stenting in both healthy volunteers and patients with coronary artery disease., J. Cardiovasc. Pharmacol.
Hall et al., 2007, Characterization and NMR solution structure of a novel cyclic pentapeptide inhibitor of pathogenic hantaviruses., Chem Biol Drug Des
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Weber et al., 2002, Low incidence of paradoxical platelet activation by glycoprotein IIb/IIIa inhibitors., Thromb. Res.
Romagnoli et al., 2007, Rationale for intracoronary administration of abciximab., J. Thromb. Thrombolysis
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

ABCIXIMAB ITGA2B

Interaction Score: 5.16

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor

Direct Interaction yes

Trial Name abciximab, c7E3,ReoPro

PMIDs:
20938371 18510478 12749745 19499855

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
ABCIXIMAB VTN

Interaction Score: 4.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12749745 17160551

Sources:
DrugBank
ABCIXIMAB ITGB3

Interaction Score: 3.99

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor

Direct Interaction yes

Trial Name abciximab, c7E3,ReoPro

PMIDs:
20938371 18510478 11588534 12749745 17441904 11752352 12165285

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
ABCIXIMAB FGG

Interaction Score: 2.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20938371

Sources:
PharmGKB
ABCIXIMAB FCGR2B

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ABCIXIMAB FCGR2A

Interaction Score: 1.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
ABCIXIMAB FGB

Interaction Score: 1.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20938371

Sources:
PharmGKB
ABCIXIMAB FGA

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20938371

Sources:
PharmGKB
ABCIXIMAB ITGAV

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-V/beta-3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

DrugBank: DB00054

Version: 5.1.7

Alternate Names:

ABCIXIMAB DrugBank Drug Name

143653-53-6 CAS Number

Reopro Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Categories amino acids, peptides, and proteins

Publications:

Mazzaferri et al., 2008, Abciximab: a review and update for clinicians., Expert Rev Cardiovasc Ther

Ibbotson et al., 2003, Abciximab: an updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation., Drugs

Gibbs, 2009, Point-of-care assessment of antiplatelet agents in the perioperative period: a review., Anaesth Intensive Care

TEND: ABCIXIMAB
- Version: 01-August-2011
Alternate Names:

ABCIXIMAB Primary Drug Name

Drug Info:

Drug Class antiplatelet agents

Drug Class anticoagulants

Year of Approval 1997

Publications:
TdgClinicalTrial: ABCIXIMAB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anticoagulant

Drug Class monoclonal antibody

FDA Approval approved

Publications:
PharmGKB: abciximab
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
TTD: Abciximab
- Version: 2020.06.01
Alternate Names:

D0P3TX TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201584
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201584
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Integrin alpha-IIb/beta-3 inhibitor
Direct Interaction	yes
Trial Name	abciximab, c7E3,ReoPro

Mechanism of Interaction	Integrin alpha-V/beta-3 inhibitor
Direct Interaction	yes

ABCIXIMAB	DrugBank Drug Name
143653-53-6	CAS Number
Reopro	Drug Brand

Drug Type	biotech
Drug Groups	approved
Drug Categories	amino acids, peptides, and proteins

antibody (inhibitory)
antagonist (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
antagonist (inhibitory)
inhibitor (inhibitory)

ABCIXIMAB Drug Record

ABCIXIMAB chembl:CHEMBL1201584 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor Direct Interaction yes Trial Name abciximab, c7E3,ReoPro

PMIDs: 20938371 18510478 12749745 19499855

Sources: TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12749745 17160551

Sources: DrugBank

Interaction Types & Directionality: antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor Direct Interaction yes Trial Name abciximab, c7E3,ReoPro

PMIDs: 20938371 18510478 11588534 12749745 17441904 11752352 12165285

Sources: TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20938371

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20938371

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20938371

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-V/beta-3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DrugBank: DB00054

Alternate Names: ABCIXIMAB DrugBank Drug Name 143653-53-6 CAS Number Reopro Drug Brand

Drug Info: Drug Type biotech Drug Groups approved Drug Categories amino acids, peptides, and proteins

TEND: ABCIXIMAB

Alternate Names: ABCIXIMAB Primary Drug Name

Drug Info: Drug Class antiplatelet agents Drug Class anticoagulants Year of Approval 1997

Publications:

TdgClinicalTrial: ABCIXIMAB

Alternate Names:

Drug Info: Drug Indications anticoagulant Drug Class monoclonal antibody FDA Approval approved

Publications:

PharmGKB: abciximab

Alternate Names:

Drug Info:

Publications: Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics

TTD: Abciximab

Alternate Names: D0P3TX TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201584

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201584

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor

Direct Interaction yes

Trial Name abciximab, c7E3,ReoPro

PMIDs:
20938371 18510478 12749745 19499855

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
12749745 17160551

Sources:
DrugBank

Interaction Types & Directionality:

antibody (inhibitory)

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor

Direct Interaction yes

Trial Name abciximab, c7E3,ReoPro

PMIDs:
20938371 18510478 11588534 12749745 17441904 11752352 12165285

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20938371

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
20938371

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20938371

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-V/beta-3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

ABCIXIMAB DrugBank Drug Name

143653-53-6 CAS Number

Reopro Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Categories amino acids, peptides, and proteins

Alternate Names:

ABCIXIMAB Primary Drug Name

Drug Info:

Drug Class antiplatelet agents

Drug Class anticoagulants

Year of Approval 1997

Drug Info:

Drug Indications anticoagulant

Drug Class monoclonal antibody

FDA Approval approved

Publications:

Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics

Alternate Names:

D0P3TX TTD Drug ID